{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:06:28Z","timestamp":1776132388338,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DC012596"],"award-info":[{"award-number":["1R01DC012596"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIU"},{"DOI":"10.13039\/100012803","name":"RFUMS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012803","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.bbr.2017.10.012","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T20:03:04Z","timestamp":1508011384000},"page":"76-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Antisense oligonucleotide therapy rescues disruptions in organization of exploratory movements associated with Usher syndrome type 1C in mice"],"prefix":"10.1016","volume":"338","author":[{"given":"Tia N.","family":"Donaldson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey T.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia A.","family":"Cherep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"McNeela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic F.","family":"Depreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine M.","family":"Jodelka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Hastings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas G.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bbr.2017.10.012_bib0005","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/brain\/122.9.1613","article-title":"Topographical disorientation: a synthesis and taxonomy","volume":"122","author":"Aguirre","year":"1999","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.bbr.2017.10.012_bib0010","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbr.2009.03.033","article-title":"Mice with vestibular deficiency display hyperactivity, disorientation, and signs of anxiety","volume":"202","author":"Avni","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.10.012_bib0015","series-title":"Circular Statistics in Biology","author":"Batschelet","year":"1981"},{"issue":"4","key":"10.1016\/j.bbr.2017.10.012_bib0020","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/hipo.20942","article-title":"Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors","volume":"22","author":"Besnard","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2017.10.012_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2017.02.031","article-title":"Otolith dysfunction alters exploratory movement in mice","volume":"325","author":"Blankenship","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.bbr.2017.10.012_bib0030","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.physbeh.2006.01.026","article-title":"Motor activity (exploration) and formation of home bases in mice (C57BL\/6) influenced by visual and tactile cues: modification of movement distribution, distance, location, and speed","volume":"87","author":"Clark","year":"2006","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.bbr.2017.10.012_bib0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbr.2005.04.007","article-title":"Movements of exploration intact in rats with hippocampal lesions","volume":"163","author":"Clark","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"20","key":"10.1016\/j.bbr.2017.10.012_bib0040","first-page":"9519","article-title":"Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse","volume":"44","author":"Depreux","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bbr.2017.10.012_bib0045","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0166-4328(01)00290-X","article-title":"Rats and mice share common ethologically relevant parameters of exploratory behavior","volume":"125","author":"Drai","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2017.10.012_bib0050","doi-asserted-by":"crossref","first-page":"e1000638","DOI":"10.1371\/journal.pcbi.1000638","article-title":"Knots: attractive places with high path tortuosity in mouse open field exploration","volume":"6","author":"Dvorkin","year":"2010","journal-title":"PLoS Comput. Biol."},{"issue":"4","key":"10.1016\/j.bbr.2017.10.012_bib0055","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1186\/gb-2007-8-4-r47","article-title":"Deafblindness in French Canadians from Quebec: a predominant founder mutation in the USH1C gene provides the first genetic link with the Acadian population","volume":"8","author":"Ebermann","year":"2007","journal-title":"Genome Biol."},{"issue":"3","key":"10.1016\/j.bbr.2017.10.012_bib0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-4328(89)80102-0","article-title":"Home base behavior of rats (Rattus norvegicus) exploring a novel environment","volume":"34","author":"Eilam","year":"1989","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2017.10.012_bib0065","series-title":"The Organization of Learning","author":"Gallistel","year":"1990"},{"issue":"10","key":"10.1016\/j.bbr.2017.10.012_bib0070","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cub.2016.03.040","article-title":"Mice develop efficient strategies for foraging and navigation using complex natural stimuli","volume":"26","author":"Gire","year":"2016","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.bbr.2017.10.012_bib0075","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1037\/0735-7044.122.2.448","article-title":"Locomotor and exploratory behavior in the rat following bilateral vestibular deafferentation","volume":"122","author":"Goddard","year":"2008","journal-title":"Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2017.10.012_bib0080","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0166-4328(05)80263-3","article-title":"Stopping behavior: constraints on exploration in rats (Rattus norvegicus)","volume":"53","author":"Golani","year":"1993","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.bbr.2017.10.012_bib0085","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1101\/lm.53002","article-title":"Fimbria-fornix lesions disrupt the dead reckoning (homing) component of exploratory behavior in mice","volume":"9","author":"Gorny","year":"2002","journal-title":"Learn. Mem."},{"issue":"3","key":"10.1016\/j.bbr.2017.10.012_bib0090","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neuron.2009.04.006","article-title":"Harmonin mutations cause mechanotransduction defects in cochlear hair cells","volume":"62","author":"Grillet","year":"2009","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.bbr.2017.10.012_bib0095","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1111\/j.1460-9568.2005.04412.x","article-title":"Home bases formed to visual cues but not to self-movement (dead reckoning) cues in exploring hippocampectomized rats","volume":"22","author":"Hines","year":"2005","journal-title":"Eur. J. Neurosci."