{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:45:37Z","timestamp":1790232337748,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271395"],"award-info":[{"award-number":["81271395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81130027"],"award-info":[{"award-number":["81130027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhi Q"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bbr.2016.08.008","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T15:34:31Z","timestamp":1470411271000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Brain structure alterations and cognitive impairment following repetitive mild head impact: An in vivo MRI and behavioral study in rat"],"prefix":"10.1016","volume":"340","author":[{"given":"Yang","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gai-Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Hua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Wen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Bao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2016.08.008_bib0005","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00001199-200609000-00001","article-title":"The epidemiology and impact of traumatic brain injury: a brief overview","volume":"21","author":"Langlois","year":"2006","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.bbr.2016.08.008_bib0010","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1016\/j.apmr.2013.08.300","article-title":"Systematic review of the prognosis after mild traumatic brain injury in adults: cognitive, psychiatric, and mortality outcomes: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis","volume":"95","author":"Carroll","year":"2014","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.bbr.2016.08.008_bib0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.csm.2010.09.001","article-title":"The molecular pathophysiology of concussive brain injury","volume":"30","author":"Barkhoudarian","year":"2011","journal-title":"Clin. Sports Med."},{"key":"10.1016\/j.bbr.2016.08.008_bib0020","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.1016\/j.jalz.2014.04.006","article-title":"Cognitive changes and dementia risk after traumatic brain injury: implications for aging military personnel","volume":"10","author":"Vincent","year":"2014","journal-title":"Alzheimer\u2019s Dementia: J. Alzheimer\u2019s Assoc."},{"key":"10.1016\/j.bbr.2016.08.008_bib0025","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1089\/neu.2013.2941","article-title":"Biopsychosocial outcome after uncomplicated mild traumatic brain injury","volume":"31","author":"Waljas","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0030","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fneur.2013.00079","article-title":"Amyloid-beta peptides and tau protein as biomarkers in cerebrospinal and interstitial fluid following traumatic brain injury: a review of experimental and clinical studies","volume":"4","author":"Tsitsopoulos","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbr.2016.08.008_bib0035","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrneurol.2013.29","article-title":"Chronic neuropathologies of single and repetitive TBI: substrates of dementia?","volume":"9","author":"Smith","year":"2013","journal-title":"Nature Rev. Neurol."},{"key":"10.1016\/j.bbr.2016.08.008_bib0040","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/neu.2008.0845","article-title":"Repeated traumatic brain injury affects composite cognitive function in piglets","volume":"26","author":"Friess","year":"2009","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0045","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/jcbfm.2014.6","article-title":"Repeated mild traumatic brain injury results in long-term white-matter disruption","volume":"34","author":"Donovan","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2016.08.008_bib0050","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1089\/neu.2012.2498","article-title":"Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes","volume":"29","author":"Mouzon","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0055","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ana.24064","article-title":"Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model","volume":"75","author":"Mouzon","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2016.08.008_bib0060","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pharmthera.2011.01.001","article-title":"Animal models of traumatic brain injury: a critical evaluation","volume":"130","author":"O'Connor","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbr.2016.08.008_bib0065","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1089\/neu.2010.1427","article-title":"Craniotomy: true sham for traumatic brain injury, or a sham of a sham","volume":"28","author":"Cole","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jneumeth.2011.09.003","article-title":"A mouse model of human repetitive mild traumatic brain injury","volume":"203","author":"Kane","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2016.08.008_bib0075","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1152\/jn.00970.2014","article-title":"Repetitive mild traumatic brain injury induces ventriculomegaly and cortical thinning in juvenile rats","volume":"113","author":"Goddeyne","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbr.2016.08.008_bib0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.mvr.2006.02.002","article-title":"Calponin and caldesmon cellular domains in reacting microvessels following traumatic brain injury","volume":"71","author":"Kreipke","year":"2006","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.bbr.2016.08.008_bib0085","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3171\/jns.1994.80.2.0291","article-title":"A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics","volume":"80","author":"Marmarou","year":"1994","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bbr.2016.08.008_bib0090","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1089\/neu.2013.3132","article-title":"Assessment of an experimental rodent model of pediatric mild traumatic brain injury","volume":"31","author":"Mychasiuk","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0095","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.expneurol.2012.03.012","article-title":"Mild traumatic brain injury in the rat alters neuronal number in the limbic system and increases conditioned fear and anxiety-like behaviors","volume":"235","author":"Meyer","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2016.08.008_bib0100","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1227\/01.NEU.0000163407.92769.ED","article-title":"Chronic traumatic encephalopathy in a National Football League player","volume":"57","author":"Omalu","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bbr.2016.08.008_bib0105","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0079-6123(06)61018-2","article-title":"Experimental models of repetitive brain injuries","volume":"161","author":"Weber","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.bbr.2016.08.008_bib0110","doi-asserted-by":"crossref","first-page":"e0126110","DOI":"10.1371\/journal.pone.0126110","article-title":"Cognitive improvement after mild traumatic brain injury measured with functional neuroimaging during the acute period","volume":"10","author":"Wylie","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2016.08.008_bib0115","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3346\/jkms.2015.30.10.1496","article-title":"Effects of repetitive transcranial magnetic stimulation on behavioral recovery during early stage of traumatic brain injury in rats","volume":"30","author":"Yoon","year":"2015","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.bbr.2016.08.008_bib0120","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.neuroimage.2009.10.022","article-title":"B-value