{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:48:06Z","timestamp":1788220086247,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H04252"],"award-info":[{"award-number":["17H04252"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K10195"],"award-info":[{"award-number":["16K10195"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["K10195,17H04252"],"award-info":[{"award-number":["K10195,17H04252"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07931"],"award-info":[{"award-number":["20K07931"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007877","name":"Fujita Health University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bbr.2021.113191","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T04:31:01Z","timestamp":1613536261000},"page":"113191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of \u03b17 nicotinic acetylcholine receptors by kynurenic acid"],"prefix":"10.1016","volume":"405","author":[{"given":"Yuko","family":"Mori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-4041","authenticated-orcid":false,"given":"Akihiro","family":"Mouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kunisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Hirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayoshi","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aika","family":"Kosuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe","family":"Niijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Kurahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-4486","authenticated-orcid":false,"given":"Takashi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwako","family":"Fujigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetsugu","family":"Fujigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Nabeshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10161","key":"10.1016\/j.bbr.2021.113191_bib0005","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2021.113191_bib0010","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"6","key":"10.1016\/j.bbr.2021.113191_bib0015","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/sj.mp.4001920","article-title":"Serotonergic vulnerability and depression: assumptions, experimental evidence and implications","volume":"12","author":"Jans","year":"2007","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0098-2997(83)90005-5","article-title":"Biochemistry of tryptophan in health and disease","volume":"6","author":"Bender","year":"1983","journal-title":"Mol. Aspects Med."},{"issue":"6","key":"10.1016\/j.bbr.2021.113191_bib0025","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/febs.14026","article-title":"Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism","volume":"284","author":"Li","year":"2017","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.bbr.2021.113191_bib0030","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/10253890701754068","article-title":"A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression","volume":"11","author":"Miura","year":"2008","journal-title":"Stress"},{"key":"10.1016\/j.bbr.2021.113191_bib0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuropharm.2014.03.004","article-title":"A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats","volume":"82","author":"Koshy Cherian","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113191_bib0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jad.2019.05.028","article-title":"Changes in tryptophan metabolism during pregnancy and postpartum periods: potential involvement in postpartum depressive symptoms","volume":"255","author":"Teshigawara","year":"2019","journal-title":"J. Affect. Disord."},{"issue":"1\u20132","key":"10.1016\/j.bbr.2021.113191_bib0045","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0006-8993(89)90901-3","article-title":"Regulation of striatal serotonin release by the lateral habenula-dorsal raphe pathway in the rat as demonstrated by in vivo microdialysis: role of excitatory amino acids and GABA","volume":"492","author":"Kalen","year":"1989","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0165-0327(00)00292-5","article-title":"Association study of nicotinic-receptor variants and major depressive disorder","volume":"66","author":"Lai","year":"2001","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2021.113191_bib0055","doi-asserted-by":"crossref","first-page":"36705","DOI":"10.1038\/srep36705","article-title":"Depression-like phenotype by deletion of alpha7 nicotinic acetylcholine receptor: role of BDNF-TrkB in nucleus accumbens","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.bbr.2021.113191_bib0060","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1001\/jama.284.20.2606","article-title":"Smoking and mental illness: a population-based prevalence study","volume":"284","author":"Lasser","year":"2000","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0065","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00213-006-0516-y","article-title":"Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial","volume":"189","author":"McClernon","year":"2006","journal-title":"Psychopharmacology (Berl.)"},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s002130050879","article-title":"Antidepressant effects of nicotine in an animal model of depression","volume":"142","author":"Tizabi","year":"1999","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.bbr.2021.113191_bib0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbr.2019.03.019","article-title":"Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice","volume":"366","author":"Alzarea","year":"2019","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0080","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.drudis.2015.11.001","article-title":"Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors","volume":"21","author":"Smith","year":"2016","journal-title":"Drug Discov. Today"},{"issue":"Pt B","key":"10.1016\/j.bbr.2021.113191_bib0085","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuropharm.2016.05.020","article-title":"The kynurenine pathway in schizophrenia and bipolar disorder","volume":"112","author":"Erhardt","year":"2017","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/abbi.1997.0220","article-title":"Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens","volume":"344","author":"Koushik","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0095","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0306-4522(87)90066-2","article-title":"Quinolinate neurotoxicity in cortical cell culture","volume":"23","author":"Kim","year":"1987","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1471-4159.1998.70010299.x","article-title":"3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity","volume":"70","author":"Okuda","year":"1998","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00702-011-0763-x","article-title":"Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery","volume":"119","author":"Moroni","year":"2012","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"10","key":"10.1016\/j.bbr.2021.113191_bib0110","doi-asserted-by":"crossref","first-page":"e918","DOI":"10.1038\/tp.2016.200","article-title":"Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation","volume":"6","author":"Parrott","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113191_bib0115","article-title":"The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies","author":"Marx","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113191_bib0120","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2016.09.050","article-title":"Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions","volume":"317","author":"Tashiro","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0125","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbr.2009.03.004","article-title":"The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex","volume":"201","author":"Koenigs","year":"2009","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/j.bbr.2021.113191_bib0130","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1176\/appi.ajp.2017.16080883","article-title":"A