{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:59:25Z","timestamp":1790650765526,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001721","name":"University of Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bbr.2016.11.023","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T19:14:15Z","timestamp":1479323655000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats"],"prefix":"10.1016","volume":"319","author":[{"given":"Leonie","family":"Gouweleeuw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris B.","family":"Hovens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L.","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regien G.","family":"Schoemaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2016.11.023_bib0005","doi-asserted-by":"crossref","first-page":"e79624","DOI":"10.1371\/journal.pone.0079624","article-title":"Role of peripheral inflammatory markers in postoperative cognitive dysfunction (POCD): a meta-analysis","volume":"8","author":"Peng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2016.11.023_bib0010","doi-asserted-by":"crossref","first-page":"14641","DOI":"10.1523\/JNEUROSCI.2173-12.2012","article-title":"Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats","volume":"32","author":"Barrientos","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.023_bib0015","doi-asserted-by":"crossref","first-page":"R88","DOI":"10.1186\/cc9019","article-title":"The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction","volume":"14","author":"Terrando","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbr.2016.11.023_bib0020","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22082","article-title":"Role of interleukin-1beta in postoperative cognitive dysfunction","volume":"68","author":"Cibelli","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2016.11.023_bib0025","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.bbi.2012.06.004","article-title":"Thinking through postoperative cognitive dysfunction: how to bridge the gap between clinical and pre-clinical perspectives","volume":"26","author":"Hovens","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2016.11.023_bib0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbi.2014.12.026","article-title":"The role of neutrophil gelatinase associated lipocalin (NGAL) as biological constituent linking depression and cardiovascular disease","volume":"46","author":"Gouweleeuw","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2016.11.023_bib0035","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1096\/fj.11-202457","article-title":"Lipocalin 2: novel component of proinflammatory signaling in Alzheimer\u2019s disease","volume":"26","author":"Naud\u00e9","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.bbr.2016.11.023_bib0040","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jpsychores.2013.08.023","article-title":"Neutrophil gelatinase-associated lipocalin: a novel inflammatory marker associated with late-life depression","volume":"75","author":"Naud\u00e9","year":"2013","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.bbr.2016.11.023_bib0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.psyneuen.2014.06.016","article-title":"Sex-specific associations between Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cognitive domains in late-life depression","volume":"48","author":"Naud\u00e9","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2016.11.023_bib0050","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron","volume":"432","author":"Flo","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2016.11.023_bib0055","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nchembio.402","article-title":"Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex","volume":"6","author":"Bao","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbr.2016.11.023_bib0060","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.4049\/jimmunol.179.5.3231","article-title":"A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia","volume":"179","author":"Lee","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbr.2016.11.023_bib0065","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/sj.jcbfm.9600557","article-title":"Lipocalin 2 is a choroid plexus acute-phase protein","volume":"28","author":"Marques","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2016.11.023_bib0070","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbi.2016.02.003","article-title":"Postoperative cognitive dysfunction and neuroinflammation; cardiac surgery and abdominal surgery are not the same","volume":"54","author":"Hovens","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2016.11.023_bib0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.physbeh.2016.04.040","article-title":"Differences in the association between behavior and neutrophil gelatinase-associated lipocalin in male and female rats after coronary artery ligation","volume":"163","author":"Gouweleeuw","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2016.11.023_bib0080","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.exger.2013.07.011","article-title":"Surgery-induced behavioral changes in aged rats","volume":"48","author":"Hovens","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbr.2016.11.023_bib0085","doi-asserted-by":"crossref","first-page":"R148","DOI":"10.1152\/ajpregu.00002.2015","article-title":"Prior infection exacerbates postoperative cognitive dysfunction in aged rats","volume":"309","author":"Hovens","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbr.2016.11.023_bib0090","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0031-9384(94)90305-0","article-title":"Behavioral changes following chronic myocardial infarction in rats","volume":"56","author":"Schoemaker","year":"1994","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2016.11.023_bib0095","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/2347-8659.139719","article-title":"A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining: cell body to cell size ratio","volume":"1","author":"Hovens","year":"2014","journal-title":"Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.bbr.2016.11.023_bib0100","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12011-012-9564-9","article-title":"Surgical trauma induces iron accumulation and oxidative stress in a rodent model of postoperative cognitive dysfunction","volume":"151","author":"An","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbr.2016.11.023_bib0105","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbi.2010.10.015","article-title":"Immune modulation of learning memory, neural plasticity and neurogenesis","volume":"25","author":"Yirmiya","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2016.11.023_bib0110","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbi.2014.02.002","article-title":"Postoperative cognitive dysfunction: involvement of neuroinflammation and neuronal functioning","volume":"38","author":"Hovens","year":"2014","journal-title":"Brain Behav. Immun."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816306271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816306271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T12:57:12Z","timestamp":1536238632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816306271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":22,"alternative-id":["S0166432816306271"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.11.023","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.11.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}