{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:47:14Z","timestamp":1761598034959,"version":"3.37.3"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key R&D Program of China","award":["2018YFC1314600"],"award-info":[{"award-number":["2018YFC1314600"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771472","81271496","30971040"],"award-info":[{"award-number":["81771472","81271496","30971040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.bbr.2019.01.059","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:54:12Z","timestamp":1548982452000},"page":"103-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["DNA methylation of the Tacr2 gene in a CUMS model of depression"],"prefix":"10.1016","volume":"365","author":[{"given":"Dan","family":"Xiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qirong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.bbr.2019.01.059_bib0005","first-page":"S231","article-title":"Recognising and treating depression in the elderly","volume":"27","author":"Singh","year":"2015","journal-title":"Psychiatr. Danub."},{"key":"10.1016\/j.bbr.2019.01.059_bib0010","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/bmb\/lds004","article-title":"The neurobiology of depression","volume":"101","author":"Palazidou","year":"2012","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbr.2019.01.059_bib0015","first-page":"D7954","article-title":"Antidepressants versus placebo for depression in primary care","author":"Arroll","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbr.2019.01.059_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1477-7827-7-77","article-title":"Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus","volume":"7","author":"Pinto","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.bbr.2019.01.059_bib0025","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.lfs.2003.09.039","article-title":"Tachykinins and tachykinin receptors: a growing family","volume":"74","author":"Pennefather","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2019.01.059_bib0030","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2174\/138161209788168074","article-title":"Tachykinin\u2009 receptors as therapeutic targets in stress-related disorders","volume":"15","author":"Ebner","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbr.2019.01.059_bib0035","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0306-4522(02)00748-0","article-title":"Autoradiographic\u2009 distribution of tachykinin NK2 binding sites in the rat brain: comparison with NK1 and NK3 binding sites","volume":"116","author":"Saffroy","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.01.059_bib0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s002130100830","article-title":"Effects of SR48968, a selective non-peptide NK2 receptor antagonist on emotional processes in rodents","volume":"158","author":"Griebel","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2019.01.059_bib0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pbb.2008.04.003","article-title":"Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions","volume":"90","author":"Micale","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2019.01.059_bib0050","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0306-4522(02)00748-0","article-title":"Autoradiographic distribution of tachykinin NK2 binding sites in the rat brain: comparison with NK1 and NK3 binding sites","volume":"116","author":"Saffroy","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.01.059_bib0055","first-page":"449","article-title":"Selective blockade of neurokinin-2 receptors produces antidepressant-like effects associated with reduced corticotropin-releasing factor function","volume":"299","author":"Steinberg","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2019.01.059_bib0060","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.pbb.2010.05.006","article-title":"Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression","volume":"96","author":"Overstreet","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2019.01.059_bib0065","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1017\/S1461145712000612","article-title":"Behavioural and neurochemical changes\u2009 induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant","volume":"16","author":"Tamburella","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2019.01.059_bib0070","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.nutr.27.061406.093705","article-title":"Epigenetic epidemiology of the developmental origins hypothesis","volume":"27","author":"Waterland","year":"2007","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbr.2019.01.059_bib0075","doi-asserted-by":"crossref","first-page":"419","DOI":"10.31887\/DCNS.2014.16.3\/aguidotti","article-title":"DNA methylation and demethylation as targets for antipsychotic therapy","volume":"16","author":"Guidotti","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.059_bib0080","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1007\/s13311-013-0213-6","article-title":"Epigenetics and psychiatry","volume":"10","author":"Mahgoub","year":"2013","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbr.2019.01.059_bib0085","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/1073858415608147","article-title":"Epigenetic basis of mental illness","volume":"22","author":"Nestler","year":"2016","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbr.2019.01.059_bib0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuropharm.2014.01.013","article-title":"The role\u2009 of DNA methylation in stress-related psychiatric disorders","volume":"80","author":"Klengel","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2019.01.059_bib0095","article-title":"Genome-wide methylome analyses reveal novel epigenetic regulation patterns in schizophrenia and bipolar disorder","author":"Li","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.bbr.2019.01.059_bib0100","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neubiorev.2016.06.010","article-title":"The