{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:20:10Z","timestamp":1790745610195,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.bbr.2016.08.017","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T10:32:23Z","timestamp":1470738743000},"page":"159-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Reduced white matter integrity and its correlation with clinical symptom in first-episode, treatment-naive generalized anxiety disorder"],"prefix":"10.1016","volume":"314","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-2303","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowen","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuolin","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2016.08.017_bib0005","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0010","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1017\/S0033291712002383","article-title":"Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders","volume":"43","author":"Ball","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbr.2016.08.017_bib0015","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.biopsycho.2011.10.010","article-title":"Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder","volume":"89","author":"Klumpp","year":"2012","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.bbr.2016.08.017_bib0020","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.biopsych.2012.04.013","article-title":"Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia\/generalized anxiety disorder","volume":"72","author":"Blair","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0025","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1176\/appi.ajp.2008.07101682","article-title":"Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response","volume":"166","author":"Nitschke","year":"2009","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0030","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1002\/da.21961","article-title":"Neurocircuitry of generalized anxiety disorder in adolescents: a pilot functional neuroimaging and functional connectivity study","volume":"29","author":"Strawn","year":"2012","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.bbr.2016.08.017_bib0035","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jad.2014.01.022","article-title":"Neural structures, functioning and connectivity in Generalized Anxiety Disorder and interaction with neuroendocrine systems: a systematic review","volume":"158","author":"Hilbert","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2016.08.017_bib0040","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jaac.2012.12.010","article-title":"Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder","volume":"52","author":"Roy","year":"2013","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0045","article-title":"Aberrant regional neural fluctuations and functional connectivity in generalized anxiety disorder revealed by resting-state functional magnetic resonance imaging","author":"Wang","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2016.08.017_bib0050","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.pscychresns.2015.10.009","article-title":"Gray and white matter volume abnormalities in generalized anxiety disorder by categorical and dimensional characterization","volume":"234","author":"Hilbert","year":"2015","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbr.2016.08.017_bib0055","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1001\/archgenpsychiatry.2011.2178","article-title":"Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder","volume":"69","author":"Tromp","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0060","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/nbm.1940080707","article-title":"Inferring microstructural features and the physiological state of tissues from diffusion-weighted images","volume":"8","author":"Basser","year":"1995","journal-title":"NMR Biomed."},{"key":"10.1016\/j.bbr.2016.08.017_bib0065","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system \u2212 a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.bbr.2016.08.017_bib0070","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.neuroimage.2008.09.041","article-title":"A study of diffusion tensor imaging by tissue-specific, smoothing-compensated voxel-based analysis","volume":"44","author":"Lee","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbr.2016.08.017_bib0075","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1038\/npp.2013.122","article-title":"Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder","volume":"38","author":"Chen","year":"2013","journal-title":"Neuropsychopharmacol: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2016.08.017_bib0080","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1017\/S0033291715000586","article-title":"Attention network functioning in children with anxiety disorders, attention-deficit\/hyperactivity disorder and non-clinical anxiety","volume":"45","author":"Mogg","year":"2015","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbr.2016.08.017_bib0085","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1471-244X-14-41","article-title":"White matter abnormalities in adolescents with generalized anxiety disorder: a diffusion tensor imaging study","volume":"14","author":"Liao","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0090","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jad.2011.03.040","article-title":"Different white matter abnormalities between the first-episode, treatment-naive patients with posttraumatic stress disorder and generalized anxiety disorder without comorbid conditions","volume":"133","author":"Zhang","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2016.08.017_bib0095","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jad.2012.11.060","article-title":"White matter integrity alterations in first episode, treatment-naive generalized anxiety disorder","volume":"148","author":"Zhang","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2016.08.017_bib0100","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders. Patient Edition (SCID-I\/P)","author":"MSR","year":"1995"},{"key":"10.1016\/j.bbr.2016.08.017_bib0105","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"key":"10.1016\/j.bbr.2016.08.017_bib0110","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.janxdis.2014.06.002","article-title":"Beyond generalized anxiety disorder: psychometric properties of the GAD-7 in a heterogeneous psychiatric sample","volume":"28","author":"Beard","year":"2014","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.bbr.2016.08.017_bib0115","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0120","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.neuroimage.2007.12.035","article-title":"Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template","volume":"40","author":"Mori","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbr.2016.08.017_bib0125","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.neuroimage.2007.07.053","article-title":"Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification","volume":"39","author":"Hua","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbr.2016.08.017_bib0130","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1001\/archpsyc.64.1.97","article-title":"Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder","volume":"64","author":"McClure","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0135","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1176\/ajp.2006.163.6.1091","article-title":"Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder","volume":"163","author":"Monk","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0140","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1001\/archpsyc.65.5.568","article-title":"Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder","volume":"65","author":"Monk","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0145","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1176\/appi.ajp.2009.09070931","article-title":"Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder","volume":"167","author":"Etkin","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2016.08.017_bib0150","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/npp.2009.121","article-title":"Changing fear: the neurocircuitry of emotion regulation","volume":"35","author":"Hartley","year":"2010","journal-title":"Neuropsychopharmacol: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2016.08.017_bib0155","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.neuron.2008.06.029","article-title":"Neural circuitry underlying the regulation of conditioned fear and its relation to extinction","volume":"59","author":"Delgado","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2016.08.017_bib0160","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.jad.2014.06.041","article-title":"A systematic review of fMRI studies in generalized anxiety disorder: evaluating its neural and cognitive basis","volume":"167","author":"Mochcovitch","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2016.08.017_bib0165","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1037\/a0012910","article-title":"Trouble crossing the bridge: altered interhemispheric communication of emotional images in anxiety","volume":"8","author":"Compton","year":"2008","journal-title":"Emotion"},{"key":"10.1016\/j.bbr.2016.08.017_bib0170","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.jad.2012.09.022","article-title":"Fronto-occipital fasciculus, corpus callosum and superior longitudinal fasciculus tract alterations of first-episode, medication-naive and late-onset panic disorder patients","volume":"146","author":"Lai","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2016.08.017_bib0175","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1017\/S0033291711001255","article-title":"White-matter abnormalities in the right posterior hemisphere in generalized anxiety disorder: a diffusion imaging study","volume":"42","author":"Brambilla","year":"2012","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbr.2016.08.017_bib0180","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1109\/JSTSP.2008.2006718","article-title":"Multimodal and multi-tissue measures of connectivity revealed by joint independent component analysis","volume":"2","author":"Franco","year":"2008","journal-title":"IEEE J. Sel. Top. Signal Process."},{"key":"10.1016\/j.bbr.2016.08.017_bib0185","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.neuroimage.2003.07.005","article-title":"Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia","volume":"20","author":"Song","year":"2003","journal-title":"Neuroimage"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816305095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816305095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T06:25:51Z","timestamp":1536474351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816305095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":37,"alternative-id":["S0166432816305095"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.08.017","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced white matter integrity and its correlation with clinical symptom in first-episode, treatment-naive generalized anxiety disorder","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}