{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:33:08Z","timestamp":1790404388430,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.bbr.2014.02.039","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T03:02:00Z","timestamp":1394074920000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"special_numbering":"C","title":["The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats"],"prefix":"10.1016","volume":"266","author":[{"given":"Yuxin","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mali","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisi","family":"OuYang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2014.02.039_bib0005","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.stem.2010.01.004","article-title":"Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats","volume":"6","author":"Martinez-Cerdeno","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbr.2014.02.039_bib0010","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0306-4522(95)00571-4","article-title":"Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by instrastriatal 6-hydroxydopamine in the rat","volume":"72","author":"Lee","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.02.039_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneumeth.2004.10.004","article-title":"Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's disease","volume":"144","author":"Yuan","year":"2005","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2014.02.039_bib0020","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/exnr.2002.7891","article-title":"Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway","volume":"175","author":"Deumens","year":"2002","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bbr.2014.02.039_bib0025","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1523\/JNEUROSCI.15-05-03808.1995","article-title":"Effects of dopamine depletion on the morphology of medium spiny neurons in the shell and core of the rat nucleus accumbens","volume":"15","author":"Meredith","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0030","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0736-5748(93)90059-M","article-title":"Postnatal development of functional dopamine, opioid and tachykinin receptors that regulate acetylcholine release from rat neostriatal slices. Effect of 6-hydroxydopamine lesion","volume":"11","author":"Perez-Navarro","year":"1993","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0035","article-title":"Morphological diversity of GABAergic and cholinergic interneurons in the striatal dorsolateral and ventromedial regions of rats","author":"Ma","year":"2013","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.bbr.2014.02.039_bib0040","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.euroneuro.2006.04.009","article-title":"Amphetamine induced rotation in the assessment of lesions and grafts in the unilateral rat model of Parkinson's disease","volume":"17","author":"Torres","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2014.02.039_bib0045","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2006"},{"key":"10.1016\/j.bbr.2014.02.039_bib0050","doi-asserted-by":"crossref","DOI":"10.1007\/s12031-013-0208-0","article-title":"EPO-dependent activation of PI3K\/Akt\/FoxO3a signalling mediates neuroprotection in in vitro and in vivo models of Parkinson's disease","author":"Jia","year":"2014","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0055","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejphar.2008.10.005","article-title":"Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats","volume":"600","author":"Jin","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2014.02.039_bib0060","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0278-5846(98)00070-0","article-title":"Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease","volume":"22","author":"Shear","year":"1998","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.039_bib0065","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bbr.2014.02.039_bib0070","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0306-4522(95)00066-R","article-title":"Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine","volume":"67","author":"Przedborski","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.02.039_bib0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0306-4522(88)90224-2","article-title":"Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway \u2013 II. Differential localization of dopamine and cholecystokinin receptors","volume":"27","author":"Beresford","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.02.039_bib0080","article-title":"Anatomical and electrophysiological changes in striatal TH interneurons after loss of the nigrostriatal dopaminergic pathway","author":"Unal","year":"2013","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.bbr.2014.02.039_bib0085","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1460-9568.2008.06040.x","article-title":"Tyrosine hydroxylase cells appearing in the mouse striatum after dopamine denervation are likely to be projection neurones regulated by L-DOPA","volume":"27","author":"Darmopil","year":"2008","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0090","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0006-8993(81)90759-9","article-title":"Grafts of embryonic substantia nigra reinnervating the ventrolateral striatum ameliorate sensorimotor impairments and akinesia in rats with 6-OHDA lesions of the nigrostriatal pathway","volume":"229","author":"Dunnett","year":"1981","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2014.02.039_bib0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuroscience.2011.08.018","article-title":"Investigating striatal function through cell-type-specific manipulations","volume":"198","author":"Kreitzer","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.02.039_bib0100","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1037\/0735-7044.100.5.652","article-title":"Dopamine in the lateral caudate-putamen