{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:58:24Z","timestamp":1791809904961,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Project grant from Australia\u2019s National Health and Medical Research Council","award":["APP1109283"],"award-info":[{"award-number":["APP1109283"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.bbr.2018.08.016","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T13:49:57Z","timestamp":1535032197000},"page":"358-364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Maternal immune activation in mid-late gestation alters amphetamine sensitivity and object recognition, but not other schizophrenia-related behaviours in adult rats"],"prefix":"10.1016","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8524-333X","authenticated-orcid":false,"given":"A.","family":"Gray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tattoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-6722","authenticated-orcid":false,"given":"A.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.T.","family":"Michie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2268-8654","authenticated-orcid":false,"given":"L.","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2018.08.016_bib0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pharmthera.2015.01.001","article-title":"The Poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery","volume":"149","author":"Reisinger","year":"2015","journal-title":"Pharmacol. Ther."},{"issue":"12","key":"10.1016\/j.bbr.2018.08.016_bib0010","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1038\/npp.2010.129","article-title":"Late prenatal immune activation in mice leads to behavioral and neurochemical abnormalities relevant to the negative symptoms of schizophrenia","volume":"35","author":"Bitanihirwe","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.bbr.2018.08.016_bib0015","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bbi.2007.09.012","article-title":"Adult brain and behavioral pathological markers of prenatal immune challenge during early\/middle and late fetal development in mice","volume":"22","author":"Meyer","year":"2008","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbr.2018.08.016_bib0020","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbr.2008.02.021","article-title":"Immune activation during mid-gestation disrupts sensorimotor gating in rat offspring","volume":"190","author":"Wolff","year":"2008","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2018.08.016_bib0025","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbr.2011.07.033","article-title":"Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia","volume":"225","author":"Wolff","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"10","key":"10.1016\/j.bbr.2018.08.016_bib0030","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1038\/sj.npp.1300248","article-title":"Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia","volume":"28","author":"Zuckerman","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2018.08.016_bib0035","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbi.2016.07.144","article-title":"Effects of immune activation during early or late gestation on schizophrenia-related behaviour in adult rat offspring","volume":"63","author":"Meehan","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2018.08.016_bib0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fpsyt.2017.00077","article-title":"Effects of immune activation during early or late gestation on N-Methyl-d-Aspartate receptor measures in adult rat offspring","volume":"8","author":"Rahman","year":"2017","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2018.08.016_bib0045","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.pnpbp.2015.09.006","article-title":"Increased white matter neuron density in a rat model of maternal immune activation - implications for schizophrenia","volume":"65","author":"Duchatel","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2018.08.016_bib0050","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.neuroscience.2008.04.031","article-title":"Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy","volume":"154","author":"Meyer","year":"2008","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bbr.2018.08.016_bib0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00018-005-5387-6","article-title":"Development of dopaminergic neurons in the mammalian brain","volume":"63","author":"Prakash","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.bbr.2018.08.016_bib0060","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jpsychires.2004.08.008","article-title":"Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring","volume":"39","author":"Zuckerman","year":"2005","journal-title":"J. Psychiatr. Res."},{"issue":"6","key":"10.1016\/j.bbr.2018.08.016_bib0065","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.neubiorev.2004.10.012","article-title":"Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia","volume":"29","author":"Meyer","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.bbr.2018.08.016_bib0070","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.bbr.2007.04.016","article-title":"Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy","volume":"181","author":"Fortier","year":"2007","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.bbr.2018.08.016_bib0075","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.biopsych.2006.02.033","article-title":"Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: an animal model of schizophrenia","volume":"60","author":"Kesby","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.bbr.2018.08.016_bib0080","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/syn.21561","article-title":"Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC","volume":"66","author":"Vorhees","year":"2012","journal-title":"Synapse"},{"issue":"9","key":"10.1016\/j.bbr.2018.08.016_bib0085","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.jpsychires.2012.05.010","article-title":"Increased affective ultrasonic communication during fear learning in adult male rats exposed to maternal immune activation","volume":"46","author":"Yee","year":"2012","journal-title":"J. Psychiatr. Res."