{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:06:38Z","timestamp":1771337198792,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bbr.2016.11.010","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T18:18:38Z","timestamp":1478801918000},"page":"25-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice"],"prefix":"10.1016","volume":"319","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Uchiumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Ogiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Shui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieko","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2016.11.010_bib0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbr.2016.11.010_bib0010","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2016.11.010_bib0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.cellbio.14.1.111","article-title":"Functions of lipid rafts in biological membranes","volume":"14","author":"Brown","year":"1998","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbr.2016.11.010_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-0102(02)00080-9","article-title":"Lipid rafts at postsynaptic sites: distribution: function and linkage to postsynaptic density","volume":"44","author":"Suzuki","year":"2002","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbr.2016.11.010_bib0025","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0166-2236(02)02215-4","article-title":"Lipid rafts in neuronal signaling and function","volume":"25","author":"Tsui-Pierchala","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2016.11.010_bib0030","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/1073858410393977","article-title":"Building excitable membranes: lipid rafts and multiple controls on trafficking of electrogenic molecules","volume":"18","author":"Prister\u00e1","year":"2012","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbr.2016.11.010_bib0035","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bbalip.2015.02.001","article-title":"Lipid membrane domains in the brain","volume":"1851","author":"Aureli","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbr.2016.11.010_bib0040","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1242\/dmm.010124","article-title":"Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases","volume":"5","author":"Vance","year":"2012","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.bbr.2016.11.010_bib0045","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1074\/jbc.M205406200","article-title":"Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neurons","volume":"278","author":"Karten","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2016.11.010_bib0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cmet.2010.07.004","article-title":"Transfer of cholesterol by the NPC team","volume":"12","author":"Vance","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbr.2016.11.010_bib0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mp.2015.14","article-title":"The impact of chronic stress on the rat brain lipidome","volume":"21","author":"Oliveira","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2016.11.010_bib0060","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/jnc.13537","article-title":"A sphingolipid mechanism for behavioral extinction","volume":"137","author":"Huston","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2016.11.010_bib0065","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/jnc.13589","article-title":"The role of sphingolipids in neuronal plasticity of the brain","volume":"137","author":"Sonnino","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2016.11.010_bib0070","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.bbalip.2014.12.014","article-title":"Brain membrane lipids in major depression and anxiety disorder","volume":"1851","author":"M\u00fcller","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbr.2016.11.010_bib0075","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1073\/pnas.55.2.366","article-title":"The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick diseae","volume":"55","author":"Brady","year":"1966","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2016.11.010_bib0080","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/jnc.13145","article-title":"A central role for the acid sphingomyelinase\/ceramide system in neurogenesis and major depression","volume":"134","author":"Gulbins","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2016.11.010_bib0085","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nm.3214","article-title":"Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs","volume":"19","author":"Gulbins","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbr.2016.11.010_bib0090","doi-asserted-by":"crossref","first-page":"29421","DOI":"10.1074\/jbc.R600021200","article-title":"The multigenic sphingomyelin synthase family","volume":"281","author":"Tafesse","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2016.11.010_bib0095","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/ATVBAHA.108.168682","article-title":"Sphingomyelin synthase 2 deficiency attenuates NF-B activation","volume":"28","author":"Hailemariam","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbr.2016.11.010_bib0100","doi-asserted-by":"crossref","first-page":"28544","DOI":"10.1074\/jbc.M111.255646","article-title":"Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity fatty liver, and type 2 diabetes","volume":"286","author":"Mitsutake","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2016.11.010_bib0105","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1113\/jphysiol.2012.235846","article-title":"Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice","volume":"590","author":"Lu","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbr.2016.11.010_bib0110","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.physbeh.2014.10.005","article-title":"Fear conditioning suppresses large-conductance calcium-activated potassium channels in lateral amygdala neurons","volume":"138","author":"Sun","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2016.11.010_bib0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuropharm.2014.12.033","article-title":"Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer\u2019s disease","volume":"92","author":"Wang","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2016.11.010_bib0120","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neuropharm.2015.05.027","article-title":"Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer\u2019s