{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:41:17Z","timestamp":1788777677489,"version":"build-2803163510"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 MH099114"],"award-info":[{"award-number":["R01 MH099114"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K01 MH094464"],"award-info":[{"award-number":["K01 MH094464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["F31 MH099807"],"award-info":[{"award-number":["F31 MH099807"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 EY030169"],"award-info":[{"award-number":["R01 EY030169"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.bbr.2021.113378","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T16:46:34Z","timestamp":1621615594000},"page":"113378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Genetic disruption of Grm5 causes complex alterations in motor activity, anxiety and social behaviors"],"prefix":"10.1016","volume":"411","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5143-8550","authenticated-orcid":false,"given":"Jian","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Kraniotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8786-831X","authenticated-orcid":false,"given":"Toshihiro","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis","family":"Contractor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2021.113378_bib0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","article-title":"Metabotropic glutamate receptors: physiology, pharmacology, and disease","volume":"50","author":"Niswender","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbr.2021.113378_bib0010","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1523\/JNEUROSCI.17-13-05196.1997","article-title":"Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP","volume":"17","author":"Lu","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0015","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.neuropharm.2009.01.002","article-title":"Metabotropic glutamate receptor-dependent long-term potentiation","volume":"56","author":"Anwyl","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0020","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.288.5469.1254","article-title":"Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression","volume":"288","author":"Huber","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbr.2021.113378_bib0025","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuron.2010.01.016","article-title":"Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease","volume":"65","author":"Luscher","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113378_bib0030","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2004.08.036","article-title":"Endocannabinoid-mediated metaplasticity in the hippocampus","volume":"43","author":"Chevaleyre","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113378_bib0035","doi-asserted-by":"crossref","first-page":"16762","DOI":"10.1523\/JNEUROSCI.2869-13.2014","article-title":"Hippocampal metaplasticity is required for the formation of temporal associative memories","volume":"34","author":"Xu","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0040","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1523\/JNEUROSCI.21-16-05925.2001","article-title":"Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function","volume":"21","author":"Mannaioni","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0045","doi-asserted-by":"crossref","first-page":"10238","DOI":"10.1523\/JNEUROSCI.23-32-10238.2003","article-title":"Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5","volume":"23","author":"Sourdet","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0050","doi-asserted-by":"crossref","first-page":"13028","DOI":"10.1523\/JNEUROSCI.2600-08.2008","article-title":"mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex","volume":"28","author":"Wijetunge","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0055","doi-asserted-by":"crossref","first-page":"E305","DOI":"10.1073\/pnas.1214705110","article-title":"Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening","volume":"110","author":"Oh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2021.113378_bib0060","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/npp.2009.30","article-title":"mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning","volume":"34","author":"Ayala","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0065","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/cercor\/bhq147","article-title":"Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons","volume":"21","author":"Fontanez-Nuin","year":"2011","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbr.2021.113378_bib0070","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1101\/lm.031666.113","article-title":"Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning","volume":"20","author":"Xu","year":"2013","journal-title":"Learn. Mem."},{"key":"10.1016\/j.bbr.2021.113378_bib0075","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.nbd.2010.05.001","article-title":"A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys","volume":"39","author":"Rylander","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2021.113378_bib0080","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13041-015-0113-2","article-title":"The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates","volume":"8","author":"Guimaraes","year":"2015","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbr.2021.113378_bib0085","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.biopsych.2016.04.023","article-title":"Increased metabotropic glutamate receptor 5 signaling underlies obsessive-compulsive disorder-like behavioral and striatal circuit abnormalities in mice","volume":"80","author":"Ade","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113378_bib0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13041-019-0441-8","article-title":"Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses","volume":"12","author":"Lim","year":"2019","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbr.2021.113378_bib0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2009.12.042","article-title":"Group 5 metabotropic glutamate receptors: role in modulating cortical activity and relevance to cognition","volume":"639","author":"Homayoun","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113378_bib0100","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejphar.2009.12.039","article-title":"Metabotropic glutamate receptor subtype 5 antagonism in learning and memory","volume":"639","author":"Simonyi","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113378_bib0105","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1073\/pnas.122205699","article-title":"Altered synaptic plasticity in a mouse model of fragile X mental retardation","volume":"99","author":"Huber","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2021.113378_bib0110","doi-asserted-by":"crossref","first-page":"11946","DOI":"10.1523\/JNEUROSCI.0672-16.2016","article-title":"Negative allosteric modulation of mGluR5 partially corrects pathophysiology in a mouse model of rett syndrome","volume":"36","author":"Tao","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0115","doi-asserted-by":"crossref","first-page":"11459","DOI":"10.1038\/ncomms11459","article-title":"Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2021.113378_bib0120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature10658","article-title":"Mutations