{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:13:56Z","timestamp":1792059236391,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"The Science Research Promotion Fund of the Promotion and Mutual Aid Corporation for Private Schools of Japan"},{"name":"Jichi Medical University Young Investigator Award"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.bbr.2014.06.048","type":"journal-article","created":{"date-parts":[[2014,6,29]],"date-time":"2014-06-29T08:45:26Z","timestamp":1404031526000},"page":"100-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Heterozygous mice deficient in Atp1a3 exhibit motor deficits by chronic restraint stress"],"prefix":"10.1016","volume":"272","author":[{"given":"Hiroki","family":"Sugimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2014.06.048_bib0005","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1093\/brain\/aws193","article-title":"Late-onset Parkinsonism in NF\u03baB\/c-Rel-deficient mice","volume":"135","author":"Baiguera","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2014.06.048_bib0010","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1212\/WNL.0b013e3182074c2f","article-title":"Na+, K+-ATPase: functions in the nervous system and involvement in neurologic disease","volume":"76","author":"Benarroch","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2014.06.048_bib0015","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1093\/hmg\/ddp170","article-title":"A C-terminal mutation of ATP1A3 underscores the crucial role of sodium affinity in the pathophysiology of rapid-onset dystonia-parkinsonism","volume":"18","author":"Blanco-Arias","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.bbr.2014.06.048_bib0020","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.nbd.2010.11.015","article-title":"Molecular pathways in dystonia","volume":"42","author":"Bragg","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2014.06.048_bib0025","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1212\/WNL.48.4.1066","article-title":"Rapid-onset dystonia-parkinsonism in a second family","volume":"48","author":"Brashear","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2014.06.048_bib0030","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/brain\/awl340","article-title":"The phenotypic spectrum of rapid-onset dystonia-parkinsonism (RDP) and mutations in the ATP1A3 gene","volume":"130","author":"Brashear","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2014.06.048_bib0035","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1469-8749.2012.04421.x","article-title":"ATP1A3 mutations in infants: a new rapid-onset dystonia-Parkinsonism phenotype characterized by motor delay and ataxia","volume":"54","author":"Brashear","year":"2012","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.bbr.2014.06.048_bib0040","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrn2337","article-title":"The pathophysiological basis of dystonias","volume":"9","author":"Breakefield","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2014.06.048_bib0045","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1601-183X.2004.00072.x","article-title":"Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: Motor tests","volume":"3","author":"Brooks","year":"2004","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.bbr.2014.06.048_bib0050","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2652","article-title":"Tests to assess motor phenotype in mice: a user's guide","volume":"10","author":"Brooks","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2014.06.048_bib0055","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/cne.22524","article-title":"Distribution of Na\/K-ATPase alpha 3 isoform, a sodium\u2013potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain","volume":"519","author":"B\u00f8ttger","year":"2011","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bbr.2014.06.048_bib0060","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.neubiorev.2011.10.005","article-title":"Migraine- and dystonia-related disease-mutations of Na+\/K+-ATPases: relevance of behavioral studies in mice to disease symptoms and neurological manifestations in humans","volume":"36","author":"B\u00f8ttger","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2014.06.048_bib0065","doi-asserted-by":"crossref","first-page":"14085","DOI":"10.1073\/pnas.0904817106","article-title":"Mutation I810N in the \u03b13 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS","volume":"106","author":"Clapcote","year":"2009","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.bbr.2014.06.048_bib0070","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuron.2004.06.028","article-title":"Mutations in the Na+\/K+-ATPase \u03b13 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism","volume":"43","author":"de Carvalho Aguiar","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2014.06.048_bib0075","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.bbr.2010.09.009","article-title":"Characterization of Atp1a3 mutant mice as a model of rapid-onset dystonia with parkinsonism","volume":"216","author":"DeAndrade","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.06.048_bib0080","doi-asserted-by":"crossref","first-page":"S431","DOI":"10.1002\/mds.21849","article-title":"The clinical spectrum of freezing of gait in atypical