{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:49:10Z","timestamp":1770511750443,"version":"3.49.0"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health grants","doi-asserted-by":"crossref","award":["R01 AA019462"],"award-info":[{"award-number":["R01 AA019462"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health grants","doi-asserted-by":"crossref","award":["R01 AA019884"],"award-info":[{"award-number":["R01 AA019884"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bbr.2016.11.036","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T01:11:57Z","timestamp":1479863517000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Ifenprodil infusion in agranular insular cortex alters social behavior and vocalizations in rats exposed to moderate levels of ethanol during prenatal development"],"prefix":"10.1016","volume":"320","author":[{"given":"Clark W.","family":"Bird","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Barto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy M.","family":"Magcalas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos I.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tia","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzy","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel D.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2016.11.036_bib0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-2008-1071418","article-title":"The psychomotor development during the first year of life of infants exposed to intrauterine alcohol of various duration. Fetal alcohol exposure and development","volume":"22","author":"Autti-R\u00e4m\u00f6","year":"1991","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.bbr.2016.11.036_bib0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0166-4328(03)00028-7","article-title":"Children with Fetal Alcohol Syndrome are impaired at place learning but not cued-navigation in a virtual Morris water task","volume":"143","author":"Hamilton","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0015","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neubiorev.2006.06.020","article-title":"Defining the behavioral phenotype in children with fetal alcohol spectrum disorders: a review","volume":"31","author":"Kodituwakku","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2016.11.036_bib0020","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1017\/S1355617799555082","article-title":"Implicit and explicit memory functioning in children with heavy prenatal alcohol exposure","volume":"5","author":"Mattson","year":"1999","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.bbr.2016.11.036_bib0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1530-0277.2012.01952.x","article-title":"Further development of a neurobehavioral profile of fetal alcohol spectrum disorders","volume":"37","author":"Mattson","year":"2013","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ntt.2012.11.003","article-title":"Children with heavy prenatal alcohol exposure have different frequency domain signal characteristics when producing isometric force","volume":"35","author":"Nguyen","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11065-011-9166-x","article-title":"Fetal alcohol spectrum disorders: an overview","volume":"21","author":"Riley","year":"2011","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.bbr.2016.11.036_bib0040","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1017\/S1355617704104116","article-title":"Bimanual coordination in alcohol-exposed children: role of the corpus callosum","volume":"10","author":"Roebuck-Spencer","year":"2004","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.bbr.2016.11.036_bib0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.alcohol.2010.02.013","article-title":"Motor response programming and movement time in children with heavy prenatal alcohol exposure","volume":"44","author":"Simmons","year":"2010","journal-title":"Alcohol"},{"key":"10.1016\/j.bbr.2016.11.036_bib0050","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/acer.12225","article-title":"Sensory-motor deficits in children with fetal alcohol spectrum disorder assessed using a robotic virtual reality platform","volume":"38","author":"Williams","year":"2014","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0055","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/DBP.0b013e3181d5a4e2","article-title":"Neurodevelopmental functioning in children with FAS, pFAS, and ARND","volume":"31","author":"Chasnoff","year":"2010","journal-title":"J. Dev. Behav. Pediatr."},{"key":"10.1016\/j.bbr.2016.11.036_bib0060","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1542\/peds.2013-3319","article-title":"Prevalence and characteristics of fetal alcohol spectrum disorders","volume":"134","author":"May","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbr.2016.11.036_bib0065","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1530-0277.1990.tb01222.x","article-title":"Neuropsychological deficits in fetal alcohol syndrome and fetal alcohol effects","volume":"14","author":"Conry","year":"1990","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0070","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1001\/jama.1991.03460150065025","article-title":"Fetal alcohol syndrome in adolescents and adults","volume":"265","author":"Streissguth","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.bbr.2016.11.036_bib0075","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1530-0277.1990.tb01224.x","article-title":"Moderate prenatal alcohol exposure: effects on child IQ and learning problems at age 7 1\/2 years","volume":"14","author":"Streissguth","year":"1990","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0080","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tins.2012.01.006","article-title":"Does moderate drinking harm the fetal brain: insights from animal models","volume":"35","author":"Valenzuela","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0085","first-page":"76","article-title":"Consumo de tabaco y bebidas alcoh\u00f3licas durante el embarazo","volume":"55","author":"Miguez","year":"2009","journal-title":"Acta Psiqui\u00e1trica y Psicol\u00f3gica de Am\u00e9rica Latina"},{"key":"10.1016\/j.bbr.2016.11.036_bib0090","first-page":"273","article-title":"Alcohol use among women of childbearing age\u2013United States, 