{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:26:11Z","timestamp":1790335571813,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006488","name":"INRA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006488","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Bordeaux \u201cInvestissements d'avenir Initiative d'excellence\u201d"},{"name":"Associated International Laboratory"},{"name":"ANR \u201cSynLip\u201d"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bbr.2019.112348","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T12:36:05Z","timestamp":1573216565000},"page":"112348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice"],"prefix":"10.1016","volume":"379","author":[{"given":"H.","family":"Fanet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ducrocq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tournissac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Oummadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bourrassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"De Smedt-Peyrusse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Azzougen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Capuron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lay\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Moussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Trifilieff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Calon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vancassel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2019.112348_bib0005","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuron.2012.10.021","article-title":"The mysterious motivational functions of mesolimbic dopamine","volume":"76","author":"Salamone","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2019.112348_bib0010","first-page":"180","article-title":"Rewards wanted: molecular mechanisms of motivation","volume":"4","author":"Wise","year":"2004","journal-title":"Discov. Med."},{"key":"10.1016\/j.bbr.2019.112348_bib0015","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/bs.pbr.2016.05.007","article-title":"The role of dopamine in the pathophysiology and treatment of apathy","volume":"229","author":"Chong","year":"2016","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.bbr.2019.112348_bib0020","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/cns.12998","article-title":"A brain network model for depression: from symptom understanding to disease intervention","volume":"24","author":"Li","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbr.2019.112348_bib0025","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1200\/JCO.2003.04.070","article-title":"Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program","volume":"21","author":"Morrow","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbr.2019.112348_bib0030","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/0269881106069938","article-title":"The other face of depression, reduced positive affect: the role of catecholamines in causation and cure","volume":"21","author":"Nutt","year":"2007","journal-title":"J. Psychopharmacol. (Oxford)"},{"key":"10.1016\/j.bbr.2019.112348_bib0035","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1017\/S0033291711001905","article-title":"Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms","volume":"42","author":"Uher","year":"2012","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbr.2019.112348_bib0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pneurobio.2008.01.003","article-title":"Getting connected in the dopamine system","volume":"85","author":"Van den Heuvel","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2019.112348_bib0045","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrn.2017.130","article-title":"The dopamine motive system: implications for drug and food addiction","volume":"18","author":"Volkow","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2019.112348_bib0050","doi-asserted-by":"crossref","first-page":"41150","DOI":"10.1074\/jbc.M102237200","article-title":"Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice","volume":"276","author":"Sumi-Ichinose","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"Pt 1","key":"10.1016\/j.bbr.2019.112348_bib0055","first-page":"1","article-title":"Tetrahydrobiopterin biosynthesis, regeneration and functions","volume":"347","author":"Th\u00f6ny","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbr.2019.112348_bib0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/7854_2016_13","article-title":"The role of dopamine in inflammation-associated depression: mechanisms and therapeutic implications","volume":"31","author":"Felger","year":"2017","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2019.112348_bib0065","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2217\/pgs.11.138","article-title":"The tetrahydrobiopterin pathway: a novel target for the treatment of depression","volume":"12","author":"McHugh","year":"2011","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.bbr.2019.112348_bib0070","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1126\/science.8502995","article-title":"Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity","volume":"260","author":"Harada","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.bbr.2019.112348_bib0075","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/BJ20110293","article-title":"Tetrahydrobiopterin: biochemistry and pathophysiology","volume":"438","author":"Werner","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbr.2019.112348_bib0080","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1046\/j.1471-4159.1995.65020827.x","article-title":"Characterization of a dopamine-releasing action of 6R-L-erythro-tetrahydrobiopterin: comparison with a 6S-form","volume":"65","author":"Koshimura","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.112348_bib0085","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0006-8993(91)90914-H","article-title":"6R-tetrahydrobiopterin perfusion enhances dopamine, serotonin, and glutamate outputs in dialysate from rat striatum and frontal cortex","volume":"551","author":"Mataga","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2019.112348_bib0090","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/jnc.12287","article-title":"The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain","volume":"126","author":"Homma","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.112348_bib0095","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1744-8069-9-5","article-title":"Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain","volume":"9","author":"Nasser","year":"2013","journal-title":"Mol. Pain"},{"key":"10.1016\/j.bbr.2019.112348_bib0100","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neures.2014.08.015","article-title":"Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin","volume":"89","author":"Nasser","year":"2014","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbr.2019.112348_bib0105","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0022-3565(25)39572-8","article-title":"Autoradiographic distribution of [14C]tetrahydrobiopterin and its developmental change in mice","volume":"267","author":"Hoshiga","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2019.112348_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164305","article-title":"Tetrahydrobiopterin supplementation: elevation of tissue biopterin levels accompanied by a relative increase in dihydrobiopterin in the blood and the role of probenecid-sensitive uptake in scavenging dihydrobiopterin in the liver and kidney of rats","volume":"11","author":"Ohashi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2019.112348_bib0115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.neuropharm.2014.02.010","article-title":"Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer\u2019s disease","volume":"81","author":"Do