{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:43:46Z","timestamp":1786985026575,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS052470"],"award-info":[{"award-number":["R01 NS052470"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS039538"],"award-info":[{"award-number":["R01 NS039538"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21 MH090494"],"award-info":[{"award-number":["R21 MH090494"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1 TR000448"],"award-info":[{"award-number":["UL1 TR000448"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.bbr.2014.10.010","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T13:00:18Z","timestamp":1413982818000},"page":"342-347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Brain structure and cognitive correlates of body mass index in healthy older adults"],"prefix":"10.1016","volume":"278","author":[{"given":"Jacob D.","family":"Bolzenius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Laidlaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Cabeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Conturo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R.","family":"McMichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi M.","family":"Heaps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Salminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie M.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci E.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Cooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gunstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbr.2014.10.010_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1467-789X.2005.00165.x","article-title":"Prevalence of obesity in the United States","volume":"6","author":"Baskin","year":"2005","journal-title":"Obes Rev"},{"issue":"3","key":"10.1016\/j.bbr.2014.10.010_bib0010","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.2009.2014","article-title":"Prevalence and trends in obesity among US adults, 1999\u20132008","volume":"303","author":"Flegal","year":"2010","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.bbr.2014.10.010_bib0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/qjmed\/hcl085","article-title":"The medical complications of obesity","volume":"99","author":"Malnick","year":"2006","journal-title":"QJM"},{"issue":"14","key":"10.1016\/j.bbr.2014.10.010_bib0020","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1212\/01.wnl.0000306313.89165.ef","article-title":"Central obesity and increased risk of dementia more than three decades later","volume":"71","author":"Whitmer","year":"2008","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.bbr.2014.10.010_bib0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1377\/hlthaff.21.2.245","article-title":"The effects of obesity, smoking, and drinking on medical problems and costs","volume":"21","author":"Sturm","year":"2002","journal-title":"Health Aff (Millwood)"},{"issue":"5","key":"10.1016\/j.bbr.2014.10.010_bib0030","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.bbadis.2008.09.004","article-title":"Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: a systematic comparison of their impact on cognition","volume":"1792","author":"van den Berg","year":"2009","journal-title":"Biochim Biophys Acta (BBA) \u2013 Mol Basis Dis"},{"key":"10.1016\/j.bbr.2014.10.010_bib0035","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000238082.13860.50","article-title":"Relation between body mass index and cognitive function in healthy middle-aged men and women","volume":"67","author":"Cournot","year":"2006","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.bbr.2014.10.010_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.comppsych.2006.05.001","article-title":"Elevated body mass index is associated with executive dysfunction in otherwise healthy adults","volume":"48","author":"Gunstad","year":"2007","journal-title":"Compr Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2014.10.010_bib0045","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3945\/ajcn.2008.26482","article-title":"Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort study","volume":"89","author":"Sabia","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"11","key":"10.1016\/j.bbr.2014.10.010_bib0050","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1080\/00207450701392282","article-title":"Relationship between body mass index and brain volume in healthy adults","volume":"118","author":"Gunstad","year":"2008","journal-title":"Int J Neurosci"},{"issue":"9","key":"10.1016\/j.bbr.2014.10.010_bib0055","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/hbm.21113","article-title":"The effects of physical activity, education, and body mass index on the aging brain","volume":"32","author":"Ho","year":"2011","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"10.1016\/j.bbr.2014.10.010_bib0060","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hbm.20870","article-title":"Brain structure and