{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:05:27Z","timestamp":1792695927713,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.bbr.2021.113230","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T22:34:52Z","timestamp":1615070092000},"page":"113230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The absence of the aryl hydrocarbon receptor in the R6\/1 transgenic mouse model of Huntington\u2019s disease improves the neurological phenotype"],"prefix":"10.1016","volume":"408","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9874-1864","authenticated-orcid":false,"given":"Quetzalli D.","family":"Angeles-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Garc\u00eda-Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Aguirre-Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6940-5899","authenticated-orcid":false,"given":"Rolando","family":"Casta\u00f1eda-Arellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Elizondo-Azuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"P\u00e9rez-Severiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8215-4772","authenticated-orcid":false,"given":"Jos\u00e9","family":"Segovia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2021.113230_bib0005","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell."},{"key":"10.1016\/j.bbr.2021.113230_bib0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jns.2018.09.022","article-title":"Huntington disease: a quarter century of progress since the gene discovery","volume":"396","author":"Testa","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbr.2021.113230_bib0015","series-title":"Handb. Clin. Neurol.","first-page":"255","article-title":"Huntington disease","author":"Ghosh","year":"2018"},{"key":"10.1016\/j.bbr.2021.113230_bib0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ana.410310412","article-title":"Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington\u2019s disease","volume":"31","author":"Albin","year":"1992","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2021.113230_bib0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0006-8993(00)02082-5","article-title":"Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington\u2019s disease","volume":"862","author":"P\u00e9rez-Severiano","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2021.113230_bib0030","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1023\/B:NERE.0000018843.83770.4b","article-title":"Increased formation of reactive oxygen species, but No changes in glutathione peroxidase activity, in Striata of mice transgenic for the Huntington\u2019s disease mutation","volume":"29","author":"P\u00e9rez-Severiano","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2021.113230_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a024240","article-title":"Huntington\u2019s disease: mechanisms of pathogenesis and therapeutic strategies","volume":"7","author":"Jimenez-Sanchez","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbr.2021.113230_bib0040","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","article-title":"Role of brain-derived neurotrophic factor in Huntington\u2019s disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2021.113230_bib0045","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntinqton\u2019s disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbr.2021.113230_bib0050","doi-asserted-by":"crossref","first-page":"22480","DOI":"10.1073\/pnas.0911503106","article-title":"Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms","volume":"106","author":"Bradford","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2021.113230_bib0055","first-page":"487","article-title":"Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington\u2019s disease mouse model","volume":"28","author":"Wood","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2021.113230_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnana.2017.00004","article-title":"Embryonic and postnatal expression of aryl hydrocarbon receptor mRNA in mouse brain","volume":"11","author":"Kimura","year":"2017","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.bbr.2021.113230_bib0065","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.21947","article-title":"TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain","volume":"31","author":"Gonz\u00e1lez-Barbosa","year":"2017","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbr.2021.113230_bib0070","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrc3846","article-title":"Aryl hydrocarbon receptor ligands in cancer: friend and foe","volume":"14","author":"Murray","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbr.2021.113230_bib0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/toxsci\/kfq024","article-title":"Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling","volume":"115","author":"DiNatale","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbr.2021.113230_bib0080","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.4049\/jimmunol.0903670","article-title":"An interaction between Kynurenine and the aryl hydrocarbon receptor can generate regulatory t cells","volume":"185","author":"Mezrich","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbr.2021.113230_bib0085","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1073\/pnas.85.11.4079","article-title":"3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims","volume":"85","author":"Schwarcz","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2021.113230_bib0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.nbd.2004.07.006","article-title":"Neostriatal and cortical quinolinate levels are increased in early grade Huntington\u2019s