{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:52:30Z","timestamp":1773975150184,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008199","name":"RTI International","doi-asserted-by":"crossref","award":["R01DK103625"],"award-info":[{"award-number":["R01DK103625"]}],"id":[{"id":"10.13039\/100008199","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["U01HG004085"],"award-info":[{"award-number":["U01HG004085"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CSD Consortium","award":["U01HG004080"],"award-info":[{"award-number":["U01HG004080"]}]},{"name":"KOMP"},{"name":"CHORI","award":["U42RR024244"],"award-info":[{"award-number":["U42RR024244"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD","award":["U54 HD079124"],"award-info":[{"award-number":["U54 HD079124"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bbr.2020.113059","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T08:46:39Z","timestamp":1607676399000},"page":"113059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Aplnr knockout mice display sex-specific changes in conditioned fear"],"prefix":"10.1016","volume":"400","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6181-0136","authenticated-orcid":false,"given":"Lucas T.","family":"Laudermilk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-0032","authenticated-orcid":false,"given":"Kathryn M.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl S.","family":"Moy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Runyon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly","family":"Koller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-6800","authenticated-orcid":false,"given":"Rangan","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1-2","key":"10.1016\/j.bbr.2020.113059_bib0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0378-1119(93)90495-O","article-title":"A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11","volume":"136","author":"O\u2019Dowd","year":"1993","journal-title":"Gene"},{"issue":"1-2","key":"10.1016\/j.bbr.2020.113059_bib0010","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0925-4773(99)00081-7","article-title":"Amino acid sequence and embryonic expression of msr\/apj, the mouse homolog of Xenopus X-msr and human APJ","volume":"84","author":"Devic","year":"1999","journal-title":"Mechanisms of development"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0015","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0167-4781(00)00072-5","article-title":"Distribution of mRNA encoding B78\/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues","volume":"1492","author":"O\u2019Carroll","year":"2000","journal-title":"Biochimica et biophysica acta"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0167-4889(99)00114-7","article-title":"Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum","volume":"1452","author":"Habata","year":"1999","journal-title":"Biochimica et biophysica acta"},{"issue":"5","key":"10.1016\/j.bbr.2020.113059_bib0025","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.0000033522.37861.69","article-title":"Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility","volume":"91","author":"Szokodi","year":"2002","journal-title":"Circulation research"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cardiores.2004.08.018","article-title":"The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo","volume":"65","author":"Ashley","year":"2005","journal-title":"Cardiovascular research"},{"issue":"4","key":"10.1016\/j.bbr.2020.113059_bib0035","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1161\/CIRCRESAHA.107.158659","article-title":"Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload","volume":"101","author":"Kuba","year":"2007","journal-title":"Circulation research"},{"issue":"3","key":"10.1016\/j.bbr.2020.113059_bib0040","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/HYPERTENSIONAHA.109.134619","article-title":"[Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease","volume":"54","author":"Maguire","year":"2009","journal-title":"Hypertension (Dallas, Tex: 1979)"},{"issue":"3","key":"10.1016\/j.bbr.2020.113059_bib0045","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3892\/ijmm.2014.1829","article-title":"Effect of apelin on the cardiac hemodynamics in hypertensive rats with heart failure","volume":"34","author":"Pang","year":"2014","journal-title":"International journal of molecular medicine"},{"issue":"6","key":"10.1016\/j.bbr.2020.113059_bib0050","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1210\/en.2006-1270","article-title":"Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice","volume":"148","author":"Higuchi","year":"2007","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.bbr.2020.113059_bib0055","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1530\/EJE-08-0039","article-title":"Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ","volume":"158","author":"Castan-Laurell","year":"2008","journal-title":"European journal of endocrinology"},{"issue":"5","key":"10.1016\/j.bbr.2020.113059_bib0060","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cmet.2008.10.003","article-title":"Apelin stimulates glucose utilization in normal and obese insulin-resistant mice","volume":"8","author":"Dray","year":"2008","journal-title":"Cell metabolism"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0065","first-page":"E59","article-title":"Apelin is necessary for the maintenance of insulin sensitivity, American journal of physiology","volume":"298","author":"Yue","year":"2010","journal-title":"Endocrinology and