{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:43:53Z","timestamp":1762508633738,"version":"3.44.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bbr.2021.113651","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T18:22:53Z","timestamp":1635704573000},"page":"113651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Antipanic-like effect of esketamine and buprenorphine in rats exposed to acute hypoxia"],"prefix":"10.1016","volume":"418","author":[{"given":"Jhonatan Christian","family":"Maraschin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana Tercino","family":"Frias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma Molina","family":"Hernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Fitipaldi","family":"Batistela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Motta","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e2mia Regiane Louren\u00e7o","family":"Joca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico Guilherme","family":"Graeff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth Aparecida","family":"Audi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Telma Gon\u00e7alves Carneiro","family":"Spera de Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"H\u00e9lio","family":"Zangrossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2021.113651_bib1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/ijnp\/pyz041","article-title":"R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism","volume":"22","author":"Ago","year":"2019","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4103\/0253-7176.211765","article-title":"Anxiety treatment of opioid dependent patients with buprenorphine: a randomized, double-blind, clinical trial","volume":"39","author":"Ahmadi","year":"2017","journal-title":"Indian J. Psychol. Med."},{"year":"2013","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","key":"10.1016\/j.bbr.2021.113651_bib3"},{"key":"10.1016\/j.bbr.2021.113651_bib4","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.neuropharm.2016.02.003","article-title":"Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin\/orphanin FQ receptor ligands","volume":"105","author":"Asth","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113651_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2021.113651_bib6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1037\/0021-843X.108.3.473","article-title":"Exaggerated anxiety is not unique to CO2 in panic disorder: a comparison of hypercapnic and hypoxic challenges","volume":"108","author":"Beck","year":"1999","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.bbr.2021.113651_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/ijnp\/pyx077","article-title":"Effects of buprenorphine on responses to emotional stimuli in individuals with a range of mood symptomatology","volume":"21","author":"Bershad","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbr.2014.10.014","article-title":"Antidepressant-like effects of buprenorphine in rats are strain dependent","volume":"278","author":"Browne","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113651_bib9","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1017\/S146114570999112X","article-title":"Panicolytic-like effect of BDNF in the rat dorsal periaqueductal grey matter: The role of 5-HT and GABA","volume":"13","author":"Casarotto","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.euroneuro.2015.03.004","article-title":"BDNF-TRKB signaling system of the dorsal periaqueductal gray matter is implicated in the panicolytic-like effect of antidepressant drugs","volume":"25","author":"Casarotto","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib11","unstructured":"CIOMS, ICLAS, 2012. International Guiding Principles for Biomedical Research Involving Animals, Revised. ed, International guiding principles for biomedical research involving animals. Council for International Organizations of Medical Sciences (CIOMS) and the International Council for Laboratory Animal Science (ICLAS), Geneva, Switzerland."},{"key":"10.1016\/j.bbr.2021.113651_bib12","first-page":"416","article-title":"Opioid Use Disorder: Medical Treatment Options","volume":"100","author":"Coffa","year":"2019","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.bbr.2021.113651_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/108135","article-title":"Panic Disorder: Is the PAG Involved?","volume":"2009","author":"Del-Ben","year":"2009","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbr.2021.113651_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2019.172837","article-title":"Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine","volume":"188","author":"Deyama","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2021.113651_bib15","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1038\/npp.2014.330","article-title":"Evaluation of Opioid Modulation in Major Depressive Disorder","volume":"40","author":"Ehrich","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113651_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neulet.2017.04.043","article-title":"The effects of methamphetamine and buprenorphine, and their interaction on anxiety-like behavior and locomotion in male rats","volume":"655","author":"Etaee","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2021.113651_bib17","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00213-014-3723-y","article-title":"Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice","volume":"232","author":"Falcon","year":"2015","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.bbr.2021.113651_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1176\/appi.ajp.2015.15070921","article-title":"Opioid Modulation With Buprenorphine\/Samidorphan as Adjunctive Treatment for Inadequate Response to Antidepressants: A Randomized Double-Blind Placebo-Controlled Trial","volume":"173","author":"Fava","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pnpbp.2019.02.003","article-title":"Nitric oxide in the dorsal periaqueductal gray mediates the panic-like escape response evoked by exposure to hypoxia. Prog","volume":"92","author":"Fernandes","year":"2019","journal-title":"Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.neuropharm.2018.05.009","article-title":"Ketamine facilitates extinction of avoidance behavior and enhances synaptic plasticity in a rat model of anxiety vulnerability: Implications for the pathophysiology and treatment of anxiety