obesity","volume":"31","author":"Raji","year":"2010","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"10.1016\/j.bbr.2014.10.010_bib0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2377-5-23","article-title":"The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study","volume":"5","author":"Ward","year":"2005","journal-title":"BMC Neurol"},{"issue":"3","key":"10.1016\/j.bbr.2014.10.010_bib0070","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jmrb.1996.0086","article-title":"Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI","volume":"111","author":"Basser","year":"1996","journal-title":"J Magn Reson Ser B"},{"issue":"10","key":"10.1016\/j.bbr.2014.10.010_bib0075","doi-asserted-by":"crossref","first-page":"e77741","DOI":"10.1371\/journal.pone.0077741","article-title":"Body mass and white matter integrity: the influence of vascular and inflammatory markers","volume":"8","author":"Bettcher","year":"2013","journal-title":"PLOS ONE"},{"issue":"3","key":"10.1016\/j.bbr.2014.10.010_bib0080","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/oby.2010.312","article-title":"Obesity is associated with reduced white matter integrity in otherwise healthy adults","volume":"19","author":"Stanek","year":"2011","journal-title":"Obesity"},{"issue":"5","key":"10.1016\/j.bbr.2014.10.010_bib0085","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/hbm.21491","article-title":"Body mass index correlates negatively with white matter integrity in the fornix and corpus callosum: a diffusion tensor imaging study","volume":"34","author":"Xu","year":"2011","journal-title":"Hum Brain Mapp"},{"issue":"7","key":"10.1016\/j.bbr.2014.10.010_bib0090","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/PSY.0b013e318261909c","article-title":"Increased body mass index is associated with a global and distributed decrease in white matter microstructural integrity","volume":"74","author":"Verstynen","year":"2012","journal-title":"Psychosom Med"},{"issue":"1","key":"10.1016\/j.bbr.2014.10.010_bib0095","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1007\/BF03327747","article-title":"Obesity is associated with memory deficits in young and middle-aged adults","volume":"11","author":"Gunstad","year":"2006","journal-title":"Eat Weight Disord: EWD"},{"issue":"4","key":"10.1016\/j.bbr.2014.10.010_bib0100","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1152\/japplphysiol.00347.2003","article-title":"Invited review: aging and sarcopenia","volume":"95","author":"Doherty","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.bbr.2014.10.010_bib0105","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s11906-011-0195-x","article-title":"Vascular mechanisms in the pathogenesis of stroke","volume":"13","author":"Sierra","year":"2011","journal-title":"Curr Hypertens Rep"},{"issue":"10","key":"10.1016\/j.bbr.2014.10.010_bib0110","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/gerona\/glq113","article-title":"Mechanisms of vascular aging: new perspectives","volume":"65A","author":"Ungvari","year":"2010","journal-title":"J Gerontol Ser A: Biol Sci Med Sci"},{"issue":"2","key":"10.1016\/j.bbr.2014.10.010_bib0115","doi-asserted-by":"crossref","first-page":"470S","DOI":"10.1093\/ajcn\/83.2.470S","article-title":"Inflammation and neurodegenerative diseases","volume":"83","author":"Griffin","year":"2006","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1016\/j.bbr.2014.10.010_bib0120","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4067\/S0716-97602005000400011","article-title":"Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation","volume":"38","author":"Roth","year":"2005","journal-title":"Biol Res"},{"issue":"4","key":"10.1016\/j.bbr.2014.10.010_bib0125","doi-asserted-by":"crossref","first-page":"e18544","DOI":"10.1371\/journal.pone.0018544","article-title":"Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging","volume":"6","author":"Mueller","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bbr.2014.10.010_bib0130","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000165381","article-title":"The role of the uncinate fasciculus in memory and emotional recognition in amnestic mild cognitive impairment","volume":"26","author":"Fujie","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"2","key":"10.1016\/j.bbr.2014.10.010_bib0135","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.neuroimage.2008.03.057","article-title":"Cognitive processing speed and the structure of white matter pathways: convergent evidence from normal variation and lesion studies","volume":"42","author":"Turken","year":"2008","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.bbr.2014.10.010_bib0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neurobiolaging.2010.02.009","article-title":"Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study","volume":"33","author":"Voineskos","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"2","key":"10.1016\/j.bbr.2014.10.010_bib0145","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.bbr.2014.10.010_bib0150","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.neuroimage.2007.02.049","article-title":"Reproducibility of quantitative tractography methods applied to cerebral white