of the rat is essential for somatosensory orientation","volume":"100","author":"Fairley","year":"1986","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0105","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/syn.20270","article-title":"Relation between rotation in the 6-OHDA lesioned rat and dopamine loss in striatal and substantia nigra subregions","volume":"59","author":"Olds","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.bbr.2014.02.039_bib0110","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.neuro.25.112701.142937","article-title":"Learning and memory functions of the Basal Ganglia","volume":"25","author":"Packard","year":"2002","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0115","doi-asserted-by":"crossref","first-page":"12831","DOI":"10.1523\/JNEUROSCI.3177-09.2009","article-title":"Corticostriatal interactions during learning, memory processing, and decision making","volume":"29","author":"Pennartz","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0120","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1523\/JNEUROSCI.3709-06.2007","article-title":"Cholinergic interneurons control the excitatory input to the striatum","volume":"27","author":"Pakhotin","year":"2007","journal-title":"J Neurosci"},{"issue":"Suppl. 4","key":"10.1016\/j.bbr.2014.02.039_bib0125","first-page":"S7","article-title":"Anticholinergic therapies in the treatment of Parkinson's disease","volume":"17","author":"Lang","year":"2002","journal-title":"Mov Disord"},{"key":"10.1016\/j.bbr.2014.02.039_bib0130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijdevneu.2004.12.007","article-title":"The vulnerability of striatal projection neurons and interneurons to excitotoxicity is differentially regulated by dopamine during development","volume":"23","author":"Pezzi","year":"2005","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0135","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0165-0173(00)00039-4","article-title":"Chemical anatomy of striatal interneurons in normal individuals and in patients with Huntington's disease","volume":"34","author":"Cicchetti","year":"2000","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.bbr.2014.02.039_bib0140","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.nbd.2009.03.006","article-title":"Changes to interneuron-driven striatal microcircuits in a rat model of Parkinson's disease","volume":"34","author":"Salin","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2014.02.039_bib0145","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00702-003-0021-y","article-title":"Cerebral alterations in a MPTP-mouse model of Parkinson's disease \u2013 an immunocytochemical study","volume":"110","author":"Muramatsu","year":"2003","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bbr.2014.02.039_bib0150","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1523\/JNEUROSCI.4439-05.2006","article-title":"Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of Parkinsonian rats","volume":"26","author":"Mallet","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0155","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jnr.22591","article-title":"Preferential interneuron survival in the transition zone of 3-NP-induced striatal injury in rats","volume":"89","author":"Mu","year":"2011","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bbr.2014.02.039_bib0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuint.2011.05.009","article-title":"Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats","volume":"59","author":"Mu","year":"2011","journal-title":"Neurochem Int"},{"key":"10.1016\/j.bbr.2014.02.039_bib0165","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1369\/0022155413492159","article-title":"Melatonin ameliorates injury and specific responses of ischemic striatal neurons in rats","volume":"61","author":"Ma","year":"2013","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.bbr.2014.02.039_bib0170","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1523\/JNEUROSCI.3833-10.2011","article-title":"Functional connectome of the striatal medium spiny neuron","volume":"31","author":"Chuhma","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.02.039_bib0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fnsys.2011.00045","article-title":"Functional properties of striatal fast-spiking interneurons","volume":"5","author":"Berke","year":"2011","journal-title":"Front Syst Neurosci"},{"issue":"2\u20133","key":"10.1016\/j.bbr.2014.02.039_bib0180","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0301-0082(96)00040-8","article-title":"The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments","volume":"50","author":"Schwarting","year":"1996","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bbr.2014.02.039_bib0185","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00001756-199412300-00044","article-title":"Differentiation of motor inactivation from movement asymmetry effects in an animal model of hemi-parkinsonism","volume":"6","author":"Fornaguera","year":"1994","journal-title":"NeuroReport"},{"key":"10.1016\/j.bbr.2014.02.039_bib0190","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0163-1047(93)90466-U","article-title":"Behavioral analysis of asymmetries induced by unilateral 6-OHDA injections into the substantia nigra","volume":"60","author":"Morgan","year":"1993","journal-title":"Behav Neural Biol"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814001247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814001247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T01:35:03Z","timestamp":1565228103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432814001247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":38,"alternative-id":["S0166432814001247"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.02.039","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718306575.793492274","asserted-by":"object"}]},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.02.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}