{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:32:52Z","timestamp":1790548372767,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.bbr.2019.03.043","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T18:14:38Z","timestamp":1553537678000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice"],"prefix":"10.1016","volume":"367","author":[{"given":"Qianqian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashuai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peien","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhan","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhe","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizeng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9996","key":"10.1016\/j.bbr.2019.03.043_bib0005","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2019.03.043_bib0010","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuropharm.2013.08.035","article-title":"Parkinson\u2019s disease in a dish \u2013 using stem cells as a molecular tool","volume":"76","author":"Badger","year":"2014","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.bbr.2019.03.043_bib0015","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0161-813X(02)00098-0","article-title":"Parkinson\u2019s disease: current and future challenges","volume":"23","author":"Langston","year":"2002","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.bbr.2019.03.043_bib0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2006.09.026","article-title":"Mechanisms of Parkinson\u2019s disease linked to pathological \u03b1-synuclein: new targets for drug discovery","volume":"52","author":"Lee","year":"2006","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.bbr.2019.03.043_bib0025","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0922-4106(91)90073-Q","article-title":"MPTP mechanisms of neurotoxicity and their implications for Parkinson\u2019s disease","volume":"208","author":"Gerlach","year":"1991","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbr.2019.03.043_bib0030","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/jpi.12076","article-title":"Melatonin synergizes with low doses of L-DOPA to improve dendritic spine density in the mouse striatum in experimental parkinsonism","volume":"55","author":"Naskar","year":"2014","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.bbr.2019.03.043_bib0035","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1677\/JOE-09-0132","article-title":"Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson\u2019s disease","volume":"202","author":"Kim","year":"2009","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/j.bbr.2019.03.043_bib0040","doi-asserted-by":"crossref","first-page":"II95","DOI":"10.1007\/PL00022909","article-title":"MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson\u2019s disease: neuroprotective strategies","volume":"247","author":"Gr\u00fcnblatt","year":"2000","journal-title":"J. Neurol."},{"issue":"7","key":"10.1016\/j.bbr.2019.03.043_bib0045","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1056\/NEJM196702162760703","article-title":"Aromatic amino acids and modification of parkinsonism","volume":"276","author":"Cotzias","year":"1967","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.bbr.2019.03.043_bib0050","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00019052-200208000-00011","article-title":"Treatment options for Parkinson\u2019s disease","volume":"15","author":"Tintner","year":"2002","journal-title":"Curr. Opin. Neurol."},{"issue":"4","key":"10.1016\/j.bbr.2019.03.043_bib0055","first-page":"293","article-title":"Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents","volume":"47","author":"Anupom","year":"2010","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.bbr.2019.03.043_bib0060","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1212\/WNL.41.3.380","article-title":"The occurrence of motor fluctuations in parkinsonian patients treated long term with levodopa: role of early treatment and disease progression","volume":"41","author":"Caraceni","year":"1991","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.bbr.2019.03.043_bib0065","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/jpi.12212","article-title":"Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose and protects dopaminergic neurons in MPTP-induced parkinsonism in mice","volume":"58","author":"Naskar","year":"2015","journal-title":"J. Pineal Res."},{"issue":"16","key":"10.1016\/j.bbr.2019.03.043_bib0070","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1021\/jf8007212","article-title":"Neuroprotective effects of resveratrol on MPTP-Induced neuron loss mediated by free radical scavenging","volume":"56","author":"Lu","year":"2008","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.bbr.2019.03.043_bib0075","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1002\/mnfr.201600111","article-title":"Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of \u03b1-synuclein via SIRT1-deacetylated LC3","volume":"60","author":"Guo","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbr.2019.03.043_bib0080","doi-asserted-by":"crossref","DOI":"10.1039\/C8FO00149A","article-title":"Resveratrol reverses the adverse effects of a diet-induced obese murine model on oocyte quality and zona pellucida softening","author":"Jia","year":"2018","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.bbr.2019.03.043_bib0085","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/biof.118","article-title":"Neuroprotective properties of resveratrol in different neurodegenerative disorders","volume":"36","author":"Albani","year":"2010","journal-title":"Biofactors"},{"key":"10.1016\/j.bbr.2019.03.043_bib0090","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopha.2015.08.025","article-title":"MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting \u03b1-synuclein expression in MPTP-induced Parkinson\u2019s disease mouse","volume":"74","author":"Wang","year":"2015","journal-title":"Biomed. Pharmacother."