{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:45:55Z","timestamp":1789713955578,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81201041"],"award-info":[{"award-number":["81201041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81201054"],"award-info":[{"award-number":["81201054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.bbr.2014.02.046","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T03:01:31Z","timestamp":1394074891000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action"],"prefix":"10.1016","volume":"266","author":[{"given":"Huaning","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiguo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangjin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2014.02.046_bib0005","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2147\/PPA.S29716","article-title":"Treatment-resistant depression: therapeutic trends, challenges, and future directions","volume":"6","author":"Al-Harbi","year":"2012","journal-title":"Patient Prefer Adherence"},{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2014.02.046_bib0010","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1007\/s40263-012-0032-z","article-title":"Clinical issues in use of atypical antipsychotics for depressed patients","volume":"27","author":"Pae","year":"2013","journal-title":"CNS Drugs"},{"key":"10.1016\/j.bbr.2014.02.046_bib0015","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.euroneuro.2012.02.006","article-title":"European Group for the Study of Resistant Depression (GSRD)\u2014where have we gone so far: review of clinical and genetic findings","volume":"22","author":"Schosser","year":"2012","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2014.02.046_bib0020","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/da.22045","article-title":"Predictive socioeconomic and clinical profiles of antidepressant response and remission","volume":"30","author":"Jain","year":"2013","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.bbr.2014.02.046_bib0025","first-page":"55","article-title":"ECT, rTMS, and deepTMS in pharmacoresistant drug-free patients with unipolar depression: a comparative review","volume":"8","author":"Minichino","year":"2012","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.bbr.2014.02.046_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1055\/s-2007-979535","article-title":"The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans","volume":"29","author":"Heninger","year":"1996","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0035","article-title":"The neurobiology of depression and antidepressant action","author":"Willner","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2014.02.046_bib0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuropharm.2011.07.036","article-title":"Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders","volume":"62","author":"Sanacora","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2014.02.046_bib0045","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.1222939","article-title":"Synaptic dysfunction in depression: potential therapeutic targets","volume":"338","author":"Duman","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbr.2014.02.046_bib0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11011-008-9118-1","article-title":"The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression","volume":"24","author":"Maes","year":"2009","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.bbr.2014.02.046_bib0055","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/7854_2012_211","article-title":"Inflammation and depression","volume":"14","author":"Zunszain","year":"2013","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.bbr.2014.02.046_bib0060","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.pnpbp.2010.06.014","article-title":"Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression","volume":"35","author":"Maes","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0065","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s11011-012-9323-9","article-title":"IL-1beta, IL-6, IL-8, IL-10, IFN-gamma, TNF-alpha and its relationship with lipid parameters in patients with major depression","volume":"27","author":"Hocaoglu","year":"2012","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.bbr.2014.02.046_bib0070","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000336803","article-title":"Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis\/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis\/chronic fatigue syndrome than in depression","volume":"81","author":"Maes","year":"2012","journal-title":"Psychother Psychosom"},{"key":"10.1016\/j.bbr.2014.02.046_bib0075","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1073\/pnas.0708092105","article-title":"IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress","volume":"105","author":"Koo","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2014.02.046_bib0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-8741(96)01501-2","article-title":"Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats","volume":"56","author":"Hsieh","year":"1997","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bbr.2014.02.046_bib0085","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/ptr.1246","article-title":"Ether fraction of methanol extracts of Gastrodia elata, medicinal herb protects against neuronal cell damage after transient global ischemia in gerbils","volume":"17","author":"Kim","year":"2003","journal-title":"Phytother Res"},{"key":"10.1016\/j.bbr.2014.02.046_bib0090","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0378-8741(02)00290-8","article-title":"Ethyl ether fraction of Gastrodia elata Blume protects amyloid beta peptide-induced cell death","volume":"84","author":"Kim","year":"2003","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bbr.2014.02.046_bib0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(01)02296-0","article-title":"Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus","volume":"314","author":"Kim","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2014.02.046_bib0100","doi-asserted-by":"crossref","first-page":"e21891","DOI":"10.1371\/journal.pone.0021891","article-title":"Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways","volume":"6","author":"Dai","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.02.046_bib0105","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11064-013-1203-0","article-title":"Gastrodin ameliorates depressive-like behaviors and up-regulates the expression of BDNF in the hippocampus and hippocampal-derived astrocyte of rats","volume":"39","author":"Zhang","year":"2014","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbr.2014.02.046_bib0110","doi-asserted-by":"crossref","first-page":"537","DOI":"10.33549\/physiolres.932507","article-title":"Gastrodin ameliorates anxiety-like behaviors and inhibits IL-1beta level and p38 MAPK phosphorylation of hippocampus in the rat model of posttraumatic stress disorder","volume":"62","author":"Peng","year":"2013","journal-title":"Physiol