{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:03:01Z","timestamp":1789243381031,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400889"],"award-info":[{"award-number":["81400889"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671387"],"award-info":[{"award-number":["81671387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.bbr.2017.05.066","type":"journal-article","created":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T00:32:11Z","timestamp":1496536331000},"page":"145-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"special_numbering":"C","title":["Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation"],"prefix":"10.1016","volume":"332","author":[{"given":"Jiawen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanning","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2017.05.066_bib0005","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.anclin.2015.05.008","article-title":"Postoperative cognitive dysfunction","volume":"33","author":"Berger","year":"2015","journal-title":"Anesthesiol. Clin."},{"key":"10.1016\/j.bbr.2017.05.066_bib0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2044.2011.07008.x","article-title":"A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia","volume":"67","author":"van Harten","year":"2012","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bbr.2017.05.066_bib0015","article-title":"Inflammatory response in the CNS: friend or foe?","author":"Sochocka","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2017.05.066_bib0020","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00281-015-0515-3","article-title":"Control of autoimmune CNS inflammation by astrocytes","volume":"37","author":"Rothhammer","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bbr.2017.05.066_bib0025","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S1474-4422(15)00141-6","article-title":"Innate and adaptive immune responses in the CNS","volume":"14","author":"Waisman","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbr.2017.05.066_bib0030","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0592-9","article-title":"Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis","volume":"13","author":"Zhang","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbr.2017.05.066_bib0035","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000452528","article-title":"Cerebral mast cells participate in postoperative cognitive dysfunction by promoting astrocyte activation","volume":"40","author":"Zhang","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.bbr.2017.05.066_bib0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pneurobio.2013.02.001","article-title":"Current status of chemokines in the adult CNS","volume":"104","author":"R\u00e9aux-Le Goazigo","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2017.05.066_bib0045","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s12272-013-0161-z","article-title":"Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases","author":"Bose","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bbr.2017.05.066_bib0050","doi-asserted-by":"crossref","first-page":"e90463","DOI":"10.1371\/journal.pone.0090463","article-title":"CCR2 gene deletion and pharmacologic blockade ameliorate a severe murine experimental autoimmune neuritis model of Guillain-Barre syndrome","volume":"9","author":"Yuan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2017.05.066_bib0055","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1523\/JNEUROSCI.0451-15.2016","article-title":"The chemokine CCL2 mediates the seizure-enhancing effects of systemic inflammation","volume":"36","author":"Cerri","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0060","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1523\/JNEUROSCI.3016-07.2007","article-title":"Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain","volume":"27","author":"Zhang","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0065","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1523\/JNEUROSCI.4987-06.2007","article-title":"Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice","volume":"27","author":"Sheehan","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0070","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbr.2015.11.003","article-title":"Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption","volume":"298","author":"Zhang","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.05.066_bib0075","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbi.2014.10.011","article-title":"S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4\/MyD88 pathway","volume":"44","author":"Lu","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2017.05.066_bib0080","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2119\/molmed.2014.00143","article-title":"Stimulation of the alpha 7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice","volume":"21","author":"Niccol\u00f2 Terrando","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbr.2017.05.066_bib0085","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/ALN.0b013e318286d0c9","article-title":"Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome","volume":"118","author":"Feng","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbr.2017.05.066_bib0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-015-0394-5","article-title":"IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation","volume":"12","author":"Sun","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbr.2017.05.066_bib0095","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nm.3681","article-title":"Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation","volume":"20","author":"Mayo","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbr.2017.05.066_bib0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1517\/14728222.7.1.35","article-title":"Targeting monocyte chemoattractant protein-1 signalling in disease","volume":"7","author":"Dawson","year":"2003","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbr.2017.05.066_bib0105","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbi.2014.02.002","article-title":"Postoperative cognitive dysfunction: involvement of neuroinflammation and neuronal functioning","volume":"38","author":"Hovens","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2017.05.066_bib0110","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1177\/0271678X16642233","article-title":"Blood-brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice","volume":"36","author":"Stranahan","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2017.05.066_bib0115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.morpho.2016.01.002","article-title":"Aluminum adjuvants of vaccines injected into the muscle: normal fate, pathology and associated disease","volume":"100","author":"Gherardi","year":"2016","journal-title":"Morphologie"},{"key":"10.1016\/j.bbr.2017.05.066_bib0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.phrs.2013.03.008","article-title":"Liver X receptors: