{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:08:24Z","timestamp":1785438504137,"version":"3.56.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671275"],"award-info":[{"award-number":["81671275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501112"],"award-info":[{"award-number":["81501112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371401"],"award-info":[{"award-number":["81371401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2017YFC1310200"],"award-info":[{"award-number":["2017YFC1310200"]}]},{"name":"Guangdong Natural Science Foundation","award":["2017B030311015"],"award-info":[{"award-number":["2017B030311015"]}]},{"name":"Guangdong Natural Science Foundation","award":["2016A030310327"],"award-info":[{"award-number":["2016A030310327"]}]},{"name":"Guangdong Natural Science Foundation","award":["2015A030313536"],"award-info":[{"award-number":["2015A030313536"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.bbr.2019.03.054","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T16:24:06Z","timestamp":1554481446000},"page":"111885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion"],"prefix":"10.1016","volume":"368","author":[{"given":"Yuyuan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-8398","authenticated-orcid":false,"given":"Hongmei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2019.03.054_bib0005","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","article-title":"Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030","volume":"68","author":"Dorsey","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2019.03.054_bib0010","article-title":"Reverters from PD-MCI to cognitively intact are at risk for future cognitive impairment: Analysis of the PPMI cohort","author":"Jones","year":"2017","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.bbr.2019.03.054_bib0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000285518","article-title":"Prevalence and impact of cerebrovascular lesions in Alzheimer and lewy body diseases","volume":"7","author":"Jellinger","year":"2010","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.bbr.2019.03.054_bib0020","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1177\/0271678X16688919","article-title":"Structural and physiological neurovascular changes in idiopathic Parkinson\u2019s disease and its clinical phenotypes","volume":"37","author":"Al-Bachari","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2019.03.054_bib0025","article-title":"Parkinson disease-related cortical and striatal cognitive patterns in dual time F-18 FP CIT: evidence for neural correlates between the caudate and the frontal lobe","author":"Son","year":"2017","journal-title":"Q. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.bbr.2019.03.054_bib0030","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00702-017-1703-1","article-title":"Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson\u2019s disease","volume":"124","author":"Syrimi","year":"2017","journal-title":"J. Neural Transm. Vienna (Vienna)"},{"key":"10.1016\/j.bbr.2019.03.054_bib0035","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/jcbfm.2014.40","article-title":"Comparing cerebral perfusion in Alzheimer\u2019s disease and Parkinson\u2019s disease dementia: an ASL-MRI study","volume":"34","author":"Le Heron","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2019.03.054_bib0040","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s12264-014-1472-x","article-title":"Brain network markers of abnormal cerebral glucose metabolism and blood flow in Parkinson\u2019s disease","volume":"30","author":"Peng","year":"2014","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbr.2019.03.054_bib0045","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbr.2017.05.061","article-title":"Chronic cerebral hypoperfusion independently exacerbates cognitive impairment within the pathopoiesis of Parkinson\u2019s disease via microvascular pathologys","volume":"333","author":"Tang","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0050","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbr.2011.09.033","article-title":"Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson\u2019s disease","volume":"226","author":"Luchtman","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0055","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.physbeh.2009.04.021","article-title":"Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson\u2019s disease","volume":"98","author":"Luchtman","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2019.03.054_bib0060","first-page":"435","article-title":"A simple quantitative bradykinesia test in MPTP-treated mice","volume":"50","author":"Ogawa","year":"1985","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.bbr.2019.03.054_bib0065","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nn1261","article-title":"The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination","volume":"7","author":"Karnezis","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2019.03.054_bib0070","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.neuroimage.2011.01.007","article-title":"Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords","volume":"55","author":"Klawiter","year":"2011","journal-title":"NeuroImage."},{"key":"10.1016\/j.bbr.2019.03.054_bib0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainres.2009.09.006","article-title":"Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxic-ischemic brain injury","volume":"1301","author":"Huang","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0080","article-title":"Erythropoietin amplifies stroke-induced oligodendrogenesis in the rat","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2019.03.054_bib0085","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.archger.2008.09.005","article-title":"The severity of leukoaraiosis correlates with the clinical phenotype of Parkinson\u2019s disease","volume":"49","author":"Lee","year":"2009","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.bbr.2019.03.054_bib0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00401-009-0620-2","article-title":"Are there differences in cerebral white matter lesion burdens between Parkinson\u2019s disease patients with or without dementia?","volume":"119","author":"Choi","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbr.2019.03.054_bib0095","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1001\/archneurol.2008.504","article-title":"Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs","volume":"65","author":"Louis","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbr.2019.03.054_bib0100","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1212\/WNL.0b013e3182929f62","article-title":"White matter microstructure deteriorates across cognitive stages in Parkinson disease","volume":"80","author":"Melzer","year":"2013","journal-title":"Neurology."