{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:00:14Z","timestamp":1789664414069,"version":"4.0.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Brain Imaging Return to Health \u201creBIRTH\u201d"},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7-PEOPLE-2012-ITN"],"award-info":[{"award-number":["FP7-PEOPLE-2012-ITN"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001637","name":"Trinity College Dublin (TCD)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.bbr.2019.01.015","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T11:12:22Z","timestamp":1547032342000},"page":"90-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents"],"prefix":"10.1016","volume":"362","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-7262","authenticated-orcid":false,"given":"J.","family":"David","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gormley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"McIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kebede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Thuery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Varidaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.T.","family":"Coffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-216X","authenticated-orcid":false,"given":"A.","family":"Harkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2019.01.015_bib0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0010","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2015.05.053","article-title":"Pathogenesis of depression: insights from human and rodent studies","volume":"321","author":"M\u00e9nard","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.01.015_bib0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2174\/187152707780619326","article-title":"Gliogenesis and glial pathology in depression","volume":"6","author":"Rajkowska","year":"2007","journal-title":"CNS Neurol. Disord.-Drug Targets Former. Curr. Drug Targets-CNS Neurol. Disord."},{"key":"10.1016\/j.bbr.2019.01.015_bib0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00406-012-0328-5","article-title":"Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia","volume":"263","author":"Williams","year":"2013","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0025","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0006-3223(02)01404-X","article-title":"Low glial numbers in the amygdala in major depressive disorder","volume":"52","author":"Bowley","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.01.015_bib0030","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.biopsych.2004.08.022","article-title":"Cellular changes in the postmortem Hippocampus in major depression","volume":"56","author":"Stockmeier","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.01.015_bib0035","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.2174\/13894501113149990156","article-title":"Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue","volume":"14","author":"Rajkowska","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbr.2019.01.015_bib0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.brainres.2007.01.039","article-title":"Long-term effects of early life deprivation on brain glia in Fischer rats","volume":"1142","author":"Leventopoulos","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2019.01.015_bib0045","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.biopsych.2008.06.008","article-title":"Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors","volume":"64","author":"Banasr","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.01.015_bib0050","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.neuroscience.2009.02.074","article-title":"Juvenile separation stress induces rapid region-and layer-specific changes in S100\\s s-and glial fibrillary acidic protein\u2013immunoreactivity in astrocytes of the rodent medial prefrontal cortex","volume":"160","author":"Braun","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.01.015_bib0055","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.neuroscience.2008.10.018","article-title":"Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression","volume":"159","author":"Gosselin","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.01.015_bib0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pneurobio.2009.03.003","article-title":"Two different putative genetic animal models of childhood depression\u2014a review","volume":"88","author":"Malkesman","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0065","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.physbeh.2016.04.007","article-title":"Glial fibrillary acidic protein (GFAP) immunoreactivity correlates with cortical perfusion parameters determined by bolus tracking arterial spin labelling (bt-ASL) magnetic resonance (MR) imaging in the Wistar Kyoto rat","volume":"160","author":"Gormley","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2019.01.015_bib0070","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1503\/jpn.120024","article-title":"Glutamine deficiency in the prefrontal cortex increases depressive-like behaviours in male mice","volume":"38","author":"Lee","year":"2013","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0075","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/npp.2011.319","article-title":"Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats","volume":"37","author":"Sun","year":"2012","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2019.01.015_bib0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte\u2013endothelial interactions at the blood\u2013brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0085","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.tins.2008.11.005","article-title":"Astrocytes and the regulation of cerebral blood flow","volume":"32","author":"Koehler","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0090","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1017\/S1092852900010403","article-title":"Beyond monoamines: glutamatergic function in mood disorders","volume":"10","author":"Kugaya","year":"2005","journal-title":"CNS Spectr."