{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:13:37Z","timestamp":1768252417375,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R00DA040744"],"award-info":[{"award-number":["R00DA040744"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bbr.2021.113644","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T20:20:03Z","timestamp":1635452403000},"page":"113644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference"],"prefix":"10.1016","volume":"418","author":[{"given":"C.J.","family":"Babigian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.","family":"Wiedner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Wahlestedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.C.","family":"Sartor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2021.113644_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.semcdb.2009.01.005","article-title":"Histone acetylation in drug addiction","volume":"20","author":"Renthal","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbr.2021.113644_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrn3427","article-title":"Histone acetylation: molecular mnemonics on the chromatin","volume":"14","author":"Gr\u00e4ff","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2021.113644_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/npp.2012.86","article-title":"The role of histone acetylation in memory formation and cognitive impairments","volume":"38","author":"Peixoto","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib4","doi-asserted-by":"crossref","first-page":"764","DOI":"10.2174\/1871527314666150529144804","article-title":"Histone deacetylases as potential targets for cocaine addiction","volume":"14","author":"Kennedy","year":"2015","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.bbr.2021.113644_bib5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pharmthera.2016.07.001","article-title":"Modulating epigenetic HAT activity for reinstating acetylation homeostasis: a promising therapeutic strategy for neurological disorders","volume":"166","author":"Ganai","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbr.2021.113644_bib6","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018762","article-title":"Writers and readers of histone acetylation: structure, mechanism, and inhibition","volume":"6","author":"Marmorstein","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbr.2021.113644_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbr.2021.113644_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuron.2005.09.023","article-title":"Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum","volume":"48","author":"Kumar","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113644_bib9","doi-asserted-by":"crossref","first-page":"19186","DOI":"10.1073\/pnas.0509735102","article-title":"CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum","volume":"102","author":"Levine","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2021.113644_bib10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuron.2009.03.026","article-title":"Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins","volume":"62","author":"Renthal","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113644_bib11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nn.3354","article-title":"Class I HDAC inhibition blocks cocaine-induced plasticity through targeted changes in histone methylation","volume":"16","author":"Kennedy","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2021.113644_bib12","doi-asserted-by":"crossref","unstructured":"M. Malvaez, S.C. McQuown, G.A. Rogge, M. Astarabadi, V. Jacques, S. Carreiro, J.R. Rusche, M.A. Wood, HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner, Proc. Natl. Acad. Sci. USA 110, 2013 2647\u20132652. https:\/\/doi.org\/10.1073\/pnas.1213364110.","DOI":"10.1073\/pnas.1213364110"},{"key":"10.1016\/j.bbr.2021.113644_bib13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biopsych.2009.07.032","article-title":"Modulation of chromatin modification facilitates extinction of cocaine\u2013induced conditioned place preference","volume":"67","author":"Malvaez","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113644_bib14","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1523\/JNEUROSCI.4472-12.2013","article-title":"HDAC3 is a negative regulator of cocaine-context-associated memory formation","volume":"33","author":"Rogge","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113644_bib15","doi-asserted-by":"crossref","first-page":"15062","DOI":"10.1523\/JNEUROSCI.0826-15.2015","article-title":"Epigenetic readers of lysine acetylation regulate cocaine-induced plasticity","volume":"35","author":"Sartor","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113644_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12808","article-title":"Role of BRD4 phosphorylation in the nucleus accumbens in relapse to cocaine-seeking behavior in mice","volume":"25","author":"Guo","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.bbr.2021.113644_bib17","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1523\/JNEUROSCI.1604-18.2018","article-title":"Enhancement of BDNF expression and memory by HDAC inhibition requires BET bromodomain reader proteins","volume":"39","author":"Sartor","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113644_bib18","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1177\/0269881109102613","article-title":"Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors","volume":"24","author":"Thanos","year":"2010","journal-title":"J. Psychopharmacol. Oxf. Engl."},{"key":"10.1016\/j.bbr.2021.113644_bib19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000327680","article-title":"Critical evaluation of the use of extinction paradigms for the assessment of opioid-induced conditioned place preference in rats","volume":"87","author":"Rutten","year":"2011","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00213-013-3117-6","article-title":"The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice","volume":"229","author":"Ignatowska-Jankowska","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fnbeh.2020.00075","article-title":"Ketamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in mice","volume":"14","author":"McKendrick","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2021.113644_bib22","doi-asserted-by":"crossref","first-page":"40545","DOI":"10.1074\/jbc.M402229200","article-title":"Regulation of histone acetylation during memory formation in the hippocampus","volume":"279","author":"Levenson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2021.113644_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057816","article-title":"Detection of histone acetylation levels in the dorsal hippocampus reveals early tagging on specific residues of H2B and H4 histones in response to learning","volume":"8","author":"Bousiges","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2021.113644_bib24","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/npp.2016.274","article-title":"Context and auditory fear are differentially regulated by HDAC3 activity in the lateral and basal subnuclei of the