{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:28:35Z","timestamp":1784240915699,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.bbr.2017.04.009","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T17:01:29Z","timestamp":1496422889000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Maternal hypomagnesemia alters hippocampal NMDAR subunit expression and programs anxiety-like behaviour in adult offspring"],"prefix":"10.1016","volume":"328","author":[{"given":"R.N.","family":"Schlegel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.","family":"Spiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.T.","family":"Bj\u00f6rkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"Paravicini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2017.04.009_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jhn.12212","article-title":"Nutrition in early life and the programming of adult disease: a review","volume":"28","author":"Langley-Evans","year":"2015","journal-title":"J. Hum. Nutr. Diet."},{"key":"10.1016\/j.bbr.2017.04.009_bib0010","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1753-4887.2011.00465.x","article-title":"Suboptimal magnesium status in the United States: are the health consequences underestimated?","volume":"70","author":"Rosanoff","year":"2012","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbr.2017.04.009_bib0015","first-page":"116","article-title":"New data on the importance of gestational Mg deficiency","volume":"17","author":"Durlach","year":"2004","journal-title":"Magnes. Res."},{"key":"10.1016\/j.bbr.2017.04.009_bib0020","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.3390\/nu4121794","article-title":"Changes in dairy food and nutrient intakes in Australian adolescents","volume":"4","author":"Parker","year":"2012","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2017.04.009_bib0025","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.placenta.2015.03.011","article-title":"Maternal hypomagnesemia causes placental abnormalities and fetal and postnatal mortality","volume":"36","author":"Schlegel","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.bbr.2017.04.009_bib0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.psyneuen.2006.12.006","article-title":"Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring","volume":"32","author":"O\u2019Loan","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2017.04.009_bib0035","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bbr.2007.09.032","article-title":"Developmental vitamin D deficiency alters adult behaviour in 129\/SvJ and C57BL\/6J mice","volume":"187","author":"Harms","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.04.009_bib0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrn3677","article-title":"Hippocampal synaptic plasticity, spatial memory and anxiety","volume":"15","author":"Bannerman","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2017.04.009_bib0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2009.10.014","article-title":"Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion","volume":"626","author":"Barkus","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2017.04.009_bib0050","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function","volume":"62","author":"Traynelis","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbr.2017.04.009_bib0055","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2017.04.009_bib0060","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/nn.3214","article-title":"REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors","volume":"15","author":"Rodenas-Ruano","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2017.04.009_bib0065","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.neuron.2007.01.027","article-title":"Obligatory role of NR2A for metaplasticity in visual cortex","volume":"53","author":"Philpot","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2017.04.009_bib0070","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1038\/npp.2008.36","article-title":"Neonatal isolation delays the developmental decline of long-term depression in the CA1 region of rat hippocampus","volume":"33","author":"Ku","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2017.04.009_bib0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainres.2003.09.077","article-title":"Prenatal protein deprivation in rats induces changes in prepulse inhibition and NMDA receptor binding","volume":"996","author":"Palmer","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2017.04.009_bib0080","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.brainres.2008.07.089","article-title":"Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding","volume":"1237","author":"Palmer","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2017.04.009_bib0085","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1471-4159.2005.03246.x","article-title":"Maternal zinc deficiency reduces NMDA receptor expression in neonatal rat brain, which persists into early adulthood","volume":"94","author":"Chowanadisai","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2017.04.009_bib0090","doi-asserted-by":"crossref","first-page":"R1297","DOI":"10.1152\/ajpregu.00292.2013","article-title":"Fetal iron deficiency alters the proteome of adult rat hippocampal synaptosomes","volume":"305","author":"Tran","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbr.2017.04.009_bib0095","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.neuropharm.2004.08.010","article-title":"Magnesium-deficient diet alters depression- and anxiety-related behavior in mice \u2013 influence of desipramine and hypericum perforatum extract","volume":"47","author":"Singewald","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2017.04.009_bib0100","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.neuropharm.2011.07.027","article-title":"Neuropharmacology magnesium de fi ciency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment","volume":"62","author":"Sartori","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2017.04.009_bib0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nprot.2007.516","article-title":"The regular and light-dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents","volume":"3","author":"Kalueff","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbr.2017.04.009_bib0110","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbr.2017.04.009_bib0115","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbr.2017.04.009_bib0120","first-page":"1","article-title":"Maternal hypomagnesemia alters renal function but does not program changes in the cardiovascular physiology of adult offspring","author":"Schlegel","year":"2016","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.bbr.2017.04.009_bib0125","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nutres.2014.10.014","article-title":"Moderate maternal food restriction in mice impairs physical growth, behavior, and neurodevelopment of offspring","volume":"35","author":"Akitake","year":"2015","journal-title":"Nutr. Res."