dependence of DTI quantitation and sensitivity in detecting neural tissue changes","volume":"49","author":"Hui","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbr.2016.08.008_bib0125","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1089\/neu.2012.2836","article-title":"White matter\/gray matter contrast changes in chronic and diffuse traumatic brain injury","volume":"30","author":"Palacios","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0130","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1212\/WNL.0b013e3181d0ccdd","article-title":"A prospective diffusion tensor imaging study in mild traumatic brain injury","volume":"74","author":"Mayer","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2016.08.008_bib0135","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.lfs.2015.01.013","article-title":"Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury","volume":"124","author":"Farbood","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2016.08.008_bib0140","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/NEN.0b013e31821f891f","article-title":"Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity","volume":"70","author":"Shitaka","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbr.2016.08.008_bib0145","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"D'Hooge","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.bbr.2016.08.008_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psc.2013.11.004","article-title":"Cognitive sequelae of traumatic brain injury","volume":"37","author":"Rabinowitz","year":"2014","journal-title":"Psychiatric Clin. North Am."},{"key":"10.1016\/j.bbr.2016.08.008_bib0155","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/ar.22715","article-title":"Evaluation of hippocampal injury and cognitive function induced by embolization in the rat brain","volume":"296","author":"Zhang","year":"2013","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bbr.2016.08.008_bib0160","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0306-4522(97)00007-9","article-title":"Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury","volume":"80","author":"Chen","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2016.08.008_bib0165","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbr.2016.08.008_bib0170","doi-asserted-by":"crossref","DOI":"10.1007\/s00221-015-4405-7","article-title":"Beneficial effects of hyperbaric oxygen on edema in rat hippocampus following traumatic brain injury","author":"Liu","year":"2015","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.bbr.2016.08.008_bib0175","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3892\/mmr.2013.1369","article-title":"In vivo dynamic monitoring of the biological behavior of labeled C6 glioma by MRI","volume":"7","author":"Liao","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbr.2016.08.008_bib0180","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/jcbfm.2014.56","article-title":"Role of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage","volume":"34","author":"Gao","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2016.08.008_bib0185","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3171\/jns.1994.80.2.0301","article-title":"A new model of diffuse brain injury in rats. Part II: Morphological characterization","volume":"80","author":"Foda","year":"1994","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bbr.2016.08.008_bib0190","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1089\/neu.2010.1739","article-title":"Early microstructural and metabolic changes following controlled cortical impact injury in rat: a magnetic resonance imaging and spectroscopy study","volume":"28","author":"Xu","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0195","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbr.2010.11.043","article-title":"The double-H maze test, a novel, simple, water-escape memory task: acquisition, recall of recent and remote memory, and effects of systemic muscarinic or NMDA receptor blockade during training","volume":"218","author":"Pol-Bodetto","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.08.008_bib0200","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/j.1476-5381.2010.01163.x","article-title":"Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?","volume":"164","author":"Marklund","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2016.08.008_bib0205","first-page":"8","article-title":"Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury","volume":"2","author":"Cassidy","year":"2004","journal-title":"J. Rehabil. Med."},{"key":"10.1016\/j.bbr.2016.08.008_bib0210","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12974-015-0405-6","article-title":"Microglia processes associate with diffusely injured axons following mild traumatic brain injury in the micro pig","volume":"12","author":"Lafrenaye","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbr.2016.08.008_bib0215","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/revneuro-2015-0017","article-title":"Traumatic brain injury: a risk factor for neurodegenerative diseases","volume":"27","author":"Gupta","year":"2016","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.bbr.2016.08.008_bib0220","first-page":"1575","article-title":"Evidence of apoptotic cell death after experimental traumatic brain injury in the rat","volume":"147","author":"Rink","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbr.2016.08.008_bib0225","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11682-012-9178-z","article-title":"A functional MRI study of multimodal selective attention following mild traumatic brain injury","volume":"6","author":"Mayer","year":"2012","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.bbr.2016.08.008_bib0230","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1089\/neu.2011.1913","article-title":"Mild traumatic brain injury and diffuse axonal injury in swine","volume":"28","author":"Browne","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0235","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1089\/neu.2014.3677","article-title":"A threshold shear force for calcium influx in an astrocyte model of traumatic brain injury","volume":"32","author":"Maneshi","year":"2015","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.08.008_bib0240","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1002\/jnr.21677","article-title":"Selective death of newborn neurons in hippocampal dentate gyrus following moderate experimental traumatic brain injury","volume":"86","author":"Gao","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbr.2016.08.008_bib0245","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s11682-012-9164-5","article-title":"Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma","volume":"6","author":"Baugh","year":"2012","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.bbr.2016.08.008_bib0250","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/nan.12006","article-title":"Review: the long-term consequences of microglial activation following acute traumatic brain injury","volume":"39","author":"Smith","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816305009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816305009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T14:54:39Z","timestamp":1575384879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816305009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":50,"alternative-id":["S0166432816305009"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.08.008","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain structure alterations and cognitive impairment following repetitive mild head impact: An in vivo MRI and behavioral study in rat","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}