{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:37:35Z","timestamp":1791225455688,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.bbr.2020.112720","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T06:11:28Z","timestamp":1590819088000},"page":"112720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Inducible nitric oxide synthase plays a role in depression- and anxiety-like behaviors chronically induced by lipopolysaccharide in rats: Evidence from inflammation and oxidative stress"],"prefix":"10.1016","volume":"392","author":[{"given":"Farimah","family":"Beheshti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Hashemzehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Marefati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Memarpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2020.112720_bib0005","first-page":"1001","article-title":"Screening for depression across the lifespan","volume":"66","author":"Sharp","year":"2002","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.bbr.2020.112720_bib0010","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1001\/jama.1995.03530190025030","article-title":"Health-related quality of life in primary care patients with mental disorders: results from the PRIME-MD 1000 Study","volume":"274","author":"Spitzer","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.bbr.2020.112720_bib0015","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1001\/archinte.1997.00440310079008","article-title":"Treating depressed primary care patients improves their physical, mental, and social functioning","volume":"157","author":"Coulehan","year":"1997","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbr.2020.112720_bib0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0193-953X(05)70283-5","article-title":"Definition and epidemiology of treatment-resistant depression","volume":"19","author":"Fava","year":"1996","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.bbr.2020.112720_bib0025","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0149-7634(97)00058-4","article-title":"Biological bases of anxiety","volume":"22","author":"Clement","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2020.112720_bib0030","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.atherosclerosis.2005.06.001","article-title":"Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA study","volume":"185","author":"Pitsavos","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbr.2020.112720_bib0035","first-page":"7","article-title":"Depression\u2019s multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways","volume":"32","author":"Maes","year":"2011","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.bbr.2020.112720_bib0040","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.psyneuen.2010.09.012","article-title":"Inflammation-associated depression: from serotonin to kynurenine","volume":"36","author":"Dantzer","year":"2011","journal-title":"Psychoneuroendocrinology."},{"key":"10.1016\/j.bbr.2020.112720_bib0045","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2020.112720_bib0050","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.pneurobio.2010.04.005","article-title":"The putative neurodegenerative links between depression and Alzheimer\u2019s disease","volume":"91","author":"Wuwongse","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2020.112720_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-398314-5.00001-5","article-title":"Inflammation in anxiety","volume":"88","author":"Salim","year":"2012","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.bbr.2020.112720_bib0060","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbr.2020.112720_bib0065","series-title":"Anxiolytic Effects of the Aqueous Extracts of Melissa Officinalis and the Role of Opioid Receptors in Mice","year":"2005"},{"key":"10.1016\/j.bbr.2020.112720_bib0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.bbr.2020.112720_bib0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbr.2020.112720_bib0080","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902019000118099","article-title":"Effect of ethanol Adiantum capillus-veneris extract in experimental models of anxiety and depression","volume":"55","author":"Rabiei","year":"2019","journal-title":"Braz J Pharm Sci."},{"key":"10.1016\/j.bbr.2020.112720_bib0085","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/dmrr.2732","article-title":"Antioxidant treatment ameliorates experimental diabetes\u2010induced depressive\u2010like behaviour and reduces oxidative stress in brain and pancreas","volume":"32","author":"R\u00e9us","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bbr.2020.112720_bib0090","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.pbb.2007.02.010","article-title":"Effects of interleukin-1beta and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests","volume":"86","author":"Swiergiel","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2020.112720_bib0095","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cyto.2017.04.015","article-title":"The effects of thymoquinone on hippocampal cytokine level, brain oxidative stress status and memory deficits induced by lipopolysaccharide in rats","volume":"96","author":"Bargi","year":"2017","journal-title":"Cytokine."},{"key":"10.1016\/j.bbr.2020.112720_bib0100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/01480545.2017.1336173","article-title":"Protective effect against brain tissues oxidative damage as a possible mechanism for beneficial effects of L-arginine on lipopolysaccharide induced memory impairment in rats","volume":"41","author":"Hosseini","year":"2018","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.bbr.2020.112720_bib0105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.lfs.2016.10.026","article-title":"The effects of captopril on lipopolysaccharide induced learning and memory impairments and the brain cytokine levels and oxidative damage in rats","volume":"167","author":"Abareshi","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2020.112720_bib0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.lfs.2016.06.019","article-title":"Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat","volume":"158","author":"Anaeigoudari","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2020.112720_bib0115","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pharep.2015.09.004","article-title":"Neuronal nitric oxide synthase has a role in the detrimental effects of lipopolysaccharide on spatial memory and synaptic plasticity in rats","volume":"68","author":"Anaeigoudari","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbr.2020.112720_bib0120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuroscience.2015.04.065","article-title":"Early prenatal exposure to LPS results in anxiety-and depression-related behaviors in adulthood","volume":"299","author":"Depino","year":"2015","journal-title":"Neuroscience."