{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:40:30Z","timestamp":1790797230751,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA026430"],"award-info":[{"award-number":["DA026430"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM114112"],"award-info":[{"award-number":["GM114112"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bbr.2017.09.026","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T06:15:14Z","timestamp":1505801714000},"page":"34-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Sex-dependent behavioral impairments in the HdhQ350\/+ mouse line"],"prefix":"10.1016","volume":"337","author":[{"given":"Jessica K.","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Detloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nephi","family":"Stella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2017.09.026_bib0005","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2017.09.026_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2011.00055","article-title":"Huntington\u2019s disease and striatal signaling","author":"Roze","year":"2011","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.bbr.2017.09.026_bib0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2017.09.026_bib0020","first-page":"83","article-title":"Huntington\u2019s disease: from molecular pathogenesis to clinical treatment","author":"Ross","year":"2001","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbr.2017.09.026_bib0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2017.09.026_bib0030","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrn3570","article-title":"Choosing an animal model for the study of Huntington\u2019s disease","author":"Pouladi","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2017.09.026_bib0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainresbull.2006.11.004","article-title":"The HdhQ150\/Q150 knock-in mouse model of HD and the R6\/2 exon 1 model develop comparable and widespread molecular phenotypes","author":"Woodman","year":"2007","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2017.09.026_bib0040","first-page":"1","article-title":"Rodent genetic models of Huntington disease","author":"Heng","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2017.09.026_bib0045","first-page":"331","article-title":"Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6\/2 mice","author":"Morton","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2017.09.026_bib0050","first-page":"p.ddw040","article-title":"Allelic series of Huntington\u2019s disease knock-in mice reveals expression discorrelates","author":"Kumar","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2017.09.026_bib0055","doi-asserted-by":"crossref","first-page":"p.e49838","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new knock-in mouse model of huntington\u2019s disease: zQ175","author":"Menalled","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2017.09.026_bib0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","article-title":"Neurological abnormalities in a knock-in mouse model of Huntington\u2019s disease","author":"Lin","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2017.09.026_bib0065","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1093\/hmg\/ddq285","article-title":"Early autophagic response in a novel knock-in model of Huntington disease","author":"Heng","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2017.09.026_bib0070","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.cub.2004.06.053","article-title":"Differential corticostriatal plasticity during fast and slow motor skill learning in mice","author":"Costa","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbr.2017.09.026_bib0075","first-page":"429","article-title":"Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington\u2019s disease and mouse models","author":"Horne","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2017.09.026_bib0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neuron.2014.06.030","article-title":"ABHD6 blockade exerts antiepileptic activity in PTZ-Induced seizures and in spontaneous seizures in R6\/2 mice","author":"Naydenov","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2017.09.026_bib0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.expneurol.2012.10.014","article-title":"Circadian and sleep disorder in Huntington\u2019s disease","author":"Morton","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2017.09.026_bib0090","first-page":"88","article-title":"Behavioral patterns associated with chemotherapy-induced emesis: a potential signature for nausea in musk shrews","author":"Horn","year":"2011","journal-title":"Front Neurosci. Front."},{"key":"10.1016\/j.bbr.2017.09.026_bib0095","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.tibs.2013.05.003","article-title":"Huntington\u2019s disease: underlying molecular mechanisms and emerging concepts","author":"Labbadia","year":"2013","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbr.2017.09.026_bib0100","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/378403a0","article-title":"Polyglutamine expansion as a pathological epitope in Huntington\u2019s disease and four dominant cerebellar ataxias","author":"Trottier","year":"1995","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.bbr.2017.09.026_bib0105","first-page":"e838","article-title":"Screening for amyloid aggregation by semi-denaturing detergent-agarose gel electrophoresis","author":"Halfmann","year":"2008","journal-title":"J. Vis. Exp."