causing syndromic autism define an axis of synaptic pathophysiology","volume":"480","author":"Auerbach","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2021.113378_bib0125","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/mp.2016.30","article-title":"Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice","volume":"22","author":"Vicidomini","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113378_bib0130","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation","volume":"27","author":"Bear","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0135","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fphar.2012.00199","article-title":"Translational concepts of mGluR5 in synaptic diseases of the brain","volume":"3","author":"Piers","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113378_bib0140","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuron.2007.12.001","article-title":"Correction of fragile X syndrome in mice","volume":"56","author":"Dolen","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113378_bib0145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuron.2012.03.009","article-title":"Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice","volume":"74","author":"Michalon","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113378_bib0150","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2012.04.009","article-title":"De novo gene disruptions in children on the autistic spectrum","volume":"74","author":"Iossifov","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113378_bib0155","article-title":"High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism","volume":"7","author":"Kelleher","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2021.113378_bib0160","doi-asserted-by":"crossref","first-page":"19372","DOI":"10.1038\/srep19372","article-title":"The Role of mGluR copy number variation in genetic and environmental forms of syndromic autism spectrum disorder","volume":"6","author":"Wenger","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2021.113378_bib0165","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbi.2015.05.009","article-title":"Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: pathophysiological and neurobehavioral implications","volume":"49","author":"Chana","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2021.113378_bib0170","doi-asserted-by":"crossref","first-page":"11125","DOI":"10.1523\/JNEUROSCI.4615-14.2015","article-title":"Inhibition of group I metabotropic glutamate receptors reverses autistic-like phenotypes caused by deficiency of the translation repressor eIF4E binding protein 2","volume":"35","author":"Aguilar-Valles","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0175","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/s41467-019-09382-9","article-title":"Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice","volume":"10","author":"Edfawy","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2021.113378_bib0180","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/npp.2009.201","article-title":"Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP","volume":"35","author":"Silverman","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0185","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003501","article-title":"Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism","volume":"4","author":"Silverman","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbr.2021.113378_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026077","article-title":"mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism","volume":"6","author":"Mehta","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2021.113378_bib0195","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(13)61539-1","article-title":"Autism","volume":"383","author":"Lai","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2021.113378_bib0200","first-page":"1","article-title":"Translational mouse models of autism: advancing toward pharmacological therapeutics","volume":"28","author":"Kazdoba","year":"2016","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0205","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1523\/JNEUROSCI.5716-08.2009","article-title":"mGluR5 has a critical role in inhibitory learning","volume":"29","author":"Xu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0210","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.celrep.2017.01.073","article-title":"Complete disruption of the kainate receptor gene family results in corticostriatal dysfunction in mice","volume":"18","author":"Xu","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbr.2021.113378_bib0215","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jneumeth.2006.05.008","article-title":"Rapid isolation of synaptoneurosomes and postsynaptic densities from adult mouse hippocampus","volume":"158","author":"Villasana","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2021.113378_bib0220","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.mcn.2010.07.011","article-title":"Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses","volume":"45","author":"Antion","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0225","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0091-3057(91)90590-X","article-title":"Evaluation of marble-burying behavior as a model of anxiety","volume":"38","author":"Njung\u2019e","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2021.113378_bib0230","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00213-009-1466-y","article-title":"Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety","volume":"204","author":"Thomas","year":"2009","journal-title":"Psychopharmacology"},{"issue":"11","key":"10.1016\/j.bbr.2021.113378_bib0235","article-title":"Behavioral phenotyping for autism Spectrum disorders in mice","volume":"72","author":"Chang","year":"2017","journal-title":"Curr. Protoc. Toxicol."},{"key":"10.1016\/j.bbr.2021.113378_bib0240","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbr.2011.10.032","article-title":"Differences in BTBR T+ tf\/J and C57BL\/6J mice on probabilistic reversal learning and stereotyped behaviors","volume":"227","author":"Amodeo","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113378_bib0245","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nature11782","article-title":"Exaggerated translation causes synaptic and behavioural aberrations associated with autism","volume":"493","author":"Santini","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2021.113378_bib0250","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aad0314","article-title":"The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbr.2021.113378_bib0255","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12506","article-title":"Autism-related behaviors in the cyclooxygenase-2-deficient mouse model","volume":"18","author":"Wong","year":"2019","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2021.113378_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026549","article-title":"Reversal of fragile X phenotypes by manipulation of AbetaPP\/Abeta levels in Fmr1KO mice","volume":"6","author":"Westmark","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2021.113378_bib0265","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1038\/npp.2014.105","article-title":"Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome","volume":"39","author":"De