},{"key":"10.1016\/j.bbr.2019.03.054_bib0105","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/WAD.0b013e3181d71a13","article-title":"Influence of white matter hyperintensities on the cognition of patients with Parkinson disease","volume":"24","author":"Lee","year":"2010","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.bbr.2019.03.054_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081901","article-title":"PI3K\/Akt signal pathway involved in the cognitive impairment caused by chronic cerebral hypoperfusion in rats","volume":"8","author":"Shu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2019.03.054_bib0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.physbeh.2009.02.011","article-title":"Adopted cognitive tests for gerbils: validation by studying ageing and ischemia","volume":"97","author":"Wappler","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2019.03.054_bib0120","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/jcbfm.2013.21","article-title":"Cognitive rehabilitation reduces cognitive impairment and normalizes hippocampal CA1 architecture in a rat model of vascular dementia","volume":"33","author":"Langdon","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2019.03.054_bib0125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12640-009-9049-6","article-title":"Protection against chronic hypoperfusion-induced retinal neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases","volume":"16","author":"Mester","year":"2009","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074631","article-title":"The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach","volume":"8","author":"Soria","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2019.03.054_bib0135","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12031-012-9774-9","article-title":"Protective effects of vasoactive intestinal peptide (VIP) in ischemic retinal degeneration","volume":"48","author":"Szabadfi","year":"2012","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2019.03.054_bib0140","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1161\/01.STR.0000143725.19053.60","article-title":"White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion","volume":"35","author":"Shibata","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2019.03.054_bib0145","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1161\/STROKEAHA.110.581686","article-title":"A mouse model characterizing features of vascular dementia with hippocampal atrophy","volume":"41","author":"Nishio","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2019.03.054_bib0150","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/jnr.21925","article-title":"Intensity of chronic cerebral hypoperfusion determines white\/gray matter injury and cognitive\/motor dysfunction in mice","volume":"87","author":"Miki","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0155","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/978761","article-title":"Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes","volume":"2011","author":"Ihara","year":"2011","journal-title":"J. Aging Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0160","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1016\/j.neuroimage.2011.10.053","article-title":"Multiple white matter tract abnormalities underlie cognitive impairment in RRMS","volume":"59","author":"Yu","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.bbr.2019.03.054_bib0165","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s11936-013-0292-z","article-title":"White matter disease as a biomarker for long-term cerebrovascular disease and dementia","volume":"16","author":"Chutinet","year":"2014","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"10.1016\/j.bbr.2019.03.054_bib0170","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.neurobiolaging.2014.01.137","article-title":"Frontal white matter integrity in adults with Down syndrome with and without dementia","volume":"35","author":"Powell","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbr.2019.03.054_bib0175","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1212\/01.wnl.0000319691.50117.54","article-title":"Neuropathologic correlates of white matter hyperintensities","volume":"71","author":"Young","year":"2008","journal-title":"Neurology."},{"key":"10.1016\/j.bbr.2019.03.054_bib0180","article-title":"White matter degeneration in vascular and other ageing-related dementias","author":"Hase","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.03.054_bib0185","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/JAD-151126","article-title":"Strong impact of chronic cerebral hypoperfusion on neurovascular unit, cerebrovascular remodeling, and neurovascular trophic coupling in alzheimer\u2019s disease model mouse","volume":"52","author":"Shang","year":"2016","journal-title":"J. Alzheimer Dis."},{"key":"10.1016\/j.bbr.2019.03.054_bib0190","doi-asserted-by":"crossref","first-page":"e2206","DOI":"10.1097\/MD.0000000000002206","article-title":"Dopaminergic therapy modulates cortical perfusion in parkinson disease with and without dementia according to arterial spin labeled perfusion magnetic resonance imaging","volume":"95","author":"Lin","year":"2016","journal-title":"Medicine"},{"key":"10.1016\/j.bbr.2019.03.054_bib0195","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.expneurol.2012.12.003","article-title":"Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson\u2019s disease","volume":"241","author":"Hill","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2019.03.054_bib0200","doi-asserted-by":"crossref","first-page":"865","DOI":"10.2176\/nmc.52.865","article-title":"Preoperative regional cerebral blood flow and postoperative clinical improvement in patients with Parkinson\u2019s disease undergoing subthalamic nucleus deep brain stimulation","volume":"52","author":"Nagai","year":"2012","journal-title":"Neurol. Med. Chir. (Tokyo)"},{"key":"10.1016\/j.bbr.2019.03.054_bib0205","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4196\/kjpp.2017.21.6.643","article-title":"Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion","volume":"21","author":"Cho","year":"2017","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbr.2019.03.054_bib0210","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson\u2019s and Alzheimer\u2019s disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2019.03.054_bib0215","article-title":"White-matter changes correlates