{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:05Z","timestamp":1788872345934,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["Reed-T32 DA022616-02"],"award-info":[{"award-number":["Reed-T32 DA022616-02"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["Reed-U54GM104942"],"award-info":[{"award-number":["Reed-U54GM104942"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["Reed-NIRG-12-242187"],"award-info":[{"award-number":["Reed-NIRG-12-242187"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.bbr.2014.06.057","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T21:01:16Z","timestamp":1404594076000},"page":"181-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Effect size of memory deficits in mice with adult-onset P301L tau expression"],"prefix":"10.1016","volume":"272","author":[{"given":"Holly C.","family":"Hunsberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn C.","family":"Rudy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Weitzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Tosto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Knowlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda N.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2014.06.057_bib0005","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbadis.2004.09.008","article-title":"Tau pathology in Alzheimer disease and other tauopathies","volume":"1739","author":"Iqbal","year":"2005","journal-title":"Biochim Biophys Acta (BBA)"},{"key":"10.1016\/j.bbr.2014.06.057_bib0010","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","article-title":"Tau suppression in a neurodegenerative mouse model improves memory function","volume":"309","author":"SantaCruz","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbr.2014.06.057_bib0015","doi-asserted-by":"crossref","first-page":"10637","DOI":"10.1523\/JNEUROSCI.3279-05.2005","article-title":"Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)","volume":"25","author":"Ramsden","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.057_bib0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1750-1326-7-28","article-title":"Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult","volume":"7","author":"Rodgers","year":"2012","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.bbr.2014.06.057_bib0025","first-page":"53","article-title":"Perinatal suppression of tau P301L has a long lasting preventive effect against neurodegeneration","volume":"1","author":"Caouette","year":"2013","journal-title":"Int J Neuropathol"},{"key":"10.1016\/j.bbr.2014.06.057_bib0030","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2353\/ajpath.2008.080175","article-title":"Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease","volume":"173","author":"Paulson","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bbr.2014.06.057_bib0035","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.neuro.2007.01.014","article-title":"Extrapolating brain development from experimental species to humans","volume":"28","author":"Clancy","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbr.2014.06.057_bib0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0168-0102(92)90014-4","article-title":"The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases","volume":"15","author":"Braak","year":"1992","journal-title":"Neurosci Res"},{"key":"10.1016\/j.bbr.2014.06.057_bib0045","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","article-title":"Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration","volume":"68","author":"Hoover","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2014.06.057_bib0050","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/nlme.1999.3951","article-title":"Repeated acquisition and performance chamber for mice: a paradigm for assessment of spatial learning and memory","volume":"74","author":"Brooks","year":"2000","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.bbr.2014.06.057_bib0055","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.neurobiolaging.2007.08.007","article-title":"Impaired olfactory discrimination learning and decreased olfactory sensitivity in aged C57Bl\/6 mice","volume":"30","author":"Patel","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2014.06.057_bib0060","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.beproc.2010.04.008","article-title":"Performance of BALB\/c and C57BL\/6 mice under an incremental repeated acquisition of behavioral chains procedure","volume":"84","author":"Johnson","year":"2010","journal-title":"Behav Processes"},{"key":"10.1016\/j.bbr.2014.06.057_bib0065","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1111\/j.1460-9568.2007.05493.x","article-title":"Hippocampal activity, but not plasticity, is required for early consolidation of fear conditioning with a short trace interval","volume":"25","author":"Burman","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.057_bib0070","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1037\/0735-7044.119.6.1496","article-title":"Single neurons in the medial prefrontal cortex of the rat exhibit tonic and phasic coding during trace fear conditioning","volume":"119","author":"Gilmartin","year":"2005","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2014.06.057_bib0075","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2014.06.057_bib0080","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.274.5293.1678","article-title":"Control of memory formation through regulated expression of a CaMKII transgene","volume":"274","author":"Mayford","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbr.2014.06.057_bib0085","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.bbr.2014.06.057_bib0090","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.nbd.2010.10.009","article-title":"Increased vesicular glutamate transporter expression causes excitotoxic