1991\u20131999","volume":"51","author":"(CDC) CfDCaP","year":"2002","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.bbr.2016.11.036_bib0095","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00003081-199306000-00005","article-title":"The epidemiology of alcohol, marijuana, and cocaine use among women of childbearing age and pregnant women","volume":"36","author":"Day","year":"1993","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0100","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1186\/1471-2458-11-584","article-title":"Attitudes and behaviour predict women's intention to drink alcohol during pregnancy: the challenge for health professionals","volume":"11","author":"Peadon","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.bbr.2016.11.036_bib0105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2393-11-52","article-title":"The epidemiology of alcohol utilization during pregnancy: an analysis of the Canadian Maternity Experiences Survey (MES)","volume":"11","author":"Walker","year":"2011","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.bbr.2016.11.036_bib0110","first-page":"534","article-title":"Alcohol use and binge drinking among women of childbearing age\u2013United States, 2006\u20132010","volume":"61","author":"(CDC) CfDCaP","year":"2012","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.bbr.2016.11.036_bib0115","first-page":"529","article-title":"Alcohol use among pregnant and nonpregnant women of childbearing age\u2013United States, 1991\u20132005","volume":"58","author":"(CDC) CfDCaP","year":"2009","journal-title":"MMWR. Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.bbr.2016.11.036_bib0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0749-3797(99)00059-8","article-title":"Alcohol use prior to pregnancy recognition","volume":"17","author":"Floyd","year":"1999","journal-title":"Am. J. Prev. Med."},{"issue":"278","key":"10.1016\/j.bbr.2016.11.036_bib0125","first-page":"e1","article-title":"Alcohol use before and during pregnancy in western Washington, 1989\u20132004: implications for the prevention of fetal alcohol spectrum disorders","volume":"200","author":"Grant","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0130","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.3390\/ijerph8062331","article-title":"Prevalence of children with severe fetal alcohol spectrum disorders in communities near Rome, Italy: new estimated rates are higher than previous estimates","volume":"8","author":"May","year":"2011","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.bbr.2016.11.036_bib0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0028-3932(95)00096-8","article-title":"Spatial locations gone awry: object and spatial memory deficits in children with fetal alcohol syndrome","volume":"34","author":"Uecker","year":"1996","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.bbr.2016.11.036_bib0140","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1352\/0895-8017(1998)103<0012:SBNOMI>2.0.CO;2","article-title":"Spatial but not object memory impairments in children with fetal alcohol syndrome","volume":"103","author":"Uecker","year":"1998","journal-title":"Am. J. Ment. Retard."},{"key":"10.1016\/j.bbr.2016.11.036_bib0145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0892-0362(98)00042-7","article-title":"Prenatal substance exposure: effects on attention and impulsivity of 6-year-olds","volume":"21","author":"Leech","year":"1999","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0892-0362(99)00073-2","article-title":"Effects of prenatal alcohol exposure on social behavior in humans and other species","volume":"22","author":"Kelly","year":"2000","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0155","series-title":"10th Special Report to the U.S Congress on Alcohol and Health","author":"Alcoholism NIoAAa","year":"2000"},{"key":"10.1016\/j.bbr.2016.11.036_bib0160","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/15353702-0323006-03","article-title":"Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior","volume":"230","author":"Riley","year":"2005","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.bbr.2016.11.036_bib0165","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1530-0277.1998.tb03684.x","article-title":"Comparison of social abilities of children with fetal alcohol syndrome to those of children with similar IQ scores and normal controls","volume":"22","author":"Thomas","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0170","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2466\/pr0.1990.66.2.551","article-title":"Effects of prenatal ethanol exposure on juvenile play-fighting and postpubertal aggression in rats","volume":"66","author":"Royalty","year":"1990","journal-title":"Psychol. Rep."},{"key":"10.1016\/j.bbr.2016.11.036_bib0175","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbr.2014.04.029","article-title":"Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior","volume":"269","author":"Hamilton","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/tera.1420340102","article-title":"Social play in juvenile rats prenatally exposed to alcohol","volume":"34","author":"Meyer","year":"1986","journal-title":"Teratology"},{"key":"10.1016\/j.bbr.2016.11.036_bib0185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000337858","article-title":"Molecular substrates of social avoidance seen following prenatal ethanol exposure and its reversal by social enrichment","volume":"34","author":"Middleton","year":"2012","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0190","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbr.2016.05.003","article-title":"Acute prenatal exposure to ethanol on gestational day 12 elicits opposing deficits in social behaviors and anxiety-like behaviors in Sprague Dawley rats","volume":"310","author":"Diaz","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2016.07.018","article-title":"Effects of sex and housing on social, spatial, and motor behavior in adult rats exposed to moderate levels of alcohol during prenatal development","author":"Rodriguez","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0200","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbr.2009.10.012","article-title":"Prenatal exposure to moderate levels of ethanol alters social behavior in adult rats: relationship to structural plasticity and immediate early gene expression in frontal