{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:15:17Z","timestamp":1777540517958,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003033","name":"Ministerio de Ciencia e Innovaci\u00f3n of Spain","doi-asserted-by":"publisher","award":["SAF2009-08136"],"award-info":[{"award-number":["SAF2009-08136"]}],"id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003033","name":"Ministerio de Ciencia e Innovaci\u00f3n of Spain","doi-asserted-by":"publisher","award":["CENIT CEN-20101023"],"award-info":[{"award-number":["CENIT CEN-20101023"]}],"id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.bbr.2014.08.023","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T01:00:43Z","timestamp":1408410043000},"page":"258-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Genetic inactivation of midkine modulates behavioural responses to ethanol possibly by enhancing GABA(A) receptor sensitivity to GABA(A) acting drugs"],"prefix":"10.1016","volume":"274","author":[{"given":"Marta","family":"Vicente-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Haro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda P.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Herrad\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2014.08.023_bib0005","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/ajmg.b.32231","article-title":"Novel QTL at chromosome 6p22 for alcohol consumption: implications for the genetic liability of alcohol use disorders","volume":"165","author":"Kos","year":"2014","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.bbr.2014.08.023_bib0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0741-8329(02)00199-4","article-title":"GABA(A) receptor modulation of the rewarding and aversive effects of ethanol","volume":"26","author":"Chester","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.bbr.2014.08.023_bib0015","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/j.1360-0443.2008.02203.x","article-title":"Genetic approaches to addiction: genes and alcohol","volume":"103","author":"Ducci","year":"2008","journal-title":"Addiction"},{"key":"10.1016\/j.bbr.2014.08.023_bib0020","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s10519-014-9653-y","article-title":"Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study","volume":"44","author":"Melroy","year":"2014","journal-title":"Behav Genet"},{"key":"10.1016\/j.bbr.2014.08.023_bib0025","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2174\/138955709787847895","article-title":"Targeting the pleiotrophin\/receptor protein tyrosine phosphatase beta\/zeta signalling pathway to limit neurotoxicity induced by drug abuse","volume":"9","author":"Herradon","year":"2009","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.bbr.2014.08.023_bib0030","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/bph.12353","article-title":"Structure and function of midkine as the basis of its pharmacological effects","volume":"171","author":"Muramatsu","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2014.08.023_bib0035","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.2174\/092986709788803240","article-title":"Blocking receptor protein tyrosine phosphatase beta\/zeta: a potential therapeutic strategy for Parkinson's disease","volume":"16","author":"Herradon","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bbr.2014.08.023_bib0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbr.2013.07.026","article-title":"Regulation of extinction of cocaine-induced place preference by midkine is related to a differential phosphorylation of peroxiredoxin 6 in dorsal striatum","volume":"253","author":"Gramage","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.08.023_bib0045","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1369-1600.2009.00202.x","article-title":"The neurotrophic factor pleiotrophin modulates amphetamine-seeking behaviour and amphetamine-induced neurotoxic effects: evidence from pleiotrophin knockout mice","volume":"15","author":"Gramage","year":"2010","journal-title":"Addict Biol"},{"key":"10.1016\/j.bbr.2014.08.023_bib0050","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejphar.2012.11.011","article-title":"Maintenance of amphetamine-induced place preference does not correlate with astrocytosis","volume":"699","author":"Martin","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2014.08.023_bib0055","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2174\/138161211795164103","article-title":"Connecting Parkinson's disease and drug addiction: common players reveal unexpected disease connections and novel therapeutic approaches","volume":"17","author":"Gramage","year":"2011","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bbr.2014.08.023_bib0060","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ejphar.2008.07.067","article-title":"Pleiotrophin prevents cocaine-induced toxicity in vitro","volume":"595","author":"Gramage","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2014.08.023_bib0065","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tox.2013.02.013","article-title":"Differential phosphoproteome of the striatum from pleiotrophin knockout and midkine knockout mice treated with amphetamine: correlations with amphetamine-induced neurotoxicity","volume":"306","author":"Gramage","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.bbr.2014.08.023_bib0070","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neuroscience.2011.06.014","article-title":"Midkine regulates amphetamine-induced astrocytosis in striatum but has no effects on amphetamine-induced striatal dopaminergic denervation and addictive effects: functional differences between pleiotrophin and midkine","volume":"190","author":"Gramage","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.08.023_bib0075","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.neuroscience.2010.06.078","article-title":"Genetic inactivation of pleiotrophin triggers amphetamine-induced cell loss in the substantia nigra and enhances amphetamine neurotoxicity in the striatum","volume":"170","author":"Gramage","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.08.023_bib0080","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tox.2013.09.014","article-title":"Phosphoproteomic analysis of the striatum from pleiotrophin knockout and midkine knockout mice treated with cocaine reveals regulation of oxidative stress-related proteins potentially underlying cocaine-induced neurotoxicity and neurodegeneration","volume":"314","author":"Vicente-Rodriguez","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.bbr.2014.08.023_bib0085","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.12841","article-title":"Pleiotrophin differentially regulates the rewarding and sedative