{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:40:43Z","timestamp":1778661643183,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771462"],"award-info":[{"award-number":["81771462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371140"],"award-info":[{"award-number":["31371140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation from Hebei province, China","award":["2018206119"],"award-info":[{"award-number":["2018206119"]}]},{"name":"Health Science Foundation from HFPC of Hebei Province","award":["20170642"],"award-info":[{"award-number":["20170642"]}]},{"name":"Health Science Foundation from HFPC of Hebei Province","award":["20170471"],"award-info":[{"award-number":["20170471"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.bbr.2018.08.037","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:18:23Z","timestamp":1536193103000},"page":"288-294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Methylene blue exerts rapid neuroprotective effects on lipopolysaccharide-induced behavioral deficits in mice"],"prefix":"10.1016","volume":"356","author":[{"given":"Shuo","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Israel","family":"Velez de-la-Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haishui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbr.2018.08.037_bib0005","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.maturitas.2014.05.009","article-title":"Depression and dementia: cause, consequence or coincidence?","volume":"79","author":"Bennett","year":"2014","journal-title":"Maturitas"},{"issue":"7526","key":"10.1016\/j.bbr.2018.08.037_bib0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/515185a","article-title":"Depression: a change of mind","volume":"515","author":"Anthes","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2018.08.037_bib0015","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.pnpbp.2012.10.006","article-title":"Immune changes and neurotransmitters: possible interactions in depression?","volume":"48","author":"Sperner-Unterweger","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.08.037_bib0020","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbi.2012.11.011","article-title":"Dysregulated relationship of inflammation and oxidative stress in major depression","volume":"31","author":"Rawdin","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2018.08.037_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2016.06.001","article-title":"Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation","volume":"298","author":"Zhang","year":"2016","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.bbr.2018.08.037_bib0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5607\/en.2018.27.3.189","article-title":"Antidepressant-like effects of p-Coumaric acid on LPS-induced depressive and inflammatory changes in rats","volume":"27","author":"Lee","year":"2018","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.bbr.2018.08.037_bib0035","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fpsyt.2017.00108","article-title":"Sex differences in the peripheral immune system in patients with depression","volume":"8","author":"Birur","year":"2017","journal-title":"Front. Psychiatry"},{"issue":"5","key":"10.1016\/j.bbr.2018.08.037_bib0040","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.pnpbp.2006.01.029","article-title":"Cytokines and serotonin transporter in patients with major depression","volume":"30","author":"Tsao","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.08.037_bib0045","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.psyneuen.2016.11.031","article-title":"Oxidative stress, inflammation and treatment response in major depression","volume":"76","author":"Lindqvist","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2018.08.037_bib0050","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bcp.2018.01.015","article-title":"Heme oxygnease-1 induction by methylene blue protects RAW264.7 cells from hydrogen peroxide-induced injury","volume":"148","author":"Zhang","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbr.2018.08.037_bib0055","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/ALN.0000000000001128","article-title":"Heme Oxygenase-1 mediates neuroprotection conferred by argon in combination with hypothermia in neonatal hypoxia-ischemia brain injury","volume":"125","author":"Zhao","year":"2016","journal-title":"Anesthesiology"},{"issue":"17","key":"10.1016\/j.bbr.2018.08.037_bib0060","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.bbr.2018.08.037_bib0065","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/13510002.2015.1101889","article-title":"Decreased expression of heme oxygenase is associated with depressive symptoms and may contribute to depressive and hypertensive comorbidity","volume":"21","author":"Robaczewska","year":"2016","journal-title":"Redox Rep."},{"key":"10.1016\/j.bbr.2018.08.037_bib0070","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbr.2017.09.007","article-title":"Enhanced expression of heme oxygenase-1 in the locus coeruleus can be associated with anxiolytic-like effects","volume":"336","author":"Cazuza","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.08.037_bib0075","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pneurobio.2015.10.005","article-title":"Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: methylene blue connects the dots","volume":"157","author":"Yang","year":"2017","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.bbr.2018.08.037_bib0080","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1007\/s12035-017-0712-2","article-title":"From mitochondrial function to neuroprotection-an emerging role for methylene blue","volume":"55","author":"Tucker","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2018.08.037_bib0085","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.8b00042","article-title":"Methylene blue analogues with marginal monoamine oxidase inhibition retain antidepressant-like activity","author":"Delport","year":"2018","journal-title":"ACS Chem. Neurosci."},{"issue":"5","key":"10.1016\/j.bbr.2018.08.037_bib0090","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s11011-017-0081-6","article-title":"Methylene blue and its analogues as antidepressant compounds","volume":"32","author":"Delport","year":"2017","journal-title":"Metab. Brain Dis."},{"issue":"5","key":"10.1016\/j.bbr.2018.08.037_bib0095","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1006\/phrs.1997.0245","article-title":"Anxiolytic and antidepressant properties of methylene blue in animal models","volume":"36","author":"Eroglu","year":"1997","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bbr.2018.08.037_bib0100","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.nlm.2006.08.009","article-title":"Methylene blue facilitates the extinction of fear in an animal model of susceptibility to learned helplessness","volume":"87","author":"Wrubel","year":"2007","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.bbr.2018.08.037_bib0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2016.08.036","article-title":"Methylene Blue promotes cortical neurogenesis and ameliorates behavioral deficit after photothrombotic stroke in rats","volume":"336","author":"Ahmed","year":"2016","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bbr.2018.08.037_bib0110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/neu.2014.3514","article-title":"Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice","volume":"32","author":"Fenn","year":"2015","journal-title":"J. Neurotrauma"},{"issue":"3","key":"10.1016\/j.bbr.2018.08.037_bib0115","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1007\/s12035-017-0470-1","article-title":"Combination treatment with methylene blue and hypothermia in global cerebral ischemia","volume":"55","author":"Li","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbr.2018.08.037_bib0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0165-0327(83)90008-3","article-title":"Methylene blue. A possible treatment for manic depressive psychosis","volume":"5","author":"Narsapur","year":"1983","journal-title":"J. Affect. Disord."