{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:01:58Z","timestamp":1791277318386,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.bbr.2014.08.036","type":"journal-article","created":{"date-parts":[[2014,8,24]],"date-time":"2014-08-24T12:15:15Z","timestamp":1408882515000},"page":"307-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Modelling Alzheimer-like cognitive deficits in rats using biperiden as putative cognition impairer"],"prefix":"10.1016","volume":"274","author":[{"given":"Olga","family":"Szczodry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz Josef","family":"van der Staay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia S.","family":"Arndt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2014.08.036_bib0005","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.euroneuro.2004.11.006","article-title":"Rats with scopolamine- or MK-801-induced spatial discrimination deficits in the cone field task: animal models for impaired spatial orientation performance","volume":"15","author":"Bouger","year":"2005","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2014.08.036_bib0010","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.neubiorev.2010.04.001","article-title":"The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies","volume":"34","author":"Klinkenberg","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2014.08.036_bib0015","series-title":"Alzheimer Disease Organization Dementia: A Public Health Priority","author":"World Health Organization","year":"2012"},{"key":"10.1016\/j.bbr.2014.08.036_bib0020","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.bbr.2014.08.036_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2004.05.010","article-title":"Effects of the cholinesterase inhibitors donepezil and metrifonate on scopolamine-induced impairments in the spatial cone field orientation task in rats","volume":"156","author":"Van der Staay","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.08.036_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-2999(99)00565-8","article-title":"Metrifonate improves working but not reference memory performance in a spatial cone field task","volume":"380","author":"Prickaerts","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2014.08.036_bib0035","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00213-011-2171-1","article-title":"A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment","volume":"215","author":"Klinkenberg","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2014.08.036_bib0040","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s002130000671","article-title":"Infralimbic muscarinic M1 receptors modulate anxiety-like behaviour and spontaneous working memory in mice","volume":"155","author":"Wall","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"10.1016\/j.bbr.2014.08.036_bib0045","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2174\/138920011796504518","article-title":"Paying attention to pharmacokinetic and pharmacodynamic mechanisms to pro- gress in the area of anticholinergic use in geriatric patients","volume":"12","author":"Leon","year":"2011","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.bbr.2014.08.036_bib0050","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0022-3565(25)11335-9","article-title":"Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells","volume":"260","author":"Bolden","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bbr.2014.08.036_bib0055","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.neuron.2006.01.020","article-title":"M1 receptors play a central role in modulating AD-like pathology in transgenic mice","volume":"49","author":"Caccamo","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2014.08.036_bib0060","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neubiorev.2011.07.008","article-title":"The appetitively motivated \u201ccognitive\u201d holeboard: a family of complex spatial discrimination tasks for assessing learning and memory","volume":"36","author":"Van der Staay","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2014.08.036_bib0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-0270(90)90004-Y","article-title":"The cone field: a spatial discrimination task for the automatic and simultaneous assessment of working and reference memory in rats","volume":"31","author":"Van der Staay","year":"1990","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2014.08.036_bib0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0166-4328(89)80081-6","article-title":"Selective fimbria lesions impair acquisition of working and reference memory of rats in a complex spatial discrimination task","volume":"32","author":"Van der Staay","year":"1989","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.08.036_bib0075","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/BF00615970","article-title":"Pharmacokinetic and pharmacodynamic studies following the intravenous and oral administration of the antiparkinsonian drug biperiden to normal subjects","volume":"29","author":"Grimaldi","year":"1986","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.bbr.2014.08.036_bib0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/nlme.1998.3860","article-title":"Spatial working memory and reference memory of Brown Norway and WAG rats in a holeboard discrimination task","volume":"71","author":"Van der Staay","year":"1999","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.bbr.2014.08.036_bib0085","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/0163-1047(90)90226-V","article-title":"The effects of aging in rats on working and reference memory performance in a spatial holeboard discrimination task","volume":"53","author":"Van der Staay","year":"1990","journal-title":"Behav Neural Biol"},{"key":"10.1016\/j.bbr.2014.08.036_bib0090","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.pbb.2008.02.022","article-title":"Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats","volume":"89","author":"Myhrer","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2014.08.036_bib0095","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0006-8993(99)01526-7","article-title":"Amnesic effects of the anticholinergic drugs, trihexyphenidyl and biperiden: differences in binding properties to the brain muscarinic receptor","volume":"834","author":"Kimura","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2014.08.036_bib0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0304-3940(97)00489-8","article-title":"Selective M1 muscarinic receptor antagonists disrupt memory consolidation of inhibitory avoidance in rats","volume":"230","author":"Rold\u00e1n","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2014.08.036_bib0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/0269881108089813","article-title":"Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA\/2OlaHsd mice \u2013 influence of treatment with the CRHR1-antagonist R121919\/NBI 30775","volume":"23","author":"Erhardt","year":"2009","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.bbr.2014.08.036_bib0110","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbr.2012.03.023","article-title":"Object recognition testing: rodent species, strains, housing conditions, and estrous cycle","volume":"232","author":"Van Goethem","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.08.036_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(02)00272-3","article-title":"Glutamate receptor function in learning and memory","volume":"140","author":"Riedel","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.08.036_bib0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nprot.2006.2","article-title":"T-maze alternation in the rodent","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat Protoc"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814005488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814005488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T09:54:36Z","timestamp":1746352476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432814005488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":24,"alternative-id":["S0166432814005488"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.08.036","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modelling Alzheimer-like cognitive deficits in rats using biperiden as putative cognition impairer","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.08.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}