brain model of disturbed self-appraisal in depression","volume":"174","author":"Davey","year":"2017","journal-title":"Am. J. Psychiatry"},{"issue":"9","key":"10.1016\/j.bbr.2021.113191_bib0135","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1523\/JNEUROSCI.13-09-03839.1993","article-title":"The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress","volume":"13","author":"Diorio","year":"1993","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.bbr.2021.113191_bib0140","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0006-3223(01)01280-X","article-title":"Volumetric reduction in left subgenual prefrontal cortex in early onset depression","volume":"51","author":"Botteron","year":"2002","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0145","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biopsych.2013.01.005","article-title":"Structural changes in hippocampal subfields in major depressive disorder: a high-field magnetic resonance imaging study","volume":"74","author":"Huang","year":"2013","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2021.113191_bib0150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/laban.1219","article-title":"Aggression in group-housed laboratory mice: why can\u2019t we solve the problem?","volume":"46","author":"Weber","year":"2017","journal-title":"Lab Anim. (NY)"},{"issue":"6","key":"10.1016\/j.bbr.2021.113191_bib0155","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1167\/iovs.12-9662","article-title":"The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL\/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes","volume":"53","author":"Mattapallil","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.bbr.2021.113191_bib0160","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1017\/S146114571100085X","article-title":"Mouse strain differences in phencyclidine-induced behavioural changes","volume":"15","author":"Mouri","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0165","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1124\/jpet.109.162610","article-title":"Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model","volume":"332","author":"Zhou","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0170","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S0022-3565(25)12928-5","article-title":"Pharmacological evaluation of novel Alzheimer\u2019s disease therapeutics: acetylcholinesterase inhibitors related to galanthamine","volume":"277","author":"Bores","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.bbr.2021.113191_bib0175","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.2527\/2003.8151237x","article-title":"The toxicity and kinetics of larkspur alkaloid, methyllycaconitine, in mice","volume":"81","author":"Stegelmeier","year":"2003","journal-title":"J. Anim. Sci."},{"issue":"4","key":"10.1016\/j.bbr.2021.113191_bib0180","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2220\/biomedres.34.189","article-title":"Improvement of spontaneous alternation behavior deficit by activation of alpha4beta2 nicotinic acetylcholine receptor signaling in the ganglioside GM3-deficient mice","volume":"34","author":"Niimi","year":"2013","journal-title":"Biomed. Res."},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0185","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00213-009-1651-z","article-title":"Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons","volume":"207","author":"Mizoguchi","year":"2009","journal-title":"Psychopharmacology (Berl.)"},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1369-1600.2011.00425.x","article-title":"Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice","volume":"19","author":"Koseki","year":"2014","journal-title":"Addict. Biol."},{"issue":"13","key":"10.1016\/j.bbr.2021.113191_bib0195","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1523\/JNEUROSCI.6458-11.2012","article-title":"MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation","volume":"32","author":"Mouri","year":"2012","journal-title":"J. Neurosci."},{"issue":"14","key":"10.1016\/j.bbr.2021.113191_bib0200","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1111\/bph.15043","article-title":"Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice","volume":"177","author":"Mouri","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbr.2021.113191_bib0205","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/npp.2014.207","article-title":"Blonanserin ameliorates phencyclidine-induced visual-recognition memory deficits: the complex mechanism of blonanserin action involving D(3)-5-HT(2)A and D(1)-NMDA receptors in the mPFC","volume":"40","author":"Hida","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113191_bib0210","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.bbr.2021.113191_bib0215","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jad.2018.01.014","article-title":"Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: an exploratory pilot case-control study","volume":"231","author":"Kuwano","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2021.113191_bib0220","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.imlet.2016.11.012","article-title":"Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice","volume":"181","author":"Kubo","year":"2017","journal-title":"Immunol. Lett."},{"issue":"9","key":"10.1016\/j.bbr.2021.113191_bib0225","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.bbr.2021.113191_bib0230","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neubiorev.2006.03.006","article-title":"Habituation in rodents: a review of behavior, neurobiology, and genetics","volume":"30","author":"Leussis","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"9","key":"10.1016\/j.bbr.2021.113191_bib0235","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd1825","article-title":"The ascent of mouse: advances in modelling human depression and anxiety","volume":"4","author":"Cryan","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"11","key":"10.1016\/j.bbr.2021.113191_bib0240","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1001\/jamapsychiatry.2013.1957","article-title":"Overt irritability\/anger in unipolar major depressive episodes: past and current characteristics and implications for long-term course","volume":"70","author":"Judd","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"10.1016\/j.bbr.2021.113191_bib0245","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.neubiorev.2010.06.006","article-title":"Reconsidering anhedonia in depression: lessons from translational neuroscience","volume":"35","author":"Treadway","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.bbr.2021.113191_bib0250","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"5604","key":"10.1016\/j.bbr.2021.113191_bib0255","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"issue":"7564","key":"10.1016\/j.bbr.2021.113191_bib0260","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature14580","article-title":"Genetic compensation induced by deleterious mutations but not gene knockdowns","volume":"524","author":"Rossi","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbr.2021.113191_bib0265","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s11055-018-0580-x","article-title":"Studies of the association between the Kynurenine-3-Monooxygenase gene and depression","volume":"48","author":"Lezheiko","year":"2018","journal-title":"Neurosci. Behav. Physiol."