{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:30:46Z","timestamp":1775201446387,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.bbr.2016.01.022","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T03:31:54Z","timestamp":1452569514000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Low intensity, long term exposure to tobacco smoke inhibits hippocampal neurogenesis in adult mice"],"prefix":"10.1016","volume":"302","author":[{"given":"D\u00e1vid","family":"Csabai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kata","family":"Csek\u0151","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilla","family":"Szaiff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Varga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Miseta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Helyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boldizs\u00e1r","family":"Cz\u00e9h","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2016.01.022_bib0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.etp.2005.05.010","article-title":"Analysis of complex mixtures-cigarette smoke","volume":"57","author":"Borgerding","year":"2005","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.bbr.2016.01.022_bib0010","series-title":"The Chemical Components of Tobacco and Tobacco Smoke","first-page":"1471","author":"Rodgman","year":"2013"},{"key":"10.1016\/j.bbr.2016.01.022_bib0015","first-page":"181","article-title":"Tobacco smoking in countries of the European Union","volume":"19","author":"Zatonski","year":"2012","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.bbr.2016.01.022_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2015.06.004","article-title":"Negative affective states and cognitive impairments in nicotine dependence","author":"Hall","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2016.01.022_bib0025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/JCP.0b013e31802dffde","article-title":"Abnormal hippocampal neurochemistry in smokers: evidence from proton magnetic resonance spectroscopy at 3T","volume":"27","author":"Gallinat","year":"2007","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.bbr.2016.01.022_bib0030","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/35066584","article-title":"Neurogenesis in the adult is involved in the formation of trace memories","volume":"410","author":"Shors","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2016.01.022_bib0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrn2822","article-title":"New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?","volume":"11","author":"Deng","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2016.01.022_bib0040","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1523\/JNEUROSCI.4256-09.2010","article-title":"Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction","volume":"30","author":"Noonan","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.01.022_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2012.12.005","article-title":"Adult hippocampal neurogenesis in the pathogenesis of addiction and dual diagnosis disorders","volume":"130","author":"Chambers","year":"2013","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbr.2016.01.022_bib0050","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1523\/JNEUROSCI.22-09-03656.2002","article-title":"Nicotine self-administration impairs hippocampal plasticity","volume":"22","author":"Abrous","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.01.022_bib0055","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s00213-005-0086-4","article-title":"The effects of chronic nicotine on spatial learning and bromodeoxyuridine incorporation into the dentate gyrus of the rat","volume":"184","author":"Scerri","year":"2006","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.01.022_bib0060","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.brainres.2011.07.041","article-title":"Tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of adolescent rats","volume":"1413","author":"Bruijnzeel","year":"2011","journal-title":"Brain. Res."},{"key":"10.1016\/j.bbr.2016.01.022_bib0065","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.etp.2013.06.001","article-title":"A review of in vitro cigarette smoke exposure systems","volume":"65","author":"Thorne","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.bbr.2016.01.022_bib0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0006-8993(88)90055-8","article-title":"Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system","volume":"457","author":"Miller","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2016.01.022_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10874","article-title":"Transient expression of doublecortin during adult neurogenesis","volume":"467","author":"Brown","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbr.2016.01.022_bib0080","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.0953-816X.2003.03123.x","article-title":"Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus","volume":"19","author":"Rao","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2016.01.022_bib0085","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/cne.1040","article-title":"Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus","volume":"435","author":"Cameron","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbr.2016.01.022_bib0090","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1073\/pnas.211427898","article-title":"Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine","volume":"98","author":"Cz\u00e9h","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2016.01.022_bib0095","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0006-3223(02)01457-9","article-title":"Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis","volume":"52","author":"Cz\u00e9h","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2016.01.022_bib0100","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.1073\/pnas.120552597","article-title":"Opiates inhibit neurogenesis in the adult rat hippocampus","volume":"97","author":"Eisch","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2016.01.022_bib0105","series-title":"The