parkinsonism","volume":"23","author":"Factor","year":"2008","journal-title":"Mov Disord"},{"key":"10.1016\/j.bbr.2014.06.048_bib0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-0270(01)00485-X","article-title":"A simple method to measure stride length as an index of nigrostriatal dysfunction in mice","volume":"113","author":"Fernagut","year":"2002","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2014.06.048_bib0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0031-9384(97)00425-3","article-title":"Failure to change exploration or saccharin preference in rats exposed to chronic mild stress","volume":"63","author":"Harris","year":"1997","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2014.06.048_bib0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1254\/jjp.79.243","article-title":"Depressive state with anxiety in repeated cold-stressed mice in forced swimming tests","volume":"79","author":"Hata","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.bbr.2014.06.048_bib0100","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1254\/jjp.85.189","article-title":"Anxiety-like behavior in elevated plus-maze tests in repeatedly cold-stressed mice","volume":"85","author":"Hata","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.bbr.2014.06.048_bib0105","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/ng.2358","article-title":"De novo mutations in ATP1A3 cause alternating hemiplegia of childhood","volume":"44","author":"Heinzen","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.bbr.2014.06.048_bib0110","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00769038","article-title":"Differential distribution of (Na, K)-ATPase \u03b13 isoforms in the central nervous system","volume":"11","author":"Hieber","year":"1991","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.bbr.2014.06.048_bib0115","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1523\/JNEUROSCI.23-11-04667.2003","article-title":"Degeneration of the amygdala\/piriform cortex and enhanced fear\/anxiety behaviors in sodium pump \u03b12 subunit (Atp1a2)-deficient mice","volume":"23","author":"Ikeda","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.048_bib0120","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1113\/jphysiol.2012.247817","article-title":"Enhanced inhibitory neurotransmission in the cerebellar cortex of the Atp1a3-deficient heterozygous mice","volume":"591","author":"Ikeda","year":"2013","journal-title":"J Physiol"},{"key":"10.1016\/j.bbr.2014.06.048_bib0125","doi-asserted-by":"crossref","first-page":"e56120","DOI":"10.1371\/journal.pone.0056120","article-title":"Identification of ATP1A3 mutations by exome sequencing as the cause of alternating hemiplegia of childhood in Japanese patients","volume":"8","author":"Ishii","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.06.048_bib0130","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/01.wnl.0000310431.41036.e0","article-title":"Novel ATP1A3 mutation in a sporadic RDP patient with minimal benefit from deep brain stimulation","volume":"70","author":"Kamm","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2014.06.048_bib0135","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1601-183X.2011.00691.x","article-title":"Decreased neuronal Na+,K+-ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress","volume":"10","author":"Kirshenbaum","year":"2011","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.bbr.2014.06.048_bib0140","doi-asserted-by":"crossref","first-page":"e60141","DOI":"10.1371\/journal.pone.0060141","article-title":"Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase \u03b13 missense mutant mice","volume":"8","author":"Kirshenbaum","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.06.048_bib0145","doi-asserted-by":"crossref","first-page":"155S","DOI":"10.1592\/phco.27.12part2.155S","article-title":"Overview of Parkinson's disease","volume":"27","author":"Lew","year":"2007","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.bbr.2014.06.048_bib0150","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/mds.10103","article-title":"Possible sporadic rapid-onset dystonia-parkinsonism","volume":"17","author":"Linazasoro","year":"2002","journal-title":"Mov Disord"},{"key":"10.1016\/j.bbr.2014.06.048_bib0155","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00768847","article-title":"Na, K-ATPase: isoform structure, function, and expression","volume":"24","author":"Lingrel","year":"1992","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.bbr.2014.06.048_bib0160","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2013.01.044","article-title":"Effects of group housing on stress induced emotional and neuroendocrine alterations","volume":"1502","author":"Liu","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2014.06.048_bib0165","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1037\/0735-7044.105.5.663","article-title":"Prepartal chronic stress increases anxiety and decreases aggression in lactating female mice","volume":"105","author":"Maestripieri","year":"1991","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2014.06.048_bib0170","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1523\/JNEUROSCI.11-02-00381.1991","article-title":"Immunofluorescent localization of three Na,K-ATPase isozymes in the rat central nervous system: both neurons and glia can express more than one