{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:55:30Z","timestamp":1779364530531,"version":"3.53.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bbr.2019.01.049","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T17:07:49Z","timestamp":1548695269000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Wheel-running exercise before and during gestation against acute and sensitized cocaine psychomotor-activation in offspring"],"prefix":"10.1016","volume":"363","author":[{"given":"Louis-Ferdinand","family":"Lespine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Plenevaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Tirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bbr.2019.01.049_bib0005","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.4236\/health.2015.711162","article-title":"Exercise and smoking: a literature overview","volume":"07","author":"Hassandra","year":"2015","journal-title":"Health"},{"issue":"8","key":"10.1016\/j.bbr.2019.01.049_bib0010","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.neubiorev.2013.06.011","article-title":"Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis","volume":"37","author":"Lynch","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2019.01.049_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.drugalcdep.2015.05.037","article-title":"Does physical activity protect against drug abuse vulnerability?","volume":"153","author":"Bardo","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbr.2019.01.049_bib0020","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbr.2012.09.014","article-title":"High levels of wheel running protect against behavioral sensitization to cocaine","volume":"237","author":"Renteria Diaz","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2019.01.049_bib0025","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbr.2014.01.002","article-title":"Wheel-running mitigates psychomotor sensitization initiation but not post-sensitization conditioned activity and conditioned place preference induced by cocaine in mice","volume":"262","author":"Geuzaine","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2019.01.049_bib0030","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neuroscience.2015.10.009","article-title":"The protective effects of free wheel-running against cocaine psychomotor sensitization persist after exercise cessation in C57BL\/6J mice","volume":"310","author":"Lespine","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.01.049_bib0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbr.2018.04.054","article-title":"Evidence for a long-term protection of wheel-running exercise against cocaine psychomotor sensitization in adolescent but not in adult mice","volume":"349","author":"Lespine","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/j.bbr.2019.01.049_bib0040","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.neubiorev.2013.01.018","article-title":"Striatal ups and downs: their roles in vulnerability to addictions in humans","volume":"37","author":"Leyton","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0045","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/pr.109.001933","article-title":"Drug wanting: behavioral sensitization and relapse to drug-seeking behavior","volume":"63","author":"Steketee","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.bbr.2019.01.049_bib0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bandc.2009.08.008","article-title":"Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors","volume":"72","author":"Doremus-Fitzwater","year":"2010","journal-title":"Brain Cogn."},{"issue":"5","key":"10.1016\/j.bbr.2019.01.049_bib0055","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neubiorev.2009.12.007","article-title":"Neurobehavioral Evidence for Changes in Dopamine System Activity During Adolescence","volume":"34","author":"Wahlstrom","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.bbr.2019.01.049_bib0060","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1097\/AOG.0000000000001214","article-title":"Committee Opinion No. 650: Physical Activity and Exercise During Pregnancy and the Postpartum Period","volume":"126","year":"2015","journal-title":"Obstet. Gynecol."},{"issue":"21","key":"10.1016\/j.bbr.2019.01.049_bib0065","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1136\/bjsports-2015-094756","article-title":"Exercise during pregnancy. A narrative review asking: what do we know?","volume":"49","author":"Barakat","year":"2015","journal-title":"Br. J. Sports Med."},{"issue":"1","key":"10.1016\/j.bbr.2019.01.049_bib0070","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1600-0838.2000.010001012.x","article-title":"Effects on the foetus of exercise in pregnancy","volume":"10","author":"Riemann","year":"2000","journal-title":"Scand. J. Med. Sci. Sports"},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0075","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1249\/MSS.0b013e31826cebcb","article-title":"Health benefits of physical activity during pregnancy: an international perspective","volume":"45","author":"Mudd","year":"2013","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bbr.2019.01.049_bib0080","first-page":"9","article-title":"The influence of prenatal exercise on offspring health: a review","author":"Moyer","year":"2016","journal-title":"Clin. Med. Insights Womens Health"},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neulet.2012.03.091","article-title":"Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life","volume":"516","author":"Aksu","year":"2012","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/hipo.20903","article-title":"Early exercise promotes positive hippocampal plasticity and improves spatial memory in the adult life of rats","volume":"22","author":"Gomes da Silva","year":"2012","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.bbr.2019.01.049_bib0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2003.08.023","article-title":"Exercise during pregnancy increases hippocampal brain-derived neurotrophic factor mRNA expression and spatial learning in neonatal rat pup","volume":"352","author":"Parnpiansil","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2019.01.049_bib0100","first-page":"256","article-title":"Physical exercise during pregnancy improves object recognition memory in adult offspring","author":"Robinson","year":"2014","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0105","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/0976-500X.72351","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"1","author":"Kilkenny","year":"2010","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.bbr.2019.01.049_bib0110","series-title":"Experimental Design: Procedures for the Behavioral Sciences","author":"Kirk","year":"1995"},{"issue":"1\u20132","key":"10.1016\/j.bbr.2019.01.049_bib0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0149-7634(03)00006-X","article-title":"Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence","volume":"27","author":"Laviola","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2019.01.049_bib0120","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbr.2004.08.020","article-title":"Evidence that the relations between novelty-induced activity, locomotor stimulation and place preference induced by cocaine qualitatively depend upon the dose: a multiple regression analysis in inbred C57BL\/ 6J mice","volume":"158","author":"Brabant","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"7","key":"10.1016\/j.bbr.2019.01.049_bib0125","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0306-4530(02)00108-7","article-title":"Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change","volume":"28","author":"Pruessner","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2019.01.049_bib0130","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.bbr.2019.01.049_bib0135","series-title":"Contrast Analysis: Focused Comparisons in the Analysis of Variance","author":"Rosenthal","year":"2009"},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0140","doi-asserted-by":"crossref","first-page":"597","DOI":"10.22237\/jmasm\/1257035100","article-title":"New effect size rules of thumb","volume":"8","author":"Sawilowsky","year":"2009","journal-title":"J. Mod. Appl. Stat. Methods"},{"issue":"4","key":"10.1016\/j.bbr.2019.01.049_bib0145","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3177\/jnsv.27.333","article-title":"Voluntary exercise during pregnancy and lactation and its effect on lactational performance in mice","volume":"27","author":"Karasawa","year":"1981","journal-title":"J. Nutr. Sci. Vitaminol."