matter","volume":"36","author":"Wakana","year":"2007","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.bbr.2014.10.010_bib0155","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.neuroimage.2009.10.015","article-title":"Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical \u201cdisconnection\u201d","volume":"49","author":"Rosas","year":"2010","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.bbr.2014.10.010_bib0160","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.neuroimage.2008.05.022","article-title":"Quantitative tractography metrics of white matter integrity in diffusion-tensor MRI","volume":"42","author":"Correia","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbr.2014.10.010_bib0165","series-title":"Manual of directions and scoring","author":"Army Individual Test Battery (AITB)","year":"1944"},{"key":"10.1016\/j.bbr.2014.10.010_bib0170","series-title":"Delis-Kaplan executive function system: D-KEFS","author":"Delis","year":"2001"},{"key":"10.1016\/j.bbr.2014.10.010_bib0175","series-title":"WAIS-III administration and scoring manual","author":"Wechsler","year":"1997"},{"issue":"3","key":"10.1016\/j.bbr.2014.10.010_bib0180","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1076\/jcen.20.3.310.823","article-title":"The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity","volume":"20","author":"Randolph","year":"1998","journal-title":"J Clin Exp Neuropsychol"},{"issue":"3","key":"10.1016\/j.bbr.2014.10.010_bib0185","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11682-013-9230-7","article-title":"Impact of body mass index on neuronal fiber bundle lengths among healthy older adults","volume":"7","author":"Bolzenius","year":"2013","journal-title":"Brain Imaging Behav"},{"issue":"2","key":"10.1016\/j.bbr.2014.10.010_bib0190","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00429-011-0344-7","article-title":"Structural correlates of cognitive domains in normal aging with diffusion tensor imaging","volume":"217","author":"Sasson","year":"2012","journal-title":"Brain Struct Funct"},{"issue":"5","key":"10.1016\/j.bbr.2014.10.010_bib0195","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/ana.21377","article-title":"Body mass index and magnetic resonance markers of brain integrity in adults","volume":"63","author":"Gazdzinski","year":"2008","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1016\/j.bbr.2014.10.010_bib0200","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/sj.ijo.802225","article-title":"Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study","volume":"27","author":"Elias","year":"2003","journal-title":"Int J Obes"},{"key":"10.1016\/j.bbr.2014.10.010_bib0205","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.ijo.0803114","article-title":"Interactive relations of central versus total obesity and blood pressure to cognitive function","volume":"30","author":"Waldstein","year":"2006","journal-title":"Int J Obes"},{"issue":"5","key":"10.1016\/j.bbr.2014.10.010_bib0210","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.biopsych.2006.01.011","article-title":"Regional white matter and neuropsychological functioning across the adult lifespan","volume":"60","author":"Brickman","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"5","key":"10.1016\/j.bbr.2014.10.010_bib0215","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neurobiolaging.2005.03.026","article-title":"White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study","volume":"27","author":"Medina","year":"2006","journal-title":"Neurobiol Aging"},{"issue":"Pt 5","key":"10.1016\/j.bbr.2014.10.010_bib0220","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1042\/BST0331029","article-title":"Leptin: a potential cognitive enhancer?","volume":"33","author":"Harvey","year":"2005","journal-title":"Biochem Soc Trans"},{"issue":"11","key":"10.1016\/j.bbr.2014.10.010_bib0225","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1097\/01.ASN.0000141966.69934.21","article-title":"The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity","volume":"15","author":"Wisse","year":"2004","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.bbr.2014.10.010_bib0230","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive\u2013leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.bbr.2014.10.010_bib0235","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00005072-199603000-00002","article-title":"Correlation of astrocytic S100 [beta] expression with dystrophic neurites in amyloid plaques of Alzheimer's disease","volume":"55","author":"Mrak","year":"1996","journal-title":"J Neuropathol Exp Neurol"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814006676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814006676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T03:48:16Z","timestamp":1717472896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432814006676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":47,"alternative-id":["S0166432814006676"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.10.010","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain structure and cognitive correlates of body mass index in healthy older adults","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}