{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:19:16Z","timestamp":1792631956661,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Brazilian National Council of Scientific and Technological Development"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.bbr.2018.02.044","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T15:00:38Z","timestamp":1519916438000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Enhanced cholinergic-tone during the stress induce a depressive-like state in mice"],"prefix":"10.1016","volume":"347","author":[{"given":"Sara S.","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 P.","family":"Koth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo M.","family":"Parfitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos F.","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina S.","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Soubhia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda P.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina D.","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean P.","family":"Oses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erikson","family":"Kaszubowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela M.","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2018.02.044_bib0005","series-title":"Depression, A Global Public Health Concern","first-page":"1","author":"WHO","year":"2012"},{"key":"10.1016\/j.bbr.2018.02.044_bib0010","series-title":"Depression: Let's Talk Says Who, as Depression Tops List of Causes of Ill Health","author":"World Health Organization","year":"2017"},{"key":"10.1016\/j.bbr.2018.02.044_bib0015","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association, DSM-V, 2013. doi:https:\/\/doi.org\/10.1176\/appi.books.9780890425596.744053.","DOI":"10.1176\/appi.books.9780890425596.744053"},{"key":"10.1016\/j.bbr.2018.02.044_bib0020","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1176\/appi.ajp.2009.10030434","article-title":"Linking molecules to mood: new insight into the biology of depression","volume":"167","author":"Krishnan","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2018.02.044_bib0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression (review summaries)","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2018.02.044_bib0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bcp.2015.03.011","article-title":"Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs","volume":"95","author":"Dale","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbr.2018.02.044_bib0035","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/2167702616628523","article-title":"A unified model of depression: integrating clinical, cognitive, biological, and evolutionary perspectives","volume":"4","author":"Beck","year":"2016","journal-title":"Clin. Psychol. Sci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/15622970903131571","article-title":"Anatomical and functional correlates in major depressive disorder: the contribution of neuroimaging studies","volume":"11","author":"Rigucci","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.02.044_bib0045","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0022-3956(62)90006-7","article-title":"Plasma cortisol in depressive illness","volume":"1","author":"Gibbons","year":"1962","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2018.02.044_bib0050","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/sj.mp.4001032","article-title":"Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH\/NE states","volume":"7","author":"Gold","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.02.044_bib0055","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.neuro.051508.135620","article-title":"The influence of stress hormones on fear circuitry","volume":"32","author":"Rodrigues","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0060","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbr.2010.02.023","article-title":"The cholinergic system and depression","volume":"221","author":"Dagyte","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.02.044_bib0065","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00006842-197405000-00008","article-title":"Acetylcholine and depression","volume":"36","author":"Janowsky","year":"1974","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbr.2018.02.044_bib0070","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbr.2015.04.002","article-title":"Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test","volume":"288","author":"Addy","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.02.044_bib0075","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1254\/jphs.11R01CR","article-title":"Pharmacological aspects of the acetylcholinesterase inhibitor galantamine","volume":"116","author":"Ago","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0080","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.tips.2010.09.004","article-title":"Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis","volume":"31","author":"Mineur","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0085","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1073\/pnas.1219731110","article-title":"Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior","volume":"110","author":"Mineur","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2018.02.044_bib0090","first-page":"1","article-title":"Multiple nicotinic acetylcholine receptor subtypes in the mouse amygdala regulate affective behaviors and response to social stress","volume":"41","author":"Mineur","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2018.02.044_bib0095","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1124\/jpet.114.216804","article-title":"M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine","volume":"351","author":"Witkin","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2018.02.044_bib0100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0091-3057(91)90284-9","article-title":"Social model of depression in mice of C57BL\/6J strain","volume":"38","author":"Kudryavtseva","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2018.02.044_bib0105","first-page":"1","article-title":"Essential role of BDNF in the mesolimbic dopamine pathwayin social defeat stress","volume":"864","author":"Berton","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbr.2018.02.044_bib0110","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nature11713","article-title":"Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons","volume":"493","author":"Chaudhury","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2018.02.044_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2018.02.044_bib0120","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbr.2018.02.044_bib0125","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2017"},{"key":"10.1016\/j.bbr.2018.02.044_bib0130","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","article-title":"Simultaneous inference in general parametric models","volume":"50","author":"Hothorn","year":"2008","journal-title":"Biom. J."},{"key":"10.1016\/j.bbr.2018.02.044_bib0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0006-3223(86)90007-7","article-title":"Selective breeding for increased cholinergic function: development of a new animal model of depression","volume":"21","author":"Overstreet","year":"1986","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.02.044_bib0140","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.biopsych.2012.09.031","article-title":"Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review","volume":"73","author":"Drevets","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.02.044_bib0145","first-page":"739","article-title":"The role of muscarinic receptors in the pathophysiology of mood disorders: a potential novel treatment?","volume":"13","author":"Jeon","year":"2015","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.bbr.2018.02.044_bib0150","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0306-4530(90)90061-D","article-title":"Plasma corticosterone is increased and correlated with brain acetylcholine in physostigmine- but not in neostigmine-treated rats","volume":"15","author":"Hasey","year":"1990","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2018.02.044_bib0155","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0006-8993(85)90749-8","article-title":"Dynamics of cholinergic synaptic mechanisms in rat hippocampus after