{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:10:53Z","timestamp":1772309453702,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"the National Center for Posttraumatic Stress Disorder-Veterans Affairs Connecticut","award":["NIH R01MH098073"],"award-info":[{"award-number":["NIH R01MH098073"]}]},{"name":"the VA Cooperative Study #575B, Genomics of Posttraumatic Stress Disorder in Veterans"},{"name":"the Biological Sciences Training Program","award":["MH14276"],"award-info":[{"award-number":["MH14276"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.bbr.2016.08.010","type":"journal-article","created":{"date-parts":[[2016,8,7]],"date-time":"2016-08-07T11:42:36Z","timestamp":1470570156000},"page":"71-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect"],"prefix":"10.1016","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-8365","authenticated-orcid":false,"given":"Janitza L.","family":"Montalvo-Ortiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly A.","family":"Bordner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Becky C.","family":"Carlyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Gelernter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur A.","family":"Simen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2016.08.010_bib0005","unstructured":"DHHS, The AFCARS Report, in Adoption and Foster Care Analysis and Reporting System (AFCARS) FY 2013 data, (2014). U.S. Department of Health and Human Services, Administration for Children and Families, Administration on Children, Youth and Families, Children's Bureau, programs\/cb."},{"issue":"1","key":"10.1016\/j.bbr.2016.08.010_bib0010","first-page":"73","article-title":"Childhood and adolescent depression","volume":"75","author":"Bhatia","year":"2007","journal-title":"Am. Fam. Physician"},{"issue":"1","key":"10.1016\/j.bbr.2016.08.010_bib0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/archpsyc.64.1.49","article-title":"A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up","volume":"64","author":"Widom","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2016.08.010_bib0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.amepre.2012.10.012","article-title":"Child abuse and epigenetic mechanisms of disease risk","volume":"44","author":"Yang","year":"2013","journal-title":"Am. J. Prev. Med."},{"issue":"3","key":"10.1016\/j.bbr.2016.08.010_bib0025","doi-asserted-by":"crossref","first-page":"281","DOI":"10.31887\/DCNS.2014.16.3\/rbagot","article-title":"Epigenetic signaling in psychiatric disorders: stress and depression","volume":"16","author":"Bagot","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"issue":"22","key":"10.1016\/j.bbr.2016.08.010_bib0030","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.1073\/pnas.1408355111","article-title":"DNA methylation of BDNF as a biomarker of early-life adversity","volume":"112","author":"Kundakovic","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2016.08.010_bib0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuropharm.2014.01.013","article-title":"The role of DNA methylation in stress-related psychiatric disorders","volume":"80","author":"Klengel","year":"2014","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.bbr.2016.08.010_bib0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jaac.2013.12.025","article-title":"Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry","volume":"53","author":"Weder","year":"2014","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.010_bib0045","first-page":"p3","article-title":"Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders","volume":"3","author":"Sanacora","year":"2011","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.bbr.2016.08.010_bib0050","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ajmg.b.31212","article-title":"Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder","volume":"156B","author":"Smith","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"20","key":"10.1016\/j.bbr.2016.08.010_bib0055","doi-asserted-by":"crossref","first-page":"8302","DOI":"10.1073\/pnas.1217750110","article-title":"Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder","volume":"110","author":"Mehta","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bbr.2016.08.010_bib0060","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/mp.2013.41","article-title":"Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits","volume":"19","author":"Wong","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbr.2016.08.010_bib0065","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajmg.b.30272","article-title":"Evaluating the comparability of gene expression in blood and brain","volume":"141B","author":"Sullivan","year":"2006","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"1","key":"10.1016\/j.bbr.2016.08.010_bib0070","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajmg.b.32278","article-title":"DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain","volume":"168B","author":"Smith","year":"2015","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.bbr.2016.08.010_bib0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2202-11-123","article-title":"Maternal separation with early weaning: a novel mouse model of early life neglect","volume":"11","author":"George","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbr.2016.08.010_bib0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fpsyt.2011.00018","article-title":"Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect","volume":"2","author":"Bordner","year":"2011","journal-title":"Front Psychiatry"},{"issue":"9","key":"10.1016\/j.bbr.2016.08.010_bib0085","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.biopsych.2005.10.013","article-title":"TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting","volume":"59","author":"Simen","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2016.08.010_bib0090","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbr.2016.08.010_bib0095","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"18","key":"10.1016\/j.bbr.2016.08.010_bib0100","first-page":"18","article-title":"Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect","volume":"2","author":"Bordner","year":"2011","journal-title":"Front Psychiatry"},{"issue":"123","key":"10.1016\/j.bbr.2016.08.010_bib0105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2202-11-123","article-title":"Maternal separation with early weaning: a novel mouse model of early life neglect","volume":"11","author":"George","year":"2010","journal-title":"BMC Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2016.08.010_bib0110","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neubiorev.2003.09.003","article-title":"The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics","volume":"27","author":"Heidbreder","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"9","key":"10.1016\/j.bbr.2016.08.010_bib0115","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1523\/JNEUROSCI.13-09-03839.1993","article-title":"The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress","volume":"13","author":"Diorio","year":"1993","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.bbr.2016.08.010_bib0120","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1017\/S1092852900013754","article-title":"The subgenual anterior cingulate cortex in mood disorders","volume":"13","author":"Drevets","year":"2008","journal-title":"CNS Spectr."},{"issue":"1","key":"10.1016\/j.bbr.2016.08.010_bib0125","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/ejn.12208","article-title":"Early-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats","volume":"38","author":"Chocyk","year":"2013","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2016.08.010_bib0130","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ajmg.b.32395","article-title":"RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders","volume":"171","author":"Montalvo-Ortiz","year":"2016","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"1","key":"10.1016\/j.bbr.2016.08.010_bib0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.euroneuro.2010.06.016","article-title":"Chronic stress and impaired glutamate function elicit a depressive-like phenotype and common changes in gene expression in the mouse frontal cortex","volume":"21","author":"Tordera","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"5","key":"10.1016\/j.bbr.2016.08.010_bib0140","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/hmg\/ddt516","article-title":"Sex-biased methylome and transcriptome in human prefrontal cortex","volume":"23","author":"Xu","year":"2014","journal-title":"Hum. Mol. Genet."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816305022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816305022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T09:22:06Z","timestamp":1657012926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816305022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":28,"alternative-id":["S0166432816305022"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.08.010","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}