},{"issue":"12","key":"10.1016\/j.bbr.2017.09.026_bib0110","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1091\/mbc.e11-01-0037","article-title":"A yeast model for polyalanine-expansion aggregation and toxicity","volume":"22","author":"Konopka","year":"2011","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.bbr.2017.09.026_bib0115","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF00294227","article-title":"Synaptophysin expression in the striatum in Huntington\u2019s disease","author":"Goto","year":"1990","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbr.2017.09.026_bib0120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0306-4522(93)90352-G","article-title":"Loss of cannabinoid receptors in the substantia nigra in Huntington\u2019s disease","author":"Glass","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2017.09.026_bib0125","first-page":"140","article-title":"Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice","author":"Naydenov","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2017.09.026_bib0130","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0306-4522(00)00157-3","article-title":"Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice","author":"Denovan-Wright","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2017.09.026_bib0135","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1111\/j.1432-1033.2004.04460.x","article-title":"Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice","author":"McCaw","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbr.2017.09.026_bib0140","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1523\/JNEUROSCI.1830-07.2007","article-title":"Longitudinal evaluation of the Hdh(CAG) 150 knock-In murine model of huntington\u2019s disease","author":"Heng","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.09.026_bib0145","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1523\/JNEUROSCI.3842-04.2005","article-title":"Disintegration of the sleep-wake cycle and circadian timing in Huntington\u2019s disease","author":"Morton","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2017.09.026_bib0150","doi-asserted-by":"crossref","first-page":"e0147583","DOI":"10.1371\/journal.pone.0147583","article-title":"Sex differences in circadian dysfunction in the BACHD mouse model of Huntington\u2019s disease","author":"Kuljis","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2017.09.026_bib0155","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1093\/hmg\/ddn159","article-title":"Sex differences in a transgenic rat model of Huntington\u2019s disease: decreased 17 -estradiol levels correlate with reduced numbers of DARPP 32+ neurons in males","author":"Bode","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2017.09.026_bib0160","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbr.2012.01.015","article-title":"An open system for automatic home-cage behavioral analysis and its application to male and female mouse models of Huntington\u2019s disease","author":"Zarringhalam","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.09.026_bib0165","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/hipo.20658","article-title":"Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington\u2019s disease mice","author":"Zajac","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2017.09.026_bib0170","first-page":"1","article-title":"Corticostriatal connectivity and its role in disease","author":"Shepherd","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2017.09.026_bib0175","doi-asserted-by":"crossref","first-page":"p.e133","DOI":"10.1038\/tp.2012.58","article-title":"Environmental enrichment rescues female-specific hyperactivity of the hypothalamic-pituitary-adrenal axis in a model of Huntington\u2019s disease","volume":"33","author":"Du","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2017.09.026_bib0180","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbr.2013.07.041","article-title":"Short-term memory acquisition in female Huntington\u2019s disease mice is vulnerable to acute stress","author":"Mo","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.09.026_bib0185","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nlm.2015.10.003","article-title":"Reduced impact of emotion on choice behavior in presymptomatic BACHD rats, a transgenic rodent model for Huntington Disease","volume":"125","author":"Adjeroud","year":"2015","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.bbr.2017.09.026_bib0190","doi-asserted-by":"crossref","first-page":"e75099","DOI":"10.1371\/journal.pone.0075099","article-title":"Striatal pre-enkephalin overexpression improves Huntington\u2019s disease symptoms in the R6\/2 mouse model of Huntington's disease","author":"Bissonnette","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2017.09.026_bib0195","first-page":"1","article-title":"Progression of behavioural despair in R6\/2 and Hdh knock-in mouse models recapitulates depression in Huntington's disease","author":"Ciamei","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.09.026_bib0200","first-page":"119","article-title":"Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease","author":"Blazquez","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2017.09.026_bib0205","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neuroscience.2009.06.014","article-title":"Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease","author":"Dowie","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2017.09.026_bib0210","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng0893-398","article-title":"The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease","author":"Andrew","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbr.2017.09.026_bib0215","doi-asserted-by":"crossref","first-page":"e17119","DOI":"10.1371\/journal.pone.0017119","article-title":"Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats","author":"Duzdevich","year":"2011","journal-title":"PLoS One"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432817306939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432817306939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T01:38:49Z","timestamp":1719452329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432817306939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":43,"alternative-id":["S0166432817306939"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2017.09.026","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-dependent behavioral impairments in the HdhQ350\/+ mouse line","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2017.09.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}