Res"},{"key":"10.1016\/j.bbr.2014.02.046_bib0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/01.yco.0000194371.47685.f2","article-title":"An update on regional brain volume differences associated with mood disorders","volume":"19","author":"Campbell","year":"2006","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0120","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.biopsych.2004.08.022","article-title":"Cellular changes in the postmortem hippocampus in major depression","volume":"56","author":"Stockmeier","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.1222941","article-title":"Depression and hippocampal neurogenesis: a road to remission","volume":"338","author":"Eisch","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbr.2014.02.046_bib0130","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.biopsych.2007.02.006","article-title":"Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat","volume":"62","author":"Banasr","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0135","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.bcp.2013.01.020","article-title":"Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-kappaB and MAPKs activation via the phosphatidylinositol 3-kinase signaling","volume":"85","author":"Yang","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bbr.2014.02.046_bib0140","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.taap.2013.02.019","article-title":"Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: Involvement of NF-kappaB signaling activation in CD4+ T cells","volume":"269","author":"Shu","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.bbr.2014.02.046_bib0145","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.pnpbp.2011.07.004","article-title":"LPS inhibits the effects of fluoxetine on depression-like behavior and hippocampal neurogenesis in rats","volume":"35","author":"Wang","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0150","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"Slattery","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bbr.2014.02.046_bib0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbr.2012.04.019","article-title":"Long-lasting effects of chronic rTMS to treat chronic rodent model of depression","volume":"232","author":"Feng","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.02.046_bib0160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2014.02.046_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2013.01.032","article-title":"Ziprasidone ameliorates anxiety-like behaviors in a rat model of PTSD and up-regulates neurogenesis in the hippocampus and hippocampus-derived neural stem cells","volume":"244","author":"Peng","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.02.046_bib0170","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.yebeh.2005.12.009","article-title":"Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions","volume":"8","author":"Ojemann","year":"2006","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.bbr.2014.02.046_bib0175","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00394-010-0120-0","article-title":"Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidates","volume":"50","author":"Park","year":"2011","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.bbr.2014.02.046_bib0180","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1055\/s-2006-951709","article-title":"A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro","volume":"72","author":"Zeng","year":"2006","journal-title":"Planta Med"},{"key":"10.1016\/j.bbr.2014.02.046_bib0185","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1055\/s-2007-981523","article-title":"Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons","volume":"73","author":"Xu","year":"2007","journal-title":"Planta Med"},{"key":"10.1016\/j.bbr.2014.02.046_bib0190","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.neubiorev.2012.07.001","article-title":"Neurobiology of chronic mild stress: parallels to major depression","volume":"36","author":"Hill","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2014.02.046_bib0195","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuroscience.2012.09.018","article-title":"The consequences of adolescent chronic unpredictable stress exposure on brain and behavior","volume":"249","author":"Hollis","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.02.046_bib0200","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbr.2014.02.046_bib0205","doi-asserted-by":"crossref","first-page":"854285","DOI":"10.1155\/2012\/854285","article-title":"Functional role of adult hippocampal neurogenesis as a therapeutic strategy for mental disorders","volume":"2012","author":"Jun","year":"2012","journal-title":"Neural Plast"},{"key":"10.1016\/j.bbr.2014.02.046_bib0210","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/7854_2012_226","article-title":"Major depression: a role for hippocampal neurogenesis","volume":"14","author":"Lee","year":"2013","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.bbr.2014.02.046_bib0215","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.02.046_bib0220","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.neuroscience.2013.05.043","article-title":"Stress and excitatory synapses: From health to disease","volume":"248","author":"Timmermans","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.02.046_bib0225","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.psyneuen.2012.03.019","article-title":"Neuroplastic changes in depression: a role for the immune system","volume":"37","author":"Eyre","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2014.02.046_bib0230","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biopsych.2004.04.012","article-title":"Is impaired neurogenesis relevant to the affective symptoms of depression","volume":"56","author":"Sapolsky","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0235","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0240","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.pnpbp.2010.06.020","article-title":"Cytokines mediated inflammation and decreased neurogenesis in animal models of depression","volume":"35","author":"Song","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0245","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.pnpbp.2010.07.030","article-title":"Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders","volume":"35","author":"Gardner","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2014.02.046_bib0250","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0910658107","article-title":"Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior","volume":"107","author":"Koo","year":"2010","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814001314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814001314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T21:54:17Z","timestamp":1597528457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432814001314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":50,"alternative-id":["S0166432814001314"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.02.046","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.02.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}