{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:22:12Z","timestamp":1789694532657,"version":"4.0.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.bbr.2015.12.043","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T06:00:29Z","timestamp":1452492029000},"page":"11-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats"],"prefix":"10.1016","volume":"302","author":[{"given":"Jana","family":"Tchekalarova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlatina","family":"Nenchovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrina","family":"Atanasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Atanasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Kortenska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Stefanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Alova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Lazarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2015.12.043_bib0005","first-page":"1638","article-title":"Study on regulatory effect of Kaixin San on endogenous melatonin biosynthesis in rat depression model","volume":"37","author":"Cai","year":"2012","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.bbr.2015.12.043_bib0010","first-page":"1215","article-title":"A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression","volume":"19","author":"Claustrat","year":"1984","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0015","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0447.1985.tb02531.x","article-title":"Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome","volume":"71","author":"Beck-Friis","year":"1985","journal-title":"Acta Psychiatry Scand."},{"key":"10.1016\/j.bbr.2015.12.043_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4530(02)00123-3","article-title":"Serum melatonin and urinary 6-sulfatoxymelatonin in major depression","volume":"29","author":"Crasson","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2015.12.043_bib0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0306-4530(85)90055-1","article-title":"Melatonin: cortisol and ACTH in patients with major depressive disorder and healthy humans with special reference to the outcome of the dexamethasone suppression test","volume":"10","author":"Beck-Friis","year":"1985","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2015.12.043_bib0030","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1600-0447.1987.tb02895.x","article-title":"Depressed mood and reality disturbance correlate with decreased nocturnal melatonin in depressed patient","volume":"76","author":"Brown","year":"1987","journal-title":"Acta Psychiatry Scand."},{"key":"10.1016\/j.bbr.2015.12.043_bib0035","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1176\/appi.ajp.2010.09101525","article-title":"Issues for dsm-5: whither melancholia? The case for its classification as a distinct mood disorder","volume":"167","author":"Parker","year":"2010","journal-title":"Am J. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0040","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/sj.npp.1300091","article-title":"Effect of agomelatine in the chronic mild stress model of depression in the rat","volume":"28","author":"Papp","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2015.12.043_bib0045","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00213-004-1962-z","article-title":"Anxiolytic properties of agomelatine: an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade","volume":"177","author":"Millan","year":"2005","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2015.12.043_bib0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.euroneuro.2005.09.002","article-title":"Placebo-controlled trial of agomelatine in the treatment of major depressive disorder","volume":"16","author":"Kennedy","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0055","first-page":"661","article-title":"Efficacy of agomelatine a MT1\/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder","volume":"10","author":"Oli\u00e9","year":"2007","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0060","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/ENDO:27:2:101","article-title":"Functional MT1 and MT2 melatonin receptors in mammals","volume":"27","author":"Dubocovich","year":"2005","journal-title":"Endocrine"},{"key":"10.1016\/j.bbr.2015.12.043_bib0065","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00210-003-0751-2","article-title":"New selective ligands of human cloned melatonin MT1 and MT2 receptors","volume":"367","author":"Audinot","year":"2003","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0070","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1124\/jpet.103.051797","article-title":"The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways","volume":"306","author":"Millan","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2015.12.043_bib0075","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1111\/bph.12720","article-title":"Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties","volume":"171","author":"Guardiola-Lemaitre","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0080","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1001\/archpsyc.1990.01810170011002","article-title":"Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan","volume":"47","author":"Delgado","year":"1990","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0085","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0031-6997(24)01417-0","article-title":"Autoregulation of serotonin neurons: role in antidepressant drug action","volume":"51","author":"Pineyro","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbr.2015.12.043_bib0090","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/clinchem\/40.2.288","article-title":"Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter","volume":"40","author":"Owens","year":"1994","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbr.2015.12.043_bib0095","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0091-3057(01)00670-0","article-title":"The role of serotonin in human mood and social interaction insight from altered tryptophan levels","volume":"71","author":"Young","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2015.12.043_bib0100","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1037\/a0016242","article-title":"The bright side of being blue: depression as an adaptation for analyzing complex problems","volume":"116","author":"Andrews","year":"2009","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.bbr.2015.12.043_bib0105","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1046\/j.1471-4159.1997.69062477.x","article-title":"High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment","volume":"69","author":"Zangen","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2015.12.043_bib0110","article-title":"Serotonin and circadian rhythms","volume":"3","author":"De Bezerra","year":"2010","journal-title":"Psychol. Neurosci."