disorders","volume":"137","author":"Fortress","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113651_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpsychires.2018.02.006","article-title":"Anxiolytic effects of ascorbic acid and ketamine in mice","volume":"100","author":"Fraga","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2021.113651_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2019.02.016","article-title":"GABAA\/benzodiazepine receptors in the dorsal periaqueductal gray mediate the panicolytic but not the anxiolytic effect of alprazolam in rats","volume":"364","author":"Frias","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113651_bib23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00213-008-1112-0","article-title":"Anxiolytic-like effects of morphine and buprenorphine in the rat model of fear-potentiated startle: tolerance, cross-tolerance, and blockade by naloxone","volume":"198","author":"Glover","year":"2008","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.bbr.2021.113651_bib24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1176\/ajp.151.4.547","article-title":"Anxiogenic effects of CO2 and hyperventilation in patients with panic disorder","volume":"151","author":"Gorman","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neubiorev.2016.10.013","article-title":"Translational approach to the pathophysiology of panic disorder: Focus on serotonin and endogenous opioids","volume":"76","author":"Graeff","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2021.113651_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40122-019-00143-6","article-title":"A Narrative Pharmacological Review of Buprenorphine: A Unique Opioid for the Treatment of Chronic Pain","volume":"9","author":"Gudin","year":"2020","journal-title":"Pain. Ther."},{"key":"10.1016\/j.bbr.2021.113651_bib27","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/pcn.12902","article-title":"Rapid-acting antidepressant ketamine, its metabolites and other candidates: a historical overview and future perspective","volume":"73","author":"Hashimoto","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.bbr.2021.113651_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/FBP.0000000000000014","article-title":"Ketamine, but not MK-801, produces antidepressant-like effects in rats responding on a differential-reinforcement-of-low-rate operant schedule","volume":"25","author":"Hillhouse","year":"2014","journal-title":"Behav. Pharm."},{"key":"10.1016\/j.bbr.2021.113651_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jphs.2017.11.001","article-title":"Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine","volume":"135","author":"Ide","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bbr.2021.113651_bib30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.psyneuen.2012.05.002","article-title":"Reduced fear-recognition sensitivity following acute buprenorphine administration in healthy volunteers","volume":"38","author":"Ipser","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2021.113651_bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fphar.2017.00978","article-title":"S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression","volume":"8","author":"du Jardin","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib32","first-page":"355","article-title":"Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent \u03b4-opioid pathways","volume":"61","author":"Javelot","year":"2010","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib33","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neubiorev.2014.07.027","article-title":"Etiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory-induced panic attacks","volume":"46","author":"Johnson","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2021.113651_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.116778","article-title":"Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents","volume":"412","author":"Kalmoe","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbr.2021.113651_bib35","doi-asserted-by":"crossref","first-page":"e785","DOI":"10.4088\/JCP.13m08725","article-title":"Safety, Tolerability, and Clinical Effect of Low-Dose Buprenorphine for Treatment-Resistant Depression in Midlife and Older Adults","volume":"75","author":"Karp","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108717","article-title":"Ketamine-induced antidepressant like effects in mice: A possible involvement of cannabinoid system","volume":"112","author":"Khakpai","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbr.2021.113651_bib37","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/ajhp\/zxaa191","article-title":"Intranasal esketamine: A novel drug for treatment-resistant depression","volume":"77","author":"Khorassani","year":"2020","journal-title":"Am. J. Heal. Pharm."},{"key":"10.1016\/j.bbr.2021.113651_bib38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/neu.2014.17","article-title":"Effects of single and combined gabapentin use in elevated plus maze and forced swimming tests","volume":"26","author":"Kilic","year":"2014","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.bbr.2021.113651_bib39","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/ajad.12860","article-title":"Buprenorphine for the treatment of posttraumatic stress disorder","volume":"28","author":"Lake","year":"2019","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.bbr.2021.113651_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112631","article-title":"Ketamine\u2019s dose related multiple mechanisms of actions: dissociative anesthetic to rapid antidepressant","volume":"390","author":"Lavender","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113651_bib41","first-page":"102","article-title":"Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation. Prog. Neuro-Psychopharmacology","volume":"93","author":"Lee","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib42","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbr.2021.113651_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2017.03.033","article-title":"Participation of dorsal periaqueductal gray 5-HT1A receptors in the panicolytic-like effect of the \u03ba-opioid receptor antagonist Nor-BNI","volume":"327","author":"Maraschin","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113651_bib44","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuropharm.2015.09.008","article-title":"Opiorphin causes a panicolytic-like effect in rat panic models mediated by \u03bc-opioid receptors in the dorsal periaqueductal gray","volume":"101","author":"Maraschin","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113651_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112263","article-title":"Effects of the adjunctive treatment of antidepressants with opiorphin on a panic-like defensive response in rats","volume":"378","author":"Maraschin","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113651_bib46","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/s41467-017-01709-8","article-title":"TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response","volume":"8","author":"Ma","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2021.113651_bib47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/bjaceaccp\/mku041","article-title":"Opioid receptors","volume":"15","author":"McDonald","year":"2015","journal-title":"BJA Educ."