{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:05:35Z","timestamp":1759104335884,"version":"3.44.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bbr.2021.113200","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T16:31:08Z","timestamp":1614097868000},"page":"113200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Involvement of Nrf-2\/HO-1 pathway in sevoflurane-induced cognitive improvement in rats with traumatic brain injury"],"prefix":"10.1016","volume":"405","author":[{"given":"Cui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-yu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-rong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-4435","authenticated-orcid":false,"given":"Jian-bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2021.113200_bib0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neubiorev.2019.05.012","article-title":"Making sense of gut feelings in the traumatic brain injury pathogenesis","volume":"102","author":"Royes","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2021.113200_bib0010","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biomaterials.2015.08.010","article-title":"Direct hippocampal injection of pseudo lentivirus-delivered nerve growth factor gene rescues the damaged cognitive function after traumatic brain injury in the rat","volume":"69","author":"Lin","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbr.2021.113200_bib0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnsys.2016.00008","article-title":"Hippocampal neurophysiologic changes after mild traumatic brain injury and potential neuromodulation treatment approaches","volume":"10","author":"Girgis","year":"2016","journal-title":"Front. Syst. Neurosci."},{"issue":"9","key":"10.1016\/j.bbr.2021.113200_bib0020","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrneurol.2017.116","article-title":"The far-reaching scope of neuroinflammation after traumatic brain injury","volume":"13","author":"Simon","year":"2017","journal-title":"Nat. Rev. Neurol."},{"issue":"13","key":"10.1016\/j.bbr.2021.113200_bib0025","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1089\/ars.2017.7280","article-title":"Uncoupled endothelial nitric oxide synthase enhances p-Tau in chronic traumatic encephalopathy mouse model","volume":"30","author":"Shin","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbr.2021.113200_bib0030","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"8","key":"10.1016\/j.bbr.2021.113200_bib0035","doi-asserted-by":"crossref","first-page":"e104924","DOI":"10.1371\/journal.pone.0104924","article-title":"Role of Nrf2\/ARE pathway in protective effect of electroacupuncture against endotoxic shock-induced acute lung injury in rabbits","volume":"9","author":"Yu","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bbr.2021.113200_bib0040","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/ALN.0000000000001333","article-title":"Heme oxygenase-1\/carbon monoxide-regulated mitochondrial dynamic equilibrium contributes to the attenuation of endotoxin-induced acute lung injury in rats and in lipopolysaccharide-activated macrophages","volume":"125","author":"Yu","year":"2016","journal-title":"Anesthesiology"},{"issue":"10","key":"10.1016\/j.bbr.2021.113200_bib0045","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1046\/j.1460-9568.2002.01992.x","article-title":"Upregulation and activation of the Nrf-1 transcription factor in the lesioned hippocampus","volume":"15","author":"Hertel","year":"2002","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.bbr.2021.113200_bib0050","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s004010000202","article-title":"Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans","volume":"100","author":"Beschorner","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbr.2021.113200_bib0055","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.pneurobio.2014.01.001","article-title":"Neuroprotective gases--fantasy or reality for clinical use?","volume":"115","author":"Deng","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2021.113200_bib0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuroscience.2015.11.038","article-title":"Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis","volume":"313","author":"Wang","year":"2016","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bbr.2021.113200_bib0065","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.gene.2015.05.026","article-title":"Sevoflurane preconditioning improving cerebral focal ischemia-reperfusion damage in a rat model via PI3K\/Akt signaling pathway","volume":"569","author":"Zhang","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.bbr.2021.113200_bib0070","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2147\/DDDT.S158313","article-title":"Sevoflurane post-conditioning attenuates traumatic brain injury-induced neuronal apoptosis by promoting autophagy via the PI3K\/AKT signaling pathway","volume":"12","author":"He","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"issue":"3 Pt 1","key":"10.1016\/j.bbr.2021.113200_bib0075","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1164\/ajrccm.163.3.2004202","article-title":"Protective role of heme oxygenases against endotoxin-induced diaphragmatic dysfunction in rats","volume":"163","author":"Taille","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.bbr.2021.113200_bib0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/neu.2010.1383","article-title":"Post-traumatic seizures exacerbate histopathological damage after fluid-percussion brain injury","volume":"28","author":"Bao","year":"2011","journal-title":"J. Neurotrauma"},{"issue":"8","key":"10.1016\/j.bbr.2021.113200_bib0085","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/neu.2008.0733","article-title":"Correlation of CD34+ cells with tissue angiogenesis after traumatic brain injury in a rat model","volume":"26","author":"Guo","year":"2009","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.bbr.2021.113200_bib0090","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s12630-008-9023-4","article-title":"Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats","volume":"56","author":"Richebe","year":"2009","journal-title":"Can. J. Anaesth."