Filippis","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0270","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbr.2013.10.052","article-title":"Repetitive behavior profile and supersensitivity to amphetamine in the C58\/J mouse model of autism","volume":"259","author":"Moy","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113378_bib0275","doi-asserted-by":"crossref","first-page":"14653","DOI":"10.1038\/s41598-017-15028-x","article-title":"Multiple behavior phenotypes of the Fragile-X syndrome mouse model respond to chronic inhibition of Phosphodiesterase-4D (PDE4D)","volume":"7","author":"Gurney","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2021.113378_bib0280","first-page":"5","article-title":"Behavioral phenotyping of an improved mouse model of Phelan-McDermid syndrome with a complete deletion of the Shank3 gene","author":"Drapeau","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.bbr.2021.113378_bib0285","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0022-3565(24)39029-9","article-title":"Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents","volume":"295","author":"Spooren","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2021.113378_bib0290","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nrn2851","article-title":"Behavioural phenotyping assays for mouse models of autism","volume":"11","author":"Silverman","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0295","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature09965","article-title":"Shank3 mutant mice display autistic-like behaviours and striatal dysfunction","volume":"472","author":"Peca","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2021.113378_bib0300","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1038\/npp.2015.66","article-title":"GABAB receptor agonist R-Baclofen reverses social deficits and reduces repetitive behavior in two mouse models of autism","volume":"40","author":"Silverman","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0305","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12993-016-0087-y","article-title":"Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder","volume":"12","author":"Kim","year":"2016","journal-title":"Behav. Brain Funct.: BBF"},{"key":"10.1016\/j.bbr.2021.113378_bib0310","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbi.2012.01.011","article-title":"Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism","volume":"26","author":"Malkova","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2021.113378_bib0315","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1038\/tp.2013.16","article-title":"Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice","volume":"3","author":"Schwartzer","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113378_bib0320","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnsyn.2014.00017","article-title":"Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf\/J mice","volume":"6","author":"Amodeo","year":"2014","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0325","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","article-title":"The functional anatomy of basal ganglia disorders","volume":"12","author":"Albin","year":"1989","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0330","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature06104","article-title":"Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice","volume":"448","author":"Welch","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2021.113378_bib0335","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0006-8993(97)01141-4","article-title":"Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons","volume":"780","author":"Tallaksen-Greene","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2021.113378_bib0340","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nn0901-873","article-title":"Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice","volume":"4","author":"Chiamulera","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0345","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0306-4522(01)00297-4","article-title":"Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons","volume":"106","author":"Pisani","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2021.113378_bib0350","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0896-6273(00)80810-7","article-title":"Coupling of mGluR\/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins","volume":"23","author":"Tu","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113378_bib0355","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nn.2741","article-title":"Dendritic spine pathology in neuropsychiatric disorders","volume":"14","author":"Penzes","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0360","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-neuro-062111-150442","article-title":"Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders","volume":"35","author":"Ting","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0365","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/WCO.0000000000000186","article-title":"Autism and the synapse: emerging mechanisms and mechanism-based therapies","volume":"28","author":"Ebrahimi-Fakhari","year":"2015","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.bbr.2021.113378_bib0370","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature11208","article-title":"Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function","volume":"486","author":"Won","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2021.113378_bib0375","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fncel.2014.00087","article-title":"Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator","volume":"8","author":"Lin","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0380","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/gbb.12256","article-title":"Behavioral phenotypes of genetic mouse models of autism","volume":"15","author":"Kazdoba","year":"2016","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2021.113378_bib0385","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/gbb.12405","article-title":"Comprehensive analysis of two Shank3 and the Cacna1c mouse models of autism spectrum disorder","volume":"17","author":"Kabitzke","year":"2018","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2021.113378_bib0390","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00213-011-2375-4","article-title":"Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome","volume":"219","author":"Thomas","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2004.11.010","article-title":"Contrasting grooming phenotypes in three mouse strains markedly different in anxiety and activity (129S1, BALB\/c and NMRI)","volume":"160","author":"Kalueff","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113378_bib0400","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/1362361301005003005","article-title":"Anxiety in high-functioning children with autism","volume":"5","author":"Gillott","year":"2001","journal-title":"Autism"},{"key":"10.1016\/j.bbr.2021.113378_bib0405","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2006.08.055","article-title":"Antiaggressive effects of MPEP, a selective antagonist of mGlu5 receptors, in agonistic interactions between male