{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:52:56Z","timestamp":1791921176751,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.bbr.2020.112781","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T14:38:44Z","timestamp":1593527924000},"page":"112781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["TRPM4 inhibition improves spatial memory impairment and hippocampal long-term potentiation deficit in chronic cerebral hypoperfused rats"],"prefix":"10.1016","volume":"393","author":[{"given":"Nurul Aqmar Mohamad Nor","family":"Hazalin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zurina","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbr.2020.112781_bib0005","first-page":"18","article-title":"A literature review on: pathogenesis and management of dementia due to Alzheimer disease","volume":"1","author":"Melesie","year":"2013","journal-title":"Bio-Genetics J."},{"issue":"3","key":"10.1016\/j.bbr.2020.112781_bib0010","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.arr.2010.04.002","article-title":"Vascular risk factor detection and control may prevent Alzheimer\u2019s disease","volume":"9","author":"de la Torre","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbr.2020.112781_bib0015","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0301-0082(00)00068-X","article-title":"Cerebral microvascular pathology in aging and Alzheimer\u2019s disease","volume":"64","author":"Farkas","year":"2001","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbr.2020.112781_bib0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas","year":"2007","journal-title":"Brain Res. Rev."},{"issue":"7","key":"10.1016\/j.bbr.2020.112781_bib0025","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/j.neuropharm.2012.02.014","article-title":"Neuropharmacology L-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia","volume":"62","author":"Xu","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2020.112781_bib0030","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bbr.2014.09.014","article-title":"Time course of motor and cognitive functions after chronic cerebral ischemia in rats","volume":"275","author":"Damodaran","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2020.112781_bib0035","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00424-013-1347-4","article-title":"TRPM4 inhibition promotes angiogenesis after ischemic stroke","volume":"466","author":"Loh","year":"2014","journal-title":"Pfl\u00e3\u00bcgers Arch. - Eur. J. Physiol."},{"issue":"8","key":"10.1016\/j.bbr.2020.112781_bib0040","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/NEN.0000000000000223","article-title":"Sur1-TRPM4 cation channel expression in human cerebral infarcts","volume":"74","author":"Mehta","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbr.2020.112781_bib0045","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-3-540-34891-7_16","article-title":"Insights into TRPM4 function, regulation and physiological role","volume":"179","author":"Vennekens","year":"2007","journal-title":"Handb. Exp. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbr.2020.112781_bib0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nm.1899","article-title":"De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury","volume":"15","author":"Gerzanich","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbr.2020.112781_bib0055","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1161\/STROKEAHA.113.002904","article-title":"Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage","volume":"44","author":"Tosun","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2020.112781_bib0060","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/cvr\/cvr135","article-title":"Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death","volume":"91","author":"Becerra","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.bbr.2020.112781_bib0065","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ceca.2011.11.004","article-title":"Endogenous cytosolic Ca(2+) buffering is necessary for TRPM4 activity in cerebral artery smooth muscle cells","volume":"51","author":"Gonzales","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbr.2020.112781_bib0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2144\/05382RR05","article-title":"Improved real-time RT-PCR method for high-throughput measurements using second derivative calculation and double correction","volume":"38","author":"Luu-The","year":"2005","journal-title":"BioTechnique"},{"key":"10.1016\/j.bbr.2020.112781_bib0075","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jep.2018.06.020","article-title":"Clitoria ternatea L. Root extract ameliorated the cognitive and hippocampal long-term potentiation deficits induced by chronic cerebral hypoperfusion in the rat","volume":"224","author":"Damodaran","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.bbr.2020.112781_bib0080","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1101\/lm.1787110","article-title":"Training-induced plasticity in the visual cortex of adult rats following visual discrimination learning","volume":"17","author":"Hager","year":"2010","journal-title":"Learn. Mem."},{"key":"10.1016\/j.bbr.2020.112781_bib0085","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1997"},{"issue":"3","key":"10.1016\/j.bbr.2020.112781_bib0090","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/0300060514566648","article-title":"Salidroside prevents cognitive impairment induced by chronic cerebral hypoperfusion in rats","volume":"43","author":"Yan","year":"2015","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.bbr.2020.112781_bib0095","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neulet.2016.03.039","article-title":"Glutamatergic and central cholinergic dysfunction in the CA1, CA2 and CA3 fields on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats","volume":"620","author":"Cao","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2020.112781_bib0100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neulet.2015.11.019","article-title":"Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat model","volume":"615","author":"Nie","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.bbr.2020.112781_bib0105","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nm.1899","article-title":"De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury","volume":"15","author":"Gerzanich","year":"2009","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.bbr.2020.112781_bib0110","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/NEN.0000000000000223","article-title":"Sur1-TRPM4 cation channel expression in human cerebral infarcts","volume":"74","author":"Mehta","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbr.2020.112781_bib0115","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1161\/STROKEAHA.113.002904","article-title":"Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage","volume":"44","author":"Tosun","year":"2013","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.bbr.2020.112781_bib0120","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00424-012-1166-z","article-title":"Transient receptor potential melastatin 4 and cell death","volume":"464","author":"Simard","year":"2012","journal-title":"Pfl\u00fcgers Archiv: European Journal of Physiology"},{"issue":"1","key":"10.1016\/j.bbr.2020.112781_bib0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12975-018-0621-3","article-title":"Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury","volume":"10","author":"Chen","year":"2018","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.bbr.2020.112781_bib0130","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/cvr\/cvr135","article-title":"Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death","volume":"91","author":"Becerra","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"12","key":"10.1016\/j.bbr.2020.112781_bib0135","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/nm.3015","article-title":"TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis","volume":"18","author":"Schattling","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbr.2020.112781_bib0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the Hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbr.2020.112781_bib0145","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00424-015-1764-7","article-title":"TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons","volume":"468","author":"Menigoz","year":"2015","journal-title":"Pfl\u00e3\u00bcgers Arch. - Eur. J. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.bbr.2020.112781_bib0150","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.brainresbull.2010.10.009","article-title":"Novel insights into CaMKII function and regulation during memory formation","volume":"85","author":"Lucchesi","year":"2011","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/j.bbr.2020.112781_bib0155","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0197-0186(95)00097-6","article-title":"CaM kinase II in long-term potentiation","volume":"28","author":"Fukunaga","year":"1996","journal-title":"Neurochem. Int."},{"issue":"8","key":"10.1016\/j.bbr.2020.112781_bib0160","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.tins.2006.06.009","article-title":"\u03b1CaMKII autophosphorylation: a fast track to memory","volume":"29","author":"Irvine","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2020.112781_bib0165","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/neu.10169","article-title":"Molecular and cellular cognitive studies of the role of synaptic plasticity in memory","volume":"54","author":"Silva","year":"2003","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.bbr.2020.112781_bib0170","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1074\/mcp.D500009-MCP200","article-title":"Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum","volume":"5","author":"Cheng","year":"2006","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.bbr.2020.112781_bib0175","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0006-3223(99)00294-2","article-title":"Molecular and cellular mechanisms of cognitive function: implications for psychiatric disorders","volume":"47","author":"Silva","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2020.112781_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-6606-2-6","article-title":"Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression","volume":"2","author":"Hasegawa","year":"2009","journal-title":"Mol. Brain"},{"issue":"9","key":"10.1016\/j.bbr.2020.112781_bib0185","first-page":"1","article-title":"Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice","volume":"3","author":"Matsuo","year":"2009","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2020.112781_bib0190","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.274.5293.1678","article-title":"Control of memory formation through regulated expression of a CaMKII transgene","volume":"274","author":"Mayford","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbr.2020.112781_bib0195","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0896-6273(02)00978-9","article-title":"Disruption of dendritic translation of CaMKII\u03b1 impairs stabilization of synaptic plasticity and memory consolidation","volume":"36","author":"Miller","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2020.112781_bib0200","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2014.10.019","article-title":"Regulation of hippocampal synaptic plasticity by BDNF","volume":"1621","author":"Leal","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2020.112781_bib0205","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pneurobio.2005.06.003","article-title":"BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis","volume":"76","author":"Bramham","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2020.112781_bib0210","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1101\/lm.51202","article-title":"From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning","volume":"9","author":"Tyler","year":"2002","journal-title":"Learn. Mem."},{"issue":"9","key":"10.1016\/j.bbr.2020.112781_bib0215","doi-asserted-by":"crossref","first-page":"8856","DOI":"10.1073\/pnas.92.19.8856","article-title":"Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic","volume":"92","author":"Korte","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbr.2020.112781_bib0220","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0896-6273(00)80853-3","article-title":"Essential role for TrkB receptors in hippocampus-mediated learning","volume":"24","author":"Minichiello","year":"1999","journal-title":"Neuron"},{"issue":"5-6","key":"10.1016\/j.bbr.2020.112781_bib0225","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00424-017-1964-4","article-title":"Neurobiology of local and intercellular BDNF signaling","volume":"469","author":"Sasi","year":"2017","journal-title":"Pfl\u00e3\u00bcgers Arch. - Eur. J. Physiol."},{"issue":"17","key":"10.1016\/j.bbr.2020.112781_bib0230","doi-asserted-by":"crossref","first-page":"7453","DOI":"10.1523\/JNEUROSCI.22-17-07453.2002","article-title":"Brain-derived neurotrophic factor triggers transcription- dependent, late phase long-term potentiation in vivo","volume":"22","author":"Messaoudi","year":"2002","journal-title":"J. Neurosci."},{"issue":"17","key":"10.1016\/j.bbr.2020.112781_bib0235","doi-asserted-by":"crossref","first-page":"6707","DOI":"10.1523\/JNEUROSCI.17-17-06707.1997","article-title":"Brain-derived neurotrophic factor enhances long-term potentiation in rat visual cortex","volume":"17","author":"Akaneya","year":"1997","journal-title":"The Journal of Neurscience"},{"key":"10.1016\/j.bbr.2020.112781_bib0240","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0896-6273(00)80140-3","article-title":"Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice","volume":"16","author":"Patterson","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2020.112781_bib0245","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0028-3908(98)00035-5","article-title":"A role for BDNF in the late-phase of hippocampal long-term potentiation","volume":"37","author":"Korte","year":"1998","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2020.112781_bib0250","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3892\/br.2012.48","article-title":"The neuroprotective roles of BDNF in hypoxic ischemic brain injury (Review)","volume":"1","author":"Chen","year":"2013","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.bbr.2020.112781_bib0255","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1006\/exnr.1999.7109","article-title":"Brain-derived neurotrophic factor improves long-term potentiation and cognitive functions after transient forebrain ischemia in the rat","volume":"159","author":"Kiprianova","year":"1999","journal-title":"Exp. Neurol."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432820304800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432820304800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:27:06Z","timestamp":1759066026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432820304800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":51,"alternative-id":["S0166432820304800"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2020.112781","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRPM4 inhibition improves spatial memory impairment and hippocampal long-term potentiation deficit in chronic cerebral hypoperfused rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2020.112781","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112781"}}