{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:12:29Z","timestamp":1792501949180,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000104","name":"National Aeronautics and Space Administration","doi-asserted-by":"publisher","award":["NNX15AK13G"],"award-info":[{"award-number":["NNX15AK13G"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bbr.2019.112377","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T11:30:37Z","timestamp":1574422237000},"page":"112377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Effects of chronic exposure to a mixed field of neutrons and photons on behavioral and cognitive performance in mice"],"prefix":"10.1016","volume":"379","author":[{"given":"Ruby E.","family":"Perez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skyler","family":"Younger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Bertheau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Fallgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Weil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Raber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2019.112377_bib0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12864-016-2581-x","article-title":"Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus","volume":"17","author":"Impey","year":"2016","journal-title":"BMC Genomics"},{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2019.112377_bib0010","doi-asserted-by":"crossref","first-page":"i95","DOI":"10.1093\/jrr\/rrt154","article-title":"The effects of low doses of proton, iron, or silicon radiation on spatial learning in a mouse model of Alzheimer\u2019s disease","volume":"55","author":"Bellone","year":"2014","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0015","first-page":"61","article-title":"16Oxygen irradiation enhances cued fear memory in B6D2F1 mice","volume":"7","author":"Raber","year":"2015","journal-title":"Life Sci. Space Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0020","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1667\/RR13935.1","article-title":"Acute effects of exposure to 56Fe and 16O particles on learning and memory","volume":"184","author":"Rabin","year":"2015","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0025","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1667\/RR13699.1","article-title":"Central nervous system effects of whole-body proton irradiation","volume":"182","author":"Sweet","year":"2014","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0030","doi-asserted-by":"crossref","first-page":"e53275","DOI":"10.1371\/journal.pone.0053275","article-title":"Galactic cosmic radiation leads to cognitive impairment and increased a? Plaque accumulation in a mouse model of Alzheimer\u2019s disease","volume":"7","author":"Cherry","year":"2012","journal-title":"PLOS One"},{"key":"10.1016\/j.bbr.2019.112377_bib0035","first-page":"586","article-title":"Effects of proton and combined proton and 56Fe irradiation on the hippocampus","volume":"184","author":"Raber","year":"2015","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0040","first-page":"179","article-title":"Combined effects of three high energy charged particle beams important for space flight on brain, behavioral and cognitive endpoints in B6D2F1 female and male mice","volume":"10","author":"Raber","year":"2019","journal-title":"Frontiers"},{"key":"10.1016\/j.bbr.2019.112377_bib0045","series-title":"Radiation Exposures in Space and the Potential for Central Nervous System Effects (Phase II), NCRP SC 1-24P2 REPORT","author":"Braby","year":"2019"},{"key":"10.1016\/j.bbr.2019.112377_bib0050","article-title":"Design and dosimetry of a facility to study health effects following exposures to fission neutrons at Low dose rates for Long durations","author":"Borak","year":"2019","journal-title":"Int. J. Radiat. Biol. P"},{"issue":"April","key":"10.1016\/j.bbr.2019.112377_bib0055","article-title":"Behavioral issues associated with long duration space expeditions: review and analysis of astronaut journals experiment 01-E104 (journals) phase 2 final report","author":"Stuster","year":"2016","journal-title":"NASA Tech. Memorandum"},{"issue":"825","key":"10.1016\/j.bbr.2019.112377_bib0060","article-title":"Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression","volume":"17","author":"Impey","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bbr.2019.112377_bib0065","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1667\/RR13347.1","article-title":"28Silicon radiation-induced enhancement of synaptic plasticity in the hippocampus of naive and cognitively tested mice","volume":"181","author":"Raber","year":"2014","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0070","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1667\/RR13951.1","article-title":"28Si irradiation impairs contextual fear memory in BD2F1 mice","volume":"183","author":"Raber","year":"2015","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/hipo.20659","article-title":"Sex-dependent effects of 56Fe irradiation on contextual fear conditioning in C56BL\/6J mice","volume":"20","author":"Villasana","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2019.112377_bib0080","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbr.2013.02.022","article-title":"Effects of whole body 56Fe radiation on contextual freezing and Arc-positive cells in the dentate gyrus","volume":"246","author":"Raber","year":"2013","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/j.bbr.2019.112377_bib0085","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1089\/ars.2012.5134","article-title":"Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation","volume":"20","author":"Tseng","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbr.2019.112377_bib0090","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12864-016-2581-x","article-title":"Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus","volume":"17","author":"Impey","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bbr.2019.112377_bib0095","doi-asserted-by":"crossref","first-page":"10227","DOI":"10.1038\/s41598-017-09191-4","article-title":"Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation","volume":"7","author":"Impey","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2019.112377_bib0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fmolb.2019.00077","article-title":"Integrated metabolomics-DNA methylation analysis reveals significant long-term tissue-dependent directional alterations in aminoacyl-tRNA biosynthesis in the left ventricle of the heart and hippocampus following proton irradiation","volume":"6","author":"Torres","year":"2019","journal-title":"Front. Mol. Biosci.