{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:22:07Z","timestamp":1790634127957,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bbr.2019.112254","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T01:47:55Z","timestamp":1568857675000},"page":"112254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness"],"prefix":"10.1016","volume":"377","author":[{"given":"Zuhair I.","family":"Abdulla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan L.","family":"Pennington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Skelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2019.112254_bib0005","series-title":"Top 10 Leading Disease\/Disorder Categories Contributing to U.S. DALYs","year":"2010"},{"key":"10.1016\/j.bbr.2019.112254_bib0010","series-title":"U.S. DALYs for Mental and Behavioral Disorders As a Percent of Total U.S. DALYs","year":"2010"},{"issue":"3","key":"10.1016\/j.bbr.2019.112254_bib0015","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.pnpbp.2010.07.030","article-title":"Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders","volume":"35","author":"Gardner","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.bbr.2019.112254_bib0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10863-014-9584-6","article-title":"A mitochondrial bioenergetic basis of depression","volume":"47","author":"Klinedinst","year":"2015","journal-title":"J. Bioenerg. Biomembr."},{"issue":"80","key":"10.1016\/j.bbr.2019.112254_bib0025","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1152\/physrev.2000.80.3.1107","article-title":"Creatine and creatinine metabolism","volume":"3","author":"Wyss","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbr.2019.112254_bib0030","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00726-011-0852-z","article-title":"Creatine deficiency syndromes and the importance of creatine synthesis in the brain","volume":"40","author":"Braissant","year":"2011","journal-title":"Amino Acids"},{"issue":"1\u20132","key":"10.1016\/j.bbr.2019.112254_bib0035","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0169-328X(00)00269-2","article-title":"Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study","volume":"86","author":"Braissant","year":"2001","journal-title":"Mol. Brain Res."},{"issue":"8","key":"10.1016\/j.bbr.2019.112254_bib0040","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00726-016-2189-0","article-title":"Creatine synthesis and exchanges between brain cells: What can be learned from human creatine deficiencies and various experimental models?","volume":"48","author":"Hanna-El-Daher","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbr.2019.112254_bib0045","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biochi.2015.10.022","article-title":"Creatine biosynthesis and transport in health and disease","volume":"119","author":"Joncquel-Chevalier Curt","year":"2015","journal-title":"Biochimie"},{"issue":"8","key":"10.1016\/j.bbr.2019.112254_bib0050","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00726-016-2291-3","article-title":"Creatine transporter deficiency leads to increased whole body and cellular metabolism","volume":"48","author":"Perna","year":"2016","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.bbr.2019.112254_bib0055","doi-asserted-by":"crossref","first-page":"e16187","DOI":"10.1371\/journal.pone.0016187","article-title":"Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency","volume":"6","author":"Skelton","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bbr.2019.112254_bib0060","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.neubiorev.2012.03.005","article-title":"Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?","volume":"36","author":"Allen","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.bbr.2019.112254_bib0065","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1007\/s12035-015-9192-4","article-title":"Involvement of PI3K\/Akt signaling pathway and its downstream intracellular targets in the antidepressant-like effect of creatine","volume":"53","author":"Cunha","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.bbr.2019.112254_bib0070","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.pharep.2014.03.004","article-title":"Involvement of PKA, PKC, CAMK-II and MEK1\/2 in the acute antidepressant-like effect of creatine in mice","volume":"66","author":"Cunha","year":"2014","journal-title":"Pharmacol. Rep."},{"issue":"11","key":"10.1016\/j.bbr.2019.112254_bib0075","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1177\/0269881112447989","article-title":"Antidepressant-like effect of creatine in mice involves dopaminergic activation","volume":"26","author":"Cunha","year":"2012","journal-title":"J. Psychopharmacol. (Oxford)"},{"issue":"4","key":"10.1016\/j.bbr.2019.112254_bib0080","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00726-014-1910-0","article-title":"The modulation of NMDA receptors and L-arginine\/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test","volume":"47","author":"Cunha","year":"2015","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbr.2019.112254_bib0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pnpbp.2013.01.014","article-title":"The activation of alpha1-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test","volume":"44","author":"Cunha","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.112254_bib0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainresbull.2013.01.005","article-title":"Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice","volume":"95","author":"Cunha","year":"2013","journal-title":"Brain Res. Bull."