{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:38:33Z","timestamp":1784864313764,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research Fellowship from CSIR"},{"DOI":"10.13039\/501100001843","name":"DST-SERB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIMHANS"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.bbr.2019.03.006","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T10:42:32Z","timestamp":1551523352000},"page":"185-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Repeated finasteride administration induces depression-like behavior in adult male rats"],"prefix":"10.1016","volume":"365","author":[{"given":"R.B.","family":"Sasibhushana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.S.","family":"Shankaranarayana Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9162-0990","authenticated-orcid":false,"given":"Bettadapura N.","family":"Srikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2019.03.006_bib0005","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1248\/bpb.31.1646","article-title":"Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism","volume":"31","author":"Mukai","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbr.2019.03.006_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0248-4900(91)90045-O","article-title":"Neurosteroids: a new function in the brain","volume":"71","author":"Baulieu","year":"1991","journal-title":"Biol. Cell"},{"key":"10.1016\/j.bbr.2019.03.006_bib0015","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1111\/j.1743-6109.2012.02846.x","article-title":"Persistent sexual side effects of finasteride: could they be permanent?","volume":"9","author":"Irwig","year":"2012","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.bbr.2019.03.006_bib0020","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jsbmb.2014.03.012","article-title":"Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma","volume":"146","author":"Caruso","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbr.2019.03.006_bib0025","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/1557988314538445","article-title":"Persistent sexual, emotional, and cognitive impairment post-finasteride: a survey of men reporting symptoms","volume":"9","author":"Ganzer","year":"2015","journal-title":"Am. J. Mens Health"},{"key":"10.1016\/j.bbr.2019.03.006_bib0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11154-015-9319-y","article-title":"Adverse effects of 5alpha-reductase inhibitors: What do we know, don\u2019t know, and need to know?","volume":"16","author":"Traish","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bbr.2019.03.006_bib0035","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1346-8138.2002.tb00200.x","article-title":"Depression circumstantially related to the administration of finasteride for androgenetic alopecia","volume":"29","author":"Altomare","year":"2002","journal-title":"J. Dermatol."},{"key":"10.1016\/j.bbr.2019.03.006_bib0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1472-6904-6-7","article-title":"Finasteride induced depression: a prospective study","volume":"6","author":"Rahimi-Ardabili","year":"2006","journal-title":"BMC Clin. Pharmacol."},{"key":"10.1016\/j.bbr.2019.03.006_bib0045","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.psyneuen.2018.09.021","article-title":"Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition","volume":"99","author":"Diviccaro","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2019.03.006_bib0050","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1055\/s-0030-1249095","article-title":"Finasteride treatment inhibits adult hippocampal neurogenesis in male mice","volume":"43","author":"R\u00f6mer","year":"2010","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.bbr.2019.03.006_bib0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00213-011-2279-3","article-title":"Oxotremorine treatment restores hippocampal neurogenesis and ameliorates depression-like behaviour in chronically stressed rats","volume":"217","author":"Veena","year":"2011","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2019.03.006_bib0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neulet.2009.03.059","article-title":"Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats","volume":"455","author":"Veena","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2019.03.006_bib0065","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbr.2019.03.006_bib0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2019.03.006_bib0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbr.2007.08.020","article-title":"Neonatal clomipramine induced endogenous depression in rats is associated with learning impairment in adulthood","volume":"187","author":"Bhagya","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2019.03.006_bib0080","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pnpbp.2017.02.025","article-title":"Environmental enrichment ameliorates chronic immobilisation stress-induced spatial learning deficits and restores the expression of BDNF, VEGF, GFAP and glucocorticoid receptors","volume":"76","author":"Shilpa","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.03.006_bib0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.physbeh.2016.05.017","article-title":"Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats","volume":"163","author":"Sadeghi","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2019.03.006_bib0090","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1006\/hbeh.2002.1763","article-title":"Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats","volume":"41","author":"Frye","year":"2002","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbr.2019.03.006_bib0095","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s00213-005-0100-x","article-title":"Inhibiting 5alpha-reductase in the amygdala attenuates antianxiety and antidepressive behavior of naturally receptive and hormone-primed ovariectomized rats","volume":"186","author":"Walf","year":"2006","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2019.03.006_bib0100","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/abio.2000.4841","article-title":"Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography\/mass spectrometry","volume":"287","author":"Vallee","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbr.2019.03.006_bib0105","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1073\/pnas.88.10.4553","article-title":"Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain","volume":"88","author":"Purdy","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2019.03.006_bib0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejphar.2005.03.029","article-title":"Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol","volume":"514","author":"Yalcin","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2019.03.006_bib0115","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1743-6109.2010.02157.x","article-title":"Adverse side effects of 5alpha-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients","volume":"8","author":"Traish","year":"2011","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.bbr.2019.03.006_bib0120","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.4088\/JCP.12m07887","article-title":"Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects","volume":"73","author":"Irwig","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2019.03.006_bib0125","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamainternmed.2017.0089","article-title":"Association of suicidality and depression with 5alpha-reductase inhibitors","volume":"177","author":"Welk","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.bbr.2019.03.006_bib0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1043-2760(01)00503-3","article-title":"Neurosteroids: biochemistry and clinical significance","volume":"13","author":"Mellon","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbr.2019.03.006_bib0135","first-page":"1003","article-title":"Neurosteroids: biochemistry, modes of action, and clinical relevance","volume":"78","author":"Mellon","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbr.2019.03.006_bib0140","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1159\/000442982","article-title":"Effects of subchronic finasteride treatment and withdrawal on neuroactive steroid levels and their receptors in the male rat brain","volume":"103","author":"Giatti","year":"2016","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.bbr.2019.03.006_bib0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0091-3057(00)00300-2","article-title":"Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test","volume":"67","author":"Khisti","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2019.03.006_bib0150","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1176\/ajp.155.7.910","article-title":"Effects of antidepressant treatment on neuroactive steroids in major depression","volume":"155","author":"Romeo","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2019.03.006_bib0155","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1073\/pnas.95.6.3239","article-title":"Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine","volume":"95","author":"Uzunova","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2019.03.006_bib0160","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/sj.mp.4001782","article-title":"Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity","volume":"11","author":"Schule","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.03.006_bib0165","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0018-506X(03)00159-4","article-title":"Effect of prenatal stress and gonadal hormone condition on depressive behaviors of female and male rats","volume":"44","author":"Frye","year":"2003","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbr.2019.03.006_bib0170","first-page":"703","article-title":"The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness","volume":"79","author":"Dallob","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbr.2019.03.006_bib0175","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1210\/jcem.84.2.5495","article-title":"Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study","volume":"84","author":"Barrett-Connor","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbr.2019.03.006_bib0180","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jnr.21907","article-title":"B.S. Shankaranarayana Rao, Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed rats","volume":"87","author":"Veena","year":"2009","journal-title":"J. Neurosci. Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818314505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818314505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T10:42:37Z","timestamp":1565174557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432818314505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":36,"alternative-id":["S0166432818314505"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.03.006","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated finasteride administration induces depression-like behavior in adult male rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}