emerging therapeutic targets for Alzheimer\u2019s disease","volume":"72","author":"Sodhi","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbr.2017.05.066_bib0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1440-1819.1997.tb02375.x","article-title":"Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer\u2019s disease","volume":"51","author":"Ishizuka","year":"1997","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1871530315666150316120920","article-title":"CCL2-CCR2 signaling in disease pathogenesis","volume":"15","author":"O'Connor","year":"2015","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.bbr.2017.05.066_bib0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3233\/JAD-2012-120598","article-title":"Elevated plasma MCP-1 concentration following traumatic brain injury as a potential predisposition factor associated with an increased risk for subsequent development of Alzheimer's disease","volume":"31","author":"Ho","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbr.2017.05.066_bib0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0165-5728(96)00203-2","article-title":"Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration","volume":"74","author":"Gourmala","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbr.2017.05.066_bib0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1750-3639.2008.00188.x","article-title":"Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease","volume":"19","author":"Sokolova","year":"2009","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbr.2017.05.066_bib0150","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2004.07.032","article-title":"Differential expression of cytokines and chemokines during secondary neuron death following brain injury in old and young mice","volume":"369","author":"Sandhir","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2017.05.066_bib0155","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00018-013-1459-1","article-title":"Monocyte chemoattractant protein-1 and the blood-brain barrier","volume":"71","author":"Yao","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0160","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1742-2094-9-136","article-title":"Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain","volume":"9","author":"Zhang","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbr.2017.05.066_bib0165","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1111\/ejn.13247","article-title":"Intrathecal administration of low-dose nociceptin\/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1","volume":"43","author":"Kawabata","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0170","doi-asserted-by":"crossref","first-page":"8175","DOI":"10.1523\/JNEUROSCI.1137-14.2014","article-title":"Conditional Ablation of Astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE","volume":"34","author":"Moreno","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0175","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.neuroscience.2007.08.014","article-title":"Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses","volume":"149","author":"Menetski","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2017.05.066_bib0180","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","article-title":"Astrocytes key regulators of neuroinflammation","volume":"37","author":"Colombo","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbr.2017.05.066_bib0185","first-page":"1","article-title":"Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation","volume":"25","author":"Jin","year":"2014","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2017.05.066_bib0190","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbi.2013.02.005","article-title":"Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro","volume":"32","author":"Chhor","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2017.05.066_bib0195","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1523\/JNEUROSCI.3585-12.2013","article-title":"SPARC regulates microgliosis and functional recovery following cortical ischemia","volume":"33","author":"Lloyd-Burton","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0200","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejpain.2008.04.017","article-title":"CCL2 is a key mediator of microglia activation in neuropathic pain states","volume":"13","author":"Thacker","year":"2009","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.bbr.2017.05.066_bib0205","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1159\/000443040","article-title":"Astrocyte-derived CCL2 is associated with M1 activation and recruitment of cultured microglial cells","volume":"38","author":"He","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.bbr.2017.05.066_bib0210","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2174\/1381612822666151125000300","article-title":"Inflammatory process in Alzheimer's and Parkinson\u2019s diseases: central role of cytokines","volume":"22","author":"Alam","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbr.2017.05.066_bib0215","first-page":"S1","article-title":"The IL-1 family and inflammatory diseases","volume":"20","author":"Dinarello","year":"2002","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.bbr.2017.05.066_bib0220","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13024-016-0136-x","article-title":"Chronic adiponectin deficiency leads to Alzheimer\u2019s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice","volume":"11","author":"Ng","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbr.2017.05.066_bib0225","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1159\/000449410","article-title":"Are CSF biomarkers useful as prognostic indicators in diagnostically unresolved cognitively impaired patients in a normal clinical setting","volume":"6","author":"Schj\u00f8nning Nielsen","year":"2016","journal-title":"Dement. Geriatr. Cogn. Dis. Extra"},{"key":"10.1016\/j.bbr.2017.05.066_bib0230","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1523\/JNEUROSCI.3623-08.2009","article-title":"JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain","volume":"29","author":"Gao","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.05.066_bib0235","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1523\/JNEUROSCI.5986-10.2011","article-title":"CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury","volume":"31","author":"Van Steenwinckel","year":"2011","journal-title":"J. Neurosci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432817304382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432817304382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:07:28Z","timestamp":1759064848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432817304382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":47,"alternative-id":["S0166432817304382"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2017.05.066","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2017.05.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}