{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:08:12Z","timestamp":1770916092256,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001849","name":"Defence Research and Development Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001849","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bbr.2020.113055","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T02:00:18Z","timestamp":1607133618000},"page":"113055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Clinical relevance of chronic neuropathic pain phenotypes in mice: A comprehensive behavioral analysis"],"prefix":"10.1016","volume":"400","author":[{"given":"Nidhi","family":"Goswami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd","family":"Aleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailash","family":"Manda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2020.113055_bib0005","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/jnr.23768","article-title":"Animal models of chronic pain: advances and challenges for clinical translation","volume":"95","author":"Burma","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbr.2020.113055_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci8010011","article-title":"Neurodegeneration and sensorimotor deficits in the mouse model of traumatic brain injury","volume":"8","author":"Bhowmick","year":"2018","journal-title":"Brain Sci."},{"key":"10.1016\/j.bbr.2020.113055_bib0015","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1523\/JNEUROSCI.5337-13.2014","article-title":"Pain reduces sexual motivation in female but not male mice","volume":"34","author":"Farmer","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2020.113055_bib0020","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.pain.2012.04.023","article-title":"Study of emotional and cognitive impairments in mononeuropathic rats: effect of duloxetine and gabapentin","volume":"153","author":"Gr\u00e9goire","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2020.113055_bib0025","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2147\/JPR.S71292","article-title":"Chronic pain, social withdrawal, and depression","volume":"7","author":"Harris","year":"2014","journal-title":"J. Pain Res."},{"key":"10.1016\/j.bbr.2020.113055_bib0030","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.pain.2009.02.018","article-title":"Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833","volume":"143","author":"Hu","year":"2009","journal-title":"PAIN\u00ae"},{"key":"10.1016\/j.bbr.2020.113055_bib0035","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.pain.2010.12.029","article-title":"Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury","volume":"152","author":"Kodama","year":"2011","journal-title":"PAIN\u00ae"},{"key":"10.1016\/j.bbr.2020.113055_bib0040","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.pain.2013.03.019","article-title":"Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats","volume":"154","author":"Leys","year":"2013","journal-title":"PAIN\u00ae"},{"key":"10.1016\/j.bbr.2020.113055_bib0045","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1046\/j.1460-9568.2003.02627.x","article-title":"A subpopulation of rats show social and sleep-waking changes typical of chronic neuropathic pain following peripheral nerve injury","volume":"17","author":"Monassi","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2020.113055_bib0050","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1037\/0021-843X.101.3.514","article-title":"Longitudinal relationships among pain, sleep problems, and depression in rheumatoid arthritis","volume":"101","author":"Nicassio","year":"1992","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.bbr.2020.113055_bib0055","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bbr.2012.01.001","article-title":"Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain","volume":"229","author":"Parent","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2020.113055_bib0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2147\/JPR.S62317","article-title":"Voices that may not otherwise be heard: a qualitative exploration into the perspectives of primary care patients living with chronic pain","volume":"7","author":"Wallace","year":"2014","journal-title":"J. Pain Res."},{"key":"10.1016\/j.bbr.2020.113055_bib0065","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.3390\/ijms21093396","article-title":"Behavioral, Biochemical and Electrophysiological Changes in Spared Nerve Injury Model of Neuropathic Pain","volume":"21","author":"Guida","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2020.113055_bib0070","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neulet.2013.12.056","article-title":"The effects of resveratrol on chronic constriction injury of sciatic nerve in rats","volume":"561","author":"Bagriyanik","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2020.113055_bib0075","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3171\/2013.9.JNS13353","article-title":"Comprehensive analysis of neurobehavior associated with histomorphological alterations in a chronic constrictive nerve injury model through use of the CatWalk XT system: laboratory investigation","volume":"120","author":"Chiang","year":"2014","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bbr.2020.113055_bib0080","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2009.07.091","article-title":"Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models","volume":"1295","author":"Piesla","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2020.113055_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ynpai.2017.09.001","article-title":"Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain","volume":"2","author":"Sheahan","year":"2017","journal-title":"Neurobiol Pain"},{"key":"10.1016\/j.bbr.2020.113055_bib0090","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/ALN.0000000000001340","article-title":"Preclinical Pain ResearchCan We Do Better?","volume":"125","author":"Clark","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbr.2020.113055_bib0095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2020.113055_bib0100","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.expneurol.2013.06.005","article-title":"Early cognitive changes due to whole body \u03b3-irradiation: a behavioral and diffusion tensor imaging study in mice","volume":"248","author":"Kumar","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2020.113055_bib0105","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jneumeth.2004.02.012","article-title":"Detection of chronic sensorimotor impairments in the ladder rung walking task in rats with endothelin-1-induced mild focal ischemia","volume":"137","author":"Riek-Burchardt","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2020.113055_bib0110","first-page":"8","article-title":"Motor coordination and balance in rodents","author":"Carter","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.bbr.2020.113055_bib0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0091-3057(81)90236-7","article-title":"The string test: an early behavioral change in thiamine deficiency","volume":"14","author":"Barclay","year":"1981","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2020.113055_bib0120","first-page":"e2609","article-title":"Measuring motor coordination in mice","author":"Deacon","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbr.2020.113055_bib0125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2020.113055_bib0130","first-page":"e2473","article-title":"Assessment of social interaction behaviors","author":"Kaidanovich-Beilin","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbr.2020.113055_bib0135","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/492141","article-title":"Myristic acid produces anxiolytic-like effects in Wistar rats in the elevated plus maze","volume":"2014","author":"Contreras","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.bbr.2020.113055_bib0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02246218","article-title":"Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine","volume":"117","author":"Monleon","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2020.113055_bib0145","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1038\/sj.npp.1300532","article-title":"Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration","volume":"29","author":"Strekalova","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2020.113055_bib0150","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/01.ajp.0000154048.68273.d8","article-title":"Quantitative