{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:23:06Z","timestamp":1774790586974,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University, China","award":["XJTU1AF-CRF-2017-025"],"award-info":[{"award-number":["XJTU1AF-CRF-2017-025"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.bbr.2018.11.011","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T02:43:45Z","timestamp":1541990625000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Identification of schizophrenia related biological pathways across eight brain regions"],"prefix":"10.1016","volume":"360","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-9781","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiancang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbr.2018.11.011_bib0005","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0896-6273(00)00111-2","article-title":"Catching up on schizophrenia: natural history and neurobiology","volume":"28","author":"Lewis","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2018.11.011_bib0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/89040","article-title":"Advances in schizophrenia","volume":"7","author":"Thaker","year":"2001","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.bbr.2018.11.011_bib0015","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.979","article-title":"Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2","volume":"43","author":"Yue","year":"2011","journal-title":"Nat. Genet."},{"issue":"7256","key":"10.1016\/j.bbr.2018.11.011_bib0020","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature08192","article-title":"Common variants on chromosome 6p22.1 are associated with schizophrenia","volume":"460","author":"Shi","year":"2009","journal-title":"Nature"},{"issue":"7256","key":"10.1016\/j.bbr.2018.11.011_bib0025","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nature08186","article-title":"Common variants conferring risk of schizophrenia","volume":"460","author":"Stefansson","year":"2009","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bbr.2018.11.011_bib0030","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/ng.980","article-title":"Common variants on 8p12 and 1q24.2 confer risk of schizophrenia","volume":"43","author":"Shi","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbr.2018.11.011_bib0035","article-title":"Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population","author":"Yu","year":"2016","journal-title":"Mol. Psychiatry"},{"issue":"7510","key":"10.1016\/j.bbr.2018.11.011_bib0040","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Working Group of the Psychiatric Genomics, Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Schizophrenia","year":"2014","journal-title":"Nature"},{"issue":"2 Pt 1","key":"10.1016\/j.bbr.2018.11.011_bib0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(81)90413-X","article-title":"Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences","volume":"27","author":"Banerji","year":"1981","journal-title":"Cell"},{"issue":"6143","key":"10.1016\/j.bbr.2018.11.011_bib0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1236254","article-title":"Developmental biology. Enhancing pluripotency and lineage specification","volume":"341","author":"Xie","year":"2013","journal-title":"Science"},{"issue":"7307","key":"10.1016\/j.bbr.2018.11.011_bib0055","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nature09266","article-title":"From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus","volume":"466","author":"Musunuru","year":"2010","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbr.2018.11.011_bib0060","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tibs.2014.02.007","article-title":"Enhancer RNAs and regulated transcriptional programs","volume":"39","author":"Lam","year":"2014","journal-title":"Trends Biochem. Sci."},{"issue":"7333","key":"10.1016\/j.bbr.2018.11.011_bib0065","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature09753","article-title":"9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response","volume":"470","author":"Harismendy","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbr.2018.11.011_bib0070","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11065-014-9248-7","article-title":"Brain networks in schizophrenia","volume":"24","author":"van den Heuvel","year":"2014","journal-title":"Neuropsychol. Rev."},{"issue":"5","key":"10.1016\/j.bbr.2018.11.011_bib0075","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1073\/pnas.052023499","article-title":"Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia","volume":"99","author":"Cannon","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2018.11.011_bib0080","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.neuro.25.112701.142754","article-title":"Schizophrenia as a disorder of neurodevelopment","volume":"25","author":"Lewis","year":"2002","journal-title":"Annu. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.bbr.2018.11.011_bib0085","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1001\/archpsyc.1987.01800190080012","article-title":"Implications of normal brain development for the pathogenesis of schizophrenia","volume":"44","author":"Weinberger","year":"1987","journal-title":"Arch. Gen. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2018.11.011_bib0090","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1172\/JCI37335","article-title":"Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies","volume":"119","author":"Lewis","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"Suppl 1","key":"10.1016\/j.bbr.2018.11.011_bib0095","doi-asserted-by":"crossref","first-page":"i171","DOI":"10.1093\/cercor\/bhm069","article-title":"Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia","volume":"17","author":"Tan","year":"2007","journal-title":"Cereb. Cortex"},{"issue":"1-3","key":"10.1016\/j.bbr.2018.11.011_bib0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.schres.2016.02.018","article-title":"GABAergic system impairment in the hippocampus and superior temporal gyrus of patients with paranoid schizophrenia: a post-mortem study","volume":"177","author":"Steiner","year":"2016","journal-title":"Schizophr. Res."