metabolism"},{"issue":"2","key":"10.1016\/j.bbr.2020.113059_bib0070","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2337\/db11-0100","article-title":"Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice","volume":"61","author":"Attan\u00e9","year":"2012","journal-title":"Diabetes"},{"issue":"20","key":"10.1016\/j.bbr.2020.113059_bib0075","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.1021\/acs.jmedchem.5b00527","article-title":"Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery","volume":"58","author":"Narayanan","year":"2015","journal-title":"Journal of medicinal chemistry"},{"issue":"4","key":"10.1016\/j.bbr.2020.113059_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115237","article-title":"Identification of potent pyrazole based APELIN receptor (APJ) agonists","volume":"28","author":"Narayanan","year":"2020","journal-title":"Bioorganic & medicinal chemistry"},{"key":"10.1016\/j.bbr.2020.113059_bib0085","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1038\/ncomms7020","article-title":"Genetic targeting of sprouting angiogenesis using Apln-CreER","volume":"6","author":"Liu","year":"2015","journal-title":"Nature communications"},{"issue":"407","key":"10.1016\/j.bbr.2020.113059_bib0090","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad4000","article-title":"Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin\u2019s glucose-lowering effects","volume":"9","author":"Hwangbo","year":"2017","journal-title":"Science translational medicine"},{"issue":"5","key":"10.1016\/j.bbr.2020.113059_bib0095","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.celrep.2018.10.015","article-title":"Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target","volume":"25","author":"Zhao","year":"2018","journal-title":"Cell reports"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0100","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1038\/s41467-020-15729-4","article-title":"Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors","volume":"11","author":"Wang","year":"2020","journal-title":"Nature communications"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0105","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/JOE-13-0227","article-title":"The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis","volume":"219","author":"O\u2019Carroll","year":"2013","journal-title":"The Journal of endocrinology"},{"issue":"120","key":"10.1016\/j.bbr.2020.113059_bib0110","article-title":"Role of the Vasopressin\/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders","volume":"8","author":"Flahault","year":"2017","journal-title":"Frontiers in Endocrinology"},{"issue":"5","key":"10.1016\/j.bbr.2020.113059_bib0115","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1046\/j.1471-4159.2003.01587.x","article-title":"Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin","volume":"84","author":"Medhurst","year":"2003","journal-title":"Journal of neurochemistry"},{"issue":"3","key":"10.1016\/j.bbr.2020.113059_bib0120","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2008.08.040","article-title":"Anatomical profiling of G protein-coupled receptor expression","volume":"135","author":"Regard","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0125","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.peptides.2011.12.005","article-title":"Central and peripheral apelin receptor distribution in the mouse: species differences with rat","volume":"33","author":"Pope","year":"2012","journal-title":"Peptides"},{"issue":"7124","key":"10.1016\/j.bbr.2020.113059_bib0130","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbr.2020.113059_bib0135","doi-asserted-by":"crossref","first-page":"H1904","DOI":"10.1152\/ajpheart.00686.2009","article-title":"Endogenous regulation of cardiovascular function by apelin-APJ, American journal of physiology","volume":"297","author":"Charo","year":"2009","journal-title":"Heart and circulatory physiology"},{"issue":"3","key":"10.1016\/j.bbr.2020.113059_bib0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1677\/JOE-09-0134","article-title":"Abnormal fluid homeostasis in apelin receptor knockout mice","volume":"202","author":"Roberts","year":"2009","journal-title":"The Journal of endocrinology"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0145","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/CIRCRESAHA.113.301324","article-title":"Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development","volume":"113","author":"Kang","year":"2013","journal-title":"Circulation research"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0150","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1530\/JOE-12-0375","article-title":"Stress-dependent and gender-specific neuroregulatory roles of the apelin receptor in the hypothalamic-pituitary-adrenal axis response to acute stress","volume":"216","author":"Newson","year":"2013","journal-title":"The Journal of endocrinology"},{"issue":"9","key":"10.1016\/j.bbr.2020.113059_bib0155","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s11064-016-1948-3","article-title":"Apelin-13 Impaires Acquisition but Not Consolidation or Expression of Contextual Fear in Rats","volume":"41","author":"Han","year":"2016","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbr.2020.113059_bib0160","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neuroscience.2018.08.018","article-title":"Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions","volume":"390","author":"Dai","year":"2018","journal-title":"Neuroscience"},{"issue":"1-3","key":"10.1016\/j.bbr.2020.113059_bib0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.regpep.2004.07.033","article-title":"Central