amygdala","volume":"42","author":"Kwapis","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib25","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/nn.4095","article-title":"BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice","volume":"18","author":"Korb","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2021.113644_bib26","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1084\/jem.20151271","article-title":"Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice","volume":"212","author":"Sullivan","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbr.2021.113644_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.202","article-title":"The BET\/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice","volume":"7","author":"Benito","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113644_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0169-328X(00)00246-1","article-title":"Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus11Published on the World Wide Web on 28 November 2000","volume":"85","author":"Kenny","year":"2000","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.bbr.2021.113644_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0006-8993(01)03400-X","article-title":"The ability of amphetamine to evoke arc (Arg 3.1) mRNA expression in the caudate, nucleus accumbens and neocortex is modulated by environmental context","volume":"930","author":"Klebaur","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2021.113644_bib30","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s11064-005-7047-5","article-title":"Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression","volume":"30","author":"Saito","year":"2005","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2021.113644_bib31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/npp.2008.58","article-title":"NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala","volume":"34","author":"Kenny","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib32","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1007\/s00213-014-3476-7","article-title":"Involvement of nucleus accumbens AMPA receptor trafficking in augmentation of D- amphetamine reward in food-restricted rats","volume":"231","author":"Peng","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2015.08.008","article-title":"Dopamine-sensitive signaling mediators modulate psychostimulant-induced ultrasonic vocalization behavior in rats","volume":"296","author":"Williams","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113644_bib34","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.biopsych.2016.09.015","article-title":"Striatal H3K27 acetylation linked to glutamatergic gene dysregulation in human heroin abusers holds promise as therapeutic target","volume":"81","author":"Egervari","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113644_bib35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00213-008-1164-1","article-title":"Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats","volume":"199","author":"Bahi","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.1222265","article-title":"BDNF is a negative modulator of morphine action","volume":"338","author":"Koo","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbr.2021.113644_bib37","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1016\/j.celrep.2018.08.080","article-title":"Single-cell RNA-seq uncovers a robust transcriptional response to morphine by glia","volume":"24","author":"Avey","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbr.2021.113644_bib38","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1111\/adb.12449","article-title":"Behavioral and transcriptional patterns of protracted opioid self-administration in mice","volume":"22","author":"Skupio","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.bbr.2021.113644_bib39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuroscience.2018.07.032","article-title":"Chronic oxycodone self-administration altered reward-related genes in the ventral and dorsal striatum of C57BL\/6J mice: an RNA-seq analysis","volume":"393","author":"Zhang","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2021.113644_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108255","article-title":"BET proteins inhibitor JQ-1 impaired the extinction of remote auditory fear memory: an effect mediated by insulin like growth factor 2","volume":"177","author":"Duan","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib41","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cell.2017.07.033","article-title":"Excess translation of epigenetic regulators contributes to Fragile X Syndrome and is alleviated by Brd4 inhibition","volume":"170","author":"Korb","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2021.113644_bib42","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2174\/1567205013666160427101832","article-title":"The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation at Ser396 in the brain of the 3xTg model of Alzheimer\u2019s disease","volume":"13","author":"Magistri","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbr.2021.113644_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108306","article-title":"BET bromodomains as novel epigenetic targets for brain health and disease","volume":"181","author":"Singh","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113644_bib44","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2021.113644_bib45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40256-015-0146-z","article-title":"Effect of the BET protein inhibitor, RVX-208, on progression of coronary atherosclerosis: results of the phase 2b, randomized, double-blind, multicenter, ASSURE trial","volume":"16","author":"Nicholls","year":"2016","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.bbr.2021.113644_bib46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13148-019-0696-z","article-title":"Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism","volume":"11","author":"Tsujikawa","year":"2019","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.bbr.2021.113644_bib47","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.bmc.2019.03.037","article-title":"Binding pocket-based design, synthesis and biological evaluation of novel selective BRD4-BD1 inhibitors","volume":"27","author":"Ma","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbr.2021.113644_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41401-020-0366-x","article-title":"Y06014 is a selective BET inhibitor for the treatment of prostate cancer","author":"Wu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbr.2021.113644_bib49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1126\/science.aaz8455","article-title":"Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation","volume":"368","author":"Gilan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bbr.2021.113644_bib50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2016.06.021","article-title":"RVX-297- a novel BD2 selective inhibitor of BET bromodomains","volume":"477","author":"Kharenko","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821005325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821005325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:33:34Z","timestamp":1759066414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432821005325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":50,"alternative-id":["S0166432821005325"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113644","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113644"}}