},{"issue":"7","key":"10.1016\/j.bbr.2018.11.011_bib0105","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tins.2008.04.001","article-title":"White matter in learning, cognition and psychiatric disorders","volume":"31","author":"Fields","year":"2008","journal-title":"Trends Neurosci."},{"issue":"10","key":"10.1016\/j.bbr.2018.11.011_bib0110","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/ng.3950","article-title":"Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines","volume":"49","author":"Cao","year":"2017","journal-title":"Nat. Genet."},{"issue":"7539","key":"10.1016\/j.bbr.2018.11.011_bib0115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Roadmap Epigenomics","year":"2015","journal-title":"Nature"},{"issue":"7493","key":"10.1016\/j.bbr.2018.11.011_bib0120","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature12787","article-title":"An atlas of active enhancers across human cell types and tissues","volume":"507","author":"Andersson","year":"2014","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bbr.2018.11.011_bib0125","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1086\/522374","article-title":"Pathway-based approaches for analysis of genomewide association studies","volume":"81","author":"Wang","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"43","key":"10.1016\/j.bbr.2018.11.011_bib0130","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2018.11.011_bib0135","series-title":"Nonparametric Statistical Methods","author":"Hollander","year":"1998"},{"issue":"1-3","key":"10.1016\/j.bbr.2018.11.011_bib0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.schres.2014.05.038","article-title":"Resequencing and association study of the NFKB activating protein-like gene (NKAPL) in schizophrenia","volume":"157","author":"Chen","year":"2014","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbr.2018.11.011_bib0145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neulet.2015.08.023","article-title":"Further evidence supporting the association of NKAPL with schizophrenia","volume":"605","author":"Wang","year":"2015","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.bbr.2018.11.011_bib0150","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/npp.2008.139","article-title":"Olfactory receptor neuron dysfunction in schizophrenia","volume":"34","author":"Turetsky","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2018.11.011_bib0155","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1186\/1471-2164-15-729","article-title":"Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules","volume":"15","author":"Grison","year":"2014","journal-title":"BMC Genomics"},{"issue":"1-3","key":"10.1016\/j.bbr.2018.11.011_bib0160","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.schres.2014.09.041","article-title":"GABAergic mechanisms of hippocampal hyperactivity in schizophrenia","volume":"167","author":"Heckers","year":"2015","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.bbr.2018.11.011_bib0165","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/npp.2014.95","article-title":"Neurodevelopment, GABA system dysfunction, and schizophrenia","volume":"40","author":"Schmidt","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.bbr.2018.11.011_bib0170","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrn845","article-title":"Modes of neuronal migration in the developing cerebral cortex","volume":"3","author":"Nadarajah","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2018.11.011_bib0175","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/cercor\/13.6.607","article-title":"Neuronal migration in the developing cerebral cortex: observations based on real-time imaging","volume":"13","author":"Nadarajah","year":"2003","journal-title":"Cereb. Cortex"},{"issue":"4","key":"10.1016\/j.bbr.2018.11.011_bib0180","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00406-013-0479-z","article-title":"Neuropathological changes in the substantia nigra in schizophrenia but not depression","volume":"264","author":"Williams","year":"2014","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2018.11.011_bib0185","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S1364-6613(03)00028-7","article-title":"Task switching","volume":"7","author":"Monsell","year":"2003","journal-title":"Trends Cogn. Sci. (Regul. Ed.)"},{"issue":"2","key":"10.1016\/j.bbr.2018.11.011_bib0190","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.acn.2007.08.010","article-title":"Assessment of executive functions: review of instruments and identification of critical issues","volume":"23","author":"Chan","year":"2008","journal-title":"Arch. Clin. Neuropsychol."},{"issue":"10","key":"10.1016\/j.bbr.2018.11.011_bib0195","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/hipo.20547","article-title":"Aerobic fitness is associated with hippocampal volume in elderly humans","volume":"19","author":"Erickson","year":"2009","journal-title":"Hippocampus"},{"issue":"Pt 12","key":"10.1016\/j.bbr.2018.11.011_bib0200","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1093\/brain\/awp271","article-title":"Voxel-based morphometry reveals reduced grey matter volume in the temporal cortex of developmental prosopagnosics","volume":"132","author":"Garrido","year":"2009","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.bbr.2018.11.011_bib0205","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMra071297","article-title":"Systemic lupus erythematosus","volume":"358","author":"Rahman","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"7589","key":"10.1016\/j.bbr.2018.11.011_bib0210","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4","volume":"530","author":"Sekar","year":"2016","journal-title":"Nature"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818314840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818314840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T10:02:03Z","timestamp":1572602523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432818314840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":42,"alternative-id":["S0166432818314840"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2018.11.011","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of schizophrenia related biological pathways across eight brain regions","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2018.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}