{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:12:43Z","timestamp":1761844363462},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.bbr.2014.04.012","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T06:04:20Z","timestamp":1397801060000},"page":"61-65","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement"],"prefix":"10.1016","volume":"269","author":[{"given":"Jason M.","family":"Uslaner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Winrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony L.","family":"Gotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Roecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pete H.","family":"Hutson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh D.","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Renger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2014.04.012_bib0005","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/cne.10783","article-title":"Overlapping distributions of orexin\/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress","volume":"464","author":"Baldo","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bbr.2014.04.012_bib0010","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0306-4522(02)00017-9","article-title":"Anatomical substrates of orexin\u2013dopamine interactions: lateral hypothalamic projections to the ventral tegmental area","volume":"111","author":"Fadel","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.04.012_bib0015","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/j.1460-9568.2008.06397.x","article-title":"Orexin B\/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons","volume":"28","author":"Borgland","year":"2008","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2014.04.012_bib0020","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neuron.2006.01.016","article-title":"Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine","volume":"49","author":"Borgland","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2014.04.012_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1523\/JNEUROSCI.23-01-00007.2003","article-title":"Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins\/hypocretins","volume":"23","author":"Korotkova","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.04.012_bib0030","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1523\/JNEUROSCI.2761-05.2006","article-title":"Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine","volume":"26","author":"Narita","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.04.012_bib0035","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1460-9568.2009.07065.x","article-title":"The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system","volume":"31","author":"Espana","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2014.04.012_bib0040","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.brainres.2009.12.035","article-title":"Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization","volume":"1317","author":"Sharf","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2014.04.012_bib0045","doi-asserted-by":"crossref","first-page":"19480","DOI":"10.1073\/pnas.0808023105","article-title":"Insular hypocretin transmission regulates nicotine reward","volume":"105","author":"Hollander","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2014.04.012_bib0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00213-010-1792-0","article-title":"Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA","volume":"209","author":"LeSage","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.04.012_bib0055","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/sj.bjp.0706789","article-title":"The orexin system regulates alcohol-seeking in rats","volume":"148","author":"Lawrence","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2014.04.012_bib0060","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.alcohol.2009.07.002","article-title":"Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol-preferring Sprague-Dawley rats","volume":"43","author":"Moorman","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.bbr.2014.04.012_bib0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00213-008-1136-5","article-title":"Inhibition of orexin-1\/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats","volume":"199","author":"Richards","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.04.012_bib0070","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1523\/JNEUROSCI.6096-08.2009","article-title":"Orexin A\/hypocretin-1 selectively promotes motivation for positive reinforcers","volume":"29","author":"Borgland","year":"2009","journal-title":"J Neurosci"},{"issue":"Suppl 1","key":"10.1016\/j.bbr.2014.04.012_bib0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuropharm.2008.06.060","article-title":"Role of lateral hypothalamic orexin neurons in reward processing and addiction","volume":"56","author":"Aston-Jones","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2014.04.012_bib0080","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1460-9568.2009.06844.x","article-title":"Orexin\/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking","volume":"30","author":"Smith","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2014.04.012_bib0085","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuropharm.2009.06.042","article-title":"Orexin\/hypocretin is necessary for context-driven cocaine-seeking","volume":"58","author":"Smith","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2014.04.012_bib0090","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00213-010-2082-6","article-title":"Involvement of the orexin\/hypocretin system in ethanol conditioned place preference","volume":"214","author":"Voorhees","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.04.012_bib0095","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature04071","article-title":"A role for lateral hypothalamic orexin neurons in reward seeking","volume":"437","author":"Harris","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2014.04.012_bib0100","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00213-010-2127-x","article-title":"Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement","volume":"215","author":"Shoblock","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.04.012_bib0105","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1016\/j.bmcl.2013.10.045","article-title":"Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)","volume":"23","author":"Mercer","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bbr.2014.04.012_bib0110","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/BF00589894","article-title":"Nicotine maintains robust self-administration in rats on a limited-access schedule","volume":"99","author":"Corrigall","year":"1989","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.04.012_bib0115","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1523\/JNEUROSCI.4895-05.2006","article-title":"Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake","volume":"26","author":"Le","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.04.012_bib0120","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0091-3057(93)90503-L","article-title":"Parameters of self-administration of cocaine in rats under a progressive-ratio schedule","volume":"45","author":"Depoortere","year":"1993","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2014.04.012_bib0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s002130051153","article-title":"Nicotine self-administration in rats on a progressive ratio schedule of reinforcement","volume":"147","author":"Donny","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.04.012_bib0130","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/sj.npp.1301454","article-title":"Nicotine self-administration, extinction responding and reinstatement in adolescent and adult male rats: evidence against a biological vulnerability to nicotine addiction during adolescence","volume":"33","author":"Shram","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2014.04.012_bib0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbr.2009.09.035","article-title":"Inhibition of glycine transporter 1 attenuates nicotine- but not food-induced cue-potentiated reinstatement for a response previously paired with sucrose","volume":"207","author":"Uslaner","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.04.012_bib0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/B978-0-444-59489-1.00010-0","article-title":"Orexin receptors as therapeutic drug targets","volume":"198","author":"Gotter","year":"2012","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.bbr.2014.04.012_bib0145","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","article-title":"The neural basis of drug craving: an incentive-sensitization theory of addiction","volume":"18","author":"Robinson","year":"1993","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.bbr.2014.04.012_bib0150","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.1523\/JNEUROSCI.20-21-08122.2000","article-title":"Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward \u201cwanting\u201d without enhanced \u201cliking\u201d or response reinforcement","volume":"20","author":"Wyvell","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.04.012_bib0155","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1124\/mol.109.055152","article-title":"Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)\/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists","volume":"76","author":"Malherbe","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bbr.2014.04.012_bib0160","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1017\/S1461145711000423","article-title":"Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking","volume":"14","author":"James","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2014.04.012_bib0165","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-2999(00)00122-9","article-title":"Role of dopamine in the behavioural actions of nicotine related to addiction","volume":"393","author":"Di Chiara","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2014.04.012_bib0170","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0306-4522(00)00371-7","article-title":"Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo","volume":"101","author":"Fu","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.04.012_bib0175","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1523\/JNEUROSCI.5095-09.2010","article-title":"Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement","volume":"30","author":"Gotti","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.04.012_bib0180","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02245266","article-title":"Conditioned responses to cocaine-related stimuli in cocaine abuse patients","volume":"107","author":"Ehrman","year":"1992","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.04.012_bib0185","first-page":"44","article-title":"Types of conditioning found in drug-dependent humans","volume":"84","author":"O\u2018Brien","year":"1988","journal-title":"NIDA Res Monogr"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814002307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814002307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T13:18:34Z","timestamp":1565356714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432814002307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":37,"alternative-id":["S0166432814002307"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.04.012","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}