TM","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2019.112348_bib0120","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/cn4001928","article-title":"Simultaneous determination of all forms of biopterin and neopterin in cerebrospinal fluid","volume":"5","author":"Guibal","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbr.2019.112348_bib0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbi.2018.07.025","article-title":"Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain","volume":"76","author":"Rey","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2019.112348_bib0130","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.bbr.2019.112348_bib0135","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/oby.22358","article-title":"Decrease in operant responding under obesogenic diet exposure is not related to deficits in incentive or hedonic processes","volume":"27","author":"Ducrocq","year":"2019","journal-title":"Obesity"},{"key":"10.1016\/j.bbr.2019.112348_bib0140","doi-asserted-by":"crossref","first-page":"28128","DOI":"10.1074\/jbc.M109.041483","article-title":"Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage","volume":"284","author":"Crabtree","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2019.112348_bib0145","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.7233193","article-title":"Peripherally administered reduced pterins do enter the brain","volume":"212","author":"Kapatos","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.bbr.2019.112348_bib0150","doi-asserted-by":"crossref","first-page":"10652","DOI":"10.1038\/ncomms10652","article-title":"Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain","volume":"7","author":"Freyberg","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2019.112348_bib0155","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s002130000580","article-title":"What is a \u2018low dose\u2019 of d-amphetamine for inducing behavioral effects in laboratory rats?","volume":"153","author":"Grilly","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2019.112348_bib0160","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1542\/peds.70.3.376","article-title":"Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin: evidence that peripherally administered tetrahydropterins enter the brain","volume":"70","author":"Kaufman","year":"1982","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbr.2019.112348_bib0165","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1471-4159.2008.05423.x","article-title":"Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase","volume":"106","author":"Th\u00f6ny","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.112348_bib0170","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ymgme.2015.11.012","article-title":"High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU)","volume":"117","author":"Winn","year":"2016","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbr.2019.112348_bib0175","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(83)91837-8","article-title":"Successful treatment of depression with tetrahydrobiopterin","volume":"1","author":"Curtius","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2019.112348_bib0180","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0140-6736(84)91648-9","article-title":"Unsuccessful treatment of depression with tetrahydrobiopterin","volume":"2","author":"Woggon","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2019.112348_bib0185","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0022-3565(25)39111-1","article-title":"Entrance of tetrahydropterin derivatives in brain after peripheral administration: effect on biogenic amine metabolism","volume":"242","author":"Levine","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2019.112348_bib0190","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0022-3565(25)20113-6","article-title":"Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat","volume":"278","author":"Bickel","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.bbr.2019.112348_bib0195","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1046\/j.1471-4159.2003.01990.x","article-title":"Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier","volume":"86","author":"Bourasset","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.112348_bib0200","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/BF00964212","article-title":"Biopterin\u202f: I. Profile and quantitation in rat brain","volume":"1","author":"Gal","year":"1976","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2019.112348_bib0205","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ymgme.2008.04.007","article-title":"Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin","volume":"94","author":"Sawabe","year":"2008","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbr.2019.112348_bib0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0006-8993(94)91423-0","article-title":"Effect of 6R-l-erythro-5,6,7,8-tetrahydrobiopterin on the extracellular levels of dopamine and serotonin in the rat striatum: a microdialysis study with tyrosine or tryptophan infusion","volume":"635","author":"Tsukada","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2019.112348_bib0215","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10545-018-0150-y","article-title":"Tetrahydrobiopterin treatment reduces brain L-Phe but only partially improves serotonin in hyperphenylalaninemic ENU1\/2 mice","volume":"41","author":"Scherer","year":"2018","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbr.2019.112348_bib0220","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(98)00452-1","article-title":"The regulation of dopamine release from striatum slices by tetrahydrobiopterin and L-arginine-derived nitric oxide","volume":"800","author":"Liang","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2019.112348_bib0225","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1046\/j.1471-4159.1994.63020649.x","article-title":"Dopamine-releasing action of 6R-L-erythro-tetrahydrobiopterin: analysis of its action site using sepiapterin","volume":"63","author":"Koshimura","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.112348_bib0230","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1471-4159.1990.tb01974.x","article-title":"Enhancement of dopamine release in vivo from the rat striatum by dialytic perfusion of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin","volume":"54","author":"Koshimura","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.112348_bib0235","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0003-9861(85)90831-8","article-title":"6R-L-erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain","volume":"239","author":"Miwa","year":"1985","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbr.2019.112348_bib0240","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1523\/JNEUROSCI.18-06-01979.1998","article-title":"Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter","volume":"18","author":"Jones","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2019.112348_bib0245","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/brain\/aww050","article-title":"Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology","volume":"139","author":"Salamone","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2019.112348_bib0250","article-title":"Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation","volume":"2018","author":"Donthamsetti","year":"2018","journal-title":"Mol. Psychiatry"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432819313841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432819313841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:19:36Z","timestamp":1759065576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432819313841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":50,"alternative-id":["S0166432819313841"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.112348","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.112348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112348"}}