{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:02:14Z","timestamp":1791838934655,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012330","name":"Cognitive Sciences and Technologies Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bbr.2020.112683","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T02:26:31Z","timestamp":1589855191000},"page":"112683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Microglia dependent BDNF and proBDNF can impair spatial memory performance during persistent inflammatory pain"],"prefix":"10.1016","volume":"390","author":[{"given":"Mola","family":"Mohammadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Manaheji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Maghsoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Danyali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoureh","family":"Baniasadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalal","family":"Zaringhalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2020.112683_bib0005","first-page":"921","article-title":"Cost of pain medication to treat adult patients with nonmalignant chronic pain in the United States","volume":"20","author":"Rasu","year":"2014","journal-title":"J. Manage. Care Pharm."},{"key":"10.1016\/j.bbr.2020.112683_bib0010","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1073\/pnas.0809897106","article-title":"Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain","volume":"106","author":"Metz","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbr.2020.112683_bib0015","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1523\/JNEUROSCI.0225-10.2010","article-title":"Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation","volume":"30","author":"Ji","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0020","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1523\/JNEUROSCI.0587-12.2012","article-title":"Abnormalities in hippocampal functioning with persistent pain","volume":"32","author":"Mutso","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0025","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pneurobio.2011.01.002","article-title":"The effect of pain on cognitive function: a review of clinical and preclinical research","volume":"93","author":"Moriarty","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2020.112683_bib0030","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1523\/JNEUROSCI.2994-12.2013","article-title":"Pain-specific modulation of hippocampal activity and functional connectivity during visual encoding","volume":"33","author":"Forkmann","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fnbeh.2017.00100","article-title":"Cognitive impairment in patients with chronic neuropathic or radicular pain: an interaction of pain and age","volume":"11","author":"Moriarty","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2007.07.054","article-title":"Altered hippocampal long-term potentiation after peripheral nerve injury in mice","volume":"574","author":"Kodama","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2020.112683_bib0045","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neulet.2008.05.078","article-title":"Suppression of enriched environment-induced neurogenesis in a rodent model of neuropathic pain","volume":"440","author":"Terada","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2020.112683_bib0050","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/npp.2010.236","article-title":"Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-\u03b1 in rodents","volume":"36","author":"Ren","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2020.112683_bib0055","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.pain.2013.07.020","article-title":"Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain","volume":"154","author":"Cardoso-Cruz","year":"2013","journal-title":"PAIN"},{"key":"10.1016\/j.bbr.2020.112683_bib0060","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.physbeh.2017.03.025","article-title":"In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain","volume":"175","author":"Saffarpour","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2020.112683_bib0065","doi-asserted-by":"crossref","first-page":"15511","DOI":"10.1523\/JNEUROSCI.3688-11.2011","article-title":"Microglia and memory: modulation by early-life infection","volume":"31","author":"Williamson","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1742-2094-11-93","article-title":"Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats","volume":"11","author":"Tan","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbr.2020.112683_bib0075","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12993-015-0075-7","article-title":"Thrombin-induced microglial activation impairs hippocampal neurogenesis and spatial memory ability in mice","volume":"11","author":"Yang","year":"2015","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.bbr.2020.112683_bib0080","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuint.2011.04.011","article-title":"Neuroprotective effects of genistein in VSC4. 1 motoneurons exposed to activated microglial cytokines","volume":"59","author":"McDowell","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbr.2020.112683_bib0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yexcr.2018.05.012","article-title":"Glycyrrhizin ameliorates inflammatory pain by inhibiting microglial activation-mediated inflammatory response via blockage of the HMGB1-TLR4-NF-kB pathway","volume":"369","author":"Sun","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbr.2020.112683_bib0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cytogfr.2017.03.005","article-title":"Cytokines and cytokine networks target neurons to modulate long-term potentiation","volume":"34","author":"Prieto","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbr.2020.112683_bib0095","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","article-title":"Glia and pain: is chronic pain a gliopathy?","volume":"154","author":"Ji","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2020.112683_bib0100","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.neures.2011.03.012","article-title":"Post-injury administration of minocycline: an effective treatment for nerve-injury induced neuropathic pain","volume":"70","author":"Mei","year":"2011","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbr.2020.112683_bib0105","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1101\/lm.51202","article-title":"From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning","volume":"9","author":"Tyler","year":"2002","journal-title":"Learn. Mem."},{"key":"10.1016\/j.bbr.2020.112683_bib0110","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1523\/JNEUROSCI.2308-08.2008","article-title":"Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain","volume":"28","author":"Ulmann","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0115","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1523\/JNEUROSCI.5714-08.2009","article-title":"P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation","volume":"29","author":"Trang","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.expneurol.2010.01.003","article-title":"Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation","volume":"222","author":"Geng","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2020.112683_bib0125","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1111\/j.1460-9568.2008.06215.x","article-title":"Differential effects of pro\u2010BDNF on sensory neurons after sciatic nerve transection in neonatal rats","volume":"27","author":"Fan","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0130","doi-asserted-by":"crossref","first-page":"12660","DOI":"10.1074\/jbc.M008104200","article-title":"Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor","volume":"276","author":"Mowla","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2020.112683_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/MN:24:1-3:001","article-title":"Anterograde axonal transport, transcytosis, and recycling of neurotrophic