},{"issue":"8","key":"10.1016\/j.bbr.2017.10.012_bib0100","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1242\/dev.012922","article-title":"A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth","volume":"135","author":"Lef\u00e8vre","year":"2008","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.bbr.2017.10.012_bib0105","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/hipo.20274","article-title":"Similar development of cued and learned home bases in control and hippocampal-damaged rats in an open field exploratory task","volume":"17","author":"Lehmann","year":"2007","journal-title":"Hippocampus"},{"issue":"4","key":"10.1016\/j.bbr.2017.10.012_bib0110","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/dneu.20771","article-title":"Deafness and retinal degeneration in a novel USH1C knock-in mouse model","volume":"70","author":"Lentz","year":"2010","journal-title":"Dev. Neurobiol."},{"issue":"3","key":"10.1016\/j.bbr.2017.10.012_bib0115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nm.3106","article-title":"Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness","volume":"19","author":"Lentz","year":"2013","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bbr.2017.10.012_bib0120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mrfmmm.2006.11.006","article-title":"Ush1c216A knock-in mouse survives Katrina","volume":"616","author":"Lentz","year":"2007","journal-title":"Mutat. Res.\/Fundam. Mol. Mech. Mutage."},{"issue":"3","key":"10.1016\/j.bbr.2017.10.012_bib0125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0163-1047(93)91034-K","article-title":"Spatial learning in an enclosed eight-arm radial maze in rats with sodium arsanilate-induced labyrinthectomies","volume":"59","author":"Ossenkopp","year":"1993","journal-title":"Behav. Neural Biol."},{"issue":"2","key":"10.1016\/j.bbr.2017.10.012_bib0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1046\/j.0009-9163.2002.00004.x","article-title":"USH1C: a rare cause of USH1 in a non-Acadian population and a founder effect of the Acadian allele","volume":"63","author":"Ouyang","year":"2003","journal-title":"Clin. Genet."},{"issue":"16","key":"10.1016\/j.bbr.2017.10.012_bib0135","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1523\/JNEUROSCI.23-16-06490.2003","article-title":"Long-term effects of permanent vestibular lesions on hippocampal spatial firing","volume":"23","author":"Russell","year":"2003","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2017.10.012_bib0140","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hipo.1112","article-title":"Hippocampal spatial representations require vestibular input","volume":"12","author":"Stackman","year":"2002","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.bbr.2017.10.012_bib0145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0165-0270(95)00050-X","article-title":"A phase plane representation of rat exploratory behavior","volume":"62","author":"Tchernichovski","year":"1995","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2017.10.012_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.lmot.2017.03.009","article-title":"Behavioral and neural subsystems of rodent exploration","author":"Thompson","year":"2017","journal-title":"Learn. Motiv."},{"issue":"18","key":"10.1016\/j.bbr.2017.10.012_bib0155","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1093\/hmg\/ddx234","article-title":"Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide","volume":"26","author":"Vijayakumar","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.bbr.2017.10.012_bib0160","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10071-006-0023-x","article-title":"Movement characteristics support a role for dead reckoning in organizing exploratory behavior","volume":"9","author":"Wallace","year":"2006","journal-title":"Anim. Cogn."},{"issue":"5","key":"10.1016\/j.bbr.2017.10.012_bib0165","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/hipo.450040507","article-title":"Short-stops in rats with fimbria-fornix lesions: evidence for change in the mobility gradient","volume":"4","author":"Whishaw","year":"1994","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.bbr.2017.10.012_bib0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-4328(01)00359-X","article-title":"Dead reckoning (path integration) requires the hippocampal formation: evidence from spontaneous exploration and spatial learning tasks in light (allothetic) and dark (idiothetic) tests","volume":"127","author":"Whishaw","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.bbr.2017.10.012_bib0175","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/jhg.2010.29","article-title":"Genetics and pathological mechanisms of usher syndrome","volume":"55","author":"Yan","year":"2010","journal-title":"J. Hum. Genet."},{"issue":"8","key":"10.1016\/j.bbr.2017.10.012_bib0180","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/hipo.22410","article-title":"Otolithic information is required for homing in the mouse","volume":"25","author":"Yoder","year":"2015","journal-title":"Hippocampus"},{"issue":"10","key":"10.1016\/j.bbr.2017.10.012_bib0185","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/hipo.22300","article-title":"Otoconia-deficient mice show selective spatial deficits","volume":"24","author":"Yoder","year":"2014","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2017.10.012_bib0190","series-title":"Paper Presented at the Annual Meeting of the Midwestern Psychological Association","article-title":"Stable place cell activity in otoconia-deficient tilted mice","author":"Yoder","year":"2014"},{"issue":"4","key":"10.1016\/j.bbr.2017.10.012_bib0195","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1523\/JNEUROSCI.1679-08.2009","article-title":"Head direction cell activity in mice: robust directional signal depends on intact otolith organs","volume":"29","author":"Yoder","year":"2009","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2017.10.012_bib0200","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbr.2004.09.022","article-title":"\u2018Looping\u2019\u2014an exploration mechanism in a dark open field","volume":"159","author":"Zadicario","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.bbr.2017.10.012_bib0205","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/hipo.20149","article-title":"Impairment and recovery on a food foraging task following unilateral vestibular deafferentation in rats","volume":"16","author":"Zheng","year":"2006","journal-title":"Hippocampus"},{"issue":"5","key":"10.1016\/j.bbr.2017.10.012_bib0210","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/hipo.20533","article-title":"Long-term deficits on a foraging task after bilateral vestibular deafferentation in rats","volume":"19","author":"Zheng","year":"2009","journal-title":"Hippocampus"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432817314213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432817314213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T10:24:50Z","timestamp":1589797490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432817314213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":42,"alternative-id":["S0166432817314213"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2017.10.012","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antisense oligonucleotide therapy rescues disruptions in organization of exploratory movements associated with Usher syndrome type 1C in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2017.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}