of peripheral neuroinflammation in patients with parkinson\u2019s disease","author":"Haghashomar","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.03.054_bib0220","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2017.10.379","article-title":"Aging and Parkinson\u2019s Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis","volume":"115","author":"Calabrese","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbr.2019.03.054_bib0225","article-title":"Isobavachalcone attenuates MPTP-Induced parkinson\u2019s disease in mice by inhibition of microglial activation through NF-\u03baB pathway","volume":"12","author":"Thomas","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2019.03.054_bib0230","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","article-title":"Neuroinflammation in Parkinson\u2019s disease: its role in neuronal death and implications for therapeutic intervention","volume":"37","author":"Tansey","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2019.03.054_bib0235","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nbd.2010.04.020","article-title":"Diagnostic cerebrospinal fluid biomarkers for Parkinson\u2019s disease: a pathogenetically based approach","volume":"39","author":"van Dijk","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2019.03.054_bib0240","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12974-017-1007-2","article-title":"Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress","volume":"14","author":"Zhao","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbr.2019.03.054_bib0245","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.neuropharm.2012.01.028","article-title":"Contributions of central and systemic inflammation to the pathophysiology of Parkinson\u2019s disease","volume":"62","author":"Collins","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2019.03.054_bib0250","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.brainres.2016.10.029","article-title":"Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson\u2019s disease mice","volume":"1655","author":"Jang","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0255","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1096\/fj.04-2751com","article-title":"Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson\u2019s disease","volume":"19","author":"Zhang","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bbr.2019.03.054_bib0260","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1096\/fj.02-0314fje","article-title":"Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson\u2019s disease","volume":"17","author":"Wilms","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.bbr.2019.03.054_bib0265","article-title":"Paeoniflorin improves regional cerebral blood flow and suppresses inflammatory factors in the hippocampus of rats with vascular dementia","author":"Zhang","year":"2015","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.bbr.2019.03.054_bib0270","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-0955-x","article-title":"Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina","volume":"14","author":"Rivera","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbr.2019.03.054_bib0275","first-page":"1","article-title":"Circulating levels of interleukin-17A, tumor necrosis factor-alpha, interleukin-18, interleukin-10, and cognitive performance of patients with relapsing-remitting multiple sclerosis","author":"Trenova","year":"2018","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0280","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0969-9961(03)00108-6","article-title":"Behavioral changes are not directly related to striatal monoamine levels, number of nigral neurons, or dose of parkinsonian toxin MPTP in mice","volume":"14","author":"Rousselet","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2019.03.054_bib0285","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S1474-4422(13)70118-2","article-title":"New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson\u2019s disease","volume":"12","author":"Calabresi","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbr.2019.03.054_bib0290","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neulet.2016.12.018","article-title":"The ameliorative effects of exercise on cognitive impairment and white matter injury from blood-brain barrier disruption induced by chronic cerebral hypoperfusion in adolescent rats","volume":"638","author":"Lee","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2019.03.054_bib0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01616412.2017.1376457","article-title":"Edaravone attenuates oxidative stress induced by chronic cerebral hypoperfusion injury: role of ERK\/Nrf2\/HO-1 signaling pathway","volume":"40","author":"Zhang","year":"2018","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbr.2019.03.054_bib0300","doi-asserted-by":"crossref","first-page":"42660","DOI":"10.1038\/srep42660","article-title":"Protective effect of 17beta-Estradiol upon hippocampal spine density and cognitive function in an animal model of vascular dementia","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2019.03.054_bib0305","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/ejn.13461","article-title":"The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity","volume":"45","author":"Soares","year":"2017","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2019.03.054_bib0310","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2017.04.022","article-title":"Cerebrolysin alleviates cognitive deficits induced by chronic cerebral hypoperfusion by increasing the levels of plasticity-related proteins and decreasing the levels of apoptosis-related proteins in the rat hippocampus","volume":"651","author":"Liu","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2019.03.054_bib0315","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbr.2015.12.047","article-title":"Chronic cerebral hypoperfusion induces long-lasting cognitive deficits accompanied by long-term hippocampal silent synapses increase in rats","volume":"301","author":"Wang","year":"2016","journal-title":"Behav. Brain Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818301359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432818301359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:11:47Z","timestamp":1759065107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432818301359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":63,"alternative-id":["S0166432818301359"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.03.054","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.03.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111885"}}