},{"issue":"5","key":"10.1016\/j.bbr.2018.08.037_bib0125","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0006-3223(87)90194-6","article-title":"A controlled trial of methylene blue in severe depressive illness","volume":"22","author":"Naylor","year":"1987","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.bbr.2018.08.037_bib0130","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/0006-3223(89)90128-5","article-title":"Methylene blue excretion in depression","volume":"26","author":"Moody","year":"1989","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbr.2018.08.037_bib0135","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1192\/bjp.bp.115.173930","article-title":"Methylene blue treatment for residual symptoms of bipolar disorder: randomised crossover study","volume":"210","author":"Alda","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.bbr.2018.08.037_bib0140","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-018-0141-6","article-title":"Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia","author":"Bhattacharya","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.bbr.2018.08.037_bib0145","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1038\/npp.2012.131","article-title":"PI3K\/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3","volume":"37","author":"Shi","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2018.08.037_bib0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2015.12.030","article-title":"Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice","volume":"301","author":"Wu","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.08.037_bib0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2016.08.062","article-title":"A bioactive ingredient of Xylocarpus granatum, produces antidepressant-like effects in adult mice","volume":"633","author":"Gao","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2018.08.037_bib0160","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbr.2016.06.001","article-title":"Infliximab ameliorates AD-associated object recognition memory impairment","volume":"311","author":"Kim","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2018.08.037_bib0165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tox.2016.01.010","article-title":"Impairment of object recognition memory by maternal bisphenol A exposure is associated with inhibition of Akt and ERK\/CREB\/BDNF pathway in the male offspring hippocampus","volume":"341\u2013343","author":"Wang","year":"2016","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.bbr.2018.08.037_bib0170","doi-asserted-by":"crossref","first-page":"9625","DOI":"10.1038\/s41598-017-10362-6","article-title":"Molecular hydrogen increases resilience to stress in mice","volume":"7","author":"Gao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2018.08.037_bib0175","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neures.2016.07.006","article-title":"Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice","volume":"113","author":"Gureev","year":"2016","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbr.2018.08.037_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2018.03.005","article-title":"From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: detecting the critical transition from health to major depression","volume":"90","author":"Stapelberg","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.bbr.2018.08.037_bib0185","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0893-133X(00)00226-8","article-title":"Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents","volume":"24","author":"Yirmiya","year":"2001","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.bbr.2018.08.037_bib0190","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/15622975.2017.1298839","article-title":"Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: modulatory activity of the antidepressant agomelatine","volume":"19","author":"Rossetti","year":"2018","journal-title":"World J. Biol. Psychiatry"},{"issue":"5994","key":"10.1016\/j.bbr.2018.08.037_bib0195","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bbr.2018.08.037_bib0200","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/mp.2017.14","article-title":"Identification of a novel, fast-acting GABAergic antidepressant","volume":"23","author":"McMurray","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2018.08.037_bib0205","first-page":"2013","article-title":"A role of Yueju in fast-onset antidepressant action on major depressive disorder and serum BDNF expression: a randomly double-blind, fluoxetine-adjunct, placebo-controlled, pilot clinical study","volume":"11","author":"Wu","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.bbr.2018.08.037_bib0210","doi-asserted-by":"crossref","first-page":"13573","DOI":"10.1038\/srep13573","article-title":"Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice","volume":"5","author":"Tang","year":"2015","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.bbr.2018.08.037_bib0215","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1590\/S0100-879X1999001200012","article-title":"Anxiolytic effect of methylene blue microinjected into the dorsal periaqueductal gray matter","volume":"32","author":"de-Oliveira","year":"1999","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"8","key":"10.1016\/j.bbr.2018.08.037_bib0220","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1007\/s12035-015-9455-0","article-title":"Neuroprotective and functional improvement effects of methylene blue in global cerebral ischemia","volume":"53","author":"Lu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2018.08.037_bib0225","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.psychres.2017.09.045","article-title":"The molecular aspects of oxidative & nitrosative stress and the tryptophan catabolites pathway (TRYCATs) as potential causes of depression","volume":"262","author":"Wigner","year":"2018","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbr.2018.08.037_bib0230","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fnhum.2017.00316","article-title":"Inflammation: the common pathway of stress-related diseases","volume":"11","author":"Liu","year":"2017","journal-title":"Front. Hum. Neurosci."},{"issue":"10","key":"10.1016\/j.bbr.2018.08.037_bib0235","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/17460441.2017.1362385","article-title":"Animal inflammation-based models of depression and their application to drug discovery","volume":"12","author":"Ma","year":"2017","journal-title":"Expert Opin. Drug Discov."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818310787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818310787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:11:11Z","timestamp":1759065071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432818310787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":47,"alternative-id":["S0166432818310787"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2018.08.037","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylene blue exerts rapid neuroprotective effects on lipopolysaccharide-induced behavioral deficits in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2018.08.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}