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A."},{"key":"10.1016\/j.bbr.2018.05.022_bib0415","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.physbeh.2009.02.035","article-title":"Sex differences in learning processes of classical and operant conditioning","volume":"97","author":"Dalla","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2018.05.022_bib0420","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.biopsych.2012.04.029","article-title":"Low estradiol levels: a vulnerability factor for the development of posttraumatic stress disorder","volume":"72","author":"Lebron-Milad","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.05.022_bib0425","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/026988119901300202","article-title":"Comparison of buspirone with diazepam and fluvoxamine on aversive classical conditioning in humans","volume":"13","author":"Hellewell","year":"1999","journal-title":"J. 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