{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:48:50Z","timestamp":1791290930529,"version":"4.3.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Institut National de la Recherche Agronomique (INRA)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.bbr.2015.05.013","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T19:42:21Z","timestamp":1432150941000},"page":"36-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Chronic variable stress exposure in male Wistar rats affects the first step of olfactory detection"],"prefix":"10.1016","volume":"291","author":[{"given":"Aur\u00e9lien","family":"Raynaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Acquistapace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bombail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2015.05.013_bib0275","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuron.2005.10.022","article-title":"Olfaction: diverse species, conserved principles","volume":"48","author":"Ache","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2015.05.013_bib0280","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nn.3598","article-title":"The missense of smell: functional variability in the human odorant receptor repertoire","volume":"17","author":"Mainland","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bbr.2015.05.013_bib0285","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.semcdb.2012.09.001","article-title":"Peripheral modulation of smell: fact or fiction","volume":"24","author":"Lucero","year":"2013","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.bbr.2015.05.013_bib0290","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/chemse\/bjs059","article-title":"Olfaction under metabolic influences","volume":"37","author":"Palouzier-Paulignan","year":"2012","journal-title":"Chem Senses"},{"key":"10.1016\/j.bbr.2015.05.013_bib0295","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.neubiorev.2008.05.003","article-title":"Olfaction: a potential cognitive marker of psychiatric disorders","volume":"32","author":"Atanasova","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2015.05.013_bib0300","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000338717","article-title":"Olfaction in affective and anxiety disorders: a review of the literature","volume":"46","author":"Buron","year":"2013","journal-title":"Psychopathology"},{"key":"10.1016\/j.bbr.2015.05.013_bib0305","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fpsyg.2014.00045","article-title":"Sadness might isolate you in a non-smelling world: olfactory perception and depression","volume":"5","author":"Schablitzky","year":"2014","journal-title":"Front Psychol"},{"key":"10.1016\/j.bbr.2015.05.013_bib0310","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jad.2006.12.012","article-title":"Reduced olfactory sensitivity in subjects with depressive symptoms","volume":"102","author":"Pollatos","year":"2007","journal-title":"J Affect Disord"},{"key":"10.1016\/j.bbr.2015.05.013_bib0315","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/da.22217","article-title":"Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV","volume":"31","author":"Uher","year":"2014","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.bbr.2015.05.013_bib0320","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.1222940","article-title":"Are we getting closer to valid translational models for major depression","volume":"338","author":"Berton","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbr.2015.05.013_bib0325","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0163-7258(97)00004-1","article-title":"The olfactory bulbectomized rat as a model of depression: an update","volume":"74","author":"Kelly","year":"1997","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bbr.2015.05.013_bib0330","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neubiorev.2005.03.010","article-title":"The olfactory bulbectomised rat as a model of depression","volume":"29","author":"Song","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2015.05.013_bib0335","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.mp.4001457","article-title":"In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice","volume":"9","author":"Cryan","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bbr.2015.05.013_bib0340","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","article-title":"Acute and chronic stress effects on open field activity in the rat: implications for a model of depression","volume":"5","author":"Katz","year":"1981","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2015.05.013_bib0345","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural\u2013neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbr.2015.05.013_bib0350","first-page":"315","article-title":"Stressed or stressed out: what is the difference","volume":"30","author":"McEwen","year":"2005","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.bbr.2015.05.013_bib0355","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bbr.2015.05.013_bib0360","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02246218","article-title":"Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine","volume":"117","author":"Monleon","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2015.05.013_bib0365","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2015.05.013_bib0370","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00008877-200605000-00008","article-title":"Selective effects of citalopram in a mouse model of stress-induced anhedonia with a control for chronic stress","volume":"17","author":"Strekalova","year":"2006","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.bbr.2015.05.013_bib0375","doi-asserted-by":"crossref","first-page":"E965","DOI":"10.1152\/ajpendo.00070.2006","article-title":"Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner","volume":"291","author":"Ulrich-Lai","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bbr.2015.05.013_bib0380","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbr.2004.04.008","article-title":"Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress","volume":"155","author":"Pothion","year":"2004","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2015.05.013_bib0385","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.bbr.2015.05.013_bib0390","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"Slattery","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bbr.2015.05.013_bib0395","doi-asserted-by":"crossref","first-page":"e45266","DOI":"10.1371\/journal.pone.0045266","article-title":"Neuropeptide Y enhances olfactory mucosa responses to odorant in hungry rats","volume":"7","author":"Negroni","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbr.2015.05.013_bib0400","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1152\/ajpregu.2002.282.1.R77","article-title":"Weight loss in rats exposed to repeated acute restraint stress is independent of energy or leptin status","volume":"282","author":"Harris","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.bbr.2015.05.013_bib0405","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0031-9384(97)00425-3","article-title":"Failure to change exploration or saccharin preference in rats exposed to chronic mild stress","volume":"63","author":"Harris","year":"1997","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2015.05.013_bib0410","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0031-9384(96)00305-8","article-title":"Chronic mild stress and sucrose consumption: validity as a model of depression","volume":"60","author":"Forbes","year":"1996","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2015.05.013_bib0415","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-9081-7-9","article-title":"Update in the methodology of the chronic stress paradigm: internal control matters","volume":"7","author":"Strekalova","year":"2011","journal-title":"Behav Brain