},{"issue":"13","key":"10.1016\/j.bbr.2019.03.043_bib0095","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1007\/PL00000671","article-title":"Alpha-synuclein and Parkinson\u2019s disease","volume":"57","author":"L\u00fccking","year":"2000","journal-title":"Cell. Mol. Life Sci. CMLS"},{"issue":"5","key":"10.1016\/j.bbr.2019.03.043_bib0100","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1111\/j.1471-4159.2009.06228.x","article-title":"The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by \u03b1-synuclein or amyloid-\u03b2 (1-42) peptide","volume":"110","author":"Albani","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.03.043_bib0105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2015.09.029","article-title":"Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson\u2019s disease","volume":"768","author":"Chen","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbr.2019.03.043_bib0110","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/ptr.4734","article-title":"Resveratrol protects cortical neurons against microglia-mediated neuroinflammation","volume":"27","author":"Zhang","year":"2013","journal-title":"Phytotherapy Research Ptr"},{"issue":"1","key":"10.1016\/j.bbr.2019.03.043_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12868-015-0192-0","article-title":"Exogenous \u03b1-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes","volume":"16","author":"Rannikko","year":"2015","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbr.2019.03.043_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2017.08.015","article-title":"Metformin lowers \u03b1-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson\u2019s disease","volume":"125","author":"Katila","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2019.03.043_bib0125","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.brainres.2015.02.038","article-title":"Resveratrol downregulates Glutamate-1 transporter expression and microglia activation in the Hippocampus following cerebral ischemia reperfusion in rats","volume":"1608","author":"Girbovan","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2019.03.043_bib0130","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1038\/srep08075","article-title":"Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation","volume":"5","author":"Kodali","year":"2015","journal-title":"Sci. Rep."},{"issue":"70","key":"10.1016\/j.bbr.2019.03.043_bib0135","first-page":"467","article-title":"Anti-apoptotic gene therapy in Parkinson\u2019s disease","volume":"70","author":"Schulz","year":"2006","journal-title":"J. Neural Transm. Suppl."},{"issue":"23","key":"10.1016\/j.bbr.2019.03.043_bib0140","doi-asserted-by":"crossref","first-page":"22297","DOI":"10.1074\/jbc.M500540200","article-title":"Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic \u03b2-Cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)\/Protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulat","volume":"280","author":"Kim","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbr.2019.03.043_bib0145","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.3390\/ijms15045596","article-title":"Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide","volume":"15","author":"Maino","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"47","key":"10.1016\/j.bbr.2019.03.043_bib0150","doi-asserted-by":"crossref","first-page":"34479","DOI":"10.1074\/jbc.M705426200","article-title":"Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling","volume":"282","author":"Weng","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2019.03.043_bib0155","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuropharm.2017.01.009","article-title":"Neuroprotection by Paeoniflorin in the MPTP mouse model of Parkinson\u2019s disease","volume":"116","author":"Zheng","year":"2017","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.bbr.2019.03.043_bib0160","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"issue":"2016-9-21","key":"10.1016\/j.bbr.2019.03.043_bib0165","first-page":"1","article-title":"Neuroprotective effects of salidroside in the MPTP mouse model of Parkinson\u2019s disease: involvement of the PI3K\/Akt\/GSK3\u03b2pathway","volume":"2016","author":"Zhang","year":"2016","journal-title":"Parkinsons Dis."},{"issue":"1","key":"10.1016\/j.bbr.2019.03.043_bib0170","first-page":"1","article-title":"Neuroprotective effects of antidepressants via upregulation of neurotrophic factors in the MPTP model of Parkinson\u2019s disease","volume":"55","author":"Shadfar","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"9","key":"10.1016\/j.bbr.2019.03.043_bib0175","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.parkreldis.2014.05.003","article-title":"Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias","volume":"20","author":"Rascol","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.bbr.2019.03.043_bib0180","series-title":"Levodopa-Induced Dyskinesia in Parkinson\u2019s Disease","author":"Fox","year":"2014"},{"issue":"7","key":"10.1016\/j.bbr.2019.03.043_bib0185","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00018-011-0850-z","article-title":"Transgenic expression and activation of PGC-1\u03b1 protect dopaminergic neurons in the MPTP mouse model of Parkinson\u2019s disease","volume":"69","author":"Mud\u00f2","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.bbr.2019.03.043_bib0190","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2011.02.025","article-title":"Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in parkinsonian rats","volume":"304","author":"Wang","year":"2011","journal-title":"J. Neurol. Sci."},{"issue":"1328","key":"10.1016\/j.bbr.2019.03.043_bib0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2010.02.031","article-title":"Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson\u2019s disease","volume":"1328","author":"Khan","year":"2010","journal-title":"Brain Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432819302013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432819302013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:10:03Z","timestamp":1759065003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432819302013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":39,"alternative-id":["S0166432819302013"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.03.043","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.03.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}