{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:40:35Z","timestamp":1773290435913,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS060005"],"award-info":[{"award-number":["NS060005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD069620"],"award-info":[{"award-number":["HD069620"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD069620-S1, NS084967"],"award-info":[{"award-number":["HD069620-S1, NS084967"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS094950"],"award-info":[{"award-number":["NS094950"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Pittsburgh Physicians\/UPMC Academic Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bbr.2016.09.049","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T07:01:10Z","timestamp":1482562870000},"page":"159-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Intermittent treatment with haloperidol or quetiapine does not disrupt motor and cognitive recovery after experimental brain trauma"],"prefix":"10.1016","volume":"340","author":[{"given":"Jillian J.","family":"Weeks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren J.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah L.","family":"Radabaugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia B.","family":"de la Tremblaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina O.","family":"Bondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony E.","family":"Kline","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2016.09.049_bib0005","doi-asserted-by":"crossref","unstructured":"M. Faul, l. Xu, M.M. Wald, V.G. Coronado, Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002\u20132006. Atlanta (GA): Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. 2010.","DOI":"10.15620\/cdc.5571"},{"key":"10.1016\/j.bbr.2016.09.049_bib0010","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/00001199-199912000-00009","article-title":"Traumatic brain injury in the United States: a public health perspective","volume":"14","author":"Thurman","year":"1999","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.bbr.2016.09.049_bib0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.HTR.0000314531.30401.39","article-title":"Incidence of long-term disability following traumatic brain injury hospitalization United States, 2003","volume":"23","author":"Selassie","year":"2008","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.bbr.2016.09.049_bib0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pneurobio.2016.05.002","article-title":"Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: is more better?","volume":"142","author":"Kline","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2016.09.049_bib0025","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1682\/JRRD.2008.09.0120","article-title":"Pharmacological management of neurobehavioral disorders following traumatic brain injury-a state-of-the-art review","volume":"46","author":"Chew","year":"2009","journal-title":"J. Rehabil. Res. Dev."},{"key":"10.1016\/j.bbr.2016.09.049_bib0030","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/01.phm.0000179438.22235.08","article-title":"Agitation after traumatic brain injury: considerations and treatment options","volume":"84","author":"Lombard","year":"2005","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.bbr.2016.09.049_bib0035","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3109\/02699052.2012.667587","article-title":"The prevalence, treatment and outcomes of agitation among patients with brain injury admitted to acute care units","volume":"26","author":"McNett","year":"2012","journal-title":"Brain Inj."},{"key":"10.1016\/j.bbr.2016.09.049_bib0040","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/01.HTR.0000314532.07530.e5","article-title":"The use of atypical antipsychotics after traumatic brain injury","volume":"23","author":"Elovic","year":"2008","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.bbr.2016.09.049_bib0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0035-1544241","article-title":"Neuropsychiatric disturbances associated with traumatic brain injury: a practical approach to evaluation and management","volume":"35","author":"Rao","year":"2015","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.bbr.2016.09.049_bib0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/026990597123494","article-title":"Cognitive effects of antipsychotic agents in persons with traumatic brain injury","volume":"11","author":"Stanislav","year":"1997","journal-title":"Brain Inj."},{"key":"10.1016\/j.bbr.2016.09.049_bib0055","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0003-9993(96)90306-8","article-title":"The agitated brain injured patient. Part 1: Definitions, differential diagnosis, and assessment","volume":"77","author":"Sandel","year":"1996","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.bbr.2016.09.049_bib0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neulet.2008.10.076","article-title":"Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury","volume":"448","author":"Kline","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2016.09.049_bib0065","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.lfs.2008.08.007","article-title":"Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits","volume":"83","author":"Hoffman","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2016.09.049_bib0070","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/01.PHM.0000091982.33232.CB","article-title":"Haloperidol but not olanzapine, impairs cognitive performance after traumatic brain injury in rats","volume":"82","author":"Wilson","year":"2003","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.bbr.2016.09.049_bib0075","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1089\/neu.2014.3711","article-title":"Divergent long-term consequences of chronic treatment with haloperidol risperidone, and bromocriptine on traumatic brain injury-induced cognitive deficits","volume":"32","author":"Phelps","year":"2015","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.09.049_bib0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0022-3956(98)00023-5","article-title":"New atypical antipsychotic medications","volume":"32","author":"Jibson","year":"1998","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2016.09.049_bib0085","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.mp.4001556","article-title":"Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs","volume":"10","author":"Miyamoto","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2016.09.049_bib0090","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/154596830201600402","article-title":"Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats","volume":"16","author":"Goldstein","year":"2002","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.bbr.2016.09.049_bib0095","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/01.CCM.0000256722.88854.C0","article-title":"Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma","volume":"35","author":"Kline","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbr.2016.09.049_bib0100","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1089\/neu.2010.1535","article-title":"Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury","volume":"27","author":"Kline","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.09.049_bib0105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/1545968310390520","article-title":"Abbreviated environmental enrichment enhances neurobehavioral recovery comparably to continuous exposure after traumatic brain injury","volume":"25","author":"de Witt","year":"2011","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.bbr.2016.09.049_bib0110","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1177\/1545968310397206","article-title":"Temporal effects of environmental enrichment-mediated functional improvement after experimental traumatic brain injury in rats","volume":"25","author":"Matter","year":"2011","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.bbr.2016.09.049_bib0115","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1089\/neu.2012.2560","article-title":"A relatively brief exposure to environmental enrichment after experimental traumatic brain injury confers long-term cognitive