},{"key":"10.1016\/j.bbr.2020.112720_bib0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2014.03.012","article-title":"Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2, 3-dioxygenase activation","volume":"41","author":"Andr\u00e9","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2020.112720_bib0130","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1523\/JNEUROSCI.14-09-05147.1994","article-title":"Gases as biological messengers: nitric oxide and carbon monoxide in the brain","volume":"14","author":"Dawson","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.112720_bib0135","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12011-016-0679-2","article-title":"Selective inducible nitric oxide synthase inhibitor reversed zinc chloride-induced spatial memory impairment via increasing cholinergic marker expression","volume":"173","author":"Tabrizian","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbr.2020.112720_bib0140","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/ndt\/gfv253","article-title":"Role of the endogenous nitric oxide inhibitor asymmetric dimethylarginine (ADMA) and brain-derived neurotrophic factor (BDNF) in depression and behavioural changes: clinical and preclinical data in chronic kidney disease","volume":"30","author":"Kielstein","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbr.2020.112720_bib0145","doi-asserted-by":"crossref","first-page":"356","DOI":"10.23736\/S0022-4707.17.06957-2","article-title":"Effects of exercise on learning and memory, oxidative stress and nNOS expression in marginal division of striatum of ovariectomized rats","volume":"58","author":"Cui","year":"2018","journal-title":"J. Sports Med. Phys. Fitness"},{"key":"10.1016\/j.bbr.2020.112720_bib0150","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bioorg.2017.09.007","article-title":"Nitric oxide inhibitory daphnane diterpenoids as potential anti-neuroinflammatory agents for AD from the twigs of Trigonostemon thyrsoideus","volume":"75","author":"Liu","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbr.2020.112720_bib0155","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.npep.2014.03.002","article-title":"Aminoguanidine treatment ameliorates inflammatory responses and memory impairment induced by amyloid-beta 25\u201335 injection in rats","volume":"48","author":"D\u00edaz","year":"2014","journal-title":"Neuropeptides."},{"key":"10.1016\/j.bbr.2020.112720_bib0160","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/JAD-2009-1034","article-title":"Hippocampal alterations in rats submitted to streptozotocin-induced dementia model are prevented by aminoguanidine","volume":"17","author":"Rodrigues","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbr.2020.112720_bib0165","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(02)00312-1","article-title":"Antidepressant-and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice","volume":"140","author":"Volke","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2020.112720_bib0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s002139900316","article-title":"Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats","volume":"149","author":"Yildiz","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2020.112720_bib0175","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1590\/0004-282X20150121","article-title":"Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole","volume":"73","author":"Anaeigoudari","year":"2015","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/j.bbr.2020.112720_bib0180","first-page":"78","article-title":"Zataria multiflora extract reverses lipopolysaccharide-induced anxiety and depression behaviors in rats","volume":"10","author":"Arab","year":"2020","journal-title":"Avicenna J. Phytomed."},{"key":"10.1016\/j.bbr.2020.112720_bib0185","first-page":"29","article-title":"Deletion of ovarian hormones induces a sickness behavior in rats comparable to the effect of lipopolysaccharide","volume":"627642","author":"Azizi-Malekabadi","year":"2015","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.bbr.2020.112720_bib0190","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1179\/1476830514Y.0000000144","article-title":"The effects of Nigella sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats","volume":"20","author":"Beheshti","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.bbr.2020.112720_bib0195","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0076-6879(72)25041-8","article-title":"Reaction of protein sulfhydryl groups with Ellman\u2019s reagent","volume":"25","author":"Habeeb","year":"1972","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbr.2020.112720_bib0200","first-page":"535","article-title":"A microtiter plate assay for superoxide using MTT reduction method","volume":"34","author":"Madesh","year":"1997","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.bbr.2020.112720_bib0205","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"[13] Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbr.2020.112720_bib0210","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pnpbp.2014.01.016","article-title":"Intranigral lipopolysaccharide induced anxiety and depression by altered BDNF mRNA expression in rat