Funct"},{"key":"10.1016\/j.bbr.2015.05.013_bib0420","doi-asserted-by":"crossref","first-page":"351","DOI":"10.31887\/DCNS.2002.4.4\/jlmoreau","article-title":"Simulating the anhedonia symptom of depression in animals","volume":"4","author":"Moreau","year":"2002","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.bbr.2015.05.013_bib0425","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.physbeh.2005.02.007","article-title":"Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions","volume":"84","author":"Gronli","year":"2005","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2015.05.013_bib0430","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00008877-200505000-00006","article-title":"Stress-induced hyperlocomotion as a confounding factor in anxiety and depression models in mice","volume":"16","author":"Strekalova","year":"2005","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.bbr.2015.05.013_bib0435","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bbi.2011.10.005","article-title":"Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses","volume":"26","author":"Frank","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.bbr.2015.05.013_bib0440","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1741-7015-11-200","article-title":"So depression is an inflammatory disease, but where does the inflammation come from?","volume":"11","author":"Berk","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.bbr.2015.05.013_bib0445","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbr.2012.03.020","article-title":"Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation","volume":"231","author":"Farooq","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2015.05.013_bib0450","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neulet.2008.06.081","article-title":"Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex","volume":"442","author":"Bachis","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2015.05.013_bib0455","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1073\/pnas.0812671106","article-title":"Dynamic regulation of mitochondrial function by glucocorticoids","volume":"106","author":"Du","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbr.2015.05.013_bib0460","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fneur.2014.00044","article-title":"Psychological stress as a modulator of functional recovery following spinal cord injury","volume":"5","author":"Maldonado Bouchard","year":"2014","journal-title":"Front Neurol"},{"key":"10.1016\/j.bbr.2015.05.013_bib0465","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1097\/00005537-199808000-00026","article-title":"Expression of glucocorticoid receptor mRNA and protein in the olfactory mucosa: physiologic and pathophysiologic implications","volume":"108","author":"Robinson","year":"1998","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bbr.2015.05.013_bib0470","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/chemse\/27.1.13","article-title":"Glucocorticoid enhances Na(+)\/K(+) ATPase mRNA expression in rat olfactory mucosa during regeneration: a possible mechanism for recovery from olfactory disturbance","volume":"27","author":"Nishimura","year":"2002","journal-title":"Chem Senses"},{"key":"10.1016\/j.bbr.2015.05.013_bib0475","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0031-9384(00)00371-1","article-title":"The effects of acute and chronic stress on motor and sensory performance in male Lewis rats","volume":"72","author":"Metz","year":"2001","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2015.05.013_bib0480","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1523\/JNEUROSCI.1835-13.2013","article-title":"When the sense of smell meets emotion: anxiety-state-dependent olfactory processing and neural circuitry adaptation","volume":"33","author":"Krusemark","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2015.05.013_bib0485","doi-asserted-by":"crossref","first-page":"e46938","DOI":"10.1371\/journal.pone.0046938","article-title":"State and trait olfactory markers of major depression","volume":"7","author":"Naudin","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbr.2015.05.013_bib0490","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.neuron.2008.10.046","article-title":"Mice with a monoclonal nose: perturbations in an olfactory map impair odor discrimination","volume":"60","author":"Fleischmann","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2015.05.013_bib0495","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1523\/JNEUROSCI.4287-11.2012","article-title":"Olfactory deficits cause anxiety-like behaviors in mice","volume":"32","author":"Glinka","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2015.05.013_bib0500","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbr.2014.08.042","article-title":"Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice","volume":"275","author":"Chen","year":"2014","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2015.05.013_bib0505","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.nbd.2014.07.008","article-title":"Effects of chronic stress on the onset and progression of Huntington's disease in transgenic mice","volume":"71","author":"Mo","year":"2014","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2015.05.013_bib0510","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nmeth.2935","article-title":"Olfactory exposure to males, including men, causes stress and related analgesia in rodents","volume":"11","author":"Sorge","year":"2014","journal-title":"Nat Methods"},{"key":"10.1016\/j.bbr.2015.05.013_bib0515","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1046\/j.0007-1331.2001.00727.x","article-title":"Chronic pain, chronic stress and depression: coincidence or consequence","volume":"13","author":"Blackburn-Munro","year":"2001","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.bbr.2015.05.013_bib0520","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.biopsych.2010.02.009","article-title":"Seeing gray when feeling blue? Depression can be measured in the eye of the diseased","volume":"68","author":"Bubl","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2015.05.013_bib0525","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/15622970701513756","article-title":"Vision in depressive disorder","volume":"10","author":"Bubl","year":"2009","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.bbr.2015.05.013_bib0530","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1167\/iovs.06-0889","article-title":"Specific activation of the glucocorticoid receptor and modulation of signal transduction pathways in human lens epithelial cells","volume":"48","author":"Gupta","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.bbr.2015.05.013_bib0535","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2014.04.047","article-title":"Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells","volume":"571","author":"Parker","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2015.05.013_bib0540","doi-asserted-by":"crossref","first-page":"e65006","DOI":"10.1371\/journal.pone.0065006","article-title":"Oral perceptions of fat and taste stimuli are modulated by affect and mood induction","volume":"8","author":"Platte","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432815003423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432815003423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T14:44:42Z","timestamp":1652021082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432815003423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":54,"alternative-id":["S0166432815003423"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2015.05.013","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic variable stress exposure in male Wistar rats affects the first step of olfactory detection","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2015.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}