},{"issue":"10","key":"10.1016\/j.bbr.2019.112254_bib0095","doi-asserted-by":"crossref","first-page":"6818","DOI":"10.1007\/s12035-015-9580-9","article-title":"Creatine, similar to ketamine, counteracts depressive-like behavior induced by corticosterone via PI3K\/Akt\/mTOR Pathway","volume":"53","author":"Pazini","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.bbr.2019.112254_bib0100","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.pbb.2012.03.005","article-title":"Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats","volume":"101","author":"Allen","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"22","key":"10.1016\/j.bbr.2019.112254_bib0105","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1073\/pnas.211427898","article-title":"Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine","volume":"98","author":"Czeh","year":"2001","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"10.1016\/j.bbr.2019.112254_bib0110","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/sj.mp.4001130","article-title":"Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume","volume":"7","author":"van der Hart","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2019.112254_bib0115","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1399-5618.2007.00532.x","article-title":"Creatine monohydrate in resistant depression: a preliminary study","volume":"9","author":"Roitman","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.bbr.2019.112254_bib0120","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1176\/appi.ajp.2012.12010009","article-title":"A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder","volume":"169","author":"Lyoo","year":"2012","journal-title":"Am J Pyschiatry"},{"issue":"1","key":"10.1016\/j.bbr.2019.112254_bib0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pscychresns.2005.12.011","article-title":"Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma","volume":"147","author":"Coplan","year":"2006","journal-title":"Psychiatry Res."},{"issue":"7","key":"10.1016\/j.bbr.2019.112254_bib0130","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1177\/070674370204700709","article-title":"Proton magnetic resonance spectroscopy of the Hippocampus and occipital white matter in PTSD: preliminary results","volume":"47","author":"Villarreal","year":"2002","journal-title":"Can. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2019.112254_bib0135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pscychresns.2007.04.011","article-title":"Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder","volume":"162","author":"Schuff","year":"2008","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.bbr.2019.112254_bib0140","doi-asserted-by":"crossref","first-page":"R698","DOI":"10.1152\/ajpregu.1999.277.3.R698","article-title":"Increase of total creatine in human brain after oral supplementation of creatine-monohydrate","volume":"277","author":"Dechent","year":"1999","journal-title":"Am. J. Physiology-Regulatory Integrative Comparative Physiology"},{"issue":"15","key":"10.1016\/j.bbr.2019.112254_bib0145","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/S0024-3205(01)01268-1","article-title":"Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species","volume":"69","author":"Ipsiroglu","year":"2001","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.bbr.2019.112254_bib0150","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10545-013-9619-x","article-title":"Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits","volume":"37","author":"Hautman","year":"2014","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbr.2019.112254_bib0155","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ntt.2013.01.001","article-title":"Neurobehavioral phenotype of C57BL\/6J mice prenatally and neonatally exposed to cigarette smoke","volume":"35","author":"Amos-Kroohs","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"issue":"4","key":"10.1016\/j.bbr.2019.112254_bib0160","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.neuroscience.2009.09.059","article-title":"Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness","volume":"164","author":"Schaefer","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2019.112254_bib0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijdevneu.2016.08.007","article-title":"Perinatal exposure to the selective serotonin reuptake inhibitor citalopram alters spatial learning and memory, anxiety, depression, and startle in Sprague-Dawley rats","volume":"54","author":"Sprowles","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbr.2019.112254_bib0170","article-title":"The tail suspension test","volume":"59","author":"Can","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbr.2019.112254_bib0175","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12391","article-title":"Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice","author":"Hufgard","year":"2017","journal-title":"Genes Brain Behav."},{"issue":"3","key":"10.1016\/j.bbr.2019.112254_bib0180","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/biomet\/93.3.491","article-title":"Adaptive linear step-up procedures that control the false discovery rate","volume":"93","author":"Benjamini","year":"2006","journal-title":"Biometrika"},{"issue":"4","key":"10.1016\/j.bbr.2019.112254_bib0185","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1037\/rev0000033","article-title":"Learned helplessness at fifty: insights from neuroscience","volume":"123","author":"Maier","year":"2016","journal-title":"Psychol. Rev."