{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:35:44Z","timestamp":1790994944835,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bbr.2018.05.027","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T22:29:03Z","timestamp":1527805743000},"page":"1-3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression"],"prefix":"10.1016","volume":"351","author":[{"given":"D.","family":"Hen-Shoval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Amar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Shbiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Smoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christeene G.","family":"Haj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mechoulam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zalsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Shoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bbr.2018.05.027_bib0005","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.mcna.2017.03.010","article-title":"Screening adults for depression in primary care","volume":"101","author":"Smithson","year":"2017","journal-title":"Med. Clin. N. Am."},{"issue":"4","key":"10.1016\/j.bbr.2018.05.027_bib0010","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.3892\/mmr.2016.5585","article-title":"Endocannabinoid system: role in depression, reward and pain control (review)","volume":"14","author":"Huang","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"7","key":"10.1016\/j.bbr.2018.05.027_bib0015","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.pnpbp.2010.11.021","article-title":"Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants","volume":"35","author":"Gorzalka","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.05.027_bib0020","series-title":"Endocannabinoids and Mental Disorders. Endocannabinoids","first-page":"261","author":"Rubino","year":"2015"},{"key":"10.1016\/j.bbr.2018.05.027_bib0025","first-page":"37","article-title":"A comparative study on some chemical and biological characteristics of various samples of Cannabis resin","volume":"14","author":"Grlie","year":"1976","journal-title":"Bull. Narc."},{"key":"10.1016\/j.bbr.2018.05.027_bib0030","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tips.2009.07.006","article-title":"Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb","volume":"30","author":"Izzo","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"issue":"October (19)","key":"10.1016\/j.bbr.2018.05.027_bib0035","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1111\/bph.13724","article-title":"Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders","volume":"174","author":"Lee","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2018.05.027_bib0040","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.pbb.2010.03.004","article-title":"Antidepressant-like effect of \u0394 9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L","volume":"95","author":"El-Alfy","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2018.05.027_bib0045","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1476-5381.2009.00521.x","article-title":"Antidepressant\u2010like effects of cannabidiol in mice: possible involvement of 5\u2010HT1A receptors","volume":"159","author":"Zanelati","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2018.05.027_bib0050","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000443890","article-title":"Pro-hedonic effect of cannabidiol in a rat model for depression","volume":"73","author":"Shoval","year":"2016","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbr.2018.05.027_bib0055","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1556-4029.2007.00603.x","article-title":"Potency of \u03949\u2013THC and other cannabinoids in Cannabis in England in 2005: implications for psychoactivity and pharmacology","volume":"53","author":"Potter","year":"2008","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.bbr.2018.05.027_bib0060","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/bph.12043","article-title":"Cannabidiolic acid prevents vomiting in Suncus murinus and nausea\u2010induced behaviour in rats by enhancing 5\u2010HT1A receptor activation","volume":"168","author":"Bolognini","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2018.05.027_bib0065","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13041-017-0306-y","article-title":"The role of 5-HT receptors in depression","volume":"10","author":"Yohn","year":"2017","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbr.2018.05.027_bib0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00213-008-1168-x","article-title":"Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats","volume":"199","author":"Campos","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2018.05.027_bib0075","series-title":"Marijuana: Chemistry, Pharmacology, Metabolism and Clinical Effects","first-page":"1","author":"Mechoulam","year":"1973"},{"key":"10.1016\/j.bbr.2018.05.027_bib0080","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jpba.2017.11.044","article-title":"Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)","volume":"149","author":"Citti","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bbr.2018.05.027_bib0085","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/bph.14073","article-title":"Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT(1A) receptor-mediated suppression of nausea and anxiety in rats","volume":"175","author":"Pertwee","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2018.05.027_bib0090","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pneurobio.2009.03.003","article-title":"Two different putative genetic animal models of childhood depression\u2014a review","volume":"88","author":"Malkesman","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2018.05.027_bib0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1124\/pr.111.005397","article-title":"The flinders sensitive line rat model of depression\u201425 years and still producing","volume":"65","author":"Overstreet","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbr.2018.05.027_bib0100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1039\/c29690000343","article-title":"Carboxylation of resorcinols with methylmagnesium carbonate. Synthesis of cannabinoid acids","volume":"7","author":"Mechoulam","year":"1969","journal-title":"J. Chem. Soc. D: Chem. Commun."},{"key":"10.1016\/j.bbr.2018.05.027_bib0105","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Th\u00e9r."},{"key":"10.1016\/j.bbr.2018.05.027_bib0110","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1007\/s00213-015-4034-7","article-title":"Treatment-resistant depression: are animal models of depression fit for purpose?","volume":"232","author":"Willner","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2018.05.027_bib0115","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/gbb.12063","article-title":"Sex differences in depressive, anxious behaviors and hippocampal transcript levels in a genetic rat model","volume":"12","author":"Mehta","year":"2013","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2018.05.027_bib0120","series-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-5\u00ae)","author":"American Psychiatric Association","year":"2013"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818304832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818304832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:06:44Z","timestamp":1759064804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432818304832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":24,"alternative-id":["S0166432818304832"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2018.05.027","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2018.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}