and peripheral cardiovascular actions of apelin in conscious rats","volume":"125","author":"Kagiyama","year":"2005","journal-title":"Regulatory peptides"},{"issue":"5","key":"10.1016\/j.bbr.2020.113059_bib0170","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1006\/bbrc.2002.6575","article-title":"The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats","volume":"291","author":"Taheri","year":"2002","journal-title":"Biochemical and biophysical research communications"},{"issue":"11","key":"10.1016\/j.bbr.2020.113059_bib0175","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1046\/j.1365-2826.2003.01102.x","article-title":"APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids","volume":"15","author":"O\u2019Carroll","year":"2003","journal-title":"Journal of neuroendocrinology"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0180","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nature neuroscience"},{"issue":"3","key":"10.1016\/j.bbr.2020.113059_bib0185","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0186-18.2018","article-title":"Mammalian TRIM67 Functions in Brain Development and Behavior","volume":"5","author":"Boyer","year":"2018","journal-title":"eNeuro"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0190","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbr.2012.02.010","article-title":"Increased sensitivity to alcohol induced changes in ERK Map kinase phosphorylation and memory disruption in adolescent as compared to adult C57BL\/6J mice","volume":"230","author":"Spanos","year":"2012","journal-title":"Behavioural brain research"},{"key":"10.1016\/j.bbr.2020.113059_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2019.107044","article-title":"Modulation of CA2 neuronal activity increases behavioral responses to fear conditioning in female mice","volume":"163","author":"Alexander","year":"2019","journal-title":"Neurobiology of learning and memory"},{"key":"10.1016\/j.bbr.2020.113059_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2018.03.006","article-title":"Assessment of depression-like behavior and anhedonia after repeated cycles of binge-like ethanol drinking in male C57BL\/6J mice","volume":"168","author":"Olney","year":"2018","journal-title":"Pharmacology, biochemistry, and behavior"},{"issue":"2","key":"10.1016\/j.bbr.2020.113059_bib0205","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/npp.2016.174","article-title":"Sex Differences in Context Fear Generalization and Recruitment of Hippocampus and Amygdala during Retrieval","volume":"42","author":"Keiser","year":"2017","journal-title":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.bbr.2020.113059_bib0210","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.tins.2019.07.009","article-title":"A Dynamic Memory Systems Framework for Sex Differences in Fear Memory","volume":"42","author":"Tronson","year":"2019","journal-title":"Trends in neurosciences"},{"issue":"26","key":"10.1016\/j.bbr.2020.113059_bib0215","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1523\/JNEUROSCI.3029-16.2017","article-title":"Dentate Gyrus Contributes to Retrieval as well as Encoding: Evidence from Context Fear Conditioning, Recall, and Extinction","volume":"37","author":"Bernier","year":"2017","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"issue":"2","key":"10.1016\/j.bbr.2020.113059_bib0220","first-page":"93","volume":"206","author":"Hoskins","year":"2015","journal-title":"Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis, The British journal of psychiatry : the journal of mental science"},{"key":"10.1016\/j.bbr.2020.113059_bib0225","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nlm.2013.11.014","article-title":"From Pavlov to PTSD: the extinction of conditioned fear in rodents, humans, and anxiety disorders","volume":"113","author":"VanElzakker","year":"2014","journal-title":"Neurobiology of learning and memory"},{"key":"10.1016\/j.bbr.2020.113059_bib0230","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2015.06.059","article-title":"The effects of intracerebroventricular infusion of apelin-13 on reproductive function in male rats","volume":"602","author":"Sandal","year":"2015","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0235","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/13813455.2016.1211709","article-title":"Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism","volume":"123","author":"Tekin","year":"2017","journal-title":"Archives of physiology and biochemistry"},{"issue":"2-3","key":"10.1016\/j.bbr.2020.113059_bib0240","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0167-0115(01)00236-1","article-title":"The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism","volume":"99","author":"Tatemoto","year":"2001","journal-title":"Regulatory peptides"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0245","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1006\/bbrc.2001.6230","article-title":"Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein","volume":"290","author":"Masri","year":"2002","journal-title":"Biochemical and biophysical research communications"},{"issue":"11","key":"10.1016\/j.bbr.2020.113059_bib0250","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.yexcr.2010.02.005","article-title":"Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons","volume":"316","author":"Zeng","year":"2010","journal-title":"Experimental cell research"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0255","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12974-019-1406-7","article-title":"Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK\/GSK-3\u03b2\/Nrf2 