},{"issue":"1\u20133","key":"10.1016\/j.bbr.2019.112254_bib0190","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainresprot.2005.09.002","article-title":"Learned helplessness: validity and reliability of depressive-like states in mice","volume":"16","author":"Chourbaji","year":"2005","journal-title":"Brain Res. Brain Res. Protoc."},{"issue":"2","key":"10.1016\/j.bbr.2019.112254_bib0195","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/15622970903131597","article-title":"Creatine transporter expression after antidepressant therapy in rats bred for learned helplessness","volume":"11","author":"Lugenbiel","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2019.112254_bib0200","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00213-009-1535-2","article-title":"Treatment with escitalopram but not desipramine decreases escape latency times in a learned helplessness model using juvenile rats","volume":"205","author":"Reed","year":"2009","journal-title":"Psychopharmacology (Berl.)"},{"issue":"17","key":"10.1016\/j.bbr.2019.112254_bib0205","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1097\/00001756-200312020-00013","article-title":"Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment","volume":"14","author":"Sartorius","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2019.112254_bib0210","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2019.112254_bib0215","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF02244871","article-title":"Behavioural and pharmacological characterisation of the elevated \"zero-maze\" as an animal model of anxiety","volume":"116","author":"Shepherd","year":"1994","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2019.112254_bib0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neubiorev.2015.10.006","article-title":"Defeat stress in rodents: from behavior to molecules","volume":"59","author":"Hammels","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.bbr.2019.112254_bib0225","doi-asserted-by":"crossref","first-page":"e12461","DOI":"10.1111\/gbb.12461","article-title":"Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8","volume":"17","author":"Udobi","year":"2018","journal-title":"Genes Brain Behav."},{"issue":"2","key":"10.1016\/j.bbr.2019.112254_bib0230","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/jcp.21533","article-title":"What do we know about serotonin?","volume":"217","author":"Jonnakuty","year":"2008","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.bbr.2019.112254_bib0235","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2006.02.047","article-title":"Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies","volume":"1085","author":"Sakowski","year":"2006","journal-title":"Brain Res."},{"issue":"1601","key":"10.1016\/j.bbr.2019.112254_bib0240","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1098\/rstb.2011.0378","article-title":"Probing the diversity of serotonin neurons","volume":"367","author":"Gaspar","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"5","key":"10.1016\/j.bbr.2019.112254_bib0245","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00969891","article-title":"Effects of p-Chloroamphetamine on brain serotonin neurons","volume":"17","author":"Fuller","year":"1992","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2019.112254_bib0250","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0166-4328(96)00065-4","article-title":"Serotonergic functions in arousal and motor activity","volume":"73","author":"Geyer","year":"1996","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2019.112254_bib0255","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0022-3565(25)39494-2","article-title":"Possible involvement of dopamine in the long term serotonin depletion by p-Chloroamphetamine and beta,beta-Difluoro p-Chloroamphetamine in rats","volume":"267","author":"Henderson","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.bbr.2019.112254_bib0260","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/jmedgenet-2013-101658","article-title":"Phenotype and genotype in 101 males with X-linked creatine transporter deficiency","volume":"50","author":"van de Kamp","year":"2013","journal-title":"J. Med. Genet."},{"issue":"1","key":"10.1016\/j.bbr.2019.112254_bib0265","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10545-012-9537-3","article-title":"New insights into creatine transporter deficiency: the importance of recycling creatine in the brain","volume":"36","author":"van de Kamp","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"issue":"5","key":"10.1016\/j.bbr.2019.112254_bib0270","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10545-014-9713-8","article-title":"X-linked creatine transporter deficiency: clinical aspects and pathophysiology","volume":"37","author":"van de Kamp","year":"2014","journal-title":"J. Inherit. Metab. Dis."},{"issue":"1","key":"10.1016\/j.bbr.2019.112254_bib0275","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10545-011-9345-1","article-title":"Long-term follow-up and treatment in nine boys with X-linked creatine transporter defect","volume":"35","author":"van de Kamp","year":"2012","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432819310605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432819310605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:15:19Z","timestamp":1759065319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432819310605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":55,"alternative-id":["S0166432819310605"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.112254","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/641845","asserted-by":"object"}]},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.112254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112254"}}