Mouse Brain in Stereotaxic Coordinates","first-page":"2001","author":"Paxinos","year":"2016"},{"key":"10.1016\/j.bbr.2016.01.022_bib0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neubiorev.2014.07.014","article-title":"Whole tobacco smoke extracts to model tobacco dependence in animals","volume":"47","author":"Brennan","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2016.01.022_bib0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/019262339802600301","article-title":"A review of chronic inhalation studies with mainstream cigarette smoke in rats and mice","volume":"26","author":"Coggins","year":"1998","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.bbr.2016.01.022_bib0120","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bcp.2011.06.021","article-title":"Nicotinic control of adult\u2013born neuron fate","volume":"82","author":"Campbell","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbr.2016.01.022_bib0125","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1089\/scd.2010.0326","article-title":"Chronic nicotine administration impairs activation of cyclic AMP-response element binding protein and survival of newborn cells in the dentate gyrus","volume":"21","author":"Wei","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bbr.2016.01.022_bib0130","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/ntr\/ntv051","article-title":"Effect of alcohol and tobacco smoke on long-term memory and cell proliferation in the hippocampus of rats","volume":"17","author":"Gomez","year":"2015","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.bbr.2016.01.022_bib0135","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuroscience.2006.12.012","article-title":"Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation","volume":"145","author":"Mudo","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2016.01.022_bib0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00213-014-3685-0","article-title":"Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus","volume":"232","author":"Cohen","year":"2015","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.01.022_bib0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00213-009-1716-z","article-title":"Tobacco smoke exposure induces nicotine dependence in rats","volume":"208","author":"Small","year":"2010","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.01.022_bib0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbi.2012.09.003","article-title":"Neurogenesis, inflammation and behavior","volume":"27","author":"Kohman","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/j.bbr.2016.01.022_bib0155","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021303","article-title":"Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation","volume":"7","author":"Lucassen","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.bbr.2016.01.022_bib0160","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tins.2014.12.006","article-title":"The role of inflammatory cytokines as key modulators of neurogenesis","volume":"38","author":"Borsini","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2016.01.022_bib0165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000097202","article-title":"Passage of cytokines across the blood-brain barrier","volume":"2","author":"Banks","year":"1995","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.bbr.2016.01.022_bib0170","series-title":"The Neuroimmunological Basis of Behavior and Mental Disorders. Part I","first-page":"3","article-title":"Cytokines and the Blood\u2013Brain Barrier","author":"Banks","year":"2009"},{"key":"10.1016\/j.bbr.2016.01.022_bib0175","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1523\/JNEUROSCI.2723-06.2006","article-title":"Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis","volume":"26","author":"Iosif","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.01.022_bib0180","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1073\/pnas.0708092105","article-title":"IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress","volume":"105","author":"Koo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2016.01.022_bib0185","first-page":"5","article-title":"Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration","volume":"5","author":"Seguin","year":"2009","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.bbr.2016.01.022_bib0190","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1523\/JNEUROSCI.22-02-00486.2002","article-title":"Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6","volume":"22","author":"Vallieres","year":"2002","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.bbr.2016.01.022_bib0195","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/hipo.22192","article-title":"p21Cip restrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation","volume":"23","author":"Zonis","year":"2013","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2016.01.022_bib0200","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fnins.2014.00083","article-title":"Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory","volume":"8","author":"Valero","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbr.2016.01.022_bib0205","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12974-015-0281-0","article-title":"Chronic intestinal inflammation alters hippocampal neurogenesis","volume":"12","author":"Zonis","year":"2015","journal-title":"J. Neuroinflammation"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816300195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816300195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T12:51:45Z","timestamp":1567515105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816300195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":41,"alternative-id":["S0166432816300195"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.01.022","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low intensity, long term exposure to tobacco smoke inhibits hippocampal neurogenesis in adult mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}