},{"key":"10.1016\/j.bbr.2021.113651_bib48","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/jnc.14544","article-title":"Subanesthetic ketamine reverses neuronal and astroglial metabolic activity deficits in a social defeat model of depression","volume":"146","author":"Mishra","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2021.113651_bib49","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/2045125316631267","article-title":"Ketamine enantiomers in the rapid and sustained antidepressant effects","volume":"6","author":"Muller","year":"2016","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib50","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-0447.2009.01408.x","article-title":"Respiratory patterns in panic disorder reviewed: a focus on biological challenge tests","volume":"120","author":"Niccolai","year":"2009","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.bbr.2021.113651_bib51","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1523\/JNEUROSCI.4998-12.2013","article-title":"Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation","volume":"33","author":"Nosyreva","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113651_bib52","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/JCP.0b013e31818638a4","article-title":"Opiate Treatment in Depression Refractory to Antidepressants and Electroconvulsive Therapy","volume":"28","author":"Nyhuis","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4088\/JCP.19r12889","article-title":"Efficacy of Esketamine Augmentation in Major Depressive Disorder","volume":"81","author":"Papakostas","year":"2020","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib54","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/cpr.12804","article-title":"Rapid anti\u2010depressant\u2010like effects of ketamine and other candidates: Molecular and cellular mechanisms","volume":"53","author":"Peng","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bbr.2021.113651_bib55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.0924-2708.2004.0080.x","article-title":"Panic disorder: from respiration to the homeostatic brain","volume":"16","author":"Perna","year":"2004","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.bbr.2021.113651_bib56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbr.2010.04.045","article-title":"Human opiorphin: The lack of physiological dependence, tolerance to antinociceptive effects and abuse liability in laboratory mice","volume":"213","author":"Popik","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113651_bib57","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1177\/0269881114554274","article-title":"Interaction between \u03bc-opioid and 5-HT 1A receptors in the regulation of panic-related defensive responses in the rat dorsal periaqueductal grey","volume":"28","author":"Rangel","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib58","first-page":"18","article-title":"Sustained Resolution of Panic Disorder, Agoraphobia, and Generalized Anxiety Disorder With a Single Ketamine Infusion","volume":"18","author":"Ray","year":"2016","journal-title":"Prim. Care Companion CNS Disord."},{"key":"10.1016\/j.bbr.2021.113651_bib59","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/dneu.22283","article-title":"A single dose of S-ketamine induces long-term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation","volume":"75","author":"R\u00e9us","year":"2015","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbr.2021.113651_bib60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbr.2016.10.050","article-title":"A role for the mu opioid receptor in the antidepressant effects of buprenorphine","volume":"319","author":"Robinson","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2021.113651_bib61","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/0269881113485144","article-title":"Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT 1A and \u00b5-receptors","volume":"27","author":"Roncon","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib62","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/0269881111434619","article-title":"The panicolytic-like effect of fluoxetine in the elevated T-maze is mediated by serotonin-induced activation of endogenous opioids in the dorsal periaqueductal grey","volume":"26","author":"Roncon","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pmr.2020.02.001","article-title":"Buprenorphine in the treatment of chronic pain","volume":"31","author":"Rudolf","year":"2020","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"10.1016\/j.bbr.2021.113651_bib64","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuroscience.2011.10.032","article-title":"Evidence of a suffocation alarm system within the periaqueductal gray matter of the rat","volume":"200","author":"Schimitel","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2021.113651_bib65","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1177\/0269881114552714","article-title":"Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine","volume":"28","author":"Schimitel","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib66","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.4088\/JCP.15m09893","article-title":"Observational Evidence for Buprenorphine\u2019s Impact on Posttraumatic Stress Symptoms in Veterans With Chronic Pain and Opioid Use Disorder","volume":"77","author":"Seal","year":"2016","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib67","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.mppsy.2007.02.005","article-title":"Pharmacological