},{"issue":"4","key":"10.1016\/j.bbr.2021.113200_bib0095","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.bbr.2021.113200_bib0100","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbr.2021.113200_bib0105","article-title":"Electroacupuncture ameliorates learning and memory and improves synaptic plasticity via activation of the PKA\/CREB signaling pathway in cerebral hypoperfusion","volume":"2016","author":"Zheng","year":"2016","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.bbr.2021.113200_bib0110","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnsyn.2018.00008","article-title":"Intravascular ketamine increases theta-burst but not high frequency tetanus induced LTP at CA3-CA1 synapses within three hours and devoid of an increase in spine density","volume":"10","author":"Widman","year":"2018","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.bbr.2021.113200_bib0115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.brainresbull.2017.01.016","article-title":"Erythropoietin rescues primary rat cortical neurons from pyroptosis and apoptosis via Erk1\/2-Nrf2\/Bach1 signal pathway","volume":"130","author":"Li","year":"2017","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.bbr.2021.113200_bib0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1213\/00000539-199201000-00014","article-title":"Systemic and regional hemodynamics of isoflurane and sevoflurane in rats","volume":"74","author":"Conzen","year":"1992","journal-title":"Anesth. Analg."},{"issue":"4","key":"10.1016\/j.bbr.2021.113200_bib0125","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1213\/00000539-199810000-00020","article-title":"The effects of sevoflurane on cerebral blood flow autoregulation in rats","volume":"87","author":"Lu","year":"1998","journal-title":"Anesth. Analg."},{"issue":"9","key":"10.1016\/j.bbr.2021.113200_bib0130","doi-asserted-by":"crossref","first-page":"14899","DOI":"10.1002\/jcb.28751","article-title":"Breviscapine provides a neuroprotective effect after traumatic brain injury by modulating the Nrf2 signaling pathway","volume":"120","author":"Li","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bbr.2021.113200_bib0135","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/jnc.13082","article-title":"Characterization of traumatic brain injury in human brains reveals distinct cellular and molecular changes in contusion and pericontusion","volume":"134","author":"Harish","year":"2015","journal-title":"J. Neurochem."},{"issue":"6731","key":"10.1016\/j.bbr.2021.113200_bib0140","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/19978","article-title":"Dendritic spine changes associated with hippocampal long-term synaptic plasticity","volume":"399","author":"Engert","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2021.113200_bib0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.neuro.31.060407.125646","article-title":"Balancing structure and function at hippocampal dendritic spines","volume":"31","author":"Bourne","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2021.113200_bib0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2017.01.051","article-title":"alpha4betadelta GABAA receptors reduce dendritic spine density in CA1 hippocampus and impair relearning ability of adolescent female mice: effects of a GABA agonist and a stress steroid","volume":"347","author":"Afroz","year":"2017","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.bbr.2021.113200_bib0155","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1002\/acn3.50878","article-title":"Dexmedetomidine attenuates neuroinflammatory-induced apoptosis after traumatic brain injury via Nrf2 signaling pathway","volume":"6","author":"Li","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"3","key":"10.1016\/j.bbr.2021.113200_bib0160","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/ANA.0b013e31828c6af5","article-title":"Propofol attenuates cerebral ischemia\/reperfusion injury partially using heme oxygenase-1","volume":"25","author":"Liang","year":"2013","journal-title":"J. Neurosurg. Anesthesiol."},{"issue":"2","key":"10.1016\/j.bbr.2021.113200_bib0165","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1089\/neu.2018.5674","article-title":"Novel metabolomic comparison of arterial and jugular venous blood in severe adult traumatic brain injury patients and the impact of pentobarbital infusion","volume":"36","author":"Wolahan","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.bbr.2021.113200_bib0170","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13054-016-1294-5","article-title":"Optimizing sedation in patients with acute brain injury","volume":"20","author":"Oddo","year":"2016","journal-title":"Crit. Care"},{"issue":"13","key":"10.1016\/j.bbr.2021.113200_bib0175","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.lfs.2006.12.022","article-title":"Anesthetic-mediated protection\/preconditioning during cerebral ischemia","volume":"80","author":"Clarkson","year":"2007","journal-title":"Life Sci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821000887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821000887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:27:29Z","timestamp":1759066049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432821000887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":35,"alternative-id":["S0166432821000887"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113200","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of Nrf-2\/HO-1 pathway in sevoflurane-induced cognitive improvement in rats with traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113200"}}