stress","volume":"343","author":"Finkelstein","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2018.02.044_bib0160","doi-asserted-by":"crossref","first-page":"11360","DOI":"10.1073\/pnas.1209293109","article-title":"Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior","volume":"109","author":"Warner-Schmidt","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2018.02.044_bib0165","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1172\/JCI85033","article-title":"GABA interneurons mediate the rapid antidepressant-like effects of scopolamine","volume":"126","author":"Wohleb","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbr.2018.02.044_bib0170","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/nn.3234","article-title":"Neurobiology of resilience","volume":"15","author":"Russo","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0175","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.expneurol.2014.05.012","article-title":"Defeating the fear: new insights into the neurobiology of stress susceptibility","volume":"261","author":"Krishnan","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2018.02.044_bib0180","first-page":"2166","article-title":"NIH public access","volume":"6","author":"D.W.G","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0185","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbr.2009.12.041","article-title":"The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning","volume":"208","author":"Denmark","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.02.044_bib0190","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/10253890.2014.910650","article-title":"Social defeat stress induces a depression-like phenotype in adolescent male c57BL\/6 mice","volume":"17","author":"I\u00f1iguez","year":"2014","journal-title":"Stress"},{"key":"10.1016\/j.bbr.2018.02.044_bib0195","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2015.00364","article-title":"Ethological evaluation of the effects of social defeat stress in mice: beyond the social interaction ratio","volume":"9","author":"Henriques-Alves","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0200","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0306-4522(02)00651-6","article-title":"Septal gabaergic and hippocampal cholinergic systems interact in the modulation of anxiety","volume":"117","author":"Degroot","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2018.02.044_bib0205","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.tics.2007.05.008","article-title":"Neurocognitive mechanisms of anxiety: an integrative account","volume":"11","author":"Bishop","year":"2007","journal-title":"Trends Cognit. Sci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0210","first-page":"1","article-title":"Bidirectional control of anxiety-related behaviors in mice: role of inputs arising from the ventral hippocampus to the lateral septum and medial prefrontal cortex","author":"Parfitt","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2018.02.044_bib0215","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2202-15-72","article-title":"Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions","volume":"15","author":"Lio","year":"2014","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0220","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.bbi.2016.05.004","article-title":"Divergent effects of repeated restraint versus chronic variable stress on prefrontal cortical immune status after LPS injection","volume":"57","author":"Smith","year":"2016","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.bbr.2018.02.044_bib0225","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.neuroscience.2011.04.054","article-title":"Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain","volume":"192","author":"Savignac","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2018.02.044_bib0230","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbr.2014.05.040","article-title":"Subchronic and mild social defeat stress accelerates food intake and body weight gain with polydipsia-like features in mice","volume":"270","author":"Goto","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.02.044_bib0235","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molmet.2017.01.001","article-title":"Cholinergic neurons in the dorsomedial hypothalamus regulate food intake","volume":"6","author":"Jeong","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bbr.2018.02.044_bib0240","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature19789","article-title":"A cholinergic basal forebrain feeding circuit modulates appetite suppression","volume":"538","author":"Herman","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2018.02.044_bib0245","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0328-16.2017","article-title":"Accumbal cholinergic interneurons differentially influence motivation related to satiety signaling","volume":"4","author":"Aitta-aho","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.bbr.2018.02.044_bib0250","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2018.02.044_bib0255","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0260","first-page":"1","article-title":"Dynamics and correlation of serum cortisol and corticosterone under different physiological or stressful conditions in mice","volume":"10","author":"Gong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2018.02.044_bib0265","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ejphar.2007.12.032","article-title":"Central CRH system in depression and anxiety\u2014evidence from clinical studies with CRH1 receptor antagonists","volume":"583","author":"Holsboer","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2018.02.044_bib0270","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.brainres.2012.05.057","article-title":"Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus","volume":"1472","author":"Pavlovsky","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2018.02.044_bib0275","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0306-4530(87)90002-3","article-title":"The stress-induced response of the septo-hippocampal cholinergic system. A vectorial outcome of psychoneuroendocrinological interactions","volume":"12","author":"Gilad","year":"1987","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2018.02.044_bib0280","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1523\/JNEUROSCI.6040-10.2011","article-title":"A common substrate for prefrontal and hippocampal inhibition of the neuroendocrine stress response","volume":"31","author":"Radley","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2018.02.044_bib0285","article-title":"Cortisol secretion in endogenous depression","author":"Halbreich","year":"1985","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2018.02.044_bib0290","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","article-title":"The corticosteroid hypothesis of depression","volume":"23","author":"Holsboer","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2018.02.044_bib0295","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2014.01.039","article-title":"Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats","volume":"264","author":"Liu","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.02.044_bib0300","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1503\/cmaj.080697","article-title":"Neurobiological mechanisms in major depressive disorder","volume":"180","author":"Rot","year":"2009","journal-title":"CMAJ"},{"key":"10.1016\/j.bbr.2018.02.044_bib0305","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jad.2014.09.032","article-title":"An adaptationist perspective on the etiology of depression","volume":"172","author":"Durisko","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2018.02.044_bib0310","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1155\/2015\/581976","article-title":"Clinical and biochemical manifestations of depression: relation to the neurobiology of stress","volume":"2015","author":"Gold","year":"2015","journal-title":"Neural Plast."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432817313360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432817313360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T14:58:23Z","timestamp":1575385103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432817313360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":62,"alternative-id":["S0166432817313360"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2018.02.044","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced cholinergic-tone during the stress induce a depressive-like state in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2018.02.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}