},{"key":"10.1016\/j.bbr.2015.12.043_bib0115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/cne.902070305","article-title":"The serotonin neurons in nucleus raphe dorsalis of adult rat: a light and electron microscope radioautographic study","volume":"207","author":"Descarries","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0120","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.brainres.2004.11.053","article-title":"Diurnal variation in serotonin immunoreactivity in the dorsal raphe nucleus","volume":"1034","author":"Birkett","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1126\/science.162.3850.277","article-title":"Brain serotonin concentration: elevation following intraperitoneal administration of melatonin","volume":"162","author":"Anton-Tay","year":"1968","journal-title":"Science"},{"key":"10.1016\/j.bbr.2015.12.043_bib0130","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/BF00995374","article-title":"Effects of pinealectomy and melatonin treatments on serotonin uptake and release from synaptosomes of rat hypothalamic regions","volume":"20","author":"Miguez","year":"1995","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0135","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1177\/0269881111408460","article-title":"Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light\u2013dark cycle","volume":"26","author":"Dom\u0131\u0301nguez-L\u00f3pez","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0140","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2015.12.043_bib0145","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbr.2006.06.038","article-title":"Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats","volume":"173","author":"Ushijima","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0150","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/PSY.0b013e31820ad12b","article-title":"Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research","volume":"73","author":"Stetler","year":"2011","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbr.2015.12.043_bib0155","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0304-3940(03)00261-1","article-title":"Modulation of the human glucocorticoid receptor function by antidepressive compounds","volume":"342","author":"Okuyama-Tamura","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2015.12.043_bib0160","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/sj.npp.1300195","article-title":"The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones","volume":"28","author":"Pariante","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2015.12.043_bib0165","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jpsychires.2009.06.012","article-title":"A pilot study of the phase angle between cortisol and melatonin in major depression\u2014a potential biomarker?","volume":"44","author":"Buckley","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0170","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.metabol.2003.11.009","article-title":"Pinealectomy alters adipose tissue adaptability to fasting in rats","volume":"53","author":"Alonso-Vale","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.bbr.2015.12.043_bib0175","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1210\/jc.2002-021048","article-title":"MT1 melatonin receptor in the primate adrenal gland: Inhibition of adrenocorticotropin-stimulated cortisol production by melatonin","volume":"88","author":"Torres-Farfan","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbr.2015.12.043_bib0180","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/FBP.0000000000000153","article-title":"Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats","volume":"26","author":"\u00dc. \u00d6zkay","year":"2015","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0185","first-page":"83","article-title":"Rapid pinealectomy in hamsters and other small rodents","volume":"24","author":"Hoffman","year":"1965","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bbr.2015.12.043_bib0190","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.yebeh.2010.12.021","article-title":"Diurnal variations of depressive-like behavior of Wistar and spontaneously hypertensive rats in kainate model of temporal lobe epilepsy","volume":"20","author":"Tchekalarova","year":"2011","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.bbr.2015.12.043_bib0195","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/brain\/awn117","article-title":"Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine","volume":"131","author":"Mazarati","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2015.12.043_bib0200","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu075","article-title":"Melancholic-like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice","volume":"18","author":"Comai","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0205","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/070674371305800402","article-title":"A case for reprising and redefining melancholia","volume":"58","author":"Parker","year":"2013","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0210","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0278-5846(99)00075-5","article-title":"Anxiolytic-like actions of melatonin 5-metoxytryptophol, 5-hydroxytryptophol and benzodiazepines on a conflict procedure","volume":"24","author":"Naranjo-Rodriguez","year":"2000","journal-title":"Progr. Neurouropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0215","first-page":"131","article-title":"Anxiolytic activity of melatonin in mice: involvement of benzodiazepine receptors","volume":"82","author":"Pierrefiche","year":"1993","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0220","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/aps.2010.80","article-title":"Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models","volume":"31","author":"Tian","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbr.2015.12.043_bib0225","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1007\/s11064-013-1134-9","article-title":"Melatonin protects against diazinon-induced neurobehavioral changes in rats","volume":"38","author":"Ahmed","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0230","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbr.2008.01.016","article-title":"Maternal pinealectomy increases depressive-like responses in Siberian hamster offspring","volume":"189","author":"Workman","year":"2008","journal-title":"Behav. Brain. Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0235","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0031-9384(99)00237-1","article-title":"Central vasopressin administration failed to influence anxiety behavior after pinealectomy in rats","volume":"68","author":"Appenrodt","year":"2000","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2015.12.043_bib0240","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pnpbp.2014.01.015","article-title":"Anxiolytic-like effects of a new 1-N substituted analog of melatonin in pinealectomized rats","volume":"51","author":"Bustamante-Garc\u00eda","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0245","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbr.2011.03.029","article-title":"The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male wistar rats","volume":"222","author":"Karaka\u015f","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0250","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4236\/nm.2012.34049","article-title":"Pinealectomy and exogenous melatonin regulate anxiety-like and depressive-like behaviors in male and female wistar rats","volume":"3","author":"Zahra","year":"2012","journal-title":"Neurosci. Med."