},{"issue":"1","key":"10.1016\/j.bbr.2019.01.049_bib0150","doi-asserted-by":"crossref","DOI":"10.1186\/s12952-015-0032-x","article-title":"Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice","volume":"14","author":"Kelly","year":"2015","journal-title":"J. Negat. Results Biomed."},{"issue":"12","key":"10.1016\/j.bbr.2019.01.049_bib0155","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1242\/jeb.078402","article-title":"Limits to sustained energy intake. XV. Effects of wheel running on the energy budget during lactation","volume":"216","author":"Zhao","year":"2013","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bbr.2019.01.049_bib0160","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/429803","article-title":"Maternal aerobic exercise during pregnancy can increase spatial learning by affecting leptin expression on offspring\u2019s early and late period in life depending on gender","author":"Dayi","year":"2012","journal-title":"Sci. World J."},{"issue":"4","key":"10.1016\/j.bbr.2019.01.049_bib0165","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijdevneu.2007.03.003","article-title":"The influence of maternal treadmill running during pregnancy on short-term memory and hippocampal cell survival in rat pups","volume":"25","author":"Kim","year":"2007","journal-title":"Int. J. Dev. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2019.01.049_bib0170","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.braindev.2005.05.007","article-title":"Maternal swimming during pregnancy enhances short-term memory and neurogenesis in the hippocampus of rat pups","volume":"28","author":"Lee","year":"2006","journal-title":"Brain Dev."},{"issue":"Suppl. 3","key":"10.1016\/j.bbr.2019.01.049_bib0175","first-page":"511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.bbr.2019.01.049_bib0180","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/jne.12175","article-title":"The Consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations","volume":"26","author":"Maccari","year":"2014","journal-title":"J. Neuroendocrinol."},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0185","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbr.2009.10.012","article-title":"Prenatal exposure to moderate levels of ethanol alters social behavior in adult rats: relationship to structural plasticity and immediate early gene expression in frontal cortex","volume":"207","author":"Hamilton","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2019.01.049_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.04.006","article-title":"Behavioral effects of perinatal opioid exposure","volume":"104","author":"Fodor","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2019.01.049_bib0195","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbr.2013.06.003","article-title":"Early gestational exposure to moderate concentrations of ethanol alters adult behaviour in C57BL\/6J mice","volume":"252","author":"Sanchez Vega","year":"2013","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0200","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/npp.2012.168","article-title":"Prenatal stress exposure increases the excitation of dopamine neurons in the Ventral Tegmental Area and alters their responses to psychostimulants","volume":"38","author":"Hausknecht","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"10.1016\/j.bbr.2019.01.049_bib0205","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ijdevneu.2010.07.229","article-title":"Effects of prenatal stress and exercise on dentate granule cells maturation and spatial memory in adolescent mice","volume":"28","author":"Bustamante","year":"2010","journal-title":"Int. J. Dev. Neurosci."},{"issue":"4","key":"10.1016\/j.bbr.2019.01.049_bib0210","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ijdevneu.2013.02.007","article-title":"Maternal exercise during pregnancy ameliorates the postnatal neuronal impairments induced by prenatal restraint stress in mice","volume":"31","author":"Bustamante","year":"2013","journal-title":"Int. J. Develop. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0215","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bbr.2010.11.005","article-title":"Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway","volume":"217","author":"Greenwood","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"12","key":"10.1016\/j.bbr.2019.01.049_bib0220","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.biopsych.2005.10.016","article-title":"Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model","volume":"59","author":"Champagne","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.01.049_bib0225","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yfrne.2015.07.001","article-title":"Sex differences in drug addiction and response to exercise intervention: from human to animal studies","volume":"40","author":"Zhou","year":"2016","journal-title":"Front. Neuroendocrinol."},{"issue":"1","key":"10.1016\/j.bbr.2019.01.049_bib0230","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2009.02.052","article-title":"Maternal enrichment affects prenatal hippocampal proliferation and open-field behaviors in female offspring mice","volume":"454","author":"Maruoka","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.bbr.2019.01.049_bib0235","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.neubiorev.2012.06.005","article-title":"Exercise offers anxiolytic potential: A role for stress and brain noradrenergic-galaninergic mechanisms","volume":"36","author":"Sciolino","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.bbr.2019.01.049_bib0240","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/bjp.2008.77","article-title":"Neuroplasticity in the mesolimbic dopamine system and cocaine addiction: neuroplasticity and cocaine addiction","volume":"154","author":"Thomas","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbr.2019.01.049_bib0245","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00213-009-1498-3","article-title":"Behavioral sensitization to cocaine: cooperation between glucocorticoids and epinephrine","volume":"204","author":"de Jong","year":"2009","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2019.01.049_bib0250","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0149-7634(03)00018-6","article-title":"Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents","volume":"27","author":"Tirelli","year":"2003","journal-title":"Neurosci. Biobehav. Rev."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818311793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818311793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T09:42:42Z","timestamp":1551865362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432818311793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":50,"alternative-id":["S0166432818311793"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.01.049","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/477505","asserted-by":"object"}]},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wheel-running exercise before and during gestation against acute and sensitized cocaine psychomotor-activation in offspring","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.01.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}