disease","volume":"17","author":"Guidetti","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2021.113230_bib0095","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1471-4159.1990.tb03143.x","article-title":"Kynurenine pathway measurements in Huntington\u2019s disease striatum: evidence for reduced formation of kynurenic acid","volume":"55","author":"Beal","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2021.113230_bib0100","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0022-510X(92)90191-M","article-title":"Kynurenic acid concentrations are reduced in Huntington\u2019s disease cerebral cortex","volume":"108","author":"Flint Beal","year":"1992","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbr.2021.113230_bib0105","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0006-8993(82)91048-4","article-title":"An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid","volume":"247","author":"Perkins","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2021.113230_bib0110","series-title":"Adv. Exp. Med. Biol","first-page":"389","article-title":"Indole-3-pyruvic and -propionic acids, kynurenic acid, and related metabolites as luminophores and free-radical scavengers","author":"Hardeland","year":"2000"},{"key":"10.1016\/j.bbr.2021.113230_bib0115","doi-asserted-by":"crossref","DOI":"10.1007\/s00894-015-2758-2","article-title":"Free-radical scavenging by tryptophan and its metabolites through electron transfer based processes","volume":"21","author":"P\u00e9rez-Gonz\u00e1lez","year":"2015","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.bbr.2021.113230_bib0120","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1476-5381.1991.tb12274.x","article-title":"A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat","volume":"102","author":"Winn","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113230_bib0125","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.05.020","article-title":"Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration","volume":"145","author":"Zwilling","year":"2011","journal-title":"Cell."},{"key":"10.1016\/j.bbr.2021.113230_bib0130","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00702-010-0573-6","article-title":"Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington\u2019s disease","volume":"118","author":"Z\u00e1dori","year":"2011","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.bbr.2021.113230_bib0135","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cub.2011.04.028","article-title":"The kynurenine pathway modulates neurodegeneration in a drosophila model of Huntington\u2019s disease","volume":"21","author":"Campesan","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbr.2021.113230_bib0140","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/jnr.23595","article-title":"Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress","volume":"93","author":"Garc\u00eda-Lara","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbr.2021.113230_bib0145","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1471-4159.2009.06364.x","article-title":"Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons","volume":"111","author":"Lin","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2021.113230_bib0150","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon I of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell."},{"key":"10.1016\/j.bbr.2021.113230_bib0155","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.neuroscience.2003.08.053","article-title":"Molecular and behavioral analysis of the R6\/1 Huntington\u2019s disease transgenic mouse","volume":"122","author":"Naver","year":"2003","journal-title":"Neuroscience."},{"key":"10.1016\/j.bbr.2021.113230_bib0160","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1126\/science.7732381","article-title":"Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor","volume":"268","author":"Fernandez-Salguero","year":"1995","journal-title":"Science (80-.)"},{"key":"10.1016\/j.bbr.2021.113230_bib0165","first-page":"1","article-title":"Norma Oficial Mexicana, Especificaciones t\u00e9cnicas para la producci\u00f3n, cuidado y uso de los animales de laboratorio","author":"Ochoa","year":"1999","journal-title":"Nom-062-Zoo."},{"key":"10.1016\/j.bbr.2021.113230_bib0170","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s10571-011-9725-y","article-title":"Adenoviral astrocyte-specific expression of BDNF in the striata of mice transgenic for Huntington\u2019s disease delays the onset of the motor phenotype","volume":"31","author":"Arregui","year":"2011","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2021.113230_bib0175","series-title":"The Open Field Test","first-page":"1","author":"Gould","year":"2009"},{"key":"10.1016\/j.bbr.2021.113230_bib0180","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0091-3057(98)00031-8","article-title":"A new approach to the light\/dark test procedure in mice","volume":"60","author":"Hasco\u00ebt","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2021.113230_bib0185","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-60761-303-9_11","article-title":"The mouse light-dark box test","volume":"42","author":"Hasco\u00ebt","year":"2003","journal-title":"Neuromethods."},{"key":"10.1016\/j.bbr.2021.113230_bib0190","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1212\/01.WNL.0000031791.10922.CF","article-title":"Weight loss in early stage of Huntington\u2019s disease","volume":"59","author":"Djouss\u00e9","year":"2002","journal-title":"Neurology."