},{"key":"10.1016\/j.bbr.2015.12.043_bib0255","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1556\/ABiol.58.2007.4.1","article-title":"Pinealectomy and melatonin administration in rats: their effects on plasma leptin levels and relationship with zinc","volume":"58","author":"Baltaci","year":"2007","journal-title":"Acta Biol. Hung."},{"key":"10.1016\/j.bbr.2015.12.043_bib0260","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1055\/s-2004-825723","article-title":"Light\/dark cycle-dependent metabolic changes in adipose tissue of pinealectomized rats","volume":"36","author":"Alonso-Vale","year":"2004","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0265","first-page":"10","article-title":"Agomelatine: a novel antidepressant","volume":"8","author":"Sansone","year":"2011","journal-title":"Innov. Clin. Neurosci."},{"key":"10.1016\/j.bbr.2015.12.043_bib0270","first-page":"9","article-title":"Anxiolitic-like activity of agomelatine and melatonin in three animal models of anxiety","volume":"17","author":"Papp","year":"2006","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0275","doi-asserted-by":"crossref","first-page":"e485","DOI":"10.1038\/tp.2014.125","article-title":"Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine","volume":"4","author":"Boulle","year":"2014","journal-title":"Translat. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0280","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.brainresbull.2015.08.006","article-title":"The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders","volume":"119","author":"Tchekalarova","year":"2015","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2015.12.043_bib0285","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrd3274","article-title":"Agomelatine, the first melatonergic antidepressant: discovery, characterization and development","volume":"9","author":"de Bodinat","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbr.2015.12.043_bib0290","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/A:1027337606929","article-title":"Melatonin effects on serotonin synthesis and metabolism in the striatum nucleus accumbens, and dorsal and median raphe nuclei of rats","volume":"22","author":"Miguez","year":"1997","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0295","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1600-079X.1993.tb00522.x","article-title":"Pineal modulation of the rat caudate-putamen spontaneous neuronal activity: roles of melatonin and vasotocin","volume":"15","author":"Castillo-Romero","year":"1993","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0300","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1046\/j.0007-1331.2001.00761.x","article-title":"V Melatonin modulates [3h]serotonin release in the rat hippocampus: effects of circadian rhythm","volume":"14","author":"Monnet","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.bbr.2015.12.043_bib0305","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1210\/endo-99-2-641","article-title":"Presence of melatonin in plasma and urine of pinealectomized rats","volume":"99","author":"Ozaki","year":"1976","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbr.2015.12.043_bib0310","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/0024-3205(93)90106-D","article-title":"Tryptophan loading increases daytime serum melatonin levels in intact and pinealectomized rats","volume":"52","author":"Yaga","year":"1993","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2015.12.043_bib0315","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000123170","article-title":"Persistence of circadian rhythms of melatonin and N-acetylserotonin in the serum of rats after pinealectomy","volume":"32","author":"Yu","year":"1981","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.bbr.2015.12.043_bib0320","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0165-1781(94)90074-4","article-title":"In vivo serotonin release and learned helplessness","volume":"52","author":"Petty","year":"1994","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0325","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0165-0173(91)90008-V","article-title":"Melatonin binding sites in the central nervous system","volume":"16","author":"Stankov","year":"1991","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.bbr.2015.12.043_bib0330","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-079X.1993.tb00484.x","article-title":"The role of the pineal in the control of the daily patterns of neurohypophysial hormone secretion","volume":"14","author":"Forsling","year":"1993","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbr.2015.12.043_bib0335","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000054312","article-title":"Chronic melatonin treatment counteracts glucocorticoid-induced dysregulation of the hypothalamic-pituitary-adrenal axis in the rat","volume":"67","author":"Konakchieva","year":"1998","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.bbr.2015.12.043_bib0340","first-page":"1215","article-title":"A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression","volume":"19","author":"Claustrat","year":"1984","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0345","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0278-5846(99)00110-4","article-title":"Modulation of estrous cycle and LH: FSH and melatonin levels by pinealectomy and sham-pinealectomy in female rats","volume":"24","author":"Dardes","year":"2000","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0350","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.pnpbp.2005.04.032","article-title":"Antidepressant action of agomelatine (S 20098) in a transgenic mouse model","volume":"29","author":"Barden","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2015.12.043_bib0355","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neurobiolaging.2005.12.004","article-title":"Pinealectomy causes hippocampal CA1 and CA3 cell loss: reversal by melatonin supplementation","volume":"28","author":"De Butte","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbr.2015.12.043_bib0360","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/npp.2009.72","article-title":"Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant agomelatine, in the adult rat hippocampus","volume":"34","author":"Soumier","year":"2009","journal-title":"Neuropsychopharmacology"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432815303545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432815303545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T02:58:27Z","timestamp":1748746707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432815303545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":72,"alternative-id":["S0166432815303545"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2015.12.043","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2015.12.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}