},{"issue":"1","key":"10.1016\/j.bbr.2018.08.016_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.schres.2004.09.007","article-title":"Identification of separable cognitive factors in schizophrenia","volume":"72","author":"Nuechterlein","year":"2004","journal-title":"Schizophr. Res."},{"issue":"6","key":"10.1016\/j.bbr.2018.08.016_bib0095","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.biopsych.2005.07.031","article-title":"Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia","volume":"59","author":"Ozawa","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbr.2018.08.016_bib0100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbr.2005.09.005","article-title":"The role of the hippocampus in object recognition in rats: examination of the influence of task parameters and lesion size","volume":"167","author":"Ainge","year":"2006","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2018.08.016_bib0105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1523\/JNEUROSCI.3827-04.2005","article-title":"Transient inactivation of perirhinal cortex disrupts encoding, retrieval, and consolidation of object recognition memory","volume":"25","author":"Winters","year":"2005","journal-title":"J. Neurosci."},{"issue":"23","key":"10.1016\/j.bbr.2018.08.016_bib0110","doi-asserted-by":"crossref","first-page":"8853","DOI":"10.1523\/JNEUROSCI.20-23-08853.2000","article-title":"Impaired recognition memory in rats after damage to the hippocampus","volume":"20","author":"Clark","year":"2000","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2018.08.016_bib0115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bbi.2011.11.004","article-title":"Effects of risperidone treatment in adolescence on hippocampal neurogenesis, parvalbumin expression, and vascularization following prenatal immune activation in rats","volume":"26","author":"Piontkewitz","year":"2012","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/j.bbr.2018.08.016_bib0120","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.biopsych.2011.06.007","article-title":"Abnormal trajectories of neurodevelopment and behavior following in utero insult in the rat","volume":"70","author":"Piontkewitz","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"17","key":"10.1016\/j.bbr.2018.08.016_bib0125","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1073\/pnas.93.17.9235","article-title":"Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects","volume":"93","author":"Laruelle","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bbr.2018.08.016_bib0130","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/schbul\/sbp006","article-title":"The dopamine hypothesis of schizophrenia: version III--the final common pathway","volume":"35","author":"Howes","year":"2009","journal-title":"Schizophr. Bull."},{"issue":"3","key":"10.1016\/j.bbr.2018.08.016_bib0135","first-page":"211","article-title":"Imaging dopamine transmission in schizophrenia. A review and meta-analysis","volume":"42","author":"Laruelle","year":"1998","journal-title":"Q. J. Nucl. Med."},{"issue":"1","key":"10.1016\/j.bbr.2018.08.016_bib0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2010.12.040","article-title":"Individual differences in maternal response to immune challenge predict offspring behavior: contribution of environmental factors","volume":"220","author":"Bronson","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.08.016_bib0145","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ntt.2014.10.007","article-title":"Prenatal immune challenge in rats: Effects of polyinosinic\u2013polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine","volume":"47","author":"Vorhees","year":"2015","journal-title":"Neurotoxicol. Teratol."},{"issue":"6","key":"10.1016\/j.bbr.2018.08.016_bib0150","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/schbul\/sbq040","article-title":"Risperidone administered during asymptomatic period of adolescence prevents the emergence of brain structural pathology and behavioral abnormalities in an animal model of schizophrenia","volume":"37","author":"Piontkewitz","year":"2011","journal-title":"Schizophr. Bull."},{"issue":"11","key":"10.1016\/j.bbr.2018.08.016_bib0155","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.biopsych.2009.07.005","article-title":"Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia","volume":"66","author":"Piontkewitz","year":"2009","journal-title":"Biol. Psychiatry"},{"issue":"Suppl. 2","key":"10.1016\/j.bbr.2018.08.016_bib0160","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/j.euroneuro.2007.02.005","article-title":"Risk factors for schizophrenia--all roads lead to dopamine","volume":"17","author":"Di Forti","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.bbr.2018.08.016_bib0165","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/schbul\/sbp132","article-title":"Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects","volume":"36","author":"van den Buuse","year":"2010","journal-title":"Schizophr. Bull."