},{"key":"10.1016\/j.bbr.2021.113230_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2008.06.005","article-title":"Rodent genetic models of Huntington disease","volume":"32","author":"Heng","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2021.113230_bib0200","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.brainresrev.2011.02.005","article-title":"Brain regions and genes affecting limb-clasping responses","volume":"67","author":"Lalonde","year":"2011","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.bbr.2021.113230_bib0205","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1046\/j.0953-816x.2001.01767.x","article-title":"Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene","volume":"14","author":"Hansson","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113230_bib0210","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jnr.1153","article-title":"Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington\u2019s disease gene","volume":"65","author":"Ishiguro","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbr.2021.113230_bib0215","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.expneurol.2007.12.026","article-title":"The metabolic profile of early Huntington\u2019s disease- a combined human and transgenic mouse study","volume":"210","author":"Goodman","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2021.113230_bib0220","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1212\/WNL.0b013e3181af0cf4","article-title":"Weight loss in Huntington disease increases with higher CAG repeat number","volume":"73","author":"Gilbert","year":"2009","journal-title":"Neurology."},{"key":"10.1016\/j.bbr.2021.113230_bib0225","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0165-6147(00)01884-8","article-title":"Mouse models of Huntington\u2019s disease","volume":"23","author":"Menalled","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbr.2021.113230_bib0230","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1281","article-title":"Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice","volume":"3","author":"Renoir","year":"2011","journal-title":"PLoS Curr."},{"key":"10.1016\/j.bbr.2021.113230_bib0235","first-page":"1","article-title":"Host\u2013microbiome interactions: the aryl hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling","author":"Ma","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbr.2021.113230_bib0240","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jphs.2019.11.004","article-title":"Involvement of the dopamine D1 receptor system in the anxiolytic effect of cedrol in the elevated plus maze and light\u2013dark box tests","volume":"142","author":"Zhang","year":"2020","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bbr.2021.113230_bib0245","doi-asserted-by":"crossref","first-page":"R289","DOI":"10.1152\/ajpregu.00029.2019","article-title":"Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor","volume":"317","author":"Aguiniga","year":"2019","journal-title":"Am. J. Physiol. - Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbr.2021.113230_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2019.00258","article-title":"The role of microglia and astrocytes in Huntington\u2019s disease","volume":"12","author":"Palpagama","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2021.113230_bib0255","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","article-title":"Neurological abnormalities in a knock-in mouse model of Huntington\u2019s disease","volume":"10","author":"Lin","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2021.113230_bib0260","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1093\/hmg\/ddq212","article-title":"In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington\u2019s disease subjects","volume":"19","author":"Faideau","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2021.113230_bib0265","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1161\/CIRCULATIONAHA.114.011394","article-title":"L-kynurenine\/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke","volume":"130","author":"Cuartero","year":"2014","journal-title":"Circulation."},{"key":"10.1016\/j.bbr.2021.113230_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-019-1572-7","article-title":"Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain","volume":"16","author":"Chen","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbr.2021.113230_bib0275","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21061983","article-title":"Aryl hydrocarbon receptor in post-mortem hippocampus and in serum from young, elder, and alzheimer\u2019s patients","volume":"21","author":"Ramos-Garc\u00eda","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2021.113230_bib0280","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tins.2015.07.006","article-title":"Do stars govern our actions? Astrocyte involvement in rodent behavior","volume":"38","author":"Oliveira","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2021.113230_bib0285","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/hmg\/ddt036","article-title":"A critical role of astrocyte-mediated nuclear factor-\u03baB-dependent inflammation in huntington\u2019s disease","volume":"22","author":"Hsiao","year":"2013","journal-title":"Hum. Mol. Genet."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821001182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821001182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:29:38Z","timestamp":1759066178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432821001182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":57,"alternative-id":["S0166432821001182"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113230","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The absence of the aryl hydrocarbon receptor in the R6\/1 transgenic mouse model of Huntington\u2019s disease improves the neurological phenotype","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113230"}}