somatosensory testing of warm and heat-pain thresholds: the effect of body region and testing method","volume":"22","author":"Defrin","year":"2006","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.bbr.2020.113055_bib0155","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF00230429","article-title":"Influence of skin temperature on heat pain threshold in humans","volume":"107","author":"Pertovaara","year":"1996","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.bbr.2020.113055_bib0160","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0160-5402(91)90014-V","article-title":"The increasing-temperature hot-plate test: an improved test of nociception in mice and rats","volume":"25","author":"Tj\u00f8lsen","year":"1991","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.bbr.2020.113055_bib0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099828","article-title":"Acute heat-evoked temperature sensation is impaired but not abolished in mice lacking TRPV1 and TRPV3 channels","volume":"9","author":"Marics","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2020.113055_bib0170","article-title":"Gait disturbances in dystrophic hamsters","volume":"2011","author":"Hampton","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.bbr.2020.113055_bib0175","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.pain.2005.03.021","article-title":"Human surrogate models of neuropathic pain","volume":"115","author":"Klein","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2020.113055_bib0180","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pain.2006.01.041","article-title":"Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values","volume":"123","author":"Rolke","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2020.113055_bib0185","first-page":"445","article-title":"Nauclea latifolia Smith (Rubiaceae) exerts antinociceptive effects in neuropathic pain induced by chronic constriction injury of the sciatic nerve","volume":"151","author":"Gs","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbr.2020.113055_bib0190","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.4065\/mcp.2009.0648","article-title":"Assessment and treatment of psychosocial comorbidities in patients with neuropathic pain","volume":"85","author":"Turk","year":"2010","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.bbr.2020.113055_bib0195","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.pain.2010.12.003","article-title":"Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity","volume":"152","author":"Urban","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2020.113055_bib0200","first-page":"109","article-title":"Major depressive disorder, anhedonia and agomelatine: an open-label study","volume":"25","author":"Di Giannantonio","year":"2011","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.bbr.2020.113055_bib0205","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archgenpsychiatry.2009.39","article-title":"The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression","volume":"66","author":"Walter","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2020.113055_bib0210","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0361-9230(91)90019-G","article-title":"Lack of anxiety in an animal model of depression with cholinergic supersensitivity","volume":"26","author":"Schiller","year":"1991","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2020.113055_bib0215","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(70)90239-6","article-title":"Differences in brain area 5-hydroxytryptamine turnover and rearing behavior in rats and mice of both sexes","volume":"9","author":"Rosecrans","year":"1970","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2020.113055_bib0220","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.npp.1300635","article-title":"Intracerebral baclofen administration decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum","volume":"30","author":"Zhou","year":"2005","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.bbr.2020.113055_bib0225","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0014-2999(81)90295-8","article-title":"Detailed analysis of the effects of apomorphine and d-amphetamine on spontaneous locomotor behaviour of rats as measured in a TV-based, automated open-field system","volume":"72","author":"Nickolson","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2020.113055_bib0230","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2003.11.077","article-title":"GABAB receptor stimulation decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum","volume":"1004","author":"Zhou","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2020.113055_bib0235","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2013.00386","article-title":"The social modulation of pain: others as predictive signals of salience \u2013 a systematic review","volume":"7","author":"Krah\u00e9","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.bbr.2020.113055_bib0240","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/7854_2014_287","article-title":"The interaction between pain and social behavior in humans and rodents","volume":"20","author":"Martin","year":"2014","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2020.113055_bib0245","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1097\/01.j.pain.0000460341.62094.77","article-title":"Social modulation of and by pain in humans and rodents","volume":"156","author":"Mogil","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2020.113055_bib0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124755","article-title":"Injury-dependent and disability-specific lumbar spinal gene regulation following sciatic nerve injury in the rat","volume":"10","author":"Austin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2020.113055_bib0255","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nn.4199","article-title":"The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain","volume":"19","author":"Ren","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2020.113055_bib0260","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2147\/JPR.S105892","article-title":"A review of chronic pain impact on patients, their social environment and the health care system","volume":"9","author":"Due\u00f1as","year":"2016","journal-title":"J. Pain Res."},{"key":"10.1016\/j.bbr.2020.113055_bib0265","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/jpepsy\/jsl049","article-title":"Judgments of infant pain: the impact of caregiver identity and infant age","volume":"32","author":"Pillai Riddell","year":"2007","journal-title":"J. Pediatr. Psychol."},{"key":"10.1016\/j.bbr.2020.113055_bib0270","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1017\/S0140525X02000080","article-title":"Facial expression of pain: an evolutionary account","volume":"25","author":"de C. Williams","year":"2002","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.bbr.2020.113055_bib0275","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.biopsych.2005.07.026","article-title":"A mouse model system for genetic analysis of sociability: C57BL\/6J versus BALB\/cJ inbred mouse strains","volume":"59","author":"Sankoorikal","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2020.113055_bib0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000344","article-title":"Publication bias in reports of animal stroke studies leads to major overstatement of efficacy","volume":"8","author":"Sena","year":"2010","journal-title":"PLoS Biol."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432820307543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432820307543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:22:10Z","timestamp":1759065730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432820307543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":56,"alternative-id":["S0166432820307543"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2020.113055","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical relevance of chronic neuropathic pain phenotypes in mice: A comprehensive behavioral analysis","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2020.113055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113055"}}