treatment of panic disorder","volume":"6","author":"Seddon","year":"2007","journal-title":"Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib68","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.pnpbp.2017.08.003","article-title":"B2-kinin receptors in the dorsal periaqueductal gray are implicated in the panicolytic-like effect of opiorphin. Prog","volume":"79","author":"Sestile","year":"2017","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib69","article-title":"Ketamine effects on anxiety and fear-related behaviors: Current literature evidence and new findings. Prog. Neuro-Psychopharmacology","volume":"100","author":"Silote","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib70","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuropharm.2018.11.015","article-title":"Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat","volume":"146","author":"Smith","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113651_bib71","first-page":"2016","article-title":"New Hippocampal Neurons Mature Rapidly in Response to Ketamine But Are Not Required for Its Acute Antidepressant Effects on Neophagia in Rats. eneuro 3","volume":"0116\u201315","author":"Soumier","year":"2016","journal-title":"ENEURO"},{"key":"10.1016\/j.bbr.2021.113651_bib72","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroscience.2015.08.045","article-title":"Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia","volume":"307","author":"Spiacci","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2021.113651_bib73","first-page":"5","article-title":"The Role of High-Potency Benzodiazepines in the Treatment of Panic Disorder","volume":"07","author":"Susman","year":"2005","journal-title":"Prim. Care Companion J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib74","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1038\/s41386-019-0451-3","article-title":"Results from a long-term open-label extension study of adjunctive buprenorphine\/samidorphan combination in patients with major depressive disorder","volume":"44","author":"Thase","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2021.113651_bib75","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejphar.2008.05.031","article-title":"Involvement of the GABA\/benzodiazepine receptor in the axiolytic-like effect of nociceptin\/orphanin FQ","volume":"590","author":"Uchiyama","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib76","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/ALN.0b013e31822f16ae","article-title":"A Single Subanesthetic Dose of Ketamine Relieves Depression-like Behaviors Induced by Neuropathic Pain in Rats","volume":"115","author":"Wang","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbr.2021.113651_bib77","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.mayocp.2019.10.007","article-title":"A practical approach for the management of the mixed opioid agonist-antagonist buprenorphine during acute pain and surgery","volume":"95","author":"Warner","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.bbr.2021.113651_bib78","doi-asserted-by":"crossref","first-page":"17979","DOI":"10.1073\/pnas.0605865103","article-title":"Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways","volume":"103","author":"Wisner","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2021.113651_bib79","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2010.12.002","article-title":"The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice","volume":"489","author":"Yang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2021.113651_bib80","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/tp.2015.136","article-title":"R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects","volume":"5","author":"Yang","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib81","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41398-019-0624-1","article-title":"Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites","volume":"9","author":"Yang","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib82","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.neubiorev.2014.03.007","article-title":"Serotonin in anxiety and panic: contributions of the elevated T-maze","volume":"46","author":"Zangrossi","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2021.113651_bib83","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/mp.2017.255","article-title":"Mechanisms of ketamine action as an antidepressant","volume":"23","author":"Zanos","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2021.113651_bib84","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms","volume":"70","author":"Zanos","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbr.2021.113651_bib85","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.neuropharm.2007.01.001","article-title":"Enhanced reactivity of 5-HT1A receptors in the rat dorsal periaqueductal gray matter after chronic treatment with fluoxetine and sertraline: Evidence from the elevated T-maze","volume":"52","author":"Zanoveli","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113651_bib86","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1017\/S146114570999099X","article-title":"Facilitation of 5-HT1A-mediated neurotransmission in dorsal periaqueductal grey matter accounts for the panicolytic-like effect of chronic fluoxetine","volume":"13","author":"Zanoveli","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2021.113651_bib87","doi-asserted-by":"crossref","first-page":"145","DOI":"10.9758\/cpn.2019.17.2.145","article-title":"Pharmacological therapy in panic disorder: current guidelines and novel drugs discovery for treatment-resistant Patient","volume":"17","author":"Zulfarina","year":"2019","journal-title":"Clin. Psychopharmacol. Neurosci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821005398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821005398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:33:04Z","timestamp":1759066384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432821005398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":87,"alternative-id":["S0166432821005398"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113651","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antipanic-like effect of esketamine and buprenorphine in rats exposed to acute hypoxia","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113651","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113651"}}