},{"key":"10.1016\/j.bbr.2019.01.015_bib0095","first-page":"240","article-title":"Role of astrocytes in memory and psychiatric disorders","volume":"108","author":"Moraga-Amaro","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-pharmtox-011613-135950","article-title":"Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds","volume":"54","author":"Niciu","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0105","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.pbb.2011.08.008","article-title":"Overview of glutamatergic neurotransmission in the nervous system","volume":"100","author":"Niciu","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2019.01.015_bib0110","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuropharm.2011.07.036","article-title":"Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders","volume":"62","author":"Sanacora","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2019.01.015_bib0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/A:1006947322342","article-title":"The glio-toxic mechanism of \u03b1-aminoadipic acid on cultured astrocytes","volume":"27","author":"Brown","year":"1998","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0120","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1523\/JNEUROSCI.04-10-02650.1984","article-title":"The glutamate analogue alpha-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro","volume":"4","author":"Huck","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-3940(80)90273-6","article-title":"Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate","volume":"19","author":"Olney","year":"1980","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2019.01.015_bib0130","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1476-5381.1994.tb17022.x","article-title":"Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate","volume":"113","author":"McBean","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0135","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/mp.2013.182","article-title":"Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats","volume":"19","author":"Lima","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.01.015_bib0140","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8056370","article-title":"Dendritic spines in depression: what we learned from animal models [WWW document]","author":"Qiao","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbr.2019.01.015_bib0145","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00280","article-title":"Astrocytes protect neurons in the hippocampal CA3 against ischemia by suppressing the intracellular Ca(2+) overload","volume":"12","author":"Sun","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0150","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/0735-7044.122.3.643","article-title":"Dissociating the roles of dorsal and ventral CA1 for the temporal processing of spatial locations, visual objects, and odors","volume":"122","author":"Hunsaker","year":"2008","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0155","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbr.2012.04.022","article-title":"Differential roles of the dorsal hippocampal regions in the acquisition of spatial and temporal aspects of episodic-like memory","volume":"232","author":"Barbosa","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2019.01.015_bib0160","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.mehy.2013.03.025","article-title":"Disruption of spine homeostasis causes depression","volume":"81","author":"Sato","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbr.2019.01.015_bib0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neulet.2015.01.022","article-title":"Spine synapse remodeling in the pathophysiology and treatment of depression","volume":"601","author":"Duman","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2019.01.015_bib0170","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1098\/rstb.2011.0357","article-title":"A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists","volume":"367","author":"Duman","year":"2012","journal-title":"Philos. Trans. Biol. Sci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0175","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tins.2012.12.010","article-title":"Neuronal plasticity and antidepressant actions","volume":"36","author":"Castr\u00e9n","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0180","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbr.2019.01.015_bib0185","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuroscience.2018.09.023","article-title":"Inhibitors of the NMDA-Nitric oxide signaling pathway protect against neuronal atrophy and synapse loss provoked by l-alpha aminoadipic acid-treated astrocytes","volume":"392","author":"David","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.01.015_bib0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbr.2014.07.019","article-title":"Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression","volume":"273","author":"Domin","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2019.01.015_bib0195","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/hipo.20631","article-title":"Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism","volume":"19","author":"Griffin","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2019.01.015_bib0200","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2019.01.015_bib0205","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0210","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/026988110201600201","article-title":"Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine","volume":"16","author":"Harkin","year":"2002","journal-title":"J. Psychopharmacol. (Oxf.)"