role of DNA methylation in the pathophysiology and\u2009 treatment of bipolar disorder","volume":"68","author":"Fries","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2019.01.059_bib0105","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior","volume":"7","author":"Weaver","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.059_bib0110","doi-asserted-by":"crossref","first-page":"e619","DOI":"10.1038\/tp.2015.114","article-title":"BDNF promoter methylation and genetic variation in late-life depression","volume":"5","author":"Januar","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2019.01.059_bib0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neubiorev.2016.08.021","article-title":"SLC6A4 methylation as an epigenetic marker of life adversity exposures in humans: a systematic review of literature","volume":"71","author":"Provenzi","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2019.01.059_bib0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.brainresbull.2008.05.010","article-title":"Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress","volume":"77","author":"Luo","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2019.01.059_bib0125","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2019.01.059_bib0130","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neubiorev.2005.03.007","article-title":"Stress, depression, and anhedonia: caveats concerning animal models","volume":"29","author":"Anisman","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2019.01.059_bib0135","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF02698502","article-title":"Learning behavior, escape behavior, and depression in an ulcer susceptible rat strain","volume":"27","author":"Pare","year":"1992","journal-title":"Integr. Physiol. Behav. Sci."},{"key":"10.1016\/j.bbr.2019.01.059_bib0140","first-page":"381","article-title":"Stress exposure, food intake and emotional state","volume":"18","author":"Ulrich-Lai","year":"2015","journal-title":"Stress"},{"key":"10.1016\/j.bbr.2019.01.059_bib0145","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbr.2012.03.020","article-title":"Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?","volume":"231","author":"Farooq","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2019.01.059_bib0150","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.psychres.2016.06.052","article-title":"Hippocampal and motor fronto-cortical neuroligin1 is increased in an animal model of depression","volume":"243","author":"Feng","year":"2016","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbr.2019.01.059_bib0155","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2174\/138161209788168074","article-title":"Tachykinin receptors as therapeutic targets in stress-related disorders","volume":"15","author":"Ebner","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbr.2019.01.059_bib0160","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0893-133X(00)00198-6","article-title":"Changed concentrations of tachykinins and neuropeptide Y in brain of a rat model of depression: lithium treatment normalizes tachykinins","volume":"24","author":"Husum","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2019.01.059_bib0165","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1017\/S1461145712000612","article-title":"Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant","volume":"16","author":"Tamburella","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2019.01.059_bib0170","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.pbb.2006.03.013","article-title":"Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils","volume":"83","author":"Salome","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2019.01.059_bib0175","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/npp.2014.140","article-title":"Early-life experience, epigenetics, and the developing brain","volume":"40","author":"Kundakovic","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2019.01.059_bib0180","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ddr.21340","article-title":"Epigenetic mechanisms in psychiatric diseases and epigenetic therapy","volume":"77","author":"Karsli-Ceppioglu","year":"2016","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.bbr.2019.01.059_bib0185","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/nn.2619","article-title":"Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens","volume":"13","author":"LaPlant","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2019.01.059_bib0190","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuropharm.2014.01.013","article-title":"The role of DNA methylation in stress-related psychiatric disorders","volume":"80","author":"Klengel","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2019.01.059_bib0195","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neubiorev.2016.06.010","article-title":"The role of DNA methylation in the pathophysiology and treatment of bipolar disorder","volume":"68","author":"Fries","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2019.01.059_bib0200","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.lfs.2014.08.003","article-title":"Epigenetics, the missing link in hypertension","volume":"129","author":"Raftopoulos","year":"2015","journal-title":"Life Sci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818315213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818315213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:10:49Z","timestamp":1606349449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432818315213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":40,"alternative-id":["S0166432818315213"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.01.059","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA methylation of the Tacr2 gene in a CUMS model of depression","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.01.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}