neurodegeneration","volume":"41","author":"Daniels","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2014.06.057_bib0095","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1523\/JNEUROSCI.22-05-01858.2002","article-title":"The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease","volume":"22","author":"Westerman","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.057_bib0100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00213-010-1801-3","article-title":"Mechanisms and performance measures in mastery-based incremental repeated acquisition: behavioral and pharmacological analyses","volume":"209","author":"Bailey","year":"2010","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.bbr.2014.06.057_bib0105","doi-asserted-by":"crossref","first-page":"11938","DOI":"10.1523\/JNEUROSCI.2357-10.2010","article-title":"Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines","volume":"30","author":"Zempel","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.057_bib0110","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol Bull"},{"key":"10.1016\/j.bbr.2014.06.057_bib0115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbr.2010.03.037","article-title":"Effect size of reference memory deficits in the Morris water maze in Tg2576 mice","volume":"212","author":"Reed","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.06.057_bib0120","series-title":"Neurological disorders: trace conditioning comprehensive phenotypic data packages","author":"Taconic","year":"2013"},{"key":"10.1016\/j.bbr.2014.06.057_bib0125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/nlme.1996.0008","article-title":"Scopolamine administered before and after training impairs both contextual and auditory-cue fear conditioning","volume":"65","author":"Rudy","year":"1996","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.bbr.2014.06.057_bib0130","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.neurobiolaging.2009.09.003","article-title":"Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease","volume":"32","author":"Kaczorowski","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2014.06.057_bib0135","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1523\/JNEUROSCI.3257-10.2011","article-title":"Upregulation of CREB-mediated transcription enhances both short- and long-term memory","volume":"31","author":"Suzuki","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.057_bib0140","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1471-4159.2003.01879.x","article-title":"Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms","volume":"86","author":"Andorfer","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2014.06.057_bib0145","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pneurobio.2008.03.002","article-title":"Microtubule-associated protein tau in development, degeneration and protection of neurons","volume":"85","author":"Wang","year":"2008","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bbr.2014.06.057_bib0150","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1523\/JNEUROSCI.19-17-07486.1999","article-title":"cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease","volume":"19","author":"Jicha","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.057_bib0155","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0304-3940(95)11484-E","article-title":"Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205","volume":"189","author":"Goedert","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2014.06.057_bib0160","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.neurobiolaging.2009.04.006","article-title":"Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy","volume":"32","author":"Yue","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2014.06.057_bib0165","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0149-7634(94)00067-B","article-title":"Repeated acquisition of response sequences: the analysis of behavior in transition","volume":"19","author":"Cohn","year":"1995","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2014.06.057_bib0170","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1460-9568.1990.tb00014.x","article-title":"Ibotenate lesions of hippocampus and\/or subiculum: dissociating components of allocentric spatial learning","volume":"2","author":"Morris","year":"1990","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2014.06.057_bib0175","doi-asserted-by":"crossref","first-page":"e80355","DOI":"10.1371\/journal.pone.0080355","article-title":"A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease","volume":"8","author":"Attar","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.06.057_bib0180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbr.2009.04.031","article-title":"Does the learning deficit observed under an incremental repeated acquisition schedule of reinforcement in Ts65Dn mice, a model for down syndrome, change as they age","volume":"203","author":"Sanders","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.06.057_bib0185","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1037\/0735-7044.119.5.1396","article-title":"Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice","volume":"119","author":"Chowdhury","year":"2005","journal-title":"Behav Neurosci"},{"issue":"45","key":"10.1016\/j.bbr.2014.06.057_bib0190","article-title":"Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden","volume":"5","author":"O\u2019Leary","year":"2010","journal-title":"Mol Neurodegener"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814004409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814004409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:04:48Z","timestamp":1759064688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432814004409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":38,"alternative-id":["S0166432814004409"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.06.057","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect size of memory deficits in mice with adult-onset P301L tau expression","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.06.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}