effects of etanol","author":"Vicente-Rodr\u00edguez","year":"2014","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2014.08.023_bib0090","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1471-4159.2004.03021.x","article-title":"Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics","volume":"93","author":"Flatscher-Bader","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2014.08.023_bib0095","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1111\/j.1530-0277.2008.00754.x","article-title":"Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex","volume":"32","author":"Flatscher-Bader","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.bbr.2014.08.023_bib0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fpsyt.2013.00046","article-title":"The plasticity of extinction: contribution of the prefrontal cortex in treating addiction through inhibitory learning","volume":"4","author":"Gass","year":"2013","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.bbr.2014.08.023_bib0105","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1046\/j.1365-2443.1998.00231.x","article-title":"Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour","volume":"3","author":"Nakamura","year":"1998","journal-title":"Genes Cells"},{"key":"10.1016\/j.bbr.2014.08.023_bib0110","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1369-1600.2007.00070.x","article-title":"Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade","volume":"12","author":"Tzschentke","year":"2007","journal-title":"Addict Biol"},{"key":"10.1016\/j.bbr.2014.08.023_bib0115","doi-asserted-by":"crossref","first-page":"e80541","DOI":"10.1371\/journal.pone.0080541","article-title":"Alterations in ethanol-induced behaviours and consumption in knock-in mice expressing ethanol-resistant NMDA receptors","volume":"8","author":"den Hartog","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.08.023_bib0120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1126\/science.290.5489.131","article-title":"Molecular and neuronal substrate for the selective attenuation of anxiety","volume":"290","author":"Low","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbr.2014.08.023_bib0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.2012.06794.x","article-title":"The genetics of alcohol dependence","volume":"1282","author":"Rietschel","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bbr.2014.08.023_bib0130","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/bph.12312","article-title":"Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives","volume":"171","author":"Herradon","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2014.08.023_bib0135","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1530-0277.2012.01775.x","article-title":"Altered expression of cytokine signalling pathway genes in peripheral blood cells of alcohol dependent subjects: preliminary findings","volume":"36","author":"Beech","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.bbr.2014.08.023_bib0140","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuropharm.2013.05.039","article-title":"Why is neuroimmunopharmacology crucial for the future of addiction research?","volume":"76","author":"Hutchinson","year":"2014","journal-title":"Neuropharmacol"},{"issue":"4","key":"10.1016\/j.bbr.2014.08.023_bib0190","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/bph.12419","article-title":"Midkine as a regulator of B cell survival in health and disease","volume":"171","author":"Cohen","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2014.08.023_bib0150","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1100\/2011\/517152","article-title":"Midkine in inflammation","volume":"11","author":"Weckbach","year":"2011","journal-title":"Sci World J"},{"issue":"2","key":"10.1016\/j.bbr.2014.08.023_bib0155","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0168-0102(02)00226-2","article-title":"Receptor-type protein tyrosine phosphatase zeta as a component of the signalling receptor complex for midkine-dependent survival of embryonic neurons","volume":"45","author":"Sakaguchi","year":"2003","journal-title":"Neurosci Res"},{"key":"10.1016\/j.bbr.2014.08.023_bib0160","doi-asserted-by":"crossref","first-page":"28683","DOI":"10.1074\/jbc.M704505200","article-title":"Anaplastic lymphoma kinase is activated through the pleiotrophin\/receptor protein-tyrosine phosphatase beta\/zeta signalling pathway: an alternative mechanism of receptor tyrosine kinase activation","volume":"282","author":"Perez-Pinera","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbr.2014.08.023_bib0165","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.bbrc.2005.05.007","article-title":"Fyn is a downstream target of the pleiotrophin\/receptor protein tyrosine phosphatase beta\/zeta-signalling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin","volume":"332","author":"Pariser","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bbr.2014.08.023_bib0170","doi-asserted-by":"crossref","first-page":"e22636","DOI":"10.1371\/journal.pone.0022636","article-title":"An evolutionary conserved role for anaplastic lymphoma kinase in behavioural responses to ethanol","volume":"6","author":"Lasek","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.08.023_bib0175","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1523\/JNEUROSCI.4749-06.2007","article-title":"Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behaviour","volume":"27","author":"Wang","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2014.08.023_bib0180","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1007\/s00213-014-3617-z","article-title":"Phosphorylation of GABA receptors influences receptor trafficking and neurosteroid actions","volume":"231","author":"Comenencia-Ortiz","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.08.023_bib0185","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mcn.2010.03.002","article-title":"Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit","volume":"44","author":"Jurd","year":"2010","journal-title":"Mol Cell Neurosci"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281400535X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281400535X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T02:09:57Z","timestamp":1572660597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016643281400535X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":37,"alternative-id":["S016643281400535X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.08.023","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic inactivation of midkine modulates behavioural responses to ethanol possibly by enhancing GABA(A) receptor sensitivity to GABA(A) acting drugs","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}