\/Metabolomics"},{"key":"10.1016\/j.bbr.2019.112377_bib0105","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00429-014-0709-9","article-title":"Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation","volume":"220","author":"Parihar","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.bbr.2019.112377_bib0110","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1667\/RR13951.1","article-title":"(28)Silicon irradiation impairs contextual fear memory in B6D2F1 mice","volume":"183","author":"Raber","year":"2015","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0115","first-page":"56","article-title":"Sex- and dose-dependent effects of calcium ion irradiation on behavioral performance of B6D2F1 mice during contextual fear conditioning training","volume":"9","author":"Raber","year":"2016","journal-title":"Life Sci. Space Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0120","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3390\/ijms19041247","article-title":"Detrimental effects of helium ion irradiation on cognitive performance and cortical levels of MAP-2 in B6D2F1 mice","volume":"19","author":"Raber","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2019.112377_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0094-19.2019","article-title":"Deep space exposures to chronic, Low dose-rate, neutron radiation","volume":"6","author":"Acharya","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.bbr.2019.112377_bib0130","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/HP.0b013e318265a257","article-title":"Animal studies of charged particle-induced carcinogenesis","volume":"103","author":"Bielefeldt-Ohmoan","year":"2012","journal-title":"Health Phys."},{"key":"10.1016\/j.bbr.2019.112377_bib0135","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nprot.2006.170","article-title":"Assessing nest building in mice","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protoc."},{"issue":"4","key":"10.1016\/j.bbr.2019.112377_bib0140","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/A:1026545316455","article-title":"Habituation of activity in an open field: a survey of inbred strains and F1 hybrids","volume":"30","author":"Bolivar","year":"2000","journal-title":"Behav. Genetics"},{"key":"10.1016\/j.bbr.2019.112377_bib0145","first-page":"1","article-title":"Automated assessment of pavlovian conditioned freezing and shock reactivity in mice using the video freeze system","volume":"4","author":"Anagnostaras","year":"2010","journal-title":"Front. Beahv. Neurosci."},{"key":"10.1016\/j.bbr.2019.112377_bib0150","first-page":"51012","article-title":"Nest building as an indicator of health and welfare in laboratory mice","volume":"82","author":"Gaskill","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbr.2019.112377_bib0155","doi-asserted-by":"crossref","first-page":"e32799","DOI":"10.1371\/journal.pone.0032799","article-title":"Heat or insulation: behavioral titration of mouse preference for warmth or access to a nest","volume":"7","author":"Gaskill","year":"2012","journal-title":"PLOS One"},{"key":"10.1016\/j.bbr.2019.112377_bib0160","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2307\/3578833","article-title":"Exposure to heavy charged particles affects thermoregulation in rats","volume":"139","author":"Kandasamy","year":"1994","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbr.2019.112377_bib0165","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ijrobp.2011.12.049","article-title":"ApoE genotype-dependent paradoxical short-term effects of 56Fe irradiation on the brain","volume":"84","author":"Haley","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bbr.2019.112377_bib0170","doi-asserted-by":"crossref","first-page":"76587","DOI":"10.18632\/oncotarget.20603","article-title":"Paradoxical effects of 137Cs irradiation on pharmacological stimulation of reactive oxygen species in hippocampal slices from apoE2 and apoE4 mice","volume":"8","author":"Villasana","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbr.2019.112377_bib0175","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/jnc.13737","article-title":"Genotype differences in anxiety and fear learning and memory of WT and ApoE4 mice associated with enhanced generation of hippocampal reactive oxygen species","volume":"138","author":"Villasana","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2019.112377_bib0180","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.pbb.2012.09.021","article-title":"Effects of alpha-lipoic acid on associative and spatial memory of shan-irradiaed and 56Fe-irradiated C57BL\/6J mice","volume":"103","author":"Villasana","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2019.112377_bib0185","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.asr.2006.11.013","article-title":"Elevated plus-maze performance of Fischer-244 rats as a function of age and exposure to56Fe particles","volume":"39","author":"Rabin","year":"2007","journal-title":"Adv. Space Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281931397X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281931397X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:22:51Z","timestamp":1778671371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016643281931397X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":37,"alternative-id":["S016643281931397X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2019.112377","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of chronic exposure to a mixed field of neutrons and photons on behavioral and cognitive performance in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2019.112377","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112377"}}