signaling","volume":"16","author":"Duan","year":"2019","journal-title":"Journal of neuroinflammation"},{"issue":"8","key":"10.1016\/j.bbr.2020.113059_bib0260","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/hr.2017.28","article-title":"The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension","volume":"40","author":"Yeganeh-Hajahmadi","year":"2017","journal-title":"Hypertension research : official journal of the Japanese Society of Hypertension"},{"issue":"27","key":"10.1016\/j.bbr.2020.113059_bib0265","doi-asserted-by":"crossref","first-page":"18317","DOI":"10.1074\/jbc.M600606200","article-title":"The apelin receptor is coupled to Gi1 or Gi2 protein and is differentially desensitized by apelin fragments","volume":"281","author":"Masri","year":"2006","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"10.1016\/j.bbr.2020.113059_bib0270","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1745-7270.2008.00403.x","article-title":"Apelin-13 induces ERK1\/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway","volume":"40","author":"Bai","year":"2008","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"6","key":"10.1016\/j.bbr.2020.113059_bib0275","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/j.1471-4159.2007.04645.x","article-title":"Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury","volume":"102","author":"O\u2019Donnell","year":"2007","journal-title":"Journal of neurochemistry"},{"issue":"15","key":"10.1016\/j.bbr.2020.113059_bib0280","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1096\/fj.04-1930fje","article-title":"Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells","volume":"18","author":"Masri","year":"2004","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"2-3","key":"10.1016\/j.bbr.2020.113059_bib0285","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.regpep.2006.02.004","article-title":"Apelin and its receptor are expressed in human osteoblasts","volume":"134","author":"Xie","year":"2006","journal-title":"Regulatory peptides"},{"issue":"1","key":"10.1016\/j.bbr.2020.113059_bib0290","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10495-006-0489-7","article-title":"Apelin suppresses apoptosis of human osteoblasts","volume":"12","author":"Xie","year":"2007","journal-title":"Apoptosis : an international journal on programmed cell death"},{"issue":"3","key":"10.1016\/j.bbr.2020.113059_bib0295","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.peptides.2006.10.005","article-title":"Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K\/Akt signaling pathways","volume":"28","author":"Tang","year":"2007","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.bbr.2020.113059_bib0300","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.neuroscience.2009.01.009","article-title":"Sex differences in contextual fear conditioning are associated with differential ventral hippocampal extracellular signal-regulated kinase activation","volume":"159","author":"Gresack","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2020.113059_bib0305","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nlm.2015.05.009","article-title":"Sex differences in fear extinction and involvements of extracellular signal-regulated kinase (ERK)","volume":"123","author":"Matsuda","year":"2015","journal-title":"Neurobiology of learning and memory"},{"issue":"12","key":"10.1016\/j.bbr.2020.113059_bib0310","first-page":"723","article-title":"PI3-kinase cascade has a differential role in acquisition and extinction of conditioned fear memory in juvenile and adult rats, Learning & memory (Cold Spring Harbor","volume":"23","author":"Slouzkey","year":"2016","journal-title":"N.Y.)"},{"issue":"10","key":"10.1016\/j.bbr.2020.113059_bib0315","first-page":"762","article-title":"Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex, Learning & memory (Cold Spring Harbor","volume":"15","author":"Sui","year":"2008","journal-title":"N.Y.)"},{"issue":"12","key":"10.1016\/j.bbr.2020.113059_bib0320","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.biopsych.2019.05.027","article-title":"Angiotensin II Type 2 Receptor-Expressing Neurons in the Central Amygdala Influence Fear-Related Behavior","volume":"86","author":"Yu","year":"2019","journal-title":"Biological psychiatry"},{"issue":"12","key":"10.1016\/j.bbr.2020.113059_bib0325","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.biopsych.2019.09.026","article-title":"Fear Extinction: Translational Evidence and Novel Receptor Targets","volume":"86","author":"Stout","year":"2019","journal-title":"Biological psychiatry"},{"issue":"10","key":"10.1016\/j.bbr.2020.113059_bib0330","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.biopsych.2017.11.019","article-title":"Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation","volume":"83","author":"Deslauriers","year":"2018","journal-title":"Biological psychiatry"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432820307580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432820307580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:23:49Z","timestamp":1759065829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432820307580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":66,"alternative-id":["S0166432820307580"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2020.113059","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aplnr knockout mice display sex-specific changes in conditioned fear","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2020.113059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113059"}}