},{"key":"10.1016\/j.bbr.2017.04.009_bib0130","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.physbeh.2014.02.051","article-title":"Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors","volume":"129","author":"Belluscio","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2017.04.009_bib0135","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/jn\/138.5.931","article-title":"Perinatal iron deficiency affects locomotor behavior and water maze performance in adult male and female rats","volume":"138","author":"Bourque","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbr.2017.04.009_bib0140","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.bbr.2007.11.003","article-title":"Effect of perinatal iron deficiency on myelination and associated behaviors in rat pups","volume":"188","author":"ling Wu","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.04.009_bib0145","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1007\/s00429-014-0779-8","article-title":"Dietary magnesium restriction reduces amygdala-hypothalamic GluN1 receptor complex levels in mice","volume":"220","author":"Ghafari","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.bbr.2017.04.009_bib0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0896-6273(93)90317-K","article-title":"Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro","volume":"10","author":"Williams","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2017.04.009_bib0155","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","article-title":"Developmental and regional expression in the rat brain and functional properties of four NMDA receptors","volume":"12","author":"Monyer","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2017.04.009_bib0160","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1523\/JNEUROSCI.2476-04.2004","article-title":"Switching of NMDA receptor 2A and 2 B subunits at thalamic and cortical synapses during early postnatal development","volume":"24","author":"Liu","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.04.009_bib0165","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1523\/JNEUROSCI.17-07-02469.1997","article-title":"NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex","volume":"17","author":"Flint","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.04.009_bib0170","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/srep01036","article-title":"Increased NR2A:NR2 B ratio compresses long-term depression range and constrains long-term memory","volume":"3","author":"Cui","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2017.04.009_bib0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00213-011-2492-0","article-title":"Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring","volume":"220","author":"Kesby","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2017.04.009_bib0180","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/dneu.20583","article-title":"Prenatal corticosteroid exposure affects hippocampal plasticity and reduces lifespan","volume":"68","author":"Noorlander","year":"2008","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbr.2017.04.009_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1145\/2525528.2525529","article-title":"Reduced levels of NR1 and NR2A with depression-like behavior in different brain regions in prenatally stressed juvenile offspring","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2017.04.009_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2013.08.044","article-title":"Involvement of NR1, NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring","volume":"257","author":"Sun","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.04.009_bib0195","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0893-133X(01)00233-0","article-title":"Estrogen-like activity of tamoxifen and raloxifene on NMDA receptor binding and expression of its subunits in rat brain","volume":"25","author":"Cyr","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2017.04.009_bib0200","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1523\/JNEUROSCI.5279-05.2006","article-title":"Estradiol-induced increase in the magnitude of long-term potentiation is prevented by blocking NR2B-containing receptors","volume":"26","author":"Smith","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.04.009_bib0205","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1582-4934.2004.tb00478.x","article-title":"Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: relationship to Morris water maze performance","volume":"8","author":"El-bakri","year":"2004","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbr.2017.04.009_bib0210","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/en.2010-0607","article-title":"Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain","volume":"152","author":"Konkle","year":"2011","journal-title":"Endocrinology"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816311755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432816311755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T10:02:42Z","timestamp":1569405762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432816311755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":42,"alternative-id":["S0166432816311755"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2017.04.009","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal hypomagnesemia alters hippocampal NMDAR subunit expression and programs anxiety-like behaviour in adult offspring","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2017.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}