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Neurosci."},{"key":"10.1016\/j.bbr.2016.05.012_bib0360","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1523\/JNEUROSCI.3523-14.2015","article-title":"Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors","volume":"359","author":"Guidi","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.05.012_bib0365","doi-asserted-by":"crossref","first-page":"15710","DOI":"10.1523\/JNEUROSCI.2176-13.2013","article-title":"Linking redox regulation of NMDAR synaptic function to cognitive decline during aging","volume":"3340","author":"Kumar","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.05.012_bib0370","doi-asserted-by":"crossref","unstructured":"C. Gemma, J. Vila, A. Bachstetter, P.C. Bickford, Oxidative stress and the aging brain: from theory to prevention. In: D.R. Riddle, (Ed.). Brain Aging: Models, Methods, and Mechanisms. Front. Neurosci. Boca Raton (FL) 2007.","DOI":"10.1201\/9781420005523-15"},{"key":"10.1016\/j.bbr.2016.05.012_bib0375","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1474-9726.2007.00294.x","article-title":"Oxidative stress and aberrant signaling in aging and cognitive decline","volume":"63","author":"Droge","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbr.2016.05.012_bib0380","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.neurobiolaging.2013.12.002","article-title":"Role of antioxidant enzymes in redox regulation of N-methyl-d-aspartate receptor function and memory in middle-aged rats","volume":"356","author":"Lee","year":"2014","journal-title":"Neurobiol. 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Brain Res."},{"key":"10.1016\/j.bbr.2016.05.012_bib0415","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbapap.2004.09.012","article-title":"Redox modulation of cellular signaling and metabolism through reversible oxidation of methionine sensors in calcium regulatory proteins","volume":"17032","author":"Bigelow","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbr.2016.05.012_bib0420","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jsb.2010.12.002","article-title":"Site-specific methionine oxidation in calmodulin affects structural integrity and interaction with Ca2+\/calmodulin-dependent protein kinase II","volume":"1741","author":"Snijder","year":"2011","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.bbr.2016.05.012_bib0425","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2007.02.087","article-title":"Oxidation of calmodulin alters activation and regulation of CaMKII","volume":"3561","author":"Robison","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbr.2016.05.012_bib0430","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neurobiolaging.2007.06.011","article-title":"Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice","volume":"302","author":"Dewachter","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbr.2016.05.012_bib0435","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-015-0002-2","article-title":"APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice","volume":"10","author":"Liu","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbr.2016.05.012_bib0440","doi-asserted-by":"crossref","first-page":"12011","DOI":"10.1073\/pnas.0914984107","article-title":"ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling","volume":"10726","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2016.05.012_bib0445","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","article-title":"Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease","volume":"466","author":"McLean","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2016.05.012_bib0450","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-beta","volume":"88","author":"Snyder","year":"2005","journal-title":"Nat. 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Neurosci."},{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2016.05.012_bib0615","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1016\/j.psyneuen.2009.06.003","article-title":"Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3-CA1 synapses","volume":"34","author":"Smith","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2016.05.012_bib0620","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hipo.22068","article-title":"Estradiol-induced increase in novel object recognition requires hippocampal NR2B-containing NMDA receptors","volume":"231","author":"Vedder","year":"2013","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2016.05.012_bib0625","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1523\/JNEUROSCI.22-09-03628.2002","article-title":"A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat","volume":"229","author":"Clayton","year":"2002","journal-title":"J. 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