disease model mice","volume":"97","author":"Wang","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2016.11.010_bib0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2015.02.008","article-title":"Homer1a disruption increases vulnerability to predictable subtle stress normally sub-threshold for behavioral change","volume":"1605","author":"Shui","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2016.11.010_bib0130","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1152\/jn.1999.82.4.1993","article-title":"Action potential-induced dendritic calcium dynamics correlated with synaptic plasticity in developing hippocampal pyramidal cells","volume":"82","author":"Isomura","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbr.2016.11.010_bib0135","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1194\/jlr.M059972","article-title":"Analysis of lipid-composition changes in plasma membrane microdomains","volume":"56","author":"Ogiso","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbr.2016.11.010_bib0140","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/metabo4010098","article-title":"Comparative analysis of biological sphingolipids with glycerophospholipids and diacylglycerol by LC-MS\/MS","volume":"4","author":"Ogiso","year":"2014","journal-title":"Metabolites"},{"key":"10.1016\/j.bbr.2016.11.010_bib0145","doi-asserted-by":"crossref","first-page":"16464","DOI":"10.1523\/JNEUROSCI.1542-11.2011","article-title":"Increase in cortical pyramidal cell excitability accompanies depression-like behavior in mice: a transcranial magnetic stimulation study","volume":"31","author":"Sun","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.010_bib0150","doi-asserted-by":"crossref","first-page":"5619","DOI":"10.1073\/pnas.091502398","article-title":"SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis","volume":"98","author":"Chamberlain","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2016.11.010_bib0155","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/emboj\/20.9.2202","article-title":"SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis","volume":"20","author":"Lang","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bbr.2016.11.010_bib0160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1083\/jcb.140.1.39","article-title":"Sphingomyelinase treatment induces ATP-independent endocytosis","volume":"140","author":"Zha","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbr.2016.11.010_bib0165","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.bbrc.2011.12.079","article-title":"Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation","volume":"417","author":"Kidani","year":"2012","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"10.1016\/j.bbr.2016.11.010_bib0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/sj.emboj.7600034","article-title":"Identification of a family of animal sphingomyelin synthases","volume":"23","author":"Huitema","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbr.2016.11.010_bib0175","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuroscience.2010.02.033","article-title":"Defects of synaptic vesicle turnover at excitatory and inhibitory synapses in Niemann-Pick C1-deficient neurons","volume":"167","author":"Xu","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2016.11.010_bib0180","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.expneurol.2008.04.019","article-title":"Cholesterol depletion inhibits synaptic transmission and synaptic plasticity in rat hippocampus","volume":"212","author":"Frank","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2016.11.010_bib0185","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tips.2003.11.007","article-title":"Targeting of ion channels to membrane microdomains: localization of KV channels to lipid rafts","volume":"25","author":"Martens","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbr.2016.11.010_bib0190","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1073\/pnas.94.14.7661","article-title":"Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases","volume":"94","author":"Gulbins","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2016.11.010_bib0195","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0006-291X(03)00763-0","article-title":"Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms","volume":"305","author":"Bock","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbr.2016.11.010_bib0200","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1523\/JNEUROSCI.23-08-03262.2003","article-title":"Lipid rafts in the maintenance of synapses dendritic spines, and surface AMPA receptor stability","volume":"23","author":"Hering","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.010_bib0205","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cell.2009.10.020","article-title":"Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory","volume":"139","author":"Kitamura","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2016.11.010_bib0210","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.30.051606.094328","article-title":"The medial temporal lobe and recognition memory","volume":"30","author":"Eichenbaum","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.010_bib0215","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.1523\/JNEUROSCI.2278-15.2015","article-title":"Bidirectional modulation of recognition memory","volume":"235","author":"Ho","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.010_bib0220","doi-asserted-by":"crossref","first-page":"22173","DOI":"10.1074\/jbc.272.35.22173","article-title":"Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase\/p38 kinases and GADD153","volume":"272","author":"Brenner","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2016.11.010_bib0225","doi-asserted-by":"crossref","first-page":"9812","DOI":"10.1074\/jbc.M109862200","article-title":"Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase","volume":"277","author":"Brann","year":"2002","journal-title":"J. Biol. Chem."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816310282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816310282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T13:12:39Z","timestamp":1568553159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816310282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":45,"alternative-id":["S0166432816310282"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.11.010","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}