factors","volume":"24","author":"von Bartheld","year":"2001","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2020.112683_bib0140","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nn.2244","article-title":"Neuronal release of proBDNF","volume":"12","author":"Yang","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0145","doi-asserted-by":"crossref","first-page":"925","DOI":"10.33549\/physiolres.932996","article-title":"ProBDNF is a major product of bdnf gene expressed in the perinatal rat cortex","volume":"64","author":"Menshanov","year":"2015","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bbr.2020.112683_bib0150","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10787-013-0174-8","article-title":"Relationship between serum IL10 level and p38MAPK enzyme activity on behavioral and cellular aspects of variation of hyperalgesia during different stages of arthritis in rats","volume":"22","author":"Zaringhalam","year":"2014","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbr.2020.112683_bib0155","first-page":"1","article-title":"Microglial-induced apoptosis is potentially responsible for hyperalgesia variations during CFA-induced inflammation","author":"Baniasadi","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbr.2020.112683_bib0160","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/417074a","article-title":"Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice","volume":"417","author":"Zhu","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2020.112683_bib0165","first-page":"23","article-title":"Increased serum IL-6 level time-dependently regulates hyperalgesia and spinal mu opioid receptor expression during CFA-induced arthritis","volume":"10","author":"Tekieh","year":"2011","journal-title":"EXCLI J."},{"key":"10.1016\/j.bbr.2020.112683_bib0170","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.intimp.2019.02.042","article-title":"Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways","volume":"70","author":"Nasseri","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbr.2020.112683_bib0175","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/EJA.0b013e328331a3d5","article-title":"Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory","volume":"27","author":"Hu","year":"2010","journal-title":"Eur. J. Anaesthesiol. (EJA)"},{"key":"10.1016\/j.bbr.2020.112683_bib0180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbi.2014.04.003","article-title":"Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling","volume":"41","author":"Dellarole","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2020.112683_bib0185","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13041-015-0139-5","article-title":"Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice","volume":"8","author":"Guida","year":"2015","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbr.2020.112683_bib0190","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.lfs.2018.08.065","article-title":"Memory deficits and hippocampal inflammation in cerebral hypoperfusion and reperfusion in male rats: neuroprotective role of vanillic acid","volume":"211","author":"Khoshnam","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2020.112683_bib0195","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11064-018-02703-2","article-title":"The administration of cadmium for 2, 3 and 4 months causes a loss of recognition memory, promotes neuronal hypotrophy and apoptosis in the Hippocampus of rats","volume":"44","author":"Pulido","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2020.112683_bib0200","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1186\/s13071-017-2565-y","article-title":"Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection","volume":"10","author":"Mengying","year":"2017","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.bbr.2020.112683_bib0205","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12974-019-1476-6","article-title":"Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain","volume":"16","author":"Zhou","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbr.2020.112683_bib0210","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation and chronic neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbr.2020.112683_bib0215","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1017\/S1740925X12000014","article-title":"Microglia and neuronal cell death","volume":"7","author":"Mar\u00edn-Teva","year":"2011","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.bbr.2020.112683_bib0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnagi.2013.00029","article-title":"Molecular mechanisms of cognitive dysfunction following traumatic brain injury","volume":"5","author":"Walker","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0225","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pneurobio.2016.01.005","article-title":"The biphasic function of microglia in ischemic stroke","volume":"157","author":"Ma","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2020.112683_bib0230","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s10753-018-0914-4","article-title":"Neuronal EphA4 regulates OGD\/R-Induced apoptosis by promoting alternative activation of microglia","volume":"42","author":"Wei","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.bbr.2020.112683_bib0235","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/dneu.20964","article-title":"Motoneuron programmed cell death in response to proBDNF","volume":"72","author":"Taylor","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbr.2020.112683_bib0240","doi-asserted-by":"crossref","first-page":"9957","DOI":"10.1523\/JNEUROSCI.0163-13.2013","article-title":"ProBDNF and mature BDNF as punishment and reward signals for synapse elimination at mouse neuromuscular junctions","volume":"33","author":"Je","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112683_bib0245","doi-asserted-by":"crossref","DOI":"10.1177\/1759091414552185","article-title":"p75NTR, but not proNGF, is upregulated following status epilepticus in mice","volume":"6","author":"VonDran","year":"2014","journal-title":"ASN Neuro"},{"key":"10.1016\/j.bbr.2020.112683_bib0250","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5607\/en.2018.27.3.155","article-title":"Astrocytic proBDNF and tonic GABA distinguish active versus reactive astrocytes in hippocampus","volume":"27","author":"Chun","year":"2018","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.bbr.2020.112683_bib0255","doi-asserted-by":"crossref","first-page":"27171","DOI":"10.1038\/srep27171","article-title":"Peripheral brain derived neurotrophic factor precursor regulates pain as an inflammatory mediator","volume":"6","author":"Luo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2020.112683_bib0260","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1083\/jcb.201306136","article-title":"Death of developing neurons: new insights and implications for connectivity","volume":"203","author":"Dekkers","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbr.2020.112683_bib0265","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13041-018-0411-6","article-title":"proBDNF is modified by advanced glycation end products in Alzheimer\u2019s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing","volume":"11","author":"Fleitas","year":"2018","journal-title":"Mol. Brain"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643282030382X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643282030382X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:22:16Z","timestamp":1759065736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016643282030382X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":53,"alternative-id":["S016643282030382X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2020.112683","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglia dependent BDNF and proBDNF can impair spatial memory performance during persistent inflammatory pain","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2020.112683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112683"}}