},{"key":"10.1016\/j.bbr.2019.01.015_bib0215","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn.2015.8","article-title":"Neurobiology of rodent self-grooming and its value for translational neuroscience","volume":"17","author":"Kalueff","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0220","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejphar.2005.03.029","article-title":"Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol","volume":"514","author":"Yalcin","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0225","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(97)00810-X","article-title":"Modulation of anxiety-related behaviours following lesions of the prelimbic or infralimbic cortex in the rat","volume":"772","author":"Jinks","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2019.01.015_bib0230","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1098-1136(199604)16:4<351::AID-GLIA7>3.0.CO;2-2","article-title":"Selective ablation of astrocytes by intracerebral injections of \u03b1\u2010aminoadipate","volume":"16","author":"Khurgel","year":"1996","journal-title":"Glia"},{"key":"10.1016\/j.bbr.2019.01.015_bib0235","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1046\/j.0953-816x.2001.01784.x","article-title":"Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus","volume":"14","author":"M\u00fcller","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0240","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.euroneuro.2009.06.010","article-title":"Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression","volume":"19","author":"Liu","year":"2009","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0245","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/glia.23136","article-title":"Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders","volume":"65","author":"Liu","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.bbr.2019.01.015_bib0250","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/hipo.1077","article-title":"Dissociating hippocampal subregions: a double dissociation between dentate gyrus and CA1","volume":"11","author":"Gilbert","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2019.01.015_bib0255","first-page":"23","article-title":"Spatial memory and hippocampal function: where are we now?","author":"Good","year":"2002","journal-title":"Psicolgica"},{"key":"10.1016\/j.bbr.2019.01.015_bib0260","first-page":"217","article-title":"Regionally specific changes in levels of cortical S100\u03b2 in bipolar 1 disorder but not schizophrenia","volume":"40","author":"Dean","year":"2006","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.bbr.2019.01.015_bib0265","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.jpsychires.2013.07.005","article-title":"S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: a postmortem study","volume":"47","author":"Gos","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2019.01.015_bib0270","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00441-012-1336-5","article-title":"Role of the lesion scar in the response to damage and repair of the central nervous system","volume":"349","author":"Kawano","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbr.2019.01.015_bib0275","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1742-2094-4-17","article-title":"Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat","volume":"4","author":"Williams","year":"2007","journal-title":"J. Neuroinflam."},{"key":"10.1016\/j.bbr.2019.01.015_bib0280","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1471-2202-8-107","article-title":"Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex","volume":"8","author":"Michelsen","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0285","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","article-title":"Glutamate NMDA receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure","volume":"69","author":"Li","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.01.015_bib0290","doi-asserted-by":"crossref","first-page":"14379","DOI":"10.1523\/JNEUROSCI.0287-13.2013","article-title":"Chronic stress-induced alterations of dendritic spine subtypes predict functional decrements in an hypothalamo\u2013pituitary\u2013adrenal-inhibitory prefrontal circuit","volume":"33","author":"Radley","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0295","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/j.bbadis.2013.08.012","article-title":"Structural plasticity of dendritic spines: the underlying mechanisms and its dysregulation in brain disorders","volume":"1832","author":"Lai","year":"2013","journal-title":"Biochim. Biophys. Acta BBA-Mol. Basis Dis."},{"key":"10.1016\/j.bbr.2019.01.015_bib0300","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/cercor\/bhm041","article-title":"Activity-dependent PSD formation and stabilization of newly formed spines in hippocampal slice cultures","volume":"18","author":"De Roo","year":"2008","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbr.2019.01.015_bib0305","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.conb.2007.04.009","article-title":"Do thin spines learn to be mushroom spines that remember?","volume":"17","author":"Bourne","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbr.2019.01.015_bib0310","doi-asserted-by":"crossref","first-page":"13592","DOI":"10.1523\/JNEUROSCI.0603-08.2008","article-title":"Principles of long-term dynamics of dendritic spines","volume":"28","author":"Yasumatsu","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.015_bib0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079077","article-title":"Acute physiological stress promotes clustering of synaptic markers and alters spine morphology in the Hippocampus","volume":"8","author":"Sebastian","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2019.01.015_bib0320","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/da.22227","article-title":"Neurobiology of stress, depression and rapid acting antidepressants: remodeling synaptic connections","volume":"31","author":"Duman","year":"2014","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.bbr.2019.01.015_bib0325","first-page":"349","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: role of \u03b1-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors","volume":"63","author":"Maeng","year":"2008","journal-title":"Stress Depress. Circuitry"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818316899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818316899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T23:38:46Z","timestamp":1565221126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432818316899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":65,"alternative-id":["S0166432818316899"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.01.015","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}