},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0270","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1038\/s41598-020-58806-w","article-title":"Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder","volume":"10","author":"Sakurai","year":"2020","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.bbr.2021.113191_bib0275","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1523\/JNEUROSCI.21-19-07463.2001","article-title":"The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications","volume":"21","author":"Hilmas","year":"2001","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.bbr.2021.113191_bib0280","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1176\/appi.ajp.2015.14080978","article-title":"CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders","volume":"172","author":"Kunii","year":"2015","journal-title":"Am. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0285","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0022-3565(25)22727-6","article-title":"Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion","volume":"271","author":"Collins","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0290","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-2999(98)00084-3","article-title":"Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands","volume":"347","author":"Molinari","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbr.2021.113191_bib0295","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0031-9384(77)90222-0","article-title":"Effects of olfactory bulbectomy and domicile on stress-induced corticosterone release in the rat","volume":"19","author":"Cairncross","year":"1977","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0300","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ntr\/ntw140","article-title":"The association of cigarette smoking with depression and anxiety: a systematic review","volume":"19","author":"Fluharty","year":"2017","journal-title":"Nicotine Tob. Res."},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0305","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neubiorev.2011.06.007","article-title":"Smoking, quitting, and psychiatric disease: a review","volume":"36","author":"Aubin","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0310","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2131\/jts.36.31","article-title":"Depression-related anhedonic behaviors caused by immobilization stress: a comparison with nicotine-induced depression-like behavioral alterations and effects of nicotine and\/or \u201cantidepressant\u201d drugs","volume":"36","author":"Hayase","year":"2011","journal-title":"J. Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.bbr.2021.113191_bib0315","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1460-9568.2008.06594.x","article-title":"Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release","volume":"29","author":"Zmarowski","year":"2009","journal-title":"Eur. J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.bbr.2021.113191_bib0320","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s12031-009-9235-2","article-title":"The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex","volume":"40","author":"Wu","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2021.113191_bib0325","article-title":"NAChR alpha4beta2 subtype and their relation with nicotine addiction, cognition, depression and hyperactivity disorder","author":"Laikowski","year":"2018","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.bbr.2021.113191_bib0330","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0026-895X(24)12219-5","article-title":"The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system","volume":"61","author":"Santos","year":"2002","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0335","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/jpet.107.123109","article-title":"Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7* nicotinic receptors","volume":"322","author":"Lopes","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.bbr.2021.113191_bib0340","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41380-018-0219-x","article-title":"Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics","volume":"24","author":"Dulawa","year":"2019","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"10.1016\/j.bbr.2021.113191_bib0345","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00213-016-4206-0","article-title":"Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats","volume":"233","author":"Papp","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"issue":"1","key":"10.1016\/j.bbr.2021.113191_bib0350","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41398-020-00928-w","article-title":"The cholinesterase inhibitor donepezil has antidepressant-like properties in the mouse forced swim test","volume":"10","author":"Fitzgerald","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113191_bib0355","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.pnpbp.2018.05.018","article-title":"Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice","volume":"86","author":"Alzarea","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.bbr.2021.113191_bib0360","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.neuropharm.2007.01.006","article-title":"Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL\/6J mice","volume":"52","author":"Mineur","year":"2007","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.bbr.2021.113191_bib0365","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.biopsych.2013.04.025","article-title":"Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses","volume":"74","author":"Voleti","year":"2013","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbr.2021.113191_bib0370","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0306-4522(01)00133-6","article-title":"Nucleus accumbens muscarinic receptors in the control of behavioral depression: antidepressant-like effects of local M1 antagonist in the Porsolt swim test","volume":"104","author":"Chau","year":"2001","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.bbr.2021.113191_bib0375","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.biopsych.2009.11.021","article-title":"Replication of scopolamine\u2019s antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial","volume":"67","author":"Drevets","year":"2010","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2021.113191_bib0380","doi-asserted-by":"crossref","first-page":"FSO73","DOI":"10.4155\/fso.15.73","article-title":"The case of galantamine: repurposing and late blooming of a cholinergic drug","volume":"1","author":"Mucke","year":"2015","journal-title":"Future Sci. OA"},{"issue":"10","key":"10.1016\/j.bbr.2021.113191_bib0385","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archpsyc.62.10.1097","article-title":"Epidemiology of major depressive disorder: results from the national epidemiologic survey on alcoholism and related conditions","volume":"62","author":"Hasin","year":"2005","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821000796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821000796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:23:40Z","timestamp":1778671420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432821000796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":77,"alternative-id":["S0166432821000796"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113191","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of \u03b17 nicotinic acetylcholine receptors by kynurenic acid","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113191"}}