{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:32:03Z","timestamp":1762079523394},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.bbr.2016.02.025","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T12:27:02Z","timestamp":1456576022000},"page":"100-107","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Conessine, an H3 receptor antagonist, alters behavioral and neurochemical effects of ethanol in mice"],"prefix":"10.1016","volume":"305","author":[{"given":"Gessynger","family":"Morais-Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariane","family":"Ferreira-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo T.","family":"Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2016.02.025_bib0005","series-title":"Global Status Report on Alcohol and Health","author":"WHO","year":"2014"},{"key":"10.1016\/j.bbr.2016.02.025_bib0010","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0140-6736(09)60746-7","article-title":"Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders","volume":"373","author":"Rehm","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2016.02.025_bib0015","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/10673220490910844","article-title":"Neurobiologic processes in drug reward and addiction","volume":"12","author":"Adinoff","year":"2004","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.bbr.2016.02.025_bib0020","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrn1919","article-title":"The role of the basal ganglia in habit formation","volume":"7","author":"Yin","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2016.02.025_bib0025","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1176\/appi.ajp.162.8.1403","article-title":"The neural basis of addiction: a pathology of motivation and choice","volume":"162","author":"Kalivas","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2016.02.025_bib0030","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrn3526","article-title":"The histaminergic network in the brain: basic organization and role in disease","volume":"14","author":"Panula","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2016.02.025_bib0035","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1248\/cpb.55.912","article-title":"Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL","volume":"55","author":"Kumar","year":"2007","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.bbr.2016.02.025_bib0040","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1021\/jm8003625","article-title":"The alkaloid conessine and analogues as potent histamine H3 receptor antagonists","volume":"51","author":"Zhao","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbr.2016.02.025_bib0045","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1124\/jpet.102.047183","article-title":"Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects","volume":"305","author":"Esbenshade","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2016.02.025_bib0050","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1007\/PL00022438","article-title":"Effect of alcohol abuse on human brain histamine and tele-methylhistamine","volume":"51","author":"Alak\u00e4rpp\u00e4","year":"2002","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0055","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/01.ALC.0000156128.28257.2E","article-title":"Thr105Ile, a functional polymorphism of histamine N-methyltransferase is associated with alcoholism in two independent populations","volume":"29","author":"Oroszi","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0060","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.drugalcdep.2006.08.006","article-title":"Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians","volume":"87","author":"Reuter","year":"2007","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbr.2016.02.025_bib0065","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0091-3057(01)00477-4","article-title":"Role of central histaminergic system in lorazepam withdrawal syndrome in rats","volume":"68","author":"Nath","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2016.02.025_bib0070","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1096\/fj.00-0545fje","article-title":"Increased brain histamine in an alcohol-preferring rat line, and modulation of ethanol consumption by H3 receptor mechanisms","volume":"15","author":"Lintunen","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.bbr.2016.02.025_bib0075","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/acer.12388","article-title":"Stress abolishes the effect of previous chronic ethanol consumption on drug place preference and on the mesocorticolimbic brain pathway","volume":"38","author":"Moreira-Silva","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0080","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.bbr.2016.02.025_bib0085","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neuropharm.2010.10.027","article-title":"Effects of histamine H3 receptor ligands on the rewarding, stimulant and motor-impairing effects of ethanol in DBA\/2J mice","volume":"60","author":"Nuutinen","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2016.02.025_bib0090","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2010.07.002","article-title":"Involvement of the brain histaminergic system in addiction and addiction-related behaviors: a comprehensive review with emphasis on the potential therapeutic use of histaminergic compounds in drug dependence","volume":"92","author":"Brabant","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2016.02.025_bib0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00213-009-1710-5","article-title":"Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice","volume":"208","author":"Nuutinen","year":"2010","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.02.025_bib0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00213-013-3019-7","article-title":"Influence of the novel histamine H3 receptor antagonist ST1283 on voluntary alcohol consumption and ethanol-induced place preference in mice","volume":"228","author":"Bahi","year":"2013","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.02.025_bib0105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bph.12170","article-title":"Histamine is required for H3 receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation","volume":"170","author":"Vanhanen","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2016.02.025_bib0110","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1124\/mol.113.090118","article-title":"Adrenaline rush: the role of adrenergic receptors in stimulant-induced behaviours","volume":"86","author":"Schmidt","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbr.2016.02.025_bib0115","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.neuropharm.2008.06.032","article-title":"Desipramine potentiation of the acute depressant effects of ethanol: Modulation by??2-adrenoreceptors and stress","volume":"55","author":"Boyce-Rustay","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2016.02.025_bib0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02431535","article-title":"Time course of ethanol\u2019s effects on locomotor activity, exploration and anxiety in mice","volume":"96","author":"Durcan","year":"1988","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.02.025_bib0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbr.2006.05.010","article-title":"Locomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL\/6J mice","volume":"172","author":"Tambour","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbr.2012.10.019","article-title":"Effects of l-histidine and histamine H3 receptor modulators on ethanol-induced sedation in mice","volume":"238","author":"Didone","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0135","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbr.2004.11.029","article-title":"The H3 antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL\/6J mice","volume":"160","author":"Brabant","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0140","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.pbb.2006.03.018","article-title":"Effects of the H3-receptor inverse agonist thioperamide on the psychomotor effects induced by acutely and repeatedly given cocaine in C57BL\/6J mice","volume":"83","author":"Brabant","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2016.02.025_bib0145","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00213-008-1345-y","article-title":"Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions","volume":"202","author":"Brabant","year":"2009","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.02.025_bib0150","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1038\/npp.2011.90","article-title":"Evidence for the role of histamine H3 receptor in alcohol consumption and alcohol reward in mice","volume":"36","author":"Nuutinen","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2016.02.025_bib0155","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1037\/a0036459","article-title":"Genetic relationship between ethanol-induced conditioned place preference and other ethanol phenotypes in 15 inbred mouse strains","volume":"128","author":"Cunningham","year":"2014","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.bbr.2016.02.025_bib0160","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0028-3932(00)00136-6","article-title":"Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers","volume":"39","author":"Bechara","year":"2001","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.bbr.2016.02.025_bib0165","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn1579","article-title":"Neural systems of reinforcement for drug addiction: from actions to habits to compulsion","volume":"8","author":"Everitt","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"Suppl","key":"10.1016\/j.bbr.2016.02.025_bib0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1360-0443.2006.01586.x","article-title":"The neurobiology of addiction: a neuroadaptational view relevant for diagnosis","volume":"101","author":"Koob","year":"2006","journal-title":"Addiction"},{"key":"10.1016\/j.bbr.2016.02.025_bib0175","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of addiction","volume":"35","author":"Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2016.02.025_bib0180","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/j.neuropharm.2012.01.011","article-title":"Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning","volume":"62","author":"Pascual","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2016.02.025_bib0185","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/acer.12042","article-title":"Intravenous ethanol increases extracellular dopamine in the medial prefrontal cortex of the Long-Evans rat","volume":"37","author":"Schier","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0190","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1523\/JNEUROSCI.23-05-01879.2003","article-title":"Norepinephrine in the prefrontal cortex is critical for amphetamine-induced reward and mesoaccumbens dopamine release","volume":"23","author":"Ventura","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.02.025_bib0195","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1097\/01.wnr.0000239964.83566.75","article-title":"Ethanol consumption and reward depend on norepinephrine in the prefrontal cortex","volume":"17","author":"Ventura","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2016.02.025_bib0200","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/cercor\/bhi066","article-title":"Prefrontal cortical norepinephrine release is critical for morphine-induced reward, reinstatement and dopamine release in the nucleus accumbens","volume":"15","author":"Ventura","year":"2005","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bbr.2016.02.025_bib0205","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0166-4328(99)00022-4","article-title":"Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies","volume":"101","author":"McBride","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0210","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/bjp.2008.51","article-title":"The neurocircuitry of addiction: an overview","volume":"154","author":"Feltenstein","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2016.02.025_bib0215","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1111\/j.1530-0277.2009.00985.x","article-title":"Sensitization of ventral tegmental area dopamine neurons to the stimulating effects of ethanol","volume":"33","author":"Ding","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.02.025_bib0220","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00013.2008","article-title":"Alcoholism: a systems approach from molecular physiology to addictive behavior","volume":"89","author":"Spanagel","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbr.2016.02.025_bib0225","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0301-0082(83)90010-2","article-title":"The relative importance of dopamine and norepinephrine in mediating locomotor activity","volume":"20","author":"Fishman","year":"1983","journal-title":"Prog. Neurobiol."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816301012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816301012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T14:46:48Z","timestamp":1654440408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816301012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":45,"alternative-id":["S0166432816301012"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.02.025","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conessine, an H3 receptor antagonist, alters behavioral and neurochemical effects of ethanol in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}