benefits","volume":"29","author":"Cheng","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.09.049_bib0120","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0278-5846(02)00221-X","article-title":"The effect of chronic treatment with typical and atypical antipsychotics on working memory and jaw movements in three-and eighteen-month-old rats","volume":"26","author":"Rosengarten","year":"2002","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2016.09.049_bib0125","article-title":"Combining the antipsychotic drug haloperidol and environmental enrichment after traumatic brain injury is a double-edged sword","author":"Folweiler","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.09.049_bib0130","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.brainres.2015.07.012","article-title":"Quetiapine attenuates cognitive impairment and decreases seizure susceptibility possibly through promoting myelin development in a rat model of malformations of cortical development","volume":"1622","author":"Ma","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2016.09.049_bib0135","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1126\/science.7100929","article-title":"Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury","volume":"217","author":"Feeney","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.bbr.2016.09.049_bib0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Development of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2016.09.049_bib0145","first-page":"209","article-title":"Haloperidol blocks amphetamine induced recovery of binocular depth perception after bilateral visual cortex ablation in cat","volume":"28","author":"Hovda","year":"1985","journal-title":"Proc. West. Pharmacol. Soc."},{"key":"10.1016\/j.bbr.2016.09.049_bib0150","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1089\/neu.2014.3328","article-title":"Environmental enrichment as a viable neurorehabilitation strategy for experimental traumatic brain injury","volume":"31","author":"Bondi","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.09.049_bib0155","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neubiorev.2014.12.004","article-title":"Found in translation: understanding the biology and behavior of experimental traumatic brain injury","volume":"58","author":"Bondi","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2016.09.049_bib0160","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1176\/jnp.2006.18.4.547","article-title":"A pilot study of quetiapine treatment of aggression due to traumatic brain injury","volume":"18","author":"Kim","year":"2006","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.bbr.2016.09.049_bib0165","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.eurpsy.2011.10.003","article-title":"Neurocognitive effectiveness of quetiapine, olanzapine, risperidone, and ziprasidone: a pragmatic, randomized trial","volume":"28","author":"Johnsen","year":"2013","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.bbr.2016.09.049_bib0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00213-011-2487-x","article-title":"Effects of quetiapine and sertindole on subchronic ketamine-induced deficits in attentional set-shifting in rats","volume":"220","author":"Nikiforuk","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2016.09.049_bib0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.33549\/physiolres.931756","article-title":"Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: implications for the treatment of posttraumatic stress disorder","volume":"59","author":"Wang","year":"2010","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bbr.2016.09.049_bib0180","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4088\/JCP.v69n0324a","article-title":"Quetiapine treatment for mania secondary to brain injury in 2 patients","volume":"69","author":"Daniels","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2016.09.049_bib0185","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/08977150252932370","article-title":"Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact","volume":"19","author":"Kline","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.09.049_bib0190","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1089\/neu.2004.21.1712","article-title":"Bromocriptine reduces lipid peroxidation and enhances spatial learning and hippocampal neuron survival in a rodent model of focal brain trauma","volume":"21","author":"Kline","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.09.049_bib0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(00)00797-7","article-title":"Chronic methylphenidate treatment enhances water maze performance following traumatic brain injury in rats","volume":"280","author":"Kline","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2016.09.049_bib0200","article-title":"The therapeutic efficacy of environmental enrichment and methylphenidate alone and in combination after controlled cortical impact injury","author":"Leary","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2016.09.049_bib0205","first-page":"285","article-title":"Amantadine improves water maze performance without affecting motor behavior following traumatic brain injury in rats","volume":"14","author":"Dixon","year":"1999","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.bbr.2016.09.049_bib0210","first-page":"161","article-title":"Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action","volume":"25","author":"Kapur","year":"2000","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.bbr.2016.09.049_bib0215","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/archpsyc.57.6.553","article-title":"A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy","volume":"57","author":"Kapur","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2016.09.049_bib0220","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0893-133X(01)00261-5","article-title":"Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects","volume":"25","author":"Wadenberg","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2016.09.049_bib0225","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1142\/S0219635214500253","article-title":"Cognitive effects of acute restraint stress in male albino rats and the impact of pretreatment with quetiapine versus ghrelin","volume":"13","author":"Amin","year":"2014","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.bbr.2016.09.049_bib0230","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbr.2006.04.009","article-title":"The effects of chronic administration of quetiapine on the methamphetamine-induced recognition memory impairment and dopaminergic terminal deficit in rats","volume":"172","author":"He","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.09.049_bib0235","first-page":"82","article-title":"Quetiapine and buspirone both elevate cortical levels of noradrenaline and dopamine in vivo, but do not have synergistic effects","volume":"14","author":"Silverstone","year":"2012","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2016.09.049_bib0240","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0006-8993(02)03570-9","article-title":"Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism","volume":"956","author":"Ichikawa","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2016.09.049_bib0245","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.brainres.2015.11.026","article-title":"5-hydroxytryptamine1A (5-HT1A) receptor agonists: a decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma","volume":"1640","author":"Cheng","year":"2016","journal-title":"Brain Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816306817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816306817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T21:40:07Z","timestamp":1658266807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816306817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":49,"alternative-id":["S0166432816306817"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.09.049","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intermittent treatment with haloperidol or quetiapine does not disrupt motor and cognitive recovery after experimental brain trauma","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.09.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}