hippocampus","volume":"51","author":"Hritcu","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2020.112720_bib0215","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.pbb.2005.04.019","article-title":"Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice","volume":"81","author":"Dunn","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2020.112720_bib0220","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2013.11.035","article-title":"Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats","author":"Rai","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2020.112720_bib0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V74.1.1.1","article-title":"The biology of interleukin-6","volume":"74","author":"Kishimoto","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.bbr.2020.112720_bib0230","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.174.4.915","article-title":"Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression","volume":"174","author":"de Waal Malefyt","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbr.2020.112720_bib0235","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejphar.2009.03.032","article-title":"Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats","volume":"610","author":"Schmatz","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2020.112720_bib0240","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0006-291X(92)91852-H","article-title":"Interleukin-10 inhibits the production of nitric oxide synthase by interferon-7 in murine macrophages","volume":"182","author":"Cuhna","year":"1992","journal-title":"Biochem Biophys Res Comm."},{"key":"10.1016\/j.bbr.2020.112720_bib0245","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2013.09.033","article-title":"Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress","volume":"1539","author":"Patki","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2020.112720_bib0250","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ejphar.2014.07.031","article-title":"Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice","volume":"740","author":"Jangra","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2020.112720_bib0255","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0891-5849(96)00219-5","article-title":"NO-induced oxidative stress and glutathione metabolism in rodent and human cells","volume":"21","author":"Luperchio","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbr.2020.112720_bib0260","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.biopha.2017.01.009","article-title":"A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice","volume":"88","author":"Abdel-Zaher","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbr.2020.112720_bib0265","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1590\/S1807-59322010001100021","article-title":"Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth","volume":"65","author":"Hosseini","year":"2010","journal-title":"Clinics Sao Paulo (Sao Paulo)"},{"key":"10.1016\/j.bbr.2020.112720_bib0270","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12011-016-0679-2","article-title":"Selective inducible nitric oxide synthase inhibitor reversed zinc chloride-induced spatial memory impairment via increasing cholinergic marker expression","volume":"173","author":"Tabrizian","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbr.2020.112720_bib0275","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.lfs.2016.06.019","article-title":"Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat","volume":"158","author":"Anaeigoudari","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2020.112720_bib0280","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/JAD-2009-1034","article-title":"Hippocampal alterations in rats submitted to streptozotocin-induced dementia model are prevented by aminoguanidine","volume":"17","author":"Rodrigues","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbr.2020.112720_bib0285","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.neuropharm.2007.02.011","article-title":"Mechanisms of regulation for interleukin-1\u03b2 in neurodegenerative disease","volume":"52","author":"Simi","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2020.112720_bib0290","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1073\/pnas.95.10.5795","article-title":"Amyloid \u03b2-peptide stimulates nitric oxide production in astrocytes through an NF\u03baB-dependent mechanism","volume":"95","author":"Akama","year":"1998","journal-title":"Proc Natl Acad Sci."},{"key":"10.1016\/j.bbr.2020.112720_bib0295","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1006\/cyto.1997.0232","article-title":"\u03b2-amyloid fragment potentiates IL-6 and TNF-\u03b1 secretion by LPS in astrocytes but not in microglia","volume":"9","author":"Forloni","year":"1997","journal-title":"Cytokine"},{"key":"10.1016\/j.bbr.2020.112720_bib0300","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.niox.2003.08.003","article-title":"FK 506 and aminoguanidine suppress iNOS induction in orthotopic corneal allografts and prolong graft survival in mice","volume":"9","author":"St\u0159e\u0161t\u0131\u0301kov\u00e1","year":"2003","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbr.2020.112720_bib0305","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(95)01415-2","article-title":"Endotoxin produces a depressive-like episode in rats","volume":"711","author":"Yirmiya","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2020.112720_bib0310","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0893-133X(00)00226-8","article-title":"Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents","volume":"24","author":"Yirmiya","year":"2001","journal-title":"Neuropsychopharmacology."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432820304198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432820304198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:19:25Z","timestamp":1759065565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432820304198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":62,"alternative-id":["S0166432820304198"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2020.112720","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inducible nitric oxide synthase plays a role in depression- and anxiety-like behaviors chronically induced by lipopolysaccharide in rats: Evidence from inflammation and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2020.112720","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112720"}}