},{"issue":"2-3","key":"10.1016\/j.bbr.2018.08.016_bib0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s002130100810","article-title":"Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies","volume":"156","author":"Braff","year":"2001","journal-title":"Psychopharmacology"},{"issue":"40","key":"10.1016\/j.bbr.2018.08.016_bib0175","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2018.08.016_bib0180","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuroscience.2011.11.011","article-title":"Altered object-in-place recognition memory, prepulse inhibition, and locomotor activity in the offspring of rats exposed to a viral mimetic during pregnancy","volume":"201","author":"Howland","year":"2012","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bbr.2018.08.016_bib0185","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s002130000369","article-title":"Role of dopamine in prepulse inhibition of acoustic startle","volume":"149","author":"Zhang","year":"2000","journal-title":"Psychopharmacology (Berl.)"},{"issue":"7","key":"10.1016\/j.bbr.2018.08.016_bib0190","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyw007","article-title":"Maternal immune activation disrupts dopamine system in the offspring","volume":"19","author":"Luchicchi","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.bbr.2018.08.016_bib0195","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/schbul\/14.2.297","article-title":"The role of serotonin in schizophrenia","volume":"14","author":"Bleich","year":"1988","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbr.2018.08.016_bib0200","first-page":"9","article-title":"Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the Hippocampus: testing the \u201cTwo hit\u201d hypothesis for the development of schizophrenia","author":"Dalton","year":"2012","journal-title":"ISRN Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2018.08.016_bib0205","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/npp.1993.32","article-title":"Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics","volume":"8","author":"Joyce","year":"1993","journal-title":"Neuropsychopharmacology"},{"issue":"1-2","key":"10.1016\/j.bbr.2018.08.016_bib0210","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuropharm.2011.04.001","article-title":"Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia","volume":"61","author":"van den Buuse","year":"2011","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.bbr.2018.08.016_bib0215","first-page":"624","article-title":"The Laboratory Rat: Relating Its Age With Human\u2019s","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"issue":"3","key":"10.1016\/j.bbr.2018.08.016_bib0220","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jpsychires.2003.10.001","article-title":"Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring","volume":"38","author":"Fortier","year":"2004","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2018.08.016_bib0225","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbr.2013.10.005","article-title":"Hypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia","volume":"258","author":"Van den Eynde","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2018.08.016_bib0230","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/sj.npp.1301413","article-title":"Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge","volume":"33","author":"Meyer","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"37","key":"10.1016\/j.bbr.2018.08.016_bib0235","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1523\/JNEUROSCI.3046-10.2010","article-title":"Abnormal long-range neural synchrony in a maternal immune activation animal model of schizophrenia","volume":"30","author":"Dickerson","year":"2010","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.bbr.2018.08.016_bib0240","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1002\/hipo.22193","article-title":"Enhanced hippocampal neuronal excitability and LTP persistence associated with reduced behavioral flexibility in the maternal immune activation model of schizophrenia","volume":"23","author":"Savanthrapadian","year":"2013","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.bbr.2018.08.016_bib0245","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1523\/JNEUROSCI.23-01-00297.2003","article-title":"Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring","volume":"23","author":"Shi","year":"2003","journal-title":"J. Neurosci."},{"issue":"18","key":"10.1016\/j.bbr.2018.08.016_bib0250","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1523\/JNEUROSCI.0099-06.2006","article-title":"The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology","volume":"26","author":"Meyer","year":"2006","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.bbr.2018.08.016_bib0255","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nn0909-1075","article-title":"Troublesome variability in mouse studies","volume":"12","year":"2009","journal-title":"Nat. Neurosci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281830545X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281830545X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:12:05Z","timestamp":1759065125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016643281830545X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":51,"alternative-id":["S016643281830545X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2018.08.016","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal immune activation in mid-late gestation alters amphetamine sensitivity and object recognition, but not other schizophrenia-related behaviours in adult rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2018.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}