Na,K-ATPase","volume":"11","author":"McGrail","year":"1991","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.048_bib0175","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/brain\/119.2.551","article-title":"Stride length regulation in Parkinson's disease: normalization strategies and underlying mechanisms","volume":"119","author":"Morris","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2014.06.048_bib0180","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1523\/JNEUROSCI.4464-06.2007","article-title":"Deficiency in Na,K-ATPase \u03b1 isoform genes alters spatial learning, motor activity, and anxiety in mice","volume":"27","author":"Moseley","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.048_bib0185","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s007020200026","article-title":"Mutations of GCH1 in Dopa-responsive dystonia","volume":"109","author":"M\u00fcller","year":"2002","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bbr.2014.06.048_bib0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1756-6606-1-7","article-title":"Comprehensive behavioral phenotyping of calpastatin-knockout mice","volume":"1","author":"Nakajima","year":"2008","journal-title":"Mol Brain"},{"key":"10.1016\/j.bbr.2014.06.048_bib0195","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1093\/brain\/awq295","article-title":"Evidence of a non-progressive course of alternating hemiplegia of childhood: study of a large cohort of children and adults","volume":"133","author":"Panagiotakaki","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2014.06.048_bib0200","doi-asserted-by":"crossref","first-page":"8414","DOI":"10.1073\/pnas.89.18.8414","article-title":"Isoforms of the Na,K-ATPase are present in both axons and dendrites of hippocampal neurons in culture","volume":"89","author":"Pietrini","year":"1992","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.bbr.2014.06.048_bib0205","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1212\/WNL.55.7.991","article-title":"Rapid-onset dystonia-parkinsonism: a clinical and genetic analysis of a new kindred","volume":"55","author":"Pittock","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2014.06.048_bib0210","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S1474-4422(12)70182-5","article-title":"Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study","volume":"11","author":"Rosewich","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.bbr.2014.06.048_bib0215","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0376-6357(00)00080-2","article-title":"Chronic mild stress alleviates anxious behaviour in female mice in two situations","volume":"49","author":"R\u00f6ssler","year":"2000","journal-title":"Behav Process"},{"key":"10.1016\/j.bbr.2014.06.048_bib0220","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1073\/pnas.85.1.284","article-title":"Tissue specificity, localization in brain, and cell-free translation of mRNA encoding the A3 isoform of Na+,K+-ATPase","volume":"85","author":"Schneider","year":"1988","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.bbr.2014.06.048_bib0225","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00415-009-5385-y","article-title":"Rapid-onset dystonia-parkinsonism: case report","volume":"257","author":"Svetel","year":"2010","journal-title":"J Neurol"},{"key":"10.1016\/j.bbr.2014.06.048_bib0230","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/mds.25669","article-title":"Neurophysiology of gait: from the spinal cord to the frontal lobe","volume":"28","author":"Takakusaki","year":"2013","journal-title":"Mov Disord"},{"key":"10.1016\/j.bbr.2014.06.048_bib0235","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neulet.2010.02.032","article-title":"SJLB mice develop tauopathy-induced parkinsonism","volume":"473","author":"Takenokuchi","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2014.06.048_bib0240","doi-asserted-by":"crossref","first-page":"e31522","DOI":"10.1371\/journal.pone.0031522","article-title":"Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease","volume":"7","author":"Wey","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.06.048_bib0245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbr.2014.06.048_bib0250","doi-asserted-by":"crossref","first-page":"e53480","DOI":"10.1371\/journal.pone.0053480","article-title":"Behavioral stress fails to accelerate the onset and progression of plaque pathology in the brain of a mouse model of Alzheimer's disease","volume":"8","author":"Yuan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.06.048_bib0255","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuroscience.2013.04.046","article-title":"The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress","volume":"246","author":"Zhao","year":"2013","journal-title":"NeuroScience"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814004318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814004318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T17:24:15Z","timestamp":1689355455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432814004318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":51,"alternative-id":["S0166432814004318"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.06.048","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterozygous mice deficient in Atp1a3 exhibit motor deficits by chronic restraint stress","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}