mice","volume":"551","author":"Navarro","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113378_bib0410","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s12035-013-8535-2","article-title":"Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring","volume":"49","author":"Kim","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2021.113378_bib0415","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nn.3927","article-title":"Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression","volume":"18","author":"Chung","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2021.113378_bib0420","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainresbull.2011.08.001","article-title":"Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: possible implications for the pharmacotherapy of autism spectrum disorders","volume":"86","author":"Burket","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2021.113378_bib0425","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2021.113378_bib0430","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbr.2006.07.030","article-title":"Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains","volume":"176","author":"Moy","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113378_bib0435","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbr.2010.04.054","article-title":"C57BL\/6J mice fail to exhibit preference for social novelty in the three-chamber apparatus","volume":"213","author":"Pearson","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113378_bib0440","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0091-3057(02)00828-6","article-title":"Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone","volume":"73","author":"Brodkin","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2021.113378_bib0445","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1124\/jpet.105.089839","article-title":"Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity","volume":"315","author":"Porter","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2021.113378_bib0450","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015085","article-title":"Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5)","volume":"5","author":"Olsen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2021.113378_bib0455","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1756-6606-7-40","article-title":"Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer\u2019s disease","volume":"7","author":"Hamilton","year":"2014","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbr.2021.113378_bib0460","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejphar.2005.03.028","article-title":"Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats","volume":"514","author":"Pietraszek","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113378_bib0465","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuropharm.2009.04.011","article-title":"The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning","volume":"57","author":"Jacob","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0470","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0028-3908(02)00332-5","article-title":"The mGluR5 antagonist MPEP, but not the mGluR2\/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity","volume":"43","author":"Henry","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0475","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1124\/jpet.103.048702","article-title":"Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents","volume":"306","author":"Kinney","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2021.113378_bib0480","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1124\/jpet.106.103143","article-title":"Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice","volume":"319","author":"Li","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2021.113378_bib0485","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s00213-003-1733-2","article-title":"Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice","volume":"174","author":"McGeehan","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0490","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0014-2999(00)00697-X","article-title":"Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats","volume":"406","author":"Spooren","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113378_bib0495","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuropharm.2005.01.027","article-title":"mGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition","volume":"49","author":"Pietraszek","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0500","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbr.2008.03.032","article-title":"MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats","volume":"191","author":"Christoffersen","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113378_bib0505","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1093\/hmg\/ddt598","article-title":"Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington\u2019s disease","volume":"23","author":"Ribeiro","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2021.113378_bib0510","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070415","article-title":"mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion","volume":"8","author":"Jew","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2021.113378_bib0515","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00213-019-05367-0","article-title":"mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity","volume":"237","author":"Wu","year":"2020","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113378_bib0520","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1093\/hmg\/ddx279","article-title":"Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors","volume":"26","author":"Jhang","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2021.113378_bib0525","doi-asserted-by":"crossref","first-page":"18335","DOI":"10.1038\/srep18335","article-title":"Characterization of social behaviors in caspase-3 deficient mice","volume":"6","author":"Lo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2021.113378_bib0530","doi-asserted-by":"crossref","first-page":"34839","DOI":"10.1074\/jbc.M111.258384","article-title":"Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses","volume":"286","author":"Verpelli","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2021.113378_bib0535","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fpsyt.2019.00038","article-title":"Brain mGluR5 in Shank3B(-\/-) mice studied with in vivo [(18)F]FPEB PET imaging and ex vivo immunoblotting","volume":"10","author":"Cai","year":"2019","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113378_bib0540","doi-asserted-by":"crossref","first-page":"16896","DOI":"10.1523\/JNEUROSCI.2462-10.2010","article-title":"mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation","volume":"30","author":"Ballester-Rosado","year":"2010","journal-title":"J. Neurosci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821002667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821002667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:23:43Z","timestamp":1778671423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432821002667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":108,"alternative-id":["S0166432821002667"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113378","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic disruption of Grm5 causes complex alterations in motor activity, anxiety and social behaviors","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113378"}}