cortex","volume":"207","author":"Hamilton","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0205","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1111\/acer.12183","article-title":"Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression","volume":"37","author":"Tunc-Ozcan","year":"2013","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0210","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbr.2013.12.016","article-title":"Acute exposure to ethanol on gestational day 15 affects social motivation of female offspring","volume":"261","author":"Varlinskaya","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0215","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0892-0362(94)90026-4","article-title":"Sexually dimorphic effects of perinatal alcohol exposure on social interactions and amygdala DNA and DOPAC concentrations","volume":"16","author":"Kelly","year":"1994","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0220","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0031-9384(02)00971-X","article-title":"Effects of alcohol exposure during development on social behavior in rats","volume":"78","author":"Lugo","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2016.11.036_bib0225","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.physbeh.2005.10.005","article-title":"Ethanol exposure during development reduces resident aggression and testosterone in rats","volume":"87","author":"Lugo","year":"2006","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2016.11.036_bib0230","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0892-0362(97)00064-0","article-title":"Alcohol exposure during development alters social recognition and social communication in rats","volume":"19","author":"Kelly","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0235","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/12194","article-title":"Impairment of social and moral behavior related to early damage in human prefrontal cortex","volume":"2","author":"Anderson","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0240","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/brain\/awf190","article-title":"An fMRI study of intentional and unintentional (embarrassing) violations of social norms","volume":"125","author":"Berthoz","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2016.11.036_bib0245","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.1089134","article-title":"Does rejection hurt: an FMRI study of social exclusion","volume":"302","author":"Eisenberger","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbr.2016.11.036_bib0250","first-page":"525","article-title":"Alterations in aversive and aggressive behaviors following orbital frontal lesions in rhesus monkeys","volume":"32","author":"Butter","year":"1972","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"10.1016\/j.bbr.2016.11.036_bib0255","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1037\/h0036969","article-title":"Social behavior of rats with chronic prefrontal lesions","volume":"87","author":"Kolb","year":"1974","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0260","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbr.2010.05.048","article-title":"Patterns of social-experience-related c-fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development","volume":"214","author":"Hamilton","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0265","doi-asserted-by":"crossref","first-page":"e0118721","DOI":"10.1371\/journal.pone.0118721","article-title":"Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex","volume":"10","author":"Bird","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2016.11.036_bib0270","doi-asserted-by":"crossref","first-page":"e36387","DOI":"10.1371\/journal.pone.0036387","article-title":"genetic overexpression of NR2B subunit enhances social recognition memory for different strains and species","volume":"7","author":"Jacobs","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2016.11.036_bib0275","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/gbb.12123","article-title":"Overexpression of the NR2A subunit in the forebrain impairs long-term social recognition and non-social olfactory memory","volume":"13","author":"Jacobs","year":"2014","journal-title":"Genes Brain Behav."},{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2016.11.036_bib0280","doi-asserted-by":"crossref","first-page":"E394","DOI":"10.1111\/j.1530-0277.2012.01926.x","article-title":"Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats","volume":"37","author":"Chappell","year":"2013","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0285","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/j.1530-0277.2010.01266.x","article-title":"Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits","volume":"34","author":"Savage","year":"2010","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0290","first-page":"52407","article-title":"Moderate prenatal alcohol exposure and quantification of social behavior in adult rats","volume":"94","author":"Hamilton","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbr.2016.11.036_bib0295","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/bj0720409","article-title":"The metabolism of acetaldehyde in mammalian tissues: reactions in rat-liver suspensions under anaerobic conditions","volume":"72","author":"Lundquist","year":"1959","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbr.2016.11.036_bib0300","doi-asserted-by":"crossref","first-page":"12608","DOI":"10.1523\/JNEUROSCI.2949-10.2010","article-title":"The basolateral amygdala is critical for the acquisition and extinction of associations between a neutral stimulus and a learned danger signal but not between two neutral stimuli","volume":"30","author":"Parkes","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0305","series-title":"A Study in Behaviour: Principles of Ethology and Behavioural Physiology Displayed Mainly in the Rat","author":"Barnett","year":"1963"},{"key":"10.1016\/j.bbr.2016.11.036_bib0310","doi-asserted-by":"crossref","DOI":"10.3758\/s13428-016-0787-0","article-title":"The Simple Video Coder: a free tool for efficiently coding social video data","author":"Barto","year":"2016","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.bbr.2016.11.036_bib0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-010-1859-y","article-title":"Identification of multiple call categories within the rich repertoire of adult rat 50-kHz ultrasonic vocalizations: effects of amphetamine and social context","volume":"211","author":"Wright","year":"2010","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.11.036_bib0320","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.bbr.2016.11.036_bib0325","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0330","series-title":"Designing Experiments and Analyzing Data: a Model Comparison Perspective","author":"Maxwell","year":"2004"},{"key":"10.1016\/j.bbr.2016.11.036_bib0335","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0741-8329(92)90057-H","article-title":"Prenatal ethanol effects: sex differences in offspring stress responsiveness","volume":"9","author":"Weinberg","year":"1992","journal-title":"Alcohol"},{"key":"10.1016\/j.bbr.2016.11.036_bib0340","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.bbr.2010.08.014","article-title":"Acute prenatal exposure to ethanol and social behavior: effects of age, sex, and timing of exposure","volume":"216","author":"Mooney","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0345","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/nlme.1995.0009","article-title":"Sex differences in vulnerability to developmental spatial learning deficits induced by limited binge alcohol exposure in neonatal rats","volume":"64","author":"Goodlett","year":"1995","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.bbr.2016.11.036_bib0350","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0892-0362(91)90049-3","article-title":"The effects of chronic postweaning amphetamine on rats exposed to alcohol in utero: weight gain and behavior","volume":"13","author":"Hannigan","year":"1991","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0355","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1530-0277.1998.tb03881.x","article-title":"Prenatal ethanol exposure induces a sexually dimorphic effect on daily water consumption in prepubertal and adult rats","volume":"22","author":"McGivern","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0360","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1530-0277.1998.tb04312.x","article-title":"Prenatal ethanol exposure differentially alters behavior in males and females on the elevated plus maze","volume":"22","author":"Osborn","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0365","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0006-8993(90)90347-E","article-title":"Sex differences in corpus callosum: influence of prenatal alcohol exposure and maternal undernutrition","volume":"537","author":"Zimmerberg","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0370","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neulet.2013.05.051","article-title":"Omega-3 fatty acids can reverse the long-term deficits in hippocampal synaptic plasticity caused by prenatal ethanol exposure","volume":"551","author":"Patten","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2016.11.036_bib0375","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/hipo.22203","article-title":"Prenatal ethanol exposure has sex-specific effects on hippocampal long-term potentiation","volume":"24","author":"Sickmann","year":"2014","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2016.11.036_bib0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2014.01.001","article-title":"Female mice liberated for inclusion in neuroscience and biomedical research","volume":"40","author":"Prendergast","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2016.11.036_bib0385","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coph.2006.08.011","article-title":"NMDA receptor subunits: function and pharmacology","volume":"7","author":"Paoletti","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0390","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0306-4522(94)90007-8","article-title":"A microtransplantation approach for cell suspension grafting in the rat Parkinson model: a detailed account of the methodology","volume":"63","author":"Nikkhah","year":"1994","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.bbr.2016.11.036_bib0395","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s11481-016-9691-8","article-title":"Effects of moderate prenatal alcohol exposure during early gestation in rats on inflammation across the maternal-fetal-Immune interface and later-life immune function in the offspring","volume":"11","author":"Terasaki","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0400","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1037\/a0012889","article-title":"Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: behavioral concomitants, relationship to reward, and self-administration of playback","volume":"122","author":"Burgdorf","year":"2008","journal-title":"J. Comp. Psychol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0405","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/265236a0","article-title":"22-kHz calls by isolated rats","volume":"265","author":"Francis","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2016.11.036_bib0410","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0031-9384(91)90423-L","article-title":"Twenty-two kHz alarm cries to presentation of a predator, by laboratory rats living in visible burrow systems","volume":"50","author":"Blanchard","year":"1991","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2016.11.036_bib0415","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF02246021","article-title":"Withdrawal from oral cocaine in rate: ultrasonic vocalizations and tactile startle","volume":"125","author":"Barros","year":"1996","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.11.036_bib0420","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbr.2007.06.015","article-title":"Tickling-induced 50-kHz ultrasonic vocalization is individually stable and predicts behaviour in tests of anxiety and depression in rats","volume":"184","author":"M\u00e4llo","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0425","first-page":"2016","article-title":"Prenatal ethanol exposure and whisker clipping disrupt ultrasonic vocalizations and play behavior in adolescent rats","author":"Waddell","year":"2016","journal-title":"Brain. Sci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0430","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0003-3472(77)90113-0","article-title":"Attack and defensive behaviour in the albino rat","volume":"25","author":"Blanchard","year":"1977","journal-title":"Anim. Behav."},{"key":"10.1016\/j.bbr.2016.11.036_bib0435","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/1098-2337(1987)13:4<227::AID-AB2480130406>3.0.CO;2-C","article-title":"Play-fighting differs from serious fighting in both target of attack and tactics of fighting in the laboratory rat Rattus norvegicus","volume":"13","author":"Pellis","year":"1987","journal-title":"Aggress. Behav."},{"key":"10.1016\/j.bbr.2016.11.036_bib0440","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.neuroscience.2011.05.001","article-title":"Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors","volume":"192","author":"Burgdorf","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2016.11.036_bib0445","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF02244954","article-title":"Morphine attenuates ultrasonic vocalization during agonistic encounters in adult male rats","volume":"111","author":"Vivian","year":"1993","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.11.036_bib0450","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02244177","article-title":"Ultrasounds during morphine withdrawal in rats","volume":"104","author":"Vivian","year":"1991","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.11.036_bib0455","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.beproc.2014.11.011","article-title":"Are 50-kHz calls used as play signals in the playful interactions of rats? II. Evidence from the effects of devocalization","volume":"111","author":"Kisko","year":"2015","journal-title":"Behav. Process."},{"key":"10.1016\/j.bbr.2016.11.036_bib0460","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbr.2013.04.050","article-title":"Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats","volume":"250","author":"Morales","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0465","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s00213-013-3278-3","article-title":"The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats","volume":"231","author":"Morales","year":"2014","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2016.11.036_bib0470","doi-asserted-by":"crossref","first-page":"20130163","DOI":"10.1098\/rstb.2013.0163","article-title":"GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity","volume":"369","author":"Shipton","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0475","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/sj.npp.1301316","article-title":"Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala","volume":"32","author":"Sotres-Bayon","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2016.11.036_bib0480","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11064-010-0342-9","article-title":"Effects of ifenprodil on morphine-induced conditioned place preference and spatial learning and memory in rats","volume":"36","author":"Ma","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2016.11.036_bib0485","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1037\/bne0000045","article-title":"Conditional loss of GluN2B in cortex and hippocampus impairs attentional set formation","volume":"129","author":"Thompson","year":"2015","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0490","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1523\/JNEUROSCI.1217-12.2013","article-title":"Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus","volume":"33","author":"Brady","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0495","doi-asserted-by":"crossref","first-page":"22771","DOI":"10.1038\/srep22771","article-title":"Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca(2+) channels, and calcineurin","volume":"6","author":"Sachser","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2016.11.036_bib0500","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/jnc.12961","article-title":"Regulation of emotional memory by hydrogen sulfide: role of GluN2B-containing NMDA receptor in the amygdala","volume":"132","author":"Wang","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2016.11.036_bib0505","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0026-895X(25)13275-6","article-title":"Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors","volume":"44","author":"Williams","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0510","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0091-6773(72)80073-7","article-title":"Intracranial chemical injection and behavior: a critical review","volume":"7","author":"Routtenberg","year":"1972","journal-title":"Behav. Biol."},{"key":"10.1016\/j.bbr.2016.11.036_bib0515","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jpba.2013.08.014","article-title":"Metabolism studies of ifenprodil, a potent GluN2B receptor antagonist","volume":"88","author":"Falck","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bbr.2016.11.036_bib0520","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1523\/JNEUROSCI.5110-07.2008","article-title":"Ethanol consumption during early pregnancy alters the disposition of tangentially migrating GABAergic interneurons in the fetal cortex","volume":"28","author":"Cuzon","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0525","doi-asserted-by":"crossref","first-page":"10977","DOI":"10.1523\/JNEUROSCI.1462-15.2015","article-title":"Persistent interneuronopathy in the prefrontal cortex of young adult offspring exposed to ethanol In utero","volume":"35","author":"Skorput","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2016.11.036_bib0530","series-title":"The Rat Brain In Stereotaxic Coordinates","author":"Paxinos","year":"2005"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816311263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816311263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T20:28:20Z","timestamp":1749760100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816311263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":106,"alternative-id":["S0166432816311263"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2016.11.036","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ifenprodil